P50, the small subunit of DNA polymerase delta, is required for mediation of the interaction of polymerase delta subassemblies with PCNA

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Wang, Yujue ^a   Zhang, Qian ^a   Chen, Huiqing ^a   Li, Xiao ^a   Mai, Weijun ^a   Chen, Keping ^a   Zhang, Sufang ^b   Lee, Ernest Y C ^b   Lee, Marietta Y W T ^b   Zhou, Yajing ^a  

^a JIANGSU UNIVERSITY   (China)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; DNA; DNA DIRECTED DNA POLYMERASE DELTA; FOCAL ADHESION KINASE 1; PROTEIN P50; PROTEIN P68; DNA DIRECTED DNA POLYMERASE GAMMA; PRIMER DNA;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SUBSTRATE COMPLEX; ENZYME SUBUNIT; FAR WESTERN BLOTTING; IMMUNOCYTOCHEMISTRY; MOUSE; NONHUMAN; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; CHEMISTRY; HUMAN; IMMUNOLOGY; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; WESTERN BLOTTING;

MAMMALIA;

BASE SEQUENCE; BLOTTING, WESTERN; DNA POLYMERASE III; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; PROLIFERATING CELL NUCLEAR ANTIGEN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 80355136489     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027092     Document Type: Article

References (42)

