Stearoyl-CoA desaturase: Rogue or innocent bystander?

Progress in Lipid Research

Volumn 52, Issue 1, 2013, Pages 15-42

  Hodson, Leanne ^a   Fielding, Barbara A ^a,b  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Adipose; Liver; Oleate; Palmitoleate; Stearoyl CoA desaturase

Indexed keywords

ACYL COENZYME A; ACYL COENZYME A DESATURASE; ALCOHOL; CELL NUCLEUS RECEPTOR; CHOLESTEROL; CLOFIBRATE; CONJUGATED LINOLEIC ACID; ESSENTIAL FATTY ACID; FATTY ACID; FATTY ACID BINDING PROTEIN; FENOFIBRATE; FRUCTOSE; GEMFIBROZIL; HORMONE SENSITIVE LIPASE; INSULIN; LEPTIN; LEPTIN RECEPTOR; MONOUNSATURATED FATTY ACID; OXYGENASE INHIBITOR; PALMITOLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; POLYUNSATURATED FATTY ACID; ROSIGLITAZONE; SATURATED FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; SUCROSE; TRIACYLGLYCEROL;

ADIPOSE TISSUE; BIOCHEMISTRY; CARBOHYDRATE ANALYSIS; COLD EXPOSURE; DIET RESTRICTION; DRUG EFFECT; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME ISOLATION; ENZYME LOCALIZATION; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; EXPERIMENTAL MODEL; FATTY LIVER; GENETIC POLYMORPHISM; HEART MUSCLE; HUMAN; HYPERTRIGLYCERIDEMIA; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; KNOCKOUT MOUSE; LIFESTYLE MODIFICATION; LIPOGENESIS; LIPOTOXICITY; LIVER PARENCHYMA; MALIGNANT NEOPLASTIC DISEASE; METABOLIC DISORDER; MOLECULAR EVOLUTION; MUSCLE TISSUE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; OSSIFICATION; PANCREAS DUCT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RISK ASSESSMENT; SEX DIFFERENCE; SHEAR STRESS; SMOKING HABIT; STREPTOZOCIN DIABETES; TISSUE SPECIFICITY;

ADIPOSE TISSUE; ANIMALS; DIET; DISEASE MODELS, ANIMAL; EVOLUTION, MOLECULAR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INSULIN; LEPTIN; LIPOGENESIS; LIVER; MALE; ORGAN SPECIFICITY; RODENTIA; STEAROYL-COA DESATURASE; SUBSTRATE SPECIFICITY; TRIGLYCERIDES;

ANIMALIA;

EID: 84867235842     PISSN: 01637827     EISSN: 18732194     Source Type: Journal    
DOI: 10.1016/j.plipres.2012.08.002     Document Type: Review

References (288)

