A Single Highly Mutable Catalytic Site Amino Acid Is Critical for DNA Polymerase Fidelity

Journal of Biological Chemistry

Volumn 276, Issue 7, 2001, Pages 5044-5051

  Patel, Premal H ^a   Kawate, Hisaya ^a   Adman, Elinor ^a   Ashbach, Matthew ^a   Loeb, Lawrence A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; DNA; ERRORS; MUTAGENESIS; POLYVINYL CHLORIDES; SUBSTITUTION REACTIONS;

HYDROPHILIC SUBSTITUTION;

ENZYMES;

AMINO ACID; DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE BETA; DNA POLYMERASE; ISOLEUCINE; NUCLEOTIDE; RIBOSE; TAQ POLYMERASE; VINYL CHLORIDE;

AMINO ACID SUBSTITUTION; ARTICLE; BACTERIUM MUTANT; BASE MISPAIRING; BASE PAIRING; BASE PAIRING FIDELITY; BINDING SITE; CATALYSIS; DNA TEMPLATE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; HYDROPHOBICITY; MUTAGENESIS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN MOTIF; STRUCTURE ACTIVITY RELATION; THERMUS AQUATICUS; BACTERIAL GENE; CHEMICAL STRUCTURE; CHEMISTRY; DNA REPLICATION; GENETICS; KINETICS; METABOLISM; MOLECULAR EVOLUTION; MUTATION;

BACTERIA (MICROORGANISMS); THERMUS; THERMUS AQUATICUS;

AMINO ACID MOTIFS; BASE PAIR MISMATCH; BINDING SITES; DNA REPLICATION; EVOLUTION, MOLECULAR; GENES, BACTERIAL; ISOLEUCINE; KINETICS; MODELS, MOLECULAR; MUTATION; POLYMERASE CHAIN REACTION; STRUCTURE-ACTIVITY RELATIONSHIP; TAQ POLYMERASE; TEMPLATES, GENETIC;

EID: 0035895911     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008701200     Document Type: Article

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