1. Kao HI, Bambara RA, (2003) The protein components and mechanism of eukaryotic Okazaki fragment maturation. Crit Rev Biochem Mol Biol 38: 433-452.
2. Liu Y, Beard WA, Shock DD, Prasad R, Hou EW, et al. (2005) DNA polymerase beta and flap endonuclease 1 enzymatic specificities sustain DNA synthesis for long patch base excision repair. J Biol Chem 280: 3665-3674.
3. Garg P, Burgers PM, (2005) How the cell deals with DNA nicks. Cell Cycle 4: 221-224.
4. Waga S, Stillman B, (1998) The DNA replication fork in eukaryotic cells. Annu Rev Biochem 67: 721-751.
5. Garg P, Burgers PM, (2005) DNA polymerases that propagate the eukaryotic DNA replication fork. Crit Rev Biochem Mol Biol 40: 115-128.
6. Nick McElhinny SA, Gordenin DA, Stith CM, Burgers PM, Kunkel TA, (2008) Division of labor at the eukaryotic replication fork. Mol Cell 30: 137-144.
7. Kunkel TA, Burgers PM, (2008) Dividing the workload at a eukaryotic replication fork. Trends Cell Biol 18: 521-527.
8. Burgers PM, (2009) Polymerase dynamics at the eukaryotic DNA replication fork. J Biol Chem 284: 4041-4045.
9. Johnson A, O'Donnell M, (2005) Cellular DNA replicases: components and dynamics at the replication fork. Annu Rev Biochem 74: 283-315.
10. Takeda DY, Dutta A, (2005) DNA replication and progression through S phase. Oncogene 24: 2827-2843.
11. Bermudez VP, MacNeill SA, Tappin I, Hurwitz J, (2002) The influence of the Cdc27 subunit on the properties of the Schizosaccharomyces pombe DNA polymerase delta. J Biol Chem 277: 36853-36862.
12. Zuo S, Bermudez V, Zhang G, Kelman Z, Hurwitz J, (2000) Structure and activity associated with multiple forms of Schizosaccharomyces pombe DNA polymerase delta. J Biol Chem 275: 5153-5162.
13. Reynolds N, Watt A, Fantes PA, MacNeill SA, (1998) Cdm1, the smallest subunit of DNA polymerase d in the fission yeast Schizosaccharomyces pombe, is non-essential for growth and division. Curr Genet 34: 250-258.
14. Gerik KJ, Li X, Pautz A, Burgers PM, (1998) Characterization of the two small subunits of Saccharomyces cerevisiae DNA polymerase delta. J Biol Chem 273: 19747-19755.
15. Burgers PM, Gerik KJ, (1998) Structure and processivity of two forms of Saccharomyces cerevisiae DNA polymerase delta. J Biol Chem 273: 19756-19762.
16. Lee MY, Tan CK, Downey KM, So AG, (1981) Structural and functional properties of calf thymus DNA polymerase delta. Prog Nucleic Acid Res Mol Biol 26: 83-96.
17. Lee MY, Tan CK, Downey KM, So AG, (1984) Further studies on calf thymus DNA polymerase delta purified to homogeneity by a new procedure. Biochemistry 23: 1906-1913.
18. Lee MY, Jiang YQ, Zhang SJ, Toomey NL, (1991) Characterization of human DNA polymerase delta and its immunochemical relationships with DNA polymerase alpha and epsilon. J Biol Chem 266: 2423-2429.
19. Jiang Y, Zhang SJ, Wu SM, Lee MY, (1995) Immunoaffinity purification of DNA polymerase delta. Arch Biochem Biophys 320: 297-304.
20. Mo J, Liu L, Leon A, Mazloum N, Lee MY, (2000) Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA. Biochemistry 39: 7245-7254.
21. Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G, (1999) Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts. Nucleic Acids Res 27: 2108-2114.
22. Shikata K, Ohta S, Yamada K, Obuse C, Yoshikawa H, et al. (2001) The human homologue of fission Yeast cdc27, p66, is a component of active human DNA polymerase delta. J Biochem 129: 699-708.
23. Liu L, Mo J, Rodriguez-Belmonte EM, Lee MY, (2000) Identification of a fourth subunit of mammalian DNA polymerase delta. J Biol Chem 275: 18739-18744.
24. Branzei D, Foiani M, (2008) Regulation of DNA repair throughout the cell cycle. Nat Rev Mol Cell Biol 9: 297-308.
25. Harper JW, Elledge SJ, (2007) The DNA damage response: ten years after. Mol Cell 28: 739-745.
26. Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S, (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 73: 39-85.
27. Zhang S, Zhou Y, Trusa S, Meng X, Lee EY, et al. (2007) A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta. J Biol Chem 282: 15330-15340.
28. Meng X, Zhou Y, Zhang S, Lee EY, Frick DN, et al. (2009) DNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primers. Nucleic Acids Res 37: 647-657.
29. Zhou Y, Chen H, Li X, Wang Y, Chen K, et al. (2011) Production of recombinant human DNA polymerase delta in a Bombyx mori bioreactor. PLoS One 6: e22224.
30. Meng X, Zhou Y, Lee EY, Lee MY, Frick DN, (2010) The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis. Biochemistry 49: 3545-3554.
31. Li H, Xie B, Zhou Y, Rahmeh A, Trusa S, et al. (2006) Functional roles of p12, the fourth subunit of human DNA polymerase delta. J Biol Chem 281: 14748-14755.
32. Zhang P, Sun Y, Hsu H, Zhang L, Zhang Y, et al. (1998) The interdomain connector loop of human PCNA is involved in a direct interaction with human polymerase delta. J Biol Chem 273: 713-719.
33. Lu X, Tan CK, Zhou JQ, You M, Carastro LM, et al. (2002) Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta. J Biol Chem 277: 24340-24345.
34. Xie B, Li H, Wang Q, Xie S, Rahmeh A, et al. (2005) Further characterization of human DNA polymerase delta interacting protein 38. J Biol Chem 280: 22375-22384.
35. Harlow E, Lane D, (1988) Antibodies: a laboratory manual. New York Cold Spring Harbor Laboratory Press.
36. Li XH, Wu XF, Yue WF, Liu JM, Li GL, et al. (2006) Proteomic analysis of the silkworm (Bombyx mori L.) hemolymph during developmental stage. J Proteome Res 5: 2809-2814.
37. Zhang P, Zhang SJ, Zhang Z, Woessner JF, Lee MY, (1995) Expression and physicochemical characterization of human proliferating cell nuclear antigen. Biochemistry 34: 10703-10712.
38. Xu H, Zhang P, Liu L, Lee MY, (2001) A novel PCNA-binding motif identified by the panning of a random peptide display library. Biochemistry 40: 4512-4520.
39. Tan CK, Castillo C, So AG, Downey KM, (1986) An auxiliary protein for DNA polymerase-delta from fetal calf thymus. J Biol Chem 261: 12310-12316.
40. Pohler JR, Otterlei M, Warbrick E, (2005) An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit. BMC Mol Biol 6: 17.
41. Cardoso MC, Sporbert A, Leonhardt H, (1999) Structure and function in the nucleus: subnuclear trafficking of DNA replication factors. J Cell Biochem Suppl 32-33: 15-23.
42. Leonhardt H, Rahn HP, Cardoso MC, (1998) Intranuclear targeting of DNA replication factors. J Cell Biochem Suppl 30-31: 243-249.