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Volumn 53, Issue 9, 2012, Pages 666-682

DNA polymerase delta in dna replication and genome maintenance

Author keywords

Cancer; DNA repair; DNA synthesis; Fidelity

Indexed keywords

BRCA2 PROTEIN; DNA DIRECTED DNA POLYMERASE DELTA; DNA REPAIR PROTEIN; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; EXONUCLEASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NUCLEOTIDYLTRANSFERASE INHIBITOR; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

EID: 84868710374     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21745     Document Type: Review
Times cited : (105)

References (199)
  • 1
    • 79955092142 scopus 로고    scopus 로고
    • The in vitro fidelity of yeast DNA polymerase delta and polymerase epsilon holoenzymes during dinucleotide microsatellite DNA synthesis
    • Abdulovic AL, Hile SE, Kunkel TA, Eckert KA. 2011. The in vitro fidelity of yeast DNA polymerase delta and polymerase epsilon holoenzymes during dinucleotide microsatellite DNA synthesis. DNA Repair (Amst) 10: 497-505.
    • (2011) DNA Repair (Amst) , vol.10 , pp. 497-505
    • Abdulovic, A.L.1    Hile, S.E.2    Kunkel, T.A.3    Eckert, K.A.4
  • 3
    • 0242605710 scopus 로고    scopus 로고
    • Nucleotide excision repair of DNA with recombinant human proteins: Definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK
    • Araujo SJ, Tirode F, Coin F, Pospiech H, Syvaoja JE, Stucki M, Hubscher U, Egly JM, Wood RD. 2000. Nucleotide excision repair of DNA with recombinant human proteins: Definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK. Genes Dev 14: 349-359.
    • (2000) Genes Dev , vol.14 , pp. 349-359
    • Araujo, S.J.1    Tirode, F.2    Coin, F.3    Pospiech, H.4    Syvaoja, J.E.5    Stucki, M.6    Hubscher, U.7    Egly, J.M.8    Wood, R.D.9
  • 4
    • 0032584219 scopus 로고    scopus 로고
    • A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides
    • Astatke M, Ng K, Grindley ND, Joyce CM. 1998. A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides. Proc Natl Acad Sci USA 95: 3402-3407.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3402-3407
    • Astatke, M.1    Ng, K.2    Grindley, N.D.3    Joyce, C.M.4
  • 5
    • 73649145169 scopus 로고    scopus 로고
    • Roles of Rev1, Pol zeta, Pol32 and Pol eta in the bypass of chromosomal abasic sites in Saccharomyces cerevisiae
    • Auerbach PA, Demple B. 2010. Roles of Rev1, Pol zeta, Pol32 and Pol eta in the bypass of chromosomal abasic sites in Saccharomyces cerevisiae. Mutagenesis 25: 63-69.
    • (2010) Mutagenesis , vol.25 , pp. 63-69
    • Auerbach, P.A.1    Demple, B.2
  • 6
    • 0037449738 scopus 로고    scopus 로고
    • Okazaki fragment maturation in yeast. I. Distribution of functions between FEN1 AND DNA2
    • Ayyagari R, Gomes XV, Gordenin DA, Burgers PM. 2003. Okazaki fragment maturation in yeast. I. Distribution of functions between FEN1 AND DNA2. J Biol Chem 278: 1618-1625.
    • (2003) J Biol Chem , vol.278 , pp. 1618-1625
    • Ayyagari, R.1    Gomes, X.V.2    Gordenin, D.A.3    Burgers, P.M.4
  • 7
    • 84861216764 scopus 로고    scopus 로고
    • DNA polymerase delta and zeta switch by sharing accessory subunits of DNA polymerase delta
    • Baranovskiy AG, Lada AG, Siebler HM, Zhang Y, Pavlov YI, Tahirov TH. 2012. DNA polymerase delta and zeta switch by sharing accessory subunits of DNA polymerase delta. J Biol Chem 287: 17281-17287.
    • (2012) J Biol Chem , vol.287 , pp. 17281-17287
    • Baranovskiy, A.G.1    Lada, A.G.2    Siebler, H.M.3    Zhang, Y.4    Pavlov, Y.I.5    Tahirov, T.H.6
  • 8
    • 0037032998 scopus 로고    scopus 로고
    • Efficiency of correct nucleotide insertion governs DNA polymerase fidelity
    • Beard WA, Shock DD, Vande Berg BJ, Wilson SH. 2002. Efficiency of correct nucleotide insertion governs DNA polymerase fidelity. J Biol Chem 277: 47393-47398.
    • (2002) J Biol Chem , vol.277 , pp. 47393-47398
    • Beard, W.A.1    Shock, D.D.2    Vande Berg, B.J.3    Wilson, S.H.4
  • 9
    • 0034437672 scopus 로고    scopus 로고
    • Streisinger revisited: DNA synthesis errors mediated by substrate misalignments
    • Bebenek K, Kunkel TA. 2000. Streisinger revisited: DNA synthesis errors mediated by substrate misalignments. Cold Spring Harb Symp Quant Biol 65: 81-91.
    • (2000) Cold Spring Harb Symp Quant Biol , vol.65 , pp. 81-91
    • Bebenek, K.1    Kunkel, T.A.2
  • 10
    • 33749012528 scopus 로고    scopus 로고
    • Efficiency of carcinogenesis with and without a mutator mutation
    • Beckman RA, Loeb LA. 2006. Efficiency of carcinogenesis with and without a mutator mutation. Proc Natl Acad Sci USA 103: 14140-14145.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 14140-14145
    • Beckman, R.A.1    Loeb, L.A.2
  • 11
    • 0027231782 scopus 로고
    • Structure of DNA polymerase I Klenow fragment bound to duplex DNA
    • Beese LS, Derbyshire V, Steitz TA. 1993. Structure of DNA polymerase I Klenow fragment bound to duplex DNA. Science 260: 352-355.
    • (1993) Science , vol.260 , pp. 352-355
    • Beese, L.S.1    Derbyshire, V.2    Steitz, T.A.3
  • 12
    • 0026019625 scopus 로고
    • Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: A two metal ion mechanism
    • Beese LS, Steitz TA. 1991. Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: A two metal ion mechanism. EMBO J 10: 25-33.
    • (1991) EMBO J , vol.10 , pp. 25-33
    • Beese, L.S.1    Steitz, T.A.2
  • 13
    • 0030906056 scopus 로고    scopus 로고
    • Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomain
    • Bell JB, Eckert KA, Joyce CM, Kunkel TA. 1997. Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomain. J Biol Chem 272: 7345-7351.
    • (1997) J Biol Chem , vol.272 , pp. 7345-7351
    • Bell, J.B.1    Eckert, K.A.2    Joyce, C.M.3    Kunkel, T.A.4
  • 14
    • 0035997368 scopus 로고    scopus 로고
    • DNA replication in eukaryotic cells
    • Bell SP, Dutta A. 2002. DNA replication in eukaryotic cells. Annu Rev Biochem 71: 333-374.
    • (2002) Annu Rev Biochem , vol.71 , pp. 333-374
    • Bell, S.P.1    Dutta, A.2
  • 15
    • 0028608961 scopus 로고
    • DNA polymerase delta is required for base excision repair of DNA methylation damage in Saccharomyces cerevisiae
    • Blank A, Kim B, Loeb LA. 1994. DNA polymerase delta is required for base excision repair of DNA methylation damage in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 91: 9047-9051.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 9047-9051
    • Blank, A.1    Kim, B.2    Loeb, L.A.3
  • 16
    • 0027959469 scopus 로고
    • The thumb subdomain of T7 RNA polymerase functions to stabilize the ternary complex during processive transcription
    • Bonner G, Lafer EM, Sousa R. 1994. The thumb subdomain of T7 RNA polymerase functions to stabilize the ternary complex during processive transcription. J Biol Chem 269: 25129-25136.
    • (1994) J Biol Chem , vol.269 , pp. 25129-25136
    • Bonner, G.1    Lafer, E.M.2    Sousa, R.3
  • 17
    • 0024430208 scopus 로고
    • Structure and function of the Saccharomyces cerevisiae CDC2 gene encoding the large subunit of DNA polymerase III
    • Boulet A, Simon M, Faye G, Bauer GA, Burgers PM. 1989. Structure and function of the Saccharomyces cerevisiae CDC2 gene encoding the large subunit of DNA polymerase III. EMBO J 8: 1849-1854.
    • (1989) EMBO J , vol.8 , pp. 1849-1854
    • Boulet, A.1    Simon, M.2    Faye, G.3    Bauer, G.A.4    Burgers, P.M.5
  • 18
    • 77649165394 scopus 로고    scopus 로고
    • Maintaining genome stability at the replication fork
    • Branzei D, Foiani M. 2010. Maintaining genome stability at the replication fork. Nat Rev Mol Cell Biol 11: 208-219.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 208-219
    • Branzei, D.1    Foiani, M.2
  • 19
    • 0023091627 scopus 로고
    • Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta
    • Bravo R, Frank R, Blundell PA, Macdonald-Bravo H. 1987. Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Nature 326: 515-517.
    • (1987) Nature , vol.326 , pp. 515-517
    • Bravo, R.1    Frank, R.2    Blundell, P.A.3    Macdonald-Bravo, H.4
  • 20
    • 77957320564 scopus 로고    scopus 로고
    • Stable interactions between DNA polymerase delta catalytic and structural subunits are essential for efficient DNA repair
    • Brocas C, Charbonnier JB, Dherin C, Gangloff S, Maloisel L. 2010. Stable interactions between DNA polymerase delta catalytic and structural subunits are essential for efficient DNA repair. DNA Repair (Amst) 9: 1098-1111.
    • (2010) DNA Repair (Amst) , vol.9 , pp. 1098-1111
    • Brocas, C.1    Charbonnier, J.B.2    Dherin, C.3    Gangloff, S.4    Maloisel, L.5
  • 21
    • 63249130106 scopus 로고    scopus 로고
    • Polymerase dynamics at the eukaryotic DNA replication fork
    • Burgers PM. 2009. Polymerase dynamics at the eukaryotic DNA replication fork. J Biol Chem 284: 4041-4045.
