Base miscoding and strand misalignment errors by mutator Klenow polymerases with amino acid substitutions at tyrosine 766 in the O helix of the fingers subdomain

Journal of Biological Chemistry

Volumn 272, Issue 11, 1997, Pages 7345-7351

  Bell, Juliette B ^a,c   Eckert, Kristin A ^a,d   Joyce, Catherine M ^b   Kunkel, Thomas A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b YALE UNIVERSITY   (United States)

^c FAYETTEVILLE STATE UNIVERSITY   (United States)

^d PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; BASE MISPAIRING; DNA HELIX; FRAMESHIFT MUTATION; GENE DELETION; GENE INSERTION; GENE MUTATION; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROTEIN DOMAIN;

BASE SEQUENCE; DNA POLYMERASE I; FRAMESHIFT MUTATION; GENE DELETION; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROTEIN FOLDING; TYROSINE;

EID: 0030906056     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.11.7345     Document Type: Article

References (34)

1. Echols, H., and Goodman, M. F. (1991) Annu. Rev. Biochem. 60, 477-511
2. Roberts, J. D., and Kunkel, T. A. (1996) in DNA Replication in Eukaryotic Cells: Concepts, Enzymes & Systems (De Pamphilis, M., ed) pp. 217-247, Cold Spring Harbor Laboratories, Cold Spring Harbor, NY
3. Johnson, K. A. (1993) Annu. Rev. Biochem. 62, 685-713
4. Streisinger, G., Okada, Y., Emrich, J., Newton, J., Tsugita, A., Terzaghi, E., and Inouye, M. (1966) Cold Spring Harbor Symp. Quant. Biol. 31, 77-84
5. Joyce, C. M., and Steitz, T. A. (1995) J. Bacteriol. 177, 6321-6329
6. Jacobo-Molina, A., Ding, J., Nanni, R. G., Clark, A. D., Jr., Lu, X., Tantillo, C., Williams, R. L., Kramer, G., Ferris, A., Clark, P., Hizi, A., Hughes, S. H., and Arnold, E. (1990) Proc. Natl. Acad. Sci. U. S. A. 90, 6320-6324
7. Bebenek, K., Abbotts, J., Roberts, J. D., Wilson, S. H., and Kunkel, T. A. (1989) J. Biol. Chem. 264, 16948-16956
8. Beard, W. A., Stahl, S. J., Kim, H.-R., Bebenek, K., Kumar, A., Strub, M.-P., Becerra, S. P., Kunkel, T. A., and Wilson, S. H. (1995) J. Biol. Chem. 269, 28091-28097
9. Bebenek, K., Beard, W. A., Casas-Finet, J. R., Kim, H.-R., Darden, T. A., Wilson, S. H., and Kunkel, T. A. (1995) J. Biol. Chem. 270, 19516-19523
10. Minnick, D. T., Astatke, M., Joyce, C. M., and Kunkel, T. A. (1996) J. Biol. Chem. 271, 24954-24961
11. Joyce, C. M., and Steitz, T. A. (1994) Annu. Rev. Biochem. 63, 777-822
12. Astatke, M., Grindley, N. D. F., and Joyce, C. M. (1995) J. Biol. Chem. 270, 1945-1954
13. Carroll, S. S., Cowart, M., and Benkovic, S. J. (1991) Biochemistry 30, 804-813
14. Tabor, S., and Richardson, C. R. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 6339-6343
15. Polesky, A. H., Steitz, T. A., Grindley, N. D. F., and Joyce, C. M. (1990) J. Biol. Chem. 265, 14579-14591
16. Derbyshire. V., Freemont, P. S., Sanderson, M. R., Beese, L., Friedman, J. M., Joyce, C. M., and Steitz, T. A. (1988) Science 240, 199-201
17. Bebenek, K, and Kunkel, T. A. (1995) Methods Enzymol. 262, 217-232
18. Eckert, K. A., and Kunkel, T. A. (1993) J. Biol. Chem. 268, 13462-13471
19. Bebenek, K, Joyce, C. M., Fitzgerald, M. P., and Kunkel, T. A. (1990) J. Biol. Chem. 265, 13878-13887
20. Cai, H., Yu, H., McEntee, K., Kunkel, T. A., and Goodman, M. F. (1995) J. Biol. Chem. 270, 15327-15335
21. Casella, G., and Berger, R. (1990) in Statistical Inference, p. 381, Wadsworth and Brooks/Cole, Pacific Grove, CA
22. Bebenek, K., Abbotts, J., Wilson, S. H., and Kunkel, T. A. (1993) J. Biol. Chem. 268, 10324-10334
23. Joyce, C. M. (1989) J. Biol. Chem. 264, 10858-10866
24. Joyce, C. M., Sun, X. C., and Grindley, N. D. F. (1992) J. Biol. Chem. 267, 24485-24500
25. Mendelman, L. V., Boosalis, M. S., Petruska, J., and Goodman, M. F. (1989) J. Biol. Chem. 264, 14415-14423
26. Mendelman, L. V., Petruska, J., and Goodman, M. F. (1990) J. Biol. Chem. 265, 2338-2346
27. Bebenek, K., and Kunkel, T. A. (1990) Proc. Natl. Acad. U. S. A. 87, 4946-4950
28. Bebenek, K., Roberts, J. D., and Kunkel, T. A. (1992) J. Biol. Chem. 267, 3589-3596
29. Kunkel, T. A., and Soni, A. (1988) J. Biol. Chem. 263, 14784-14789
30. Kunkel, T. A. (1990) Biochemistry 29, 8003-8011
31. Beese, L. S., Derbyshire, V., and Steitz, T. A. (1993) Science 260, 352-355
32. Eom, S. H., Wang, J., and Steitz, T. A. (1996) Nature 382, 278-281
33. Pelletier, H., Sawaya, M. R., Kumar, A., Wilson, S. H., and Kraut, J. (1994) Science 264, 1891-1903
34. Beard, W. A., Osheroff, W. P., Prasad, R., Sawaya, M. R., Jaju, M., Wood, T. G., Kraut, J., Kunkel, T. A., and Wilson, S. H. (1996) J. Biol. Chem. 271, 12141-12144