Base selectivity is impaired by mutants that perturb hydrogen bonding networks in the RB69 DNA polymerase active site

Biochemistry

Volumn 44, Issue 9, 2005, Pages 3338-3346

  Yang, Guangwei ^a   Wang, Jimin ^a   Konigsberg, William ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; COMPLEXATION; CRYSTAL STRUCTURE; DNA; ENZYME KINETICS; FLUORESCENCE; HYDROGEN BONDS; QUENCHING; REACTION KINETICS;

2-AMINOPURINE; BASE SELECTIVITY; NUCLEOSIDE TRIPHOSPHATES; PERTURB HYDROGEN BONDING;

MUTAGENESIS;

2 AMINOPURINE; DNA POLYMERASE; NUCLEOSIDE TRIPHOSPHATE;

ARTICLE; BASE MISPAIRING; BASE PAIRING; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; FLUORESCENCE; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL;

ALANINE; AMINO ACID SUBSTITUTION; BASE PAIR MISMATCH; BINDING SITES; DEOXYADENINE NUCLEOTIDES; DEOXYCYTOSINE NUCLEOTIDES; DEOXYGUANINE NUCLEOTIDES; DNA-DIRECTED DNA POLYMERASE; ENTEROBACTER; HYDROGEN BONDING; KINETICS; NUCLEOTIDES; PHENYLALANINE; SUBSTRATE SPECIFICITY; THYMINE NUCLEOTIDES; TOLUENE; TYROSINE; VIRAL PROTEINS;

EID: 14644432415     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi047921x     Document Type: Article

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