    • (2009) J Biol Chem , vol.284 , pp. 4041-4045
    • Burgers, P.M.1
  • 22
    • 0017169587 scopus 로고
    • A new mammalian DNA polymerase with 3' to 5' exonuclease activity: DNA polymerase delta
    • Byrnes JJ, Downey KM, Black VL, So AG. 1976. A new mammalian DNA polymerase with 3' to 5' exonuclease activity: DNA polymerase delta. Biochemistry 15: 2817-2823.
    • (1976) Biochemistry , vol.15 , pp. 2817-2823
    • Byrnes, J.J.1    Downey, K.M.2    Black, V.L.3    So, A.G.4
  • 23
    • 0028075950 scopus 로고
    • Proofreading DNA: Recognition of aberrant DNA termini by the Klenow fragment of DNA polymerase I
    • Carver TEJr, Hochstrasser RA, Millar DP. 1994. Proofreading DNA: Recognition of aberrant DNA termini by the Klenow fragment of DNA polymerase I. Proc Natl Acad Sci USA 91: 10670-10674.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10670-10674
    • Carver Jr, T.E.1    Hochstrasser, R.A.2    Millar, D.P.3
  • 24
    • 0042475409 scopus 로고    scopus 로고
    • Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae
    • Chanet R, Heude M. 2003. Characterization of mutations that are synthetic lethal with pol3-13, a mutated allele of DNA polymerase delta in Saccharomyces cerevisiae. Curr Genet 43: 337-350.
    • (2003) Curr Genet , vol.43 , pp. 337-350
    • Chanet, R.1    Heude, M.2
  • 25
    • 0027164165 scopus 로고
    • Fidelity studies of the human DNA polymerase alpha. The most conserved region among alpha-like DNA polymerases is responsible for metal-induced infidelity in DNA synthesis
    • Copeland WC, Lam NK, Wang TS. 1993. Fidelity studies of the human DNA polymerase alpha. The most conserved region among alpha-like DNA polymerases is responsible for metal-induced infidelity in DNA synthesis. J Biol Chem 268: 11041-11049.
    • (1993) J Biol Chem , vol.268 , pp. 11041-11049
    • Copeland, W.C.1    Lam, N.K.2    Wang, T.S.3
  • 26
    • 0027131738 scopus 로고
    • Cloning of a mouse cDNA encoding DNA polymerase delta: Refinement of the homology boxes
    • Cullmann G, Hindges R, Berchtold MW, Hubscher U. 1993. Cloning of a mouse cDNA encoding DNA polymerase delta: Refinement of the homology boxes. Gene 134: 191-200.
    • (1993) Gene , vol.134 , pp. 191-200
    • Cullmann, G.1    Hindges, R.2    Berchtold, M.W.3    Hubscher, U.4
  • 28
    • 76349101664 scopus 로고    scopus 로고
    • A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability
    • Daee DL, Mertz TM, Shcherbakova PV. 2010. A cancer-associated DNA polymerase delta variant modeled in yeast causes a catastrophic increase in genomic instability. Proc Natl Acad Sci USA 107: 157-162.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 157-162
    • Daee, D.L.1    Mertz, T.M.2    Shcherbakova, P.V.3
  • 30
    • 33748742873 scopus 로고    scopus 로고
    • The properties of steric gate mutants reveal different constraints within the active sites of Y-family and A-family DNA polymerases
    • DeLucia AM, Chaudhuri S, Potapova O, Grindley ND, Joyce CM. 2006. The properties of steric gate mutants reveal different constraints within the active sites of Y-family and A-family DNA polymerases. J Biol Chem 281: 27286-27291.
    • (2006) J Biol Chem , vol.281 , pp. 27286-27291
    • DeLucia, A.M.1    Chaudhuri, S.2    Potapova, O.3    Grindley, N.D.4    Joyce, C.M.5
  • 31
    • 0026589375 scopus 로고
    • Generation of single-nucleotide repair patches following excision of uracil residues from DNA
    • Dianov G, Price A, Lindahl T. 1992. Generation of single-nucleotide repair patches following excision of uracil residues from DNA. Mol Cell Biol 12: 1605-1612.
    • (1992) Mol Cell Biol , vol.12 , pp. 1605-1612
    • Dianov, G.1    Price, A.2    Lindahl, T.3
  • 33
    • 0032518398 scopus 로고    scopus 로고
    • Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution
    • Doublie S, Tabor S, Long AM, Richardson CC, Ellenberger T. 1998. Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution. Nature 391: 251-258.
    • (1998) Nature , vol.391 , pp. 251-258
    • Doublie, S.1    Tabor, S.2    Long, A.M.3    Richardson, C.C.4    Ellenberger, T.5
  • 34
    • 0027471149 scopus 로고
    • General antimutators are improbable
    • Drake JW. 1993. General antimutators are improbable. J Mol Biol 229: 8-13.
    • (1993) J Mol Biol , vol.229 , pp. 8-13
    • Drake, J.W.1
  • 36
    • 0023721948 scopus 로고
    • Involvement of DNA polymerase delta in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation
    • Dresler SL, Gowans BJ, Robinson-Hill RM, Hunting DJ. 1988. Involvement of DNA polymerase delta in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation. Biochemistry 27: 6379-6383.
    • (1988) Biochemistry , vol.27 , pp. 6379-6383
    • Dresler, S.L.1    Gowans, B.J.2    Robinson-Hill, R.M.3    Hunting, D.J.4
  • 37
    • 0025783442 scopus 로고
    • Fidelity mechanisms in DNA replication
    • Echols H, Goodman MF. 1991. Fidelity mechanisms in DNA replication. Annu Rev Biochem 60: 477-511.
    • (1991) Annu Rev Biochem , vol.60 , pp. 477-511
    • Echols, H.1    Goodman, M.F.2
  • 38
    • 66349132334 scopus 로고    scopus 로고
    • Proofreading exonuclease activity of human DNA polymerase delta and its effects on lesion-bypass DNA synthesis
    • Fazlieva R, Spittle CS, Morrissey D, Hayashi H, Yan H, Matsumoto Y. 2009. Proofreading exonuclease activity of human DNA polymerase delta and its effects on lesion-bypass DNA synthesis. Nucleic Acids Res 37: 2854-2866.
    • (2009) Nucleic Acids Res , vol.37 , pp. 2854-2866
    • Fazlieva, R.1    Spittle, C.S.2    Morrissey, D.3    Hayashi, H.4    Yan, H.5    Matsumoto, Y.6
  • 39
    • 0033559182 scopus 로고    scopus 로고
    • Detection of mutations in the DNA polymerase delta gene of human sporadic colorectal cancers and colon cancer cell lines
    • Flohr T, Dai JC, Buttner J, Popanda O, Hagmuller E, Thielmann HW. 1999. Detection of mutations in the DNA polymerase delta gene of human sporadic colorectal cancers and colon cancer cell lines. Int J Cancer 80: 919-929.
    • (1999) Int J Cancer , vol.80 , pp. 919-929
    • Flohr, T.1    Dai, J.C.2    Buttner, J.3    Popanda, O.4    Hagmuller, E.5    Thielmann, H.W.6
  • 40
    • 23844522523 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae DNA polymerase delta: High fidelity for base substitutions but lower fidelity for single- and multi-base deletions
    • Fortune JM, Pavlov YI, Welch CM, Johansson E, Burgers PM, Kunkel TA. 2005. Saccharomyces cerevisiae DNA polymerase delta: High fidelity for base substitutions but lower fidelity for single- and multi-base deletions. J Biol Chem 280: 29980-29987.
    • (2005) J Biol Chem , vol.280 , pp. 29980-29987
    • Fortune, J.M.1    Pavlov, Y.I.2    Welch, C.M.3    Johansson, E.4    Burgers, P.M.5    Kunkel, T.A.6
  • 41
    • 0035369086 scopus 로고    scopus 로고
    • Structure of the replicating complex of a pol alpha family DNA polymerase
    • Franklin MC, Wang J, Steitz TA. 2001. Structure of the replicating complex of a pol alpha family DNA polymerase. Cell 105: 657-667.
    • (2001) Cell , vol.105 , pp. 657-667
    • Franklin, M.C.1    Wang, J.2    Steitz, T.A.3
  • 43
    • 28844506236 scopus 로고    scopus 로고
    • Suffering in silence: The tolerance of DNA damage
    • Friedberg EC. 2005. Suffering in silence: The tolerance of DNA damage. Nat Rev Mol Cell Biol 6: 943-953.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 943-953
    • Friedberg, E.C.1
  • 44
    • 0038192428 scopus 로고    scopus 로고
    • Characterization of the hyperrecombination phenotype of the pol3-t mutation of Saccharomyces cerevisiae
    • Galli A, Cervelli T, Schiestl RH. 2003. Characterization of the hyperrecombination phenotype of the pol3-t mutation of Saccharomyces cerevisiae. Genetics 164: 65-79.
    • (2003) Genetics , vol.164 , pp. 65-79
    • Galli, A.1    Cervelli, T.2    Schiestl, R.H.3
  • 45
    • 31044450194 scopus 로고    scopus 로고
    • Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase
    • Garcia-Diaz M, Bebenek K, Krahn JM, Pedersen LC, Kunkel TA. 2006. Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase. Cell 124: 331-342.
    • (2006) Cell , vol.124 , pp. 331-342
    • Garcia-Diaz, M.1    Bebenek, K.2    Krahn, J.M.3    Pedersen, L.C.4    Kunkel, T.A.5
  • 46
    • 8644285427 scopus 로고    scopus 로고
    • Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication
    • Garg P, Stith CM, Sabouri N, Johansson E, Burgers PM. 2004. Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication. Genes Dev 18: 2764-2773.
    • (2004) Genes Dev , vol.18 , pp. 2764-2773
    • Garg, P.1    Stith, C.M.2    Sabouri, N.3    Johansson, E.4    Burgers, P.M.5
  • 47
    • 0032584658 scopus 로고    scopus 로고
    • Characterization of the two small subunits of Saccharomyces cerevisiae DNA polymerase delta
    • Gerik KJ, Li X, Pautz A, Burgers PM. 1998. Characterization of the two small subunits of Saccharomyces cerevisiae DNA polymerase delta. J Biol Chem 273: 19747-19755.
