Active site mutations in mammalian DNA polymerase δ alter accuracy and replication fork progression

Journal of Biological Chemistry

Volumn 285, Issue 42, 2010, Pages 32264-32272

  Schmitt, Michael W ^a   Venkatesan, Ranga N ^a   Pillaire, Marie Jeanne ^b   Hoffmann, Jean Sébastien ^b   Sidorova, Julia M ^a   Loeb, Lawrence A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACTIVE SITE RESIDUES; CATALYTIC ACTIVITY; DNA ADDUCTS; DNA POLYMERASE; DNA REPAIR; DNA STRANDS; DNA SYNTHESISS; ERROR PRONES; HIGH FREQUENCY; IN-VITRO ANALYSIS; IN-VIVO; LESION BYPASS; LIFE SPAN; MAMMALIAN DNA; MOUSE EMBRYONIC FIBROBLASTS; POLYMERASE ACTIVE SITE; PROCESSIVITY; REPLICATION FORK; REPLICATIVE POLYMERASE; SINGLE NUCLEOTIDES; WILD TYPES;

CATALYST ACTIVITY; CELL CULTURE; ESCHERICHIA COLI; MAMMALS; NUCLEOTIDES; POLYMERS; SITE SELECTION;

DNA;

DNA; DNA DIRECTED DNA POLYMERASE DELTA; HOLOENZYME; NUCLEOTIDE;

ACCURACY; ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DNA ADDUCT; DNA REPLICATION; DNA SYNTHESIS; ESCHERICHIA COLI; FIBROBLAST; GENE MUTATION; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CATALYTIC DOMAIN; DNA POLYMERASE III; DNA REPLICATION; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN ISOFORMS;

ESCHERICHIA COLI; EUKARYOTA; MAMMALIA; MUS;

EID: 77957762113     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.147017     Document Type: Article

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