Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication

Journal of Biological Chemistry

Volumn 287, Issue 17, 2012, Pages 14289-14300

  Punchihewa, Chandanamali ^a   Inoue, Akira ^a   Hishiki, Asami ^b   Fujikawa, Yoshihiro ^c   Connelly, Michele ^a   Evison, Benjamin ^a   Shao, Youming ^a   Heath, Richard ^a   Kuraoka, Isao ^d   Rodrigues, Patrick ^a   Hashimoto, Hiroshi ^b   Kawanishi, Masanobu ^c   Sato, Mamoru ^b   Yagi, Takashi ^c   Fujii, Naoaki ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b YOKOHAMA CITY UNIVERSITY   (Japan)

^c Osaka Prefecture University   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ALCOHOLS; CANCER CELLS; CIS-PLATIN; COCRYSTAL STRUCTURE; DNA POLYMERASE; DNA REPLICATION FORKS; DNA REPLICATIONS; DNA SYNTHESISS; GROWTH INHIBITION; INHIBITED GROWTH; PROLIFERATING CELL NUCLEAR ANTIGENS; S-PHASE; SMALL MOLECULES; THYROID HORMONES; TRANSLESION DNA SYNTHESIS;

ALCOHOLS; ANTIGENS; CELL DEATH; CELL PROLIFERATION; CHROMOSOMES; MOLECULES; PEPTIDES; PHOSPHORYLATION; PLATINUM COMPOUNDS;

DNA;

4 [4 (2 AMINO 3 HYDROXYPROPYL) 2,6 DIIODOPHENOXY]PHENOL; [139 PHOSPHOSERINE]HISTONE H2AX; ANTINEOPLASTIC AGENT; CARRIER PROTEINS AND BINDING PROTEINS; CHECKPOINT KINASE 1; CISPLATIN; CYCLINE; DNA DIRECTED DNA POLYMERASE DELTA; DNA DIRECTED DNA POLYMERASE DELTA 3; HISTONE H2AX; PROLIFERATING CELL NUCLEAR ANTIGEN INHIBITOR; PROLIFERATING CELL NUCLEAR ANTIGEN INTERACTING PROTEIN BOX; PROTEIN INHIBITOR; PROTEIN P21; REPLICATION FACTOR A; REPLICATION FACTOR A 32; THYROID HORMONE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CHROMATIN; CONTROLLED STUDY; DNA CROSS LINKING; DNA DAMAGE; DNA REPLICATION STRESS; DNA SYNTHESIS INHIBITION; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SENSITIVITY; DRUG STRUCTURE; HELA CELL; HIGH THROUGHPUT SCREENING; IC 50; MAMMAL CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; S PHASE CELL CYCLE CHECKPOINT;

CHEMISTRY, PHARMACEUTICAL; CHROMATIN; CRYSTALLOGRAPHY, X-RAY; DNA REPLICATION; DRUG DESIGN; FLOW CYTOMETRY; GENES, REPORTER; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MICROSCOPY, FLUORESCENCE; MOLECULAR CONFORMATION; PEPTIDES; PHOSPHORYLATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN INTERACTION MAPPING; RECOMBINANT PROTEINS;

EID: 84859965553     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.353201     Document Type: Article

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