    • (1998) J Biol Chem , vol.273 , pp. 19747-19755
    • Gerik, K.J.1    Li, X.2    Pautz, A.3    Burgers, P.M.4
  • 48
    • 0030814759 scopus 로고    scopus 로고
    • Involvement of the yeast DNA polymerase delta in DNA repair in vivo
    • Giot L, Chanet R, Simon M, Facca C, Faye G. 1997. Involvement of the yeast DNA polymerase delta in DNA repair in vivo. Genetics 146: 1239-1251.
    • (1997) Genetics , vol.146 , pp. 1239-1251
    • Giot, L.1    Chanet, R.2    Simon, M.3    Facca, C.4    Faye, G.5
  • 51
    • 0030924437 scopus 로고    scopus 로고
    • Hydrogen bonding revisited: geometric selection as a principal determinant of DNA replication fidelity
    • Goodman MF. 1997. Hydrogen bonding revisited: geometric selection as a principal determinant of DNA replication fidelity. Proc Natl Acad Sci USA 94: 10493-10495.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10493-10495
    • Goodman, M.F.1
  • 52
    • 0035014740 scopus 로고    scopus 로고
    • Identification of a mutant DNA polymerase delta in Saccharomyces cerevisiae with an antimutator phenotype for frameshift mutations
    • Hadjimarcou MI, Kokoska RJ, Petes TD, Reha-Krantz LJ. 2001. Identification of a mutant DNA polymerase delta in Saccharomyces cerevisiae with an antimutator phenotype for frameshift mutations. Genetics 158: 177-186.
    • (2001) Genetics , vol.158 , pp. 177-186
    • Hadjimarcou, M.I.1    Kokoska, R.J.2    Petes, T.D.3    Reha-Krantz, L.J.4
  • 53
    • 35549010590 scopus 로고    scopus 로고
    • Pol32 is required for Pol zeta-dependent translesion synthesis and prevents double-strand breaks at the replication fork
    • Hanna M, Ball LG, Tong AH, Boone C, Xiao W. 2007. Pol32 is required for Pol zeta-dependent translesion synthesis and prevents double-strand breaks at the replication fork. Mutat Res 625: 164-176.
    • (2007) Mutat Res , vol.625 , pp. 164-176
    • Hanna, M.1    Ball, L.G.2    Tong, A.H.3    Boone, C.4    Xiao, W.5
  • 54
    • 0033782569 scopus 로고    scopus 로고
    • Sequence composition and context effects on the generation and repair of frameshift intermediates in mononucleotide runs in Saccharomyces cerevisiae
    • Harfe BD, Jinks-Robertson S. 2000. Sequence composition and context effects on the generation and repair of frameshift intermediates in mononucleotide runs in Saccharomyces cerevisiae. Genetics 156: 571-578.
    • (2000) Genetics , vol.156 , pp. 571-578
    • Harfe, B.D.1    Jinks-Robertson, S.2
  • 55
    • 0345060498 scopus 로고    scopus 로고
    • Fidelity of DNA polymerase delta holoenzyme from Saccharomyces cerevisiae: The sliding clamp proliferating cell nuclear antigen decreases its fidelity
    • Hashimoto K, Shimizu K, Nakashima N, Sugino A. 2003. Fidelity of DNA polymerase delta holoenzyme from Saccharomyces cerevisiae: The sliding clamp proliferating cell nuclear antigen decreases its fidelity. Biochemistry 42: 14207-14213.
    • (2003) Biochemistry , vol.42 , pp. 14207-14213
    • Hashimoto, K.1    Shimizu, K.2    Nakashima, N.3    Sugino, A.4
  • 58
    • 2342537864 scopus 로고    scopus 로고
    • Crystallographic snapshots of a replicative DNA polymerase encountering an abasic site
    • Hogg M, Wallace SS, Doublie S. 2004. Crystallographic snapshots of a replicative DNA polymerase encountering an abasic site. EMBO J 23: 1483-1493.
    • (2004) EMBO J , vol.23 , pp. 1483-1493
    • Hogg, M.1    Wallace, S.S.2    Doublie, S.3
  • 59
    • 0033525095 scopus 로고    scopus 로고
    • Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases
    • Holmes AM, Haber JE. 1999. Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases. Cell 96: 415-424.
    • (1999) Cell , vol.96 , pp. 415-424
    • Holmes, A.M.1    Haber, J.E.2
  • 60
    • 81855189485 scopus 로고    scopus 로고
    • Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates
    • Hombauer H, Campbell CS, Smith CE, Desai A, Kolodner RD. 2011. Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates. Cell 147: 1040-1053.
    • (2011) Cell , vol.147 , pp. 1040-1053
    • Hombauer, H.1    Campbell, C.S.2    Smith, C.E.3    Desai, A.4    Kolodner, R.D.5
  • 61
    • 0036242094 scopus 로고    scopus 로고
    • Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase delta, suppresses genomic deletions and is involved in the mutagenic bypass pathway
    • Huang ME, Rio AG, Galibert MD, Galibert F. 2002. Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase delta, suppresses genomic deletions and is involved in the mutagenic bypass pathway. Genetics 160: 1409-1422.
    • (2002) Genetics , vol.160 , pp. 1409-1422
    • Huang, M.E.1    Rio, A.G.2    Galibert, M.D.3    Galibert, F.4
  • 64
    • 0033562536 scopus 로고    scopus 로고
    • Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts
    • Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G. 1999. Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts. Nucleic Acids Res 27: 2108-2114.
    • (1999) Nucleic Acids Res , vol.27 , pp. 2108-2114
    • Hughes, P.1    Tratner, I.2    Ducoux, M.3    Piard, K.4    Baldacci, G.5
  • 65
    • 0026149320 scopus 로고
    • DNA polymerase delta mediates excision repair in growing cells damaged with ultraviolet radiation
    • Hunting DJ, Gowans BJ, Dresler SL. 1991. DNA polymerase delta mediates excision repair in growing cells damaged with ultraviolet radiation. Biochem Cell Biol 69: 303-308.
    • (1991) Biochem Cell Biol , vol.69 , pp. 303-308
    • Hunting, D.J.1    Gowans, B.J.2    Dresler, S.L.3
  • 66
    • 0037163128 scopus 로고    scopus 로고
    • DNA template requirements for human mismatch repair in vitro
    • Iams K, Larson ED, Drummond JT. 2002. DNA template requirements for human mismatch repair in vitro. J Biol Chem 277: 30805-30814.
    • (2002) J Biol Chem , vol.277 , pp. 30805-30814
    • Iams, K.1    Larson, E.D.2    Drummond, J.T.3
  • 67
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
    • Ionov Y, Peinado MA, Malkhosyan S, Shibata D, Perucho M. 1993. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363: 558-561.
    • (1993) Nature , vol.363 , pp. 558-561
    • Ionov, Y.1    Peinado, M.A.2    Malkhosyan, S.3    Shibata, D.4    Perucho, M.5
  • 68
    • 33947381026 scopus 로고    scopus 로고
    • The roles of Tyr391 and Tyr619 in RB69 DNA polymerase replication fidelity
    • Jacewicz A, Makiela K, Kierzek A, Drake JW, Bebenek A. 2007. The roles of Tyr391 and Tyr619 in RB69 DNA polymerase replication fidelity. J Mol Biol 368: 18-29.
    • (2007) J Mol Biol , vol.368 , pp. 18-29
    • Jacewicz, A.1    Makiela, K.2    Kierzek, A.3    Drake, J.W.4    Bebenek, A.5
  • 69
    • 70350704561 scopus 로고    scopus 로고
    • Structural insights into yeast DNA polymerase delta by small angle X-ray scattering
    • Jain R, Hammel M, Johnson RE, Prakash L, Prakash S, Aggarwal AK. 2009. Structural insights into yeast DNA polymerase delta by small angle X-ray scattering. J Mol Biol 394: 377-382.
    • (2009) J Mol Biol , vol.394 , pp. 377-382
    • Jain, R.1    Hammel, M.2    Johnson, R.E.3    Prakash, L.4    Prakash, S.5    Aggarwal, A.K.6
  • 70
    • 73149101630 scopus 로고    scopus 로고
    • Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells
    • Janssen A, Kops GJ, Medema RH. 2009. Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells. Proc Natl Acad Sci USA 106: 19108-19113.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 19108-19113
    • Janssen, A.1    Kops, G.J.2    Medema, R.H.3
  • 71
    • 0037449727 scopus 로고    scopus 로고
    • Okazaki fragment maturation in yeast. II. Cooperation between the polymerase and 3'-5'-exonuclease activities of Pol delta in the creation of a ligatable nick
    • Jin YH, Ayyagari R, Resnick MA, Gordenin DA, Burgers PM. 2003. Okazaki fragment maturation in yeast. II. Cooperation between the polymerase and 3'-5'-exonuclease activities of Pol delta in the creation of a ligatable nick. J Biol Chem 278: 1626-1633.
    • (2003) J Biol Chem , vol.278 , pp. 1626-1633
    • Jin, Y.H.1    Ayyagari, R.2    Resnick, M.A.3    Gordenin, D.A.4    Burgers, P.M.5
  • 72
    • 19944401050 scopus 로고    scopus 로고
    • The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains
    • Jin YH, Garg P, Stith CM, Al-Refai H, Sterling JF, Murray LJ, Kunkel TA, Resnick MA, Burgers PM, Gordenin DA. 2005. The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains. Mol Cell Biol 25: 461-471.
    • (2005) Mol Cell Biol , vol.25 , pp. 461-471
    • Jin, Y.H.1    Garg, P.2    Stith, C.M.3    Al-Refai, H.4    Sterling, J.F.5    Murray, L.J.6    Kunkel, T.A.7    Resnick, M.A.8    Burgers, P.M.9    Gordenin, D.A.10
  • 73
    • 0035942104 scopus 로고    scopus 로고
    • The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability
    • Jin YH, Obert R, Burgers PM, Kunkel TA, Resnick MA, Gordenin DA. 2001. The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability. Proc Natl Acad Sci USA 98: 5122-5127.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5122-5127
    • Jin, Y.H.1    Obert, R.2    Burgers, P.M.3    Kunkel, T.A.4    Resnick, M.A.5    Gordenin, D.A.6
  • 74
    • 0027220197 scopus 로고
    • Conformational coupling in DNA polymerase fidelity
    • Johnson KA. 1993. Conformational coupling in DNA polymerase fidelity. Annu Rev Biochem 62: 685-713.
