Efficiency of carcinogenesis with and without a mutator mutation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 38, 2006, Pages 14140-14145

  Beckman, Robert A ^a   Loeb, Lawrence A ^b  

^a CENTOCOR INC   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Mathematical model; Mutator hypothesis

Indexed keywords

MUTAGENIC AGENT;

ARTICLE; CANCER GENETICS; CARCINOGENESIS; GENE MUTATION; GENOMIC INSTABILITY; HUMAN; MALIGNANT NEOPLASTIC DISEASE; MATHEMATICAL MODEL; NONHUMAN; ONCOGENE; PREDICTION; PRIORITY JOURNAL; PROBABILITY; QUANTITATIVE ANALYSIS; TUMOR SUPPRESSOR GENE;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; MATHEMATICS; MODELS, THEORETICAL; MUTATION; NEOPLASMS; PHENOTYPE; PROBABILITY;

EID: 33749012528     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0606271103     Document Type: Article

References (34)

1. Nordling CO (1953) Br J Cancer 7:68-72.
2. Armitage P, Doll R (1954) Br J Cancer 8:1-12.
3. Cook PJ, Doll R, Fellingham SA (1969) Int J Cancer 4:93-112.
4. Hanahan D, Weinberg RA (2000) Cell 100:57-70.
5. Rangarajan A, Hong SJ, Gifford A, Weinberg RA (2004) Cancer Cell 6:171-183.
6. Loeb LA, Springgate CF, Battula N (1974) Cancer Res 34:2311-2321.
7. Ionov Y, Peinado MA, Malkhoysan S, Shibata S, Perucho M (1993) Nature 363:558-561.
8. Fishel R, Lescoe MK, Rao MRS, Copeland NG, Jenkins NA, Garber J, Kane M, Kolodner R (1993) Cell 75:1027-1038.
9. Lengauer C, Kinzler KW, Vogelstein B (1998) Nature 396:643-649.
10. Paulovich AG, Toczyski DP, Hartwell LH (1997) Cell 88:315-321.
11. Nowell PC (1976) Science 194:23-28.
12. Tomlinson IPM, Novelli MR, Bodmer WF (1996) Proc Natl Acad Sci USA 93:14800-14803.
13. Fisher JC (1958) Nature 181:651-652.
14. Cairns J (1975) Nature 255:197-200.
15. Beckman RA, Loeb LA (2005) Genetics 171:2123-2131.
16. Fearon ER, Vogelstein B (1990) Cell 61:759-767.
17. Balaban GB, Herlyn M, Clark WH, Jr, Nowell PC (1986) Cancer Genet Cytogenet 19:112-122.
18. Knudson AG (1993) Proc Natl Acad Sci USA 90:10914-10921.
19. Nowak MA, Michor F, Komarova NL, Iwasa Y (2004) Proc Natl Acad Sci USA 101:10635-10638.
20. Knudson AG (1971) Proc Natl Acad Sci USA 101:820-823.
21. Cook PJ, Doll R, Fellingham SA (1969) Int J Cancer 4:93-112.
22. Beckman RA, Loeb LA (2005) Semin Cancer Biol 15:423-435.
23. Cervantes RB, Stringer JR, Shao C, Tischfield JA, Stambrook PJ (2002) Proc Natl Acad Sci USA 99:3586-3590.
24. Albertini RJ, Nicklas JA, O'Neill JP, Robison SH (1990) Annu Rev Genet 24:305-326.
25. Baca OG, Tacheeni OS, Akporiaye ET, Deblasie R, Crissman HA (1985) Infect Immun 47:366-369.
26. Baker FL, Sanger LJ, Rodgers RW, Jabboury K, Mangini OR (1995) Cell Prolif 28:1-15.
27. Tomlinson I, Sasieni P, Bodmer W (2002) Am J Pathol 100:755-758.
28. Kolodner RD, Putnam CD, Myung K (2002) Science 297:552-557.
29. Guo HH, Choe J, Loeb LA (2004) Proc Natl Acad Sci USA 101:9205-9210.
30. Beckman RA, Loeb LA (1993) Q Rev Biophys 26:225-331.
31. Camps M, Naukkarinen J, Johnson BP, Loeb LA (2003) Proc Natl Acad Sci USA 100:9727-9732.
32. Hethcote HW, Knudson AG (1978) Proc Natl Acad Sci USA 75:2453-2457.
33. Venkatesan N, Hsu JJ, Lawrence NA, Preston BD, Loeb LA (2006) J Biol Chem, in press.
34. Eigen M (2002) Proc Natl Acad Sci USA 99:13374-13376.