A cancer-associated DNA polymerase δ variant modeled in yeast causes a catastrophic increase in genomic instability

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 1, 2010, Pages 157-162

  Daee, Danielle L ^a,b   Mertz, Tony M ^a   Shcherbakova, Polina V ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

Colon cancer; DNA synthesis fidelity; Mutator; SNP; Transient hypermutagenesis

Indexed keywords

DNA; DNA POLYMERASE;

AMINO ACID SUBSTITUTION; ARTICLE; CANCER GROWTH; CELL DEATH; COLORECTAL CARCINOMA; CONTROLLED STUDY; DIPLOIDY; DNA DAMAGE; DNA SYNTHESIS; FUNGAL STRAIN; GENE EXPRESSION; GENE MUTATION; GENETIC VARIABILITY; GENOMIC INSTABILITY; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; LABELING INDEX; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; WILD TYPE; YEAST;

AMINO ACID SEQUENCE; DNA DAMAGE; DNA POLYMERASE III; GENOMIC INSTABILITY; HUMANS; ISOENZYMES; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS; POLYMORPHISM, GENETIC; SACCHAROMYCES CEREVISIAE;

EUKARYOTA;

EID: 76349101664     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0907526106     Document Type: Article

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