    • (1993) Annu Rev Biochem , vol.62 , pp. 685-713
    • Johnson, K.A.1
  • 75
    • 84864512844 scopus 로고    scopus 로고
    • Pol31 and Pol32 subunits of yeast DNA polymerase delta are also essential subunits of DNA polymerase zeta
    • Johnson RE, Prakash L, Prakash S. 2012. Pol31 and Pol32 subunits of yeast DNA polymerase delta are also essential subunits of DNA polymerase zeta. Proc Natl Acad Sci USA 109: 12455-12460.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 12455-12460
    • Johnson, R.E.1    Prakash, L.2    Prakash, S.3
  • 76
    • 1642588255 scopus 로고    scopus 로고
    • Structures of mismatch replication errors observed in a DNA polymerase
    • Johnson SJ, Beese LS. 2004. Structures of mismatch replication errors observed in a DNA polymerase. Cell 116: 803-816.
    • (2004) Cell , vol.116 , pp. 803-816
    • Johnson, S.J.1    Beese, L.S.2
  • 77
    • 0031042722 scopus 로고    scopus 로고
    • Choosing the right sugar: How polymerases select a nucleotide substrate
    • Joyce CM. 1997. Choosing the right sugar: How polymerases select a nucleotide substrate. Proc Natl Acad Sci USA 94: 1619-1622.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1619-1622
    • Joyce, C.M.1
  • 78
    • 0028881713 scopus 로고
    • Polymerase structures and function: Variations on a theme?
    • Joyce CM, Steitz TA. 1995. Polymerase structures and function: Variations on a theme? J Bacteriol 177: 6321-6329.
    • (1995) J Bacteriol , vol.177 , pp. 6321-6329
    • Joyce, C.M.1    Steitz, T.A.2
  • 80
    • 0032587610 scopus 로고    scopus 로고
    • DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viability
    • Kesti T, Flick K, Keranen S, Syvaoja JE, Wittenberg C. 1999. DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viability. Mol Cell 3: 679-685.
    • (1999) Mol Cell , vol.3 , pp. 679-685
    • Kesti, T.1    Flick, K.2    Keranen, S.3    Syvaoja, J.E.4    Wittenberg, C.5
  • 81
    • 80052713687 scopus 로고    scopus 로고
    • Ub-family modifications at the replication fork: Regulating PCNA-interacting components
    • Kirchmaier AL. 2011. Ub-family modifications at the replication fork: Regulating PCNA-interacting components. FEBS Lett 585: 2920-2928.
    • (2011) FEBS Lett , vol.585 , pp. 2920-2928
    • Kirchmaier, A.L.1
  • 82
    • 0033800646 scopus 로고    scopus 로고
    • Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase delta
    • Kokoska RJ, Stefanovic L, DeMai J, Petes TD. 2000. Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase delta. Mol Cell Biol 20: 7490-7504.
    • (2000) Mol Cell Biol , vol.20 , pp. 7490-7504
    • Kokoska, R.J.1    Stefanovic, L.2    DeMai, J.3    Petes, T.D.4
  • 83
    • 0035997351 scopus 로고    scopus 로고
    • Active site tightness and substrate fit in DNA replication
    • Kool ET. 2002. Active site tightness and substrate fit in DNA replication. Annu Rev Biochem 71: 191-219.
    • (2002) Annu Rev Biochem , vol.71 , pp. 191-219
    • Kool, E.T.1
  • 84
    • 0030025084 scopus 로고    scopus 로고
    • Exonucleolytic proofreading during replication of repetitive DNA
    • Kroutil LC, Register K, Bebenek K, Kunkel TA. 1996. Exonucleolytic proofreading during replication of repetitive DNA. Biochemistry 35: 1046-1053.
    • (1996) Biochemistry , vol.35 , pp. 1046-1053
    • Kroutil, L.C.1    Register, K.2    Bebenek, K.3    Kunkel, T.A.4
  • 85
    • 80053562457 scopus 로고    scopus 로고
    • Balancing eukaryotic replication asymmetry with replication fidelity
    • Kunkel TA. 2011. Balancing eukaryotic replication asymmetry with replication fidelity. Curr Opin Chem Biol 15: 620-626.
    • (2011) Curr Opin Chem Biol , vol.15 , pp. 620-626
    • Kunkel, T.A.1
  • 88
    • 0023790391 scopus 로고
    • Mutagenesis by transient misalignment
    • Kunkel TA, Soni A. 1988. Mutagenesis by transient misalignment. J Biol Chem 263: 14784-14789.
    • (1988) J Biol Chem , vol.263 , pp. 14784-14789
    • Kunkel, T.A.1    Soni, A.2
  • 91
    • 0021769832 scopus 로고
    • Further studies on calf thymus DNA polymerase delta purified to homogeneity by a new procedure
    • Lee MY, Tan CK, Downey KM, So AG. 1984. Further studies on calf thymus DNA polymerase delta purified to homogeneity by a new procedure. Biochemistry 23: 1906-1913.
    • (1984) Biochemistry , vol.23 , pp. 1906-1913
    • Lee, M.Y.1    Tan, C.K.2    Downey, K.M.3    So, A.G.4
  • 92
    • 79960347948 scopus 로고    scopus 로고
    • DNA polymerases and repair synthesis in NER in human cells
    • Lehmann AR. 2011. DNA polymerases and repair synthesis in NER in human cells. DNA Repair (Amst) 10: 730-733.
    • (2011) DNA Repair (Amst) , vol.10 , pp. 730-733
    • Lehmann, A.R.1
  • 93
    • 50249159576 scopus 로고    scopus 로고
    • Reduced levels of DNA polymerase delta induce chromosome fragile site instability in yeast
    • Lemoine FJ, Degtyareva NP, Kokoska RJ, Petes TD. 2008. Reduced levels of DNA polymerase delta induce chromosome fragile site instability in yeast. Mol Cell Biol 28: 5359-5368.
    • (2008) Mol Cell Biol , vol.28 , pp. 5359-5368
    • Lemoine, F.J.1    Degtyareva, N.P.2    Kokoska, R.J.3    Petes, T.D.4
  • 94
    • 38049125557 scopus 로고    scopus 로고
    • Mechanisms and functions of DNA mismatch repair
    • Li GM. 2008. Mechanisms and functions of DNA mismatch repair. Cell Res 18: 85-98.
    • (2008) Cell Res , vol.18 , pp. 85-98
    • Li, G.M.1
  • 95
    • 22144436659 scopus 로고    scopus 로고
    • Sensitivity to phosphonoacetic acid: A new phenotype to probe DNA polymerase delta in Saccharomyces cerevisiae
    • Li L, Murphy KM, Kanevets U, Reha-Krantz LJ. 2005. Sensitivity to phosphonoacetic acid: A new phenotype to probe DNA polymerase delta in Saccharomyces cerevisiae. Genetics 170: 569-580.
    • (2005) Genetics , vol.170 , pp. 569-580
    • Li, L.1    Murphy, K.M.2    Kanevets, U.3    Reha-Krantz, L.J.4
  • 96
    • 70449672959 scopus 로고    scopus 로고
    • PCNA is required for initiation of recombination-associated DNA synthesis by DNA polymerase delta
    • Li X, Stith CM, Burgers PM, Heyer WD. 2009. PCNA is required for initiation of recombination-associated DNA synthesis by DNA polymerase delta. Mol Cell 36: 704-713.
    • (2009) Mol Cell , vol.36 , pp. 704-713
    • Li, X.1    Stith, C.M.2    Burgers, P.M.3    Heyer, W.D.4
  • 97
    • 0034705617 scopus 로고    scopus 로고
    • Identification of a fourth subunit of mammalian DNA polymerase delta
    • Liu L, Mo J, Rodriguez-Belmonte EM, Lee MY. 2000. Identification of a fourth subunit of mammalian DNA polymerase delta. J Biol Chem 275: 18739-18744.
    • (2000) J Biol Chem , vol.275 , pp. 18739-18744
    • Liu, L.1    Mo, J.2    Rodriguez-Belmonte, E.M.3    Lee, M.Y.4
  • 98
    • 67650688146 scopus 로고    scopus 로고
    • Targeting the DNA damage response in cancer
    • Ljungman M. 2009. Targeting the DNA damage response in cancer. Chem Rev 109: 2929-2950.
    • (2009) Chem Rev , vol.109 , pp. 2929-2950
    • Ljungman, M.1
  • 99
    • 47649100711 scopus 로고    scopus 로고
    • DNA polymerases and human disease
    • Loeb LA, Monnat RJJr. 2008. DNA polymerases and human disease. Nat Rev Genet 9: 594-604.
    • (2008) Nat Rev Genet , vol.9 , pp. 594-604
    • Loeb, L.A.1    Monnat Jr, R.J.2
  • 100
    • 0038387494 scopus 로고    scopus 로고
    • 5-fluorouracil: Mechanisms of action and clinical strategies
    • Longley DB, Harkin DP, Johnston PG. 2003. 5-fluorouracil: Mechanisms of action and clinical strategies. Nat Rev Cancer 3: 330-338.
    • (2003) Nat Rev Cancer , vol.3 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 101
    • 0030935386 scopus 로고    scopus 로고
    • DNA polymerase delta is required for human mismatch repair in vitro
    • Longley MJ, Pierce AJ, Modrich P. 1997. DNA polymerase delta is required for human mismatch repair in vitro. J Biol Chem 272: 10917-10921.
    • (1997) J Biol Chem , vol.272 , pp. 10917-10921
    • Longley, M.J.1    Pierce, A.J.2    Modrich, P.3
  • 102
    • 34547864244 scopus 로고    scopus 로고
    • Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase
    • Luo G, Wang M, Konigsberg WH, Xie XS. 2007. Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase. Proc Natl Acad Sci USA 104: 12610-12615.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 12610-12615
    • Luo, G.1    Wang, M.2    Konigsberg, W.H.3    Xie, X.S.4
  • 103
    • 34547927220 scopus 로고    scopus 로고
    • Break-induced replication and telomerase-independent telomere maintenance require Pol32
    • Lydeard JR, Jain S, Yamaguchi M, Haber JE. 2007. Break-induced replication and telomerase-independent telomere maintenance require Pol32. Nature 448: 820-823.
