Mutation at the polymerase active site of mouse DNA polymerase δ increases genomic instability and accelerates tumorigenesis

Molecular and Cellular Biology

Volumn 27, Issue 21, 2007, Pages 7669-7682

  Venkatesan, Ranga N ^a   Treuting, Piper M ^a   Fuller, Evan D ^a   Goldsby, Robert E ^b   Norwood, Thomas H ^a   Gooley, Ted A ^c   Ladiges, Warren C ^a   Preston, Bradley D ^a   Loeb, Lawrence A ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE DELTA;

ALLELE; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA REPAIR; DNA SYNTHESIS; EMBRYO; ENZYME ACTIVE SITE; GENE; GENE MUTATION; GENETIC CONSERVATION; GENETIC RECOMBINATION; GENOMIC INSTABILITY; HETEROZYGOTE; HOMOZYGOTE; INCIDENCE; LIFESPAN; MOUSE; MUTANT; NONHUMAN; POLD1 GENE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHROMOSOMES, MAMMALIAN; DNA DAMAGE; DNA POLYMERASE III; EMBRYO, MAMMALIAN; FIBROBLASTS; GENOMIC INSTABILITY; HETEROZYGOTE; HISTONES; LONGEVITY; LOSS OF HETEROZYGOSITY; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS; PHENOTYPE; PHOSPHORYLATION; PROTEIN STRUCTURE, SECONDARY; SURVIVAL ANALYSIS;

ANIMALIA; MAMMALIA; MUS;

EID: 35648999490     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00002-07     Document Type: Article

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