Pol32, a subunit of Saccharomyces cerevisiae DNA polymerase δ, suppresses genomic deletions and is involved in the mutagenic bypass pathway

Genetics

Volumn 160, Issue 4, 2002, Pages 1409-1422

  Huang, Meng Er ^a   Rio, Anne Gaëlle ^a   Galibert, Marie Dominique ^a   Galibert, Francis ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE ALPHA; PROTEIN POL 32; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; FRAMESHIFT MUTATION; GENE DELETION; GENE MUTATION; GENE REPLICATION; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; SACCHAROMYCES CEREVISIAE;

CANAVANINE; DNA POLYMERASE III; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; DRUG RESISTANCE, FUNGAL; ENDONUCLEASES; EPISTASIS, GENETIC; FUNGAL PROTEINS; GENOME, FUNGAL; MUTAGENS; MUTATION; RAD52 DNA REPAIR AND RECOMBINATION PROTEIN; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE DELETION;

FUNGI; MYXOGASTRIA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036242094     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. exo1-dependent mutator mutations: Model system for studying functional interactions in mismatch repair
2. Lesions in DNA: Hurdles for polymerases
3. MMS2 encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway
4. DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae
5. Eukaryotic DNA polymerases in DNA replication and DNA repair
6. Structure and processivity of two forms of Saccharomyces cerevisiae DNA polymerase δ
7. Short, direct repeats at the breakpoints of deletions of the retinoblastoma gene
8. Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants
9. Chromosomal rearrangements occur in S. cerevisiae rfa1 mutator mutants due to mutagenic lesions processed by double-strand-break repair
10. Saccharomyces cerevisiae pol30 (proliferating cell nuclear antigen) mutations impair replication fidelity and mismatch repair
11. A constant rate of spontaneous mutation in DNA-based microbes
12. Characterization of the two small subunits of Saccharomyces cerevisiae DNA polymerase δ
13. Frameshift intermediates in homopolymer runs are removed efficiently by feast mismatch repair proteins
14. Spontaneous frameshift mutations in Saccharomyces cerevisiae: Accumulation during DNA replication and removal by proofreading and mismatch repair activities
15. Involvement of the yeast DNA polymerase δ in DNA repair in vivo
16. 6-methylguanine by yeast and human DNA polymerase η
17. Roles of yeast DNA polymerases δ and ζ and of Rev1 in the bypass of abasic sites
18. DNA mismatch repair and genetic instability
19. DNA polymerase ζ introduces multiple mutations when bypassing spontaneous DNA damage in Saccharomyces cerevisiae
20. Disruption of six novel yeast genes reveals three genes essential for vegetative growth and one required for growth at low temperature
21. The Saccharomyces cerevisiae protein YJR043C (Pol32) interacts with the catalytic subunit of DNA polymerase α and is required for cell cycle progression in G2/M
22. POL32, a subunit of the Saccharomyces cerevisiae DNA polymerase δ defines a link between DNA replication and the mutagenic bypass repair pathway
23. RAD1 and RAD10, but not other excision repair genes, are required for double-strand break-induced recombination in Saccharomyces cerevisiae
24. Mismatch repair defects in cancer
25. Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability
26. Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions
27. Role of DNA polymerase ζ in the bypass of a (6-4) TT photoproduct
28. Destabilization of yeast micro- and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase δ (pol3-t)
29. Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase δ or by decreases in the cellular levels of DNA polymerase δ
30. DNA replication fidelity
31. DNA sequence analysis of spontaneous mutagenesis in Saccharomyces cerevisiae
32. DNA damage-induced mutation: Tolerance via translesion synthesis
33. The distribution of the numbers of mutants in bacterial populations
34. Characterization of the large deletion in the GALC gene found in patients with Krabbe disease
35. Short direct repeats at the breakpoints of a novel large deletion in the CFTR gene suggest a likely slipped mispairing mechanism
36. Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair
37. The Saccharomyces cerevisiae RAD30 gene, a homologue of Escherichia coli dinB and umuC, is DNA damage inducible and functions in a novel error-free postreplication repair mechanism
38. The 3′→5′ exonucleases of both DNA polymerases δ and ε participate in correcting errors of DNA replication in Saccharomyces cerevisiae
39. DNA strand annealing is promoted by the yeast Rad52 protein
40. SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination
41. Suppression of spontaneous chromosomal rearrangements by S phase check-point functions in Saccharomyces cerevisiae
42. Two pathways for removal of nonhomologous DNA ends during double-strand break repair in Saccharomyces cerevisiae
43. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
44. Specificity of the yeast rev3Δ antimutator and REV3 dependency of the mutator resulting from a defect (rad1Δ) in nucleotide excision repair
45. Specificities of the Saccharomyces cerevisiae rag6, rad18, and rad52 mutators exhibit different degrees of dependence on the REV3 gene product, a putative nonessential DNA polymerase
46. Spontaneous mutagenesis: The role of DNA repair, replication and recombination
47. Microsatellite instability in yeast: Dependence on repeat unit size and DNA mismatch repair genes
48. Characterization of double-strand break-induced recombination: Homology requirements and single-stranded DNA formation
49. Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination
50. Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae
51. A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair
52. Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2
53. Replication slippage between distant short repeats in Saccharomyces cerevisiae depends on the direction of replication and the RAD50 and RAD52 genes
54. Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair
55. Replication slippage involves DNA polymerase pausing and dissociation
56. The DNA replication fork in eukaryotic cells
57. Microsatellite instability in yeast: Dependence on the length of the microsatellite
58. A plethora of lesion-replicating DNA polymerases