    • (2007) Nature , vol.448 , pp. 820-823
    • Lydeard, J.R.1    Jain, S.2    Yamaguchi, M.3    Haber, J.E.4
  • 104
    • 80053186097 scopus 로고    scopus 로고
    • Coordination of DNA replication and recombination activities in the maintenance of genome stability
    • Maher RL, Branagan AM, Morrical SW. 2011. Coordination of DNA replication and recombination activities in the maintenance of genome stability. J Cell Biochem 112: 2672-2682.
    • (2011) J Cell Biochem , vol.112 , pp. 2672-2682
    • Maher, R.L.1    Branagan, A.M.2    Morrical, S.W.3
  • 105
    • 3843078655 scopus 로고    scopus 로고
    • A role for DNA polymerase delta in gene conversion and crossing over during meiosis in Saccharomyces cerevisiae
    • Maloisel L, Bhargava J, Roeder GS. 2004. A role for DNA polymerase delta in gene conversion and crossing over during meiosis in Saccharomyces cerevisiae. Genetics 167: 1133-1142.
    • (2004) Genetics , vol.167 , pp. 1133-1142
    • Maloisel, L.1    Bhargava, J.2    Roeder, G.S.3
  • 106
    • 33746539166 scopus 로고    scopus 로고
    • DNA precursor metabolism and genomic stability
    • Mathews CK. 2006. DNA precursor metabolism and genomic stability. FASEB J 20: 1300-1304.
    • (2006) FASEB J , vol.20 , pp. 1300-1304
    • Mathews, C.K.1
  • 107
    • 0025816883 scopus 로고
    • Repair of a synthetic abasic site involves concerted reactions of DNA synthesis followed by excision and ligation
    • Matsumoto Y, Bogenhagen DF. 1991. Repair of a synthetic abasic site involves concerted reactions of DNA synthesis followed by excision and ligation. Mol Cell Biol 11: 4441-4447.
    • (1991) Mol Cell Biol , vol.11 , pp. 4441-4447
    • Matsumoto, Y.1    Bogenhagen, D.F.2
  • 108
    • 66249093490 scopus 로고    scopus 로고
    • The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases delta and eta
    • McCulloch SD, Kokoska RJ, Garg P, Burgers PM, Kunkel TA. 2009. The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases delta and eta. Nucleic Acids Res 37: 2830-2840.
    • (2009) Nucleic Acids Res , vol.37 , pp. 2830-2840
    • McCulloch, S.D.1    Kokoska, R.J.2    Garg, P.3    Burgers, P.M.4    Kunkel, T.A.5
  • 109
    • 77951690551 scopus 로고    scopus 로고
    • The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis
    • Meng X, Zhou Y, Lee EY, Lee MY, Frick DN. 2010. The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis. Biochemistry 49: 3545-3554.
    • (2010) Biochemistry , vol.49 , pp. 3545-3554
    • Meng, X.1    Zhou, Y.2    Lee, E.Y.3    Lee, M.Y.4    Frick, D.N.5
  • 110
    • 0029784881 scopus 로고    scopus 로고
    • A thumb subdomain mutant of the large fragment of Escherichia coli DNA polymerase I with reduced DNA binding affinity, processivity, and frameshift fidelity
    • Minnick DT, Astatke M, Joyce CM, Kunkel TA. 1996. A thumb subdomain mutant of the large fragment of Escherichia coli DNA polymerase I with reduced DNA binding affinity, processivity, and frameshift fidelity. J Biol Chem 271: 24954-24961.
    • (1996) J Biol Chem , vol.271 , pp. 24954-24961
    • Minnick, D.T.1    Astatke, M.2    Joyce, C.M.3    Kunkel, T.A.4
  • 111
    • 0030803659 scopus 로고    scopus 로고
    • Strand-specific mismatch repair in mammalian cells
    • Modrich P. 1997. Strand-specific mismatch repair in mammalian cells. J Biol Chem 272: 24727-24730.
    • (1997) J Biol Chem , vol.272 , pp. 24727-24730
    • Modrich, P.1
  • 112
    • 33750083332 scopus 로고    scopus 로고
    • Mechanisms in eukaryotic mismatch repair
    • Modrich P. 2006. Mechanisms in eukaryotic mismatch repair. J Biol Chem 281: 30305-30309.
    • (2006) J Biol Chem , vol.281 , pp. 30305-30309
    • Modrich, P.1
  • 113
    • 0026004621 scopus 로고
    • Eukaryotic DNA polymerase amino acid sequence required for 3'→5' exonuclease activity
    • Morrison A, Bell JB, Kunkel TA, Sugino A. 1991. Eukaryotic DNA polymerase amino acid sequence required for 3'→5' exonuclease activity. Proc Natl Acad Sci USA 88: 9473-9477.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 9473-9477
    • Morrison, A.1    Bell, J.B.2    Kunkel, T.A.3    Sugino, A.4
  • 114
    • 0027417017 scopus 로고
    • Pathway correcting DNA replication errors in Saccharomyces cerevisiae
    • Morrison A, Johnson AL, Johnston LH, Sugino A. 1993. Pathway correcting DNA replication errors in Saccharomyces cerevisiae. EMBO J 12: 1467-1473.
    • (1993) EMBO J , vol.12 , pp. 1467-1473
    • Morrison, A.1    Johnson, A.L.2    Johnston, L.H.3    Sugino, A.4
  • 115
    • 0028174896 scopus 로고
    • The 3'→5' exonucleases of both DNA polymerases delta and epsilon participate in correcting errors of DNA replication in Saccharomyces cerevisiae
    • Morrison A, Sugino A. 1994. The 3'→5' exonucleases of both DNA polymerases delta and epsilon participate in correcting errors of DNA replication in Saccharomyces cerevisiae. Mol Gen Genet 242: 289-296.
    • (1994) Mol Gen Genet , vol.242 , pp. 289-296
    • Morrison, A.1    Sugino, A.2
  • 117
    • 0030986238 scopus 로고    scopus 로고
    • Proliferating cell nuclear antigen promotes DNA synthesis past template lesions by mammalian DNA polymerase delta
    • Mozzherin DJ, Shibutani S, Tan CK, Downey KM, Fisher PA. 1997. Proliferating cell nuclear antigen promotes DNA synthesis past template lesions by mammalian DNA polymerase delta. Proc Natl Acad Sci USA 94: 6126-6131.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 6126-6131
    • Mozzherin, D.J.1    Shibutani, S.2    Tan, C.K.3    Downey, K.M.4    Fisher, P.A.5
  • 118
    • 0015524064 scopus 로고
    • Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4
    • Muzyczka N, Poland RL, Bessman MJ. 1972. Studies on the biochemical basis of spontaneous mutation. I. A comparison of the deoxyribonucleic acid polymerases of mutator, antimutator, and wild type strains of bacteriophage T4. J Biol Chem 247: 7116-7122.
    • (1972) J Biol Chem , vol.247 , pp. 7116-7122
    • Muzyczka, N.1    Poland, R.L.2    Bessman, M.J.3
  • 120
    • 0024962334 scopus 로고
    • Recognition and binding of template-primers containing defined abasic sites by Drosophila DNA polymerase alpha holoenzyme
    • Ng L, Weiss SJ, Fisher PA. 1989. Recognition and binding of template-primers containing defined abasic sites by Drosophila DNA polymerase alpha holoenzyme. J Biol Chem 264: 13018-13023.
    • (1989) J Biol Chem , vol.264 , pp. 13018-13023
    • Ng, L.1    Weiss, S.J.2    Fisher, P.A.3
  • 123
    • 34047260752 scopus 로고    scopus 로고
    • Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta
    • Nick McElhinny SA, Stith CM, Burgers PM, Kunkel TA. 2007. Inefficient proofreading and biased error rates during inaccurate DNA synthesis by a mutant derivative of Saccharomyces cerevisiae DNA polymerase delta. J Biol Chem 282: 2324-2332.
    • (2007) J Biol Chem , vol.282 , pp. 2324-2332
    • Nick McElhinny, S.A.1    Stith, C.M.2    Burgers, P.M.3    Kunkel, T.A.4
  • 126
    • 77952582936 scopus 로고    scopus 로고
    • Replication through an abasic DNA lesion: Structural basis for adenine selectivity
    • Obeid S, Blatter N, Kranaster R, Schnur A, Diederichs K, Welte W, Marx A. 2010. Replication through an abasic DNA lesion: Structural basis for adenine selectivity. EMBO J 29: 1738-1747.
    • (2010) EMBO J , vol.29 , pp. 1738-1747
    • Obeid, S.1    Blatter, N.2    Kranaster, R.3    Schnur, A.4    Diederichs, K.5    Welte, W.6    Marx, A.7
  • 127
    • 0038604759 scopus 로고    scopus 로고
    • Distinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha
    • Ogawa M, Limsirichaikul S, Niimi A, Iwai S, Yoshida S, Suzuki M. 2003. Distinct function of conserved amino acids in the fingers of Saccharomyces cerevisiae DNA polymerase alpha. J Biol Chem 278: 19071-19078.
    • (2003) J Biol Chem , vol.278 , pp. 19071-19078
    • Ogawa, M.1    Limsirichaikul, S.2    Niimi, A.3    Iwai, S.4    Yoshida, S.5    Suzuki, M.6
  • 130
    • 34047132773 scopus 로고    scopus 로고
    • DNA polymerase delta-dependent repair of DNA single strand breaks containing 3'-end proximal lesions
    • Parsons JL, Preston BD, O'Connor TR, Dianov GL. 2007. DNA polymerase delta-dependent repair of DNA single strand breaks containing 3'-end proximal lesions. Nucleic Acids Res 35: 1054-1063.
    • (2007) Nucleic Acids Res , vol.35 , pp. 1054-1063
    • Parsons, J.L.1    Preston, B.D.2    O'Connor, T.R.3    Dianov, G.L.4
  • 131
    • 0035895911 scopus 로고    scopus 로고
    • A single highly mutable catalytic site amino acid is critical for DNA polymerase fidelity
    • Patel PH, Kawate H, Adman E, Ashbach M, Loeb LA. 2001. A single highly mutable catalytic site amino acid is critical for DNA polymerase fidelity. J Biol Chem 276: 5044-5051.
    • (2001) J Biol Chem , vol.276 , pp. 5044-5051
    • Patel, P.H.1    Kawate, H.2    Adman, E.3    Ashbach, M.4    Loeb, L.A.5
  • 132
    • 0034704124 scopus 로고    scopus 로고
    • Multiple amino acid substitutions allow DNA polymerases to synthesize RNA
    • Patel PH, Loeb LA. 2000. Multiple amino acid substitutions allow DNA polymerases to synthesize RNA. J Biol Chem 275: 40266-40272.
    • (2000) J Biol Chem , vol.275 , pp. 40266-40272
    • Patel, P.H.1    Loeb, L.A.2
  • 133
    • 0026033193 scopus 로고
    • Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant
    • Patel SS, Wong I, Johnson KA. 1991. Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant. Biochemistry 30: 511-525.
    • (1991) Biochemistry , vol.30 , pp. 511-525
    • Patel, S.S.1    Wong, I.2    Johnson, K.A.3
  • 134
  • 135
    • 0038371133 scopus 로고    scopus 로고
    • Evidence for preferential mismatch repair of lagging strand DNA replication errors in yeast
    • Pavlov YI, Mian IM, Kunkel TA. 2003. Evidence for preferential mismatch repair of lagging strand DNA replication errors in yeast. Curr Biol 13: 744-748.
    • (2003) Curr Biol , vol.13 , pp. 744-748
    • Pavlov, Y.I.1    Mian, I.M.2    Kunkel, T.A.3
  • 136
    • 0036345594 scopus 로고    scopus 로고
    • Yeast origins establish a strand bias for replicational mutagenesis
    • Pavlov YI, Newlon CS, Kunkel TA. 2002. Yeast origins establish a strand bias for replicational mutagenesis. Mol Cell 10: 207-213.
    • (2002) Mol Cell , vol.10 , pp. 207-213
    • Pavlov, Y.I.1    Newlon, C.S.2    Kunkel, T.A.3
  • 137
    • 75749086797 scopus 로고    scopus 로고
    • DNA polymerases at the eukaryotic fork-20 years later
    • Pavlov YI, Shcherbakova PV. 2010. DNA polymerases at the eukaryotic fork-20 years later. Mutat Res 685: 45-53.
    • (2010) Mutat Res , vol.685 , pp. 45-53
    • Pavlov, Y.I.1    Shcherbakova, P.V.2
  • 138
    • 0034805293 scopus 로고    scopus 로고
    • In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta
    • Pavlov YI, Shcherbakova PV, Kunkel TA. 2001. In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta. Genetics 159: 47-64.
    • (2001) Genetics , vol.159 , pp. 47-64
    • Pavlov, Y.I.1    Shcherbakova, P.V.2    Kunkel, T.A.3
  • 139
    • 0025315748 scopus 로고
    • Hydrolysis of 3'-terminal mispairs in vitro by the 3'→5' exonuclease of DNA polymerase delta permits subsequent extension by DNA polymerase alpha
    • Perrino FW, Loeb LA. 1990. Hydrolysis of 3'-terminal mispairs in vitro by the 3'→5' exonuclease of DNA polymerase delta permits subsequent extension by DNA polymerase alpha. Biochemistry 29: 5226-5231.
    • (1990) Biochemistry , vol.29 , pp. 5226-5231
    • Perrino, F.W.1    Loeb, L.A.2
  • 140
    • 0037040170 scopus 로고    scopus 로고
    • Reconstitution of human DNA polymerase delta using recombinant baculoviruses: The p12 subunit potentiates DNA polymerizing activity of the four-subunit enzyme
    • Podust VN, Chang LS, Ott R, Dianov GL, Fanning E. 2002. Reconstitution of human DNA polymerase delta using recombinant baculoviruses: The p12 subunit potentiates DNA polymerizing activity of the four-subunit enzyme. J Biol Chem 277: 3894-3901.
    • (2002) J Biol Chem , vol.277 , pp. 3894-3901
    • Podust, V.N.1    Chang, L.S.2    Ott, R.3    Dianov, G.L.4    Fanning, E.5
  • 141
    • 0026713678 scopus 로고
    • Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli
    • Polesky AH, Dahlberg ME, Benkovic SJ, Grindley ND, Joyce CM. 1992. Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli. J Biol Chem 267: 8417-8428.
    • (1992) J Biol Chem , vol.267 , pp. 8417-8428
    • Polesky, A.H.1    Dahlberg, M.E.2    Benkovic, S.J.3    Grindley, N.D.4    Joyce, C.M.5
  • 142
    • 0032712407 scopus 로고    scopus 로고
    • A mutation detected in DNA polymerase delta cDNA from Novikoff hepatoma cells correlates with abnormal catalytic properties of the enzyme
    • Popanda O, Flohr T, Fox G, Thielmann HW. 1999. A mutation detected in DNA polymerase delta cDNA from Novikoff hepatoma cells correlates with abnormal catalytic properties of the enzyme. J Cancer Res Clin Oncol 125: 598-608.
    • (1999) J Cancer Res Clin Oncol , vol.125 , pp. 598-608
    • Popanda, O.1    Flohr, T.2    Fox, G.3    Thielmann, H.W.4
  • 144
    • 77957989064 scopus 로고    scopus 로고
    • The mutator phenotype in cancer: Molecular mechanisms and targeting strategies
    • Prindle MJ, Fox EJ, Loeb LA. 2010. The mutator phenotype in cancer: Molecular mechanisms and targeting strategies. Curr Drug Targets 11: 1296-1303.
    • (2010) Curr Drug Targets , vol.11 , pp. 1296-1303
    • Prindle, M.J.1    Fox, E.J.2    Loeb, L.A.3
  • 145
    • 58049215354 scopus 로고    scopus 로고
    • The p21 and PCNA partnership: A new twist for an old plot
    • Prives C, Gottifredi V. 2008. The p21 and PCNA partnership: A new twist for an old plot. Cell Cycle 7: 3840-3846.
    • (2008) Cell Cycle , vol.7 , pp. 3840-3846
    • Prives, C.1    Gottifredi, V.2
  • 146
    • 84859965553 scopus 로고    scopus 로고
    • Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication
    • Punchihewa C, Inoue A, Hishiki A, Fujikawa Y, Connelly M, Evison B, Shao Y, Heath R, Kuraoka I, Rodrigues P, et al. 2012. Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem 287: 14289-14300.
    • (2012) J Biol Chem , vol.287 , pp. 14289-14300
    • Punchihewa, C.1    Inoue, A.2    Hishiki, A.3    Fujikawa, Y.4    Connelly, M.5    Evison, B.6    Shao, Y.7    Heath, R.8    Kuraoka, I.9    Rodrigues, P.10
  • 147
    • 34250642401 scopus 로고    scopus 로고
    • Regulation of B family DNA polymerase fidelity by a conserved active site residue: Characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon
    • Pursell ZF, Isoz I, Lundstrom EB, Johansson E, Kunkel TA. 2007a. Regulation of B family DNA polymerase fidelity by a conserved active site residue: Characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon. Nucleic Acids Res 35: 3076-3086.
    • (2007) Nucleic Acids Res , vol.35 , pp. 3076-3086
    • Pursell, Z.F.1    Isoz, I.2    Lundstrom, E.B.3    Johansson, E.4    Kunkel, T.A.5
  • 148
    • 34447336941 scopus 로고    scopus 로고
    • Yeast DNA polymerase epsilon participates in leading-strand DNA replication
    • Pursell ZF, Isoz I, Lundstrom EB, Johansson E, Kunkel TA. 2007b. Yeast DNA polymerase epsilon participates in leading-strand DNA replication. Science 317: 127-130.
    • (2007) Science , vol.317 , pp. 127-130
    • Pursell, Z.F.1    Isoz, I.2    Lundstrom, E.B.3    Johansson, E.4    Kunkel, T.A.5
  • 149
    • 84863012802 scopus 로고    scopus 로고
    • Phosphorylation of the p68 subunit of Pol delta acts as a molecular switch to regulate its interaction with PCNA
    • Rahmeh AA, Zhou Y, Xie B, Li H, Lee EY, Lee MY. 2012. Phosphorylation of the p68 subunit of Pol delta acts as a molecular switch to regulate its interaction with PCNA. Biochemistry 51: 416-424.
    • (2012) Biochemistry , vol.51 , pp. 416-424
    • Rahmeh, A.A.1    Zhou, Y.2    Xie, B.3    Li, H.4    Lee, E.Y.5    Lee, M.Y.6
  • 150
    • 0031943693 scopus 로고    scopus 로고
    • Regulation of DNA polymerase exonucleolytic proofreading activity: Studies of bacteriophage T4"antimutator"DNA polymerases
    • Reha-Krantz LJ. 1998. Regulation of DNA polymerase exonucleolytic proofreading activity: Studies of bacteriophage T4"antimutator"DNA polymerases. Genetics 148: 1551-1557.
    • (1998) Genetics , vol.148 , pp. 1551-1557
    • Reha-Krantz, L.J.1
  • 151
    • 77949568225 scopus 로고    scopus 로고
    • DNA polymerase proofreading: Multiple roles maintain genome stability
    • Reha-Krantz LJ. 2010. DNA polymerase proofreading: Multiple roles maintain genome stability. Biochim Biophys Acta 1804: 1049-1063.
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 1049-1063
    • Reha-Krantz, L.J.1
  • 152
    • 0027998846 scopus 로고
    • Motif A of bacteriophage T4 DNA polymerase: role in primer extension and DNA replication fidelity. Isolation of new antimutator and mutator DNA polymerases
    • Reha-Krantz LJ, Nonay RL. 1994. Motif A of bacteriophage T4 DNA polymerase: role in primer extension and DNA replication fidelity. Isolation of new antimutator and mutator DNA polymerases. J Biol Chem 269: 5635-5643.
    • (1994) J Biol Chem , vol.269 , pp. 5635-5643
    • Reha-Krantz, L.J.1    Nonay, R.L.2
  • 153
    • 84857411787 scopus 로고    scopus 로고
    • Y-family DNA polymerases and their role in tolerance of cellular DNA damage
    • Sale JE, Lehmann AR, Woodgate R. 2012. Y-family DNA polymerases and their role in tolerance of cellular DNA damage. Nat Rev Mol Cell Biol 13: 141-152.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 141-152
    • Sale, J.E.1    Lehmann, A.R.2    Woodgate, R.3
  • 154
    • 3543069892 scopus 로고    scopus 로고
    • The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit
    • Sanchez Garcia J, Ciufo LF, Yang X, Kearsey SE, MacNeill SA. 2004. The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit. Nucleic Acids Res 32: 3005-3016.
    • (2004) Nucleic Acids Res , vol.32 , pp. 3005-3016
    • Sanchez Garcia, J.1    Ciufo, L.F.2    Yang, X.3    Kearsey, S.E.4    MacNeill, S.A.5
  • 155
    • 0028136070 scopus 로고
    • Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism
    • Sawaya MR, Pelletier H, Kumar A, Wilson SH, Kraut J. 1994. Crystal structure of rat DNA polymerase beta: evidence for a common polymerase mechanism. Science 264: 1930-1935.
    • (1994) Science , vol.264 , pp. 1930-1935
    • Sawaya, M.R.1    Pelletier, H.2    Kumar, A.3    Wilson, S.H.4    Kraut, J.5
  • 156
    • 0020650113 scopus 로고
    • Infidelity of DNA synthesis associated with bypass of apurinic sites
    • Schaaper RM, Kunkel TA, Loeb LA. 1983. Infidelity of DNA synthesis associated with bypass of apurinic sites. Proc Natl Acad Sci USA 80: 487-491.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 487-491
    • Schaaper, R.M.1    Kunkel, T.A.2    Loeb, L.A.3
  • 157
    • 67651215705 scopus 로고    scopus 로고
    • High fidelity and lesion bypass capability of human DNA polymerase delta
    • Schmitt MW, Matsumoto Y, Loeb LA. 2009. High fidelity and lesion bypass capability of human DNA polymerase delta. Biochimie 91: 1163-1172.
    • (2009) Biochimie , vol.91 , pp. 1163-1172
    • Schmitt, M.W.1    Matsumoto, Y.2    Loeb, L.A.3
  • 158
    • 77957762113 scopus 로고    scopus 로고
    • Active site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression
    • Schmitt MW, Venkatesan RN, Pillaire MJ, Hoffmann JS, Sidorova JM, Loeb LA. 2010. Active site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression. J Biol Chem 285: 32264-32272.
    • (2010) J Biol Chem , vol.285 , pp. 32264-32272
    • Schmitt, M.W.1    Venkatesan, R.N.2    Pillaire, M.J.3    Hoffmann, J.S.4    Sidorova, J.M.5    Loeb, L.A.6
  • 159
    • 0032692565 scopus 로고    scopus 로고
    • Building a replisome from interacting pieces: Sliding clamp complexed to a peptide from DNA polymerase and a polymerase editing complex
    • Shamoo Y, Steitz TA. 1999. Building a replisome from interacting pieces: Sliding clamp complexed to a peptide from DNA polymerase and a polymerase editing complex. Cell 99: 155-166.
    • (1999) Cell , vol.99 , pp. 155-166
    • Shamoo, Y.1    Steitz, T.A.2
  • 160
    • 33745823841 scopus 로고    scopus 로고
    • Ribonucleotide reductase inhibitors and future drug design
    • Shao J, Zhou B, Chu B, Yen Y. 2006. Ribonucleotide reductase inhibitors and future drug design. Curr Cancer Drug Targets 6: 409-431.
    • (2006) Curr Cancer Drug Targets , vol.6 , pp. 409-431
    • Shao, J.1    Zhou, B.2    Chu, B.3    Yen, Y.4
  • 161
    • 0035374671 scopus 로고    scopus 로고
    • The conserved active site motif A of Escherichia coli DNA polymerase I is highly mutable
    • Shinkai A, Patel PH, Loeb LA. 2001. The conserved active site motif A of Escherichia coli DNA polymerase I is highly mutable. J Biol Chem 276: 18836-18842.
    • (2001) J Biol Chem , vol.276 , pp. 18836-18842
    • Shinkai, A.1    Patel, P.H.2    Loeb, L.A.3
  • 162
    • 0030897578 scopus 로고    scopus 로고
    • Microsatellite instability in yeast: Dependence on repeat unit size and DNA mismatch repair genes
    • Sia EA, Kokoska RJ, Dominska M, Greenwell P, Petes TD. 1997. Microsatellite instability in yeast: Dependence on repeat unit size and DNA mismatch repair genes. Mol Cell Biol 17: 2851-2858.
    • (1997) Mol Cell Biol , vol.17 , pp. 2851-2858
    • Sia, E.A.1    Kokoska, R.J.2    Dominska, M.3    Greenwell, P.4    Petes, T.D.5
  • 163
    • 0025900035 scopus 로고
    • The 3' to 5' exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication
    • Simon M, Giot L, Faye G. 1991. The 3' to 5' exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication. EMBO J 10: 2165-2170.
    • (1991) EMBO J , vol.10 , pp. 2165-2170
    • Simon, M.1    Giot, L.2    Faye, G.3
  • 164
    • 0024977355 scopus 로고
    • DNA polymerase III, a second essential DNA polymerase, is encoded by the S. cerevisiae CDC2 gene
    • Sitney KC, Budd ME, Campbell JL. 1989. DNA polymerase III, a second essential DNA polymerase, is encoded by the S. cerevisiae CDC2 gene. Cell 56: 599-605.
    • (1989) Cell , vol.56 , pp. 599-605
    • Sitney, K.C.1    Budd, M.E.2    Campbell, J.L.3
  • 165
    • 62849117547 scopus 로고    scopus 로고
    • Aberrant double-strand break repair resulting in half crossovers in mutants defective for Rad51 or the DNA polymerase delta complex
    • Smith CE, Lam AF, Symington LS. 2009. Aberrant double-strand break repair resulting in half crossovers in mutants defective for Rad51 or the DNA polymerase delta complex. Mol Cell Biol 29: 1432-1441.
    • (2009) Mol Cell Biol , vol.29 , pp. 1432-1441
    • Smith, C.E.1    Lam, A.F.2    Symington, L.S.3
  • 166
    • 0028892405 scopus 로고
    • Dynamics of bacteriophage T4 DNA polymerase function: Identification of amino acid residues that affect switching between polymerase and 3'→5' exonuclease activities
    • Stocki SA, Nonay RL, Reha-Krantz LJ. 1995. Dynamics of bacteriophage T4 DNA polymerase function: Identification of amino acid residues that affect switching between polymerase and 3'→5' exonuclease activities. J Mol Biol 254: 15-28.
    • (1995) J Mol Biol , vol.254 , pp. 15-28
    • Stocki, S.A.1    Nonay, R.L.2    Reha-Krantz, L.J.3
  • 167
    • 0013997442 scopus 로고
    • Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthday
    • Streisinger G, Okada Y, Emrich J, Newton J, Tsugita A, Terzaghi E, Inouye M. 1966. Frameshift mutations and the genetic code. This paper is dedicated to Professor Theodosius Dobzhansky on the occasion of his 66th birthday. Cold Spring Harb Symp Quant Biol 31: 77-84.
    • (1966) Cold Spring Harb Symp Quant Biol , vol.31 , pp. 77-84
    • Streisinger, G.1    Okada, Y.2    Emrich, J.3    Newton, J.4    Tsugita, A.5    Terzaghi, E.6    Inouye, M.7
  • 168
    • 34247880545 scopus 로고    scopus 로고
    • Directed DNA polymerase evolution: effects of mutations in motif C on the mismatch-extension selectivity of thermus aquaticus DNA polymerase
    • Strerath M, Gloeckner C, Liu D, Schnur A, Marx A. 2007. Directed DNA polymerase evolution: effects of mutations in motif C on the mismatch-extension selectivity of thermus aquaticus DNA polymerase. Chembiochem 8: 395-401.
    • (2007) Chembiochem , vol.8 , pp. 395-401
    • Strerath, M.1    Gloeckner, C.2    Liu, D.3    Schnur, A.4    Marx, A.5
  • 169
    • 44949150331 scopus 로고    scopus 로고
    • Use of 2-aminopurine fluorescence to study the role of the beta hairpin in the proofreading pathway catalyzed by the phage T4 and RB69 DNA polymerases
    • Subuddhi U, Hogg M, Reha-Krantz LJ. 2008. Use of 2-aminopurine fluorescence to study the role of the beta hairpin in the proofreading pathway catalyzed by the phage T4 and RB69 DNA polymerases. Biochemistry 47: 6130-6137.
    • (2008) Biochemistry , vol.47 , pp. 6130-6137
    • Subuddhi, U.1    Hogg, M.2    Reha-Krantz, L.J.3
  • 170
    • 0029845979 scopus 로고    scopus 로고
    • Random mutagenesis of Thermus aquaticus DNA polymerase I: Concordance of immutable sites in vivo with the crystal structure
    • Suzuki M, Baskin D, Hood L, Loeb LA. 1996. Random mutagenesis of Thermus aquaticus DNA polymerase I: Concordance of immutable sites in vivo with the crystal structure. Proc Natl Acad Sci USA 93: 9670-9675.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9670-9675
    • Suzuki, M.1    Baskin, D.2    Hood, L.3    Loeb, L.A.4
  • 171
    • 0034693321 scopus 로고    scopus 로고
    • Thermus aquaticus DNA polymerase I mutants with altered fidelity. Interacting mutations in the O-helix
    • Suzuki M, Yoshida S, Adman ET, Blank A, Loeb LA. 2000. Thermus aquaticus DNA polymerase I mutants with altered fidelity. Interacting mutations in the O-helix. J Biol Chem 275: 32728-32735.
    • (2000) J Biol Chem , vol.275 , pp. 32728-32735
    • Suzuki, M.1    Yoshida, S.2    Adman, E.T.3    Blank, A.4    Loeb, L.A.5
  • 174
    • 0025646208 scopus 로고
    • Eukaryotic DNA replication. Enzymes and proteins acting at the fork
    • Thommes P, Hubscher U. 1990. Eukaryotic DNA replication. Enzymes and proteins acting at the fork. Eur J Biochem 194: 699-712.
    • (1990) Eur J Biochem , vol.194 , pp. 699-712
    • Thommes, P.1    Hubscher, U.2
  • 175
    • 0037154094 scopus 로고    scopus 로고
    • Determinants of DNA mismatch recognition within the polymerase domain of the Klenow fragment
    • Thompson EH, Bailey MF, van der Schans EJ, Joyce CM, Millar DP. 2002. Determinants of DNA mismatch recognition within the polymerase domain of the Klenow fragment. Biochemistry 41: 713-722.
    • (2002) Biochemistry , vol.41 , pp. 713-722
    • Thompson, E.H.1    Bailey, M.F.2    van der Schans, E.J.3    Joyce, C.M.4    Millar, D.P.5
  • 176
    • 34249935010 scopus 로고    scopus 로고
    • Maintenance of fork integrity at damaged DNA and natural pause sites
    • Tourriere H, Pasero P. 2007. Maintenance of fork integrity at damaged DNA and natural pause sites. DNA Repair (Amst) 6: 900-913.
    • (2007) DNA Repair (Amst) , vol.6 , pp. 900-913
    • Tourriere, H.1    Pasero, P.2
  • 177
    • 67349086074 scopus 로고    scopus 로고
    • Different behaviors in vivo of mutations in the beta hairpin loop of the DNA polymerases of the closely related phages T4 and RB69
    • Trzemecka A, Plochocka D, Bebenek A. 2009. Different behaviors in vivo of mutations in the beta hairpin loop of the DNA polymerases of the closely related phages T4 and RB69. J Mol Biol 389: 797-807.
    • (2009) J Mol Biol , vol.389 , pp. 797-807
    • Trzemecka, A.1    Plochocka, D.2    Bebenek, A.3
  • 178
    • 33747462891 scopus 로고    scopus 로고
    • A new paradigm for DNA polymerase specificity
    • Tsai YC, Johnson KA. 2006. A new paradigm for DNA polymerase specificity. Biochemistry 45: 9675-9687.
    • (2006) Biochemistry , vol.45 , pp. 9675-9687
    • Tsai, Y.C.1    Johnson, K.A.2
  • 180
    • 63049106529 scopus 로고    scopus 로고
    • Regulating post-translational modifications of the eukaryotic replication clamp PCNA
    • Ulrich HD. 2009. Regulating post-translational modifications of the eukaryotic replication clamp PCNA. DNA Repair (Amst) 8: 461-469.
    • (2009) DNA Repair (Amst) , vol.8 , pp. 461-469
    • Ulrich, H.D.1
  • 183
    • 78649702212 scopus 로고    scopus 로고
    • Replication and recombination factors contributing to recombination-dependent bypass of DNA lesions by template switch
    • Vanoli F, Fumasoni M, Szakal B, Maloisel L, Branzei D. 2010. Replication and recombination factors contributing to recombination-dependent bypass of DNA lesions by template switch. PLoS Genet 6: e1001205.
    • (2010) PLoS Genet , vol.6
    • Vanoli, F.1    Fumasoni, M.2    Szakal, B.3    Maloisel, L.4    Branzei, D.5
  • 184
    • 33645216188 scopus 로고    scopus 로고
    • Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta
    • Venkatesan RN, Hsu JJ, Lawrence NA, Preston BD, Loeb LA. 2006. Mutator phenotypes caused by substitution at a conserved motif A residue in eukaryotic DNA polymerase delta. J Biol Chem 281: 4486-4494.
    • (2006) J Biol Chem , vol.281 , pp. 4486-4494
    • Venkatesan, R.N.1    Hsu, J.J.2    Lawrence, N.A.3    Preston, B.D.4    Loeb, L.A.5
  • 186
    • 0031587827 scopus 로고    scopus 로고
    • Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69
    • Wang J, Sattar AK, Wang CC, Karam JD, Konigsberg WH, Steitz TA. 1997. Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69. Cell 89: 1087-1099.
    • (1997) Cell , vol.89 , pp. 1087-1099
    • Wang, J.1    Sattar, A.K.2    Wang, C.C.3    Karam, J.D.4    Konigsberg, W.H.5    Steitz, T.A.6
  • 187
    • 79952077426 scopus 로고    scopus 로고
    • Insights into base selectivity from the 1.8 A resolution structure of an RB69 DNA polymerase ternary complex
    • Wang M, Xia S, Blaha G, Steitz TA, Konigsberg WH, Wang J. 2011a. Insights into base selectivity from the 1.8 A resolution structure of an RB69 DNA polymerase ternary complex. Biochemistry 50: 581-590.
    • (2011) Biochemistry , vol.50 , pp. 581-590
    • Wang, M.1    Xia, S.2    Blaha, G.3    Steitz, T.A.4    Konigsberg, W.H.5    Wang, J.6
  • 188
    • 80355136489 scopus 로고    scopus 로고
    • P50, the small subunit of DNA polymerase delta, is required for mediation of the interaction of polymerase delta subassemblies with PCNA
    • Wang Y, Zhang Q, Chen H, Li X, Mai W, Chen K, Zhang S, Lee EY, Lee MY, Zhou Y. 2011b. P50, the small subunit of DNA polymerase delta, is required for mediation of the interaction of polymerase delta subassemblies with PCNA. PLoS One 6: e27092.
    • (2011) PLoS One , vol.6
    • Wang, Y.1    Zhang, Q.2    Chen, H.3    Li, X.4    Mai, W.5    Chen, K.6    Zhang, S.7    Lee, E.Y.8    Lee, M.Y.9    Zhou, Y.10
  • 190
    • 0028297952 scopus 로고
    • Inhibitor analysis of calf thymus DNA polymerases alpha, delta and epsilon
    • Wright GE, Hubscher U, Khan NN, Focher F, Verri A. 1994. Inhibitor analysis of calf thymus DNA polymerases alpha, delta and epsilon. FEBS Lett 341: 128-130.
    • (1994) FEBS Lett , vol.341 , pp. 128-130
    • Wright, G.E.1    Hubscher, U.2    Khan, N.N.3    Focher, F.4    Verri, A.5
  • 191
    • 0037072265 scopus 로고    scopus 로고
    • A conserved Tyr residue is required for sugar selectivity in a Pol alpha DNA polymerase
    • Yang G, Franklin M, Li J, Lin TC, Konigsberg W. 2002a. A conserved Tyr residue is required for sugar selectivity in a Pol alpha DNA polymerase. Biochemistry 41: 10256-10261.
    • (2002) Biochemistry , vol.41 , pp. 10256-10261
    • Yang, G.1    Franklin, M.2    Li, J.3    Lin, T.C.4    Konigsberg, W.5
  • 192
    • 0037176870 scopus 로고    scopus 로고
    • Correlation of the kinetics of finger domain mutants in RB69 DNA polymerase with its structure
    • Yang G, Franklin M, Li J, Lin TC, Konigsberg W. 2002b. Correlation of the kinetics of finger domain mutants in RB69 DNA polymerase with its structure. Biochemistry 41: 2526-2534.
    • (2002) Biochemistry , vol.41 , pp. 2526-2534
    • Yang, G.1    Franklin, M.2    Li, J.3    Lin, T.C.4    Konigsberg, W.5
  • 193
    • 14644432415 scopus 로고    scopus 로고
    • Base selectivity is impaired by mutants that perturb hydrogen bonding networks in the RB69 DNA polymerase active site
    • Yang G, Wang J, Konigsberg W. 2005. Base selectivity is impaired by mutants that perturb hydrogen bonding networks in the RB69 DNA polymerase active site. Biochemistry 44: 3338-3346.
    • (2005) Biochemistry , vol.44 , pp. 3338-3346
    • Yang, G.1    Wang, J.2    Konigsberg, W.3
  • 194
    • 79958072354 scopus 로고    scopus 로고
    • DNA polymerases provide a canon of strategies for translesion synthesis past oxidatively generated lesions
    • Zahn KE, Wallace SS, Doublie S. 2011. DNA polymerases provide a canon of strategies for translesion synthesis past oxidatively generated lesions. Curr Opin Struct Biol 21: 358-369.
    • (2011) Curr Opin Struct Biol , vol.21 , pp. 358-369
    • Zahn, K.E.1    Wallace, S.S.2    Doublie, S.3
  • 195
    • 34447558592 scopus 로고    scopus 로고
    • A novel DNA damage response: Rapid degradation of the p12 subunit of DNA polymerase delta
    • Zhang S, Zhou Y, Trusa S, Meng X, Lee EY, Lee MY. 2007. A novel DNA damage response: Rapid degradation of the p12 subunit of DNA polymerase delta. J Biol Chem 282: 15330-15340.
    • (2007) J Biol Chem , vol.282 , pp. 15330-15340
    • Zhang, S.1    Zhou, Y.2    Trusa, S.3    Meng, X.4    Lee, E.Y.5    Lee, M.Y.6
  • 196
    • 79951500316 scopus 로고    scopus 로고
    • Okazaki fragment maturation: Nucleases take centre stage
    • Zheng L, Shen B. 2011. Okazaki fragment maturation: Nucleases take centre stage. J Mol Cell Biol 3: 23-30.
    • (2011) J Mol Cell Biol , vol.3 , pp. 23-30
    • Zheng, L.1    Shen, B.2
  • 197
    • 47249093333 scopus 로고    scopus 로고
    • Characterization of a replicative DNA polymerase mutant with reduced fidelity and increased translesion synthesis capacity
    • Zhong X, Pedersen LC, Kunkel TA. 2008. Characterization of a replicative DNA polymerase mutant with reduced fidelity and increased translesion synthesis capacity. Nucleic Acids Res 36: 3892-3904.
    • (2008) Nucleic Acids Res , vol.36 , pp. 3892-3904
    • Zhong, X.1    Pedersen, L.C.2    Kunkel, T.A.3
  • 199
    • 84862502745 scopus 로고    scopus 로고
    • Characterization of human DNA polymerase delta and its subassemblies reconstituted by expression in the multibac system
    • Zhou Y, Meng X, Zhang S, Lee EY, Lee MY. 2012b. Characterization of human DNA polymerase delta and its subassemblies reconstituted by expression in the multibac system. PLoS One 7: e39156.
    • (2012) PLoS One , vol.7
    • Zhou, Y.1    Meng, X.2    Zhang, S.3    Lee, E.Y.4    Lee, M.Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.