1. H. Cao, K. Gerhold, J.R. Mayers, M.M. Wiest, S.M. Watkins, and G.S. Hotamisligil Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism Cell 134 2008 933 944
2. H. Sampath, and J.M. Ntambi The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation Ann NY Acad Sci 1243 2011 47 53
3. K.E. Pinnick, S.C. Collins, C. Londos, D. Gauguier, A. Clark, and B.A. Fielding Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition Obesity (Silver Spring) 16 2008 522 530
4. G.K. Pot, C.J. Prynne, C. Roberts, A. Olson, S.K. Nicholson, and C. Whitton National Diet and Nutrition Survey: fat and fatty acid intake from the first year of the rolling programme and comparison with previous surveys Br J Nutr 107 2012 405 415
5. J.M. Ntambi Regulation of stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol J Lipid Res 40 1999 1549 1558
6. M.T. Flowers, and J.M. Ntambi Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism Curr Opin Lipidol 19 2008 248 256
7. D. Mauvoisin, and C. Mounier Hormonal and nutritional regulation of SCD1 gene expression Biochimie 93 2011 78 86
8. J.M. Ntambi, and M. Miyazaki Regulation of stearoyl-CoA desaturases and role in metabolism Prog Lipid Res 43 2004 91 104
9. H. Sampath, and J.M. Ntambi Stearoyl-coenzyme A desaturase 1, sterol regulatory element binding protein-1c and peroxisome proliferator-activated receptor-alpha: independent and interactive roles in the regulation of lipid metabolism Curr Opin Clin Nutr Metab Care 9 2006 84 88
10. H. Bjermo, and U. Riserus Role of hepatic desaturases in obesity-related metabolic disorders Curr Opin Clin Nutr Metab Care 13 2010 703 708
11. H.E. Popeijus, W.H. Saris, and R.P. Mensink Role of stearoyl-CoA desaturases in obesity and the metabolic syndrome Int J Obes (Lond) 32 2008 1076 1082
12. B. Vessby, I.B. Gustafsson, S. Tengblad, M. Boberg, and A. Andersson Desaturation and elongation of fatty acids and insulin action Ann NY Acad Sci 967 2002 183 195
13. H. Evans, T. De Tomaso, M. Quail, J. Rogers, A.Y. Gracey, and A.R. Cossins Ancient and modern duplication events and the evolution of stearoyl-CoA desaturases in teleost fishes Physiol Genomics 35 2008 18 29
14. J. Wang, L. Yu, R.E. Schmidt, C. Su, X. Huang, and K. Gould Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates Biochem Biophys Res Commun 332 2005 735 742
15. L.F. Castro, J.M. Wilson, O. Goncalves, S. Galante-Oliveira, E. Rocha, and I. Cunha The evolutionary history of the stearoyl-CoA desaturase gene family in vertebrates BMC Evol Biol 11 2011 132
16. L. Zhang, L. Ge, S. Parimoo, K. Stenn, and S.M. Prouty Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites Biochem J 340 Pt 1 1999 255 264
17. F.S. Heinemann, and J. Ozols Stearoyl-CoA desaturase, a short-lived protein of endoplasmic reticulum with multiple control mechanisms Prostaglandins Leukot Essent Fatty Acids 68 2003 123 133
18. J.E. Stukey, V.M. McDonough, and C.E. Martin The OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene J Biol Chem 265 1990 20144 20149
19. W.C. Man, M. Miyazaki, K. Chu, and J.M. Ntambi Membrane topology of mouse stearoyl-CoA desaturase 1 J Biol Chem 281 2006 1251 1260
20. P. Strittmatter, and H.G. Enoch Purification of stearyl-CoA desaturase from liver Methods Enzymol 52 1978 188 193
21. J. Ozols Degradation of hepatic stearyl CoA delta 9-desaturase Mol Biol Cell 8 1997 2281 2290
22. A. Gellhorn, and W. Benjamin The intracellular localization of an enzymatic defect of lipid metabolism in diabetic rats Biochim Biophys Acta 84 1964 167 175
23. N. Oshino, and R. Sato The dietary control of the microsomal stearyl CoA desaturation enzyme system in rat liver Arch Biochem Biophys 149 1972 369 377
24. F.S. Heinemann, G. Korza, and J. Ozols A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes J Biol Chem 278 2003 42966 42975
25. R. Jeffcoat, P.R. Brawn, R. Safford, and A.T. James Properties of rat liver microsomal stearoyl-coenzyme A desaturase Biochem J 161 1977 431 437
26. H.G. Enoch, A. Catala, and P. Strittmatter Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid J Biol Chem 251 1976 5095 5103
27. S.K. Rhee, A.J. Kayani, A. Ciszek, and J.T. Brenna Desaturation and interconversion of dietary stearic and palmitic acids in human plasma and lipoproteins Am J Clin Nutr 65 1997 451 458
28. E.A. Emken, R.O. Adlof, W.K. Rohwedder, and R.M. Gulley Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans Biochim Biophys Acta 1170 1993 173 181
29. M. Miyazaki, A. Dobrzyn, P.M. Elias, and J.M. Ntambi Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development Proc Natl Acad Sci USA 102 2005 12501 12506
30. D.E. Tabor, J.B. Kim, B.M. Spiegelman, and P.A. Edwards Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1 J Biol Chem 273 1998 22052 22058
31. Y. Zheng, S.M. Prouty, A. Harmon, J.P. Sundberg, K.S. Stenn, and S. Parimoo Scd3-a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin Genomics 71 2001 182 191
32. M. Miyazaki, M.J. Jacobson, W.C. Man, P. Cohen, E. Asilmaz, and J.M. Friedman Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors J Biol Chem 278 2003 33904 33911
33. M. Miyazaki, S.M. Bruggink, and J.M. Ntambi Identification of mouse palmitoyl-coenzyme A Delta9-desaturase J Lipid Res 47 2006 700 704
34. K. Mihara Structure and regulation of rat liver microsomal stearoyl-CoA desaturase gene J Biochem 108 1990 1022 1029
35. K.H. Kaestner, J.M. Ntambi, T.J. Kelly Jr., and M.D. Lane Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase J Biol Chem 264 1989 14755 14761
36. Y. Wang, D. Botolin, J. Xu, B. Christian, E. Mitchell, and B. Jayaprakasam Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity J Lipid Res 47 2006 2028 2041
37. A.J. Lengi, and B.A. Corl Comparison of pig, sheep and chicken SCD5 homologs: evidence for an early gene duplication event Comp Biochem Physiol B: Biochem Mol Biol 150 2008 440 446
38. M. Enser Desaturation of stearic acid by liver and adipose tissue from obese-hyperglycaemic mice (ob/ob) Biochem J 148 1975 551 555
39. S.L. Archibeque, D.K. Lunt, C.D. Gilbert, R.K. Tume, and S.B. Smith Fatty acid indices of stearoyl-CoA desaturase do not reflect actual stearoyl-CoA desaturase enzyme activities in adipose tissues of beef steers finished with corn-, flaxseed-, or sorghum-based diets J Anim Sci 83 2005 1153 1166
40. B. Houdali, H.G. Wahl, M. Kresi, V. Nguyen, M. Haap, and F. Machicao Glucose oversupply increases Delta9-desaturase expression and its metabolites in rat skeletal muscle Diabetologia 46 2003 203 212
41. P.E. Tiku, A.Y. Gracey, A.I. Macartney, R.J. Beynon, and A.R. Cossins Cold-induced expression of delta 9-desaturase in carp by transcriptional and posttranslational mechanisms Science 271 1996 815 818
42. C. Su, H. Gullberg, H. Simko, M. Luthman, P.O. Edlund, and T. Lundback A novel assay of cellular stearoyl-CoA desaturase activity of primary rat hepatocytes by HPLC J Chromatogr B Analyt Technol Biomed Life Sci 878 2010 2427 2432
43. L. Hodson, C.M. Skeaff, and B.A. Fielding Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake Prog Lipid Res 47 2008 348 380
44. M. Neville, K.E. Pinnick, F. Karpe, and B.A. Fielding Evidence for tissue-specific regulation of DNL and desaturation of fatty acids in human adipose tissue Obes Rev 1 Suppl. 1 2010 177
45. S.F. Knutsen, G.E. Fraser, W.L. Beeson, K.D. Lindsted, and D.J. Shavlik Comparison of adipose tissue fatty acids with dietary fatty acids as measured by 24-hour recall and food frequency questionnaire in Black and White Adventists: the Adventist Health Study Ann Epidemiol 13 2003 119 127
46. K.E. Pinnick, M.J. Neville, B.A. Fielding, K.N. Frayn, F. Karpe, and L. Hodson Gluteofemoral adipose tissue plays a major role in production of the lipokine palmitoleate in humans Diabetes 61 2012 1399 1403
47. R.A. McCance, B. Holland, and E.M. Widdowson Royal society of chemistry (Great Britain), Great Britain. Ministry of agriculture fisheries and food McCance and Widdowson's the composition of foods vol. xiii 1993 Royal Society of Chemistry: Ministry of Agriculture, Fisheries and Food Cambridge, UK 462
48. L. Hodson, S.E. McQuaid, F. Karpe, K.N. Frayn, and B.A. Fielding Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate Am J Physiol Endocrinol Metab 296 2009 E64 E71
49. M.F. Chong, L. Hodson, A.S. Bickerton, R. Roberts, M. Neville, and F. Karpe Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding Am J Clin Nutr 87 2008 817 823
50. M.J. Rennie An introduction to the use of tracers in nutrition and metabolism Proc Nutr Soc 58 1999 935 944
51. 13C-enriched compounds: detection limits and carryover effects Rapid Commun Mass Spectrom 17 2003 2669 2674
52. P.C. Calder, D.J. Harvey, C.M. Pond, and E.A. Newsholme Site-specific differences in the fatty acid composition of human adipose tissue Lipids 27 1992 716 720
53. M. Garaulet, J.J. Hernandez-Morante, J. Lujan, F.J. Tebar, and S. Zamora Relationship between fat cell size and number and fatty acid composition in adipose tissue from different fat depots in overweight/obese humans Int J Obes (Lond) 30 2006 899 905
54. M. Garaulet, F. Perez-Llamas, M. Perez-Ayala, P. Martinez, F.S. de Medina, and F.J. Tebar Site-specific differences in the fatty acid composition of abdominal adipose tissue in an obese population from a Mediterranean area: relation with dietary fatty acids, plasma lipid profile, serum insulin, and central obesity Am J Clin Nutr 74 2001 585 591
55. G.T. Malcom, A.K. Bhattacharyya, M. Velez-Duran, M.A. Guzman, M.C. Oalmann, and J.P. Strong Fatty acid composition of adipose tissue in humans: differences between subcutaneous sites Am J Clin Nutr 50 1989 288 291
56. P.G. Pittet, D. Halliday, and P.E. Bateman Site differences in the fatty acid composition of subcutaneous adipose tissue of obese women Br J Nutr 42 1979 57 61
57. A. Peter, A. Cegan, S. Wagner, R. Lehmann, N. Stefan, and A. Konigsrainer Hepatic lipid composition and stearoyl-coenzyme A desaturase 1 mRNA expression can be estimated from plasma VLDL fatty acid ratios Clin Chem 55 2009 2113 2120
58. F. Karpe, and L. Hodson Caution on the interpretation of plasma fatty acid composition as a proxy marker for SCD1 activity: particular implications for using the 16:1/16:0 ratio in QTL studies involving hyperlipidemic patients Arterioscler Thromb Vasc Biol 28 2008 e152 author reply e153
59. A. Peter, A. Cegan, S. Wagner, M. Elcnerova, A. Konigsrainer, and I. Konigsrainer Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans Am J Physiol Endocrinol Metab 300 2011 E321 E326
60. J.M. Collins, M.J. Neville, M.B. Hoppa, and K.N. Frayn De novo lipogenesis and stearoyl-CoA desaturase are coordinately regulated in the human adipocyte and protect against palmitate-induced cell injury J Biol Chem 285 2010 6044 6052
61. J.K. Yee, C.S. Mao, H.S. Hummel, S. Lim, S. Sugano, and V.K. Rehan Compartmentalization of stearoyl-coenzyme A desaturase 1 activity in HepG2 cells J Lipid Res 49 2008 2124 2134
62. A. Aarsland, and R.R. Wolfe Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men J Lipid Res 39 1998 1280 1286
63. M. Miyazaki, Y.C. Kim, M.P. Gray-Keller, A.D. Attie, and J.M. Ntambi The biosynthesis of hepatic cholesterol esters and triglycerides is impaired in mice with a disruption of the gene for stearoyl-CoA desaturase 1 J Biol Chem 275 2000 30132 30138
64. M. Miyazaki, Y.C. Kim, and J.M. Ntambi A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis J Lipid Res 42 2001 1018 1024
65. R. Jeffcoat, P.A. Roberts, J. Ormesher, and A.T. James Stearolyl-CoA desaturase: a control enzyme in hepatic lipogenesis Eur J Biochem 101 1979 439 445
66. S.B. Weiss, E.P. Kennedy, and J.Y. Kiyasu The enzymatic synthesis of triglycerides J Biol Chem 235 1960 40 44
67. R. Suzuki, K. Tobe, M. Aoyama, K. Sakamoto, M. Ohsugi, and N. Kamei Expression of DGAT2 in white adipose tissue is regulated by central leptin action J Biol Chem 280 2005 3331 3337
68. W.C. Man, M. Miyazaki, K. Chu, and J. Ntambi Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis J Lipid Res 47 2006 1928 1939
69. J. Qi, W. Lang, J.G. Geisler, P. Wang, I. Petrounia, and S. Mai The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2 J Lipid Res 53 2012 1106 1116
70. H.R. Wurie, L. Buckett, and V.A. Zammit Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cells FEBS J 2012
71. H.J. Kim, M. Miyazaki, W.C. Man, and J.M. Ntambi Sterol regulatory element-binding proteins (SREBPs) as regulators of lipid metabolism: polyunsaturated fatty acids oppose cholesterol-mediated induction of SREBP-1 maturation Ann NY Acad Sci 967 2002 34 42
72. J.D. Horton, Y. Bashmakov, I. Shimomura, and H. Shimano Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice Proc Natl Acad Sci USA 95 1998 5987 5992
73. I. Shimomura, Y. Bashmakov, and J.D. Horton Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus J Biol Chem 274 1999 30028 30032
74. I. Shimomura, Y. Bashmakov, S. Ikemoto, J.D. Horton, M.S. Brown, and J.L. Goldstein Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes Proc Natl Acad Sci USA 96 1999 13656 13661
75. I. Shimomura, M. Matsuda, R.E. Hammer, Y. Bashmakov, M.S. Brown, and J.L. Goldstein Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice Mol Cell 6 2000 77 86
76. G. Liang, J. Yang, J.D. Horton, R.E. Hammer, J.L. Goldstein, and M.S. Brown Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c J Biol Chem 277 2002 9520 9528
77. I. Shimomura, H. Shimano, B.S. Korn, Y. Bashmakov, and J.D. Horton Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver J Biol Chem 273 1998 35299 35306
78. H. Kato, K. Sakaki, and K. Mihara Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase J Cell Sci 119 2006 2342 2353
79. S. Garcia-Serrano, I. Moreno-Santos, L. Garrido-Sanchez, C. Gutierrez-Repiso, J.M. Garcia-Almeida, and J. Garcia-Arnes Stearoyl-CoA desaturase-1 is associated with insulin resistance in morbidly obese subjects Mol Med 17 2011 273 280
80. M.R. Prasad, and V.C. Joshi Regulation of rat hepatic stearoyl coenzyme A desaturase. The roles of insulin and carbohydrate J Biol Chem 254 1979 997 999
81. J.M. Ntambi Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver J Biol Chem 267 1992 10925 10930
82. K.M. Waters, and J.M. Ntambi Insulin and dietary fructose induce stearoyl-CoA desaturase 1 gene expression of diabetic mice J Biol Chem 269 1994 27773 27777
83. I. Arbo, C. Halle, D. Malik, H.R. Brattbakk, and B. Johansen Insulin induces fatty acid desaturase expression in human monocytes Scand J Clin Lab Invest 71 2011 330 339
84. J.M. Friedman Obesity in the new millennium Nature 404 2000 632 634
85. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman Positional cloning of the mouse obese gene and its human homologue Nature 372 1994 425 432
86. L.A. Campfield, F.J. Smith, Y. Guisez, R. Devos, and P. Burn Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks Science 269 1995 546 549
87. I.S. Farooqi, S.A. Jebb, G. Langmack, E. Lawrence, C.H. Cheetham, and A.M. Prentice Effects of recombinant leptin therapy in a child with congenital leptin deficiency N Engl J Med 341 1999 879 884
88. J.L. Halaas, K.S. Gajiwala, M. Maffei, S.L. Cohen, B.T. Chait, and D. Rabinowitz Weight-reducing effects of the plasma protein encoded by the obese gene Science 269 1995 543 546
89. M.A. Pelleymounter, M.J. Cullen, M.B. Baker, R. Hecht, D. Winters, and T. Boone Effects of the obese gene product on body weight regulation in ob/ob mice Science 269 1995 540 543
90. P. Cohen, M. Miyazaki, N.D. Socci, A. Hagge-Greenberg, W. Liedtke, and A.A. Soukas Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss Science 297 2002 240 243
91. S.B. Biddinger, M. Miyazaki, J. Boucher, J.M. Ntambi, and C.R. Kahn Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c Diabetes 55 2006 2032 2041
92. J.B. Flowers, M.E. Rabaglia, K.L. Schueler, M.T. Flowers, H. Lan, and M.P. Keller Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice Diabetes 56 2007 1228 1239
93. P.M. Lippiello, C.T. Holloway, S.A. Garfield, and P.W. Holloway The effects of estradiol on stearyl-CoA desaturase activity and microsomal membrane properties in rooster liver J Biol Chem 254 1979 2004 2009
94. K.N. Lee, M.W. Pariza, and J.M. Ntambi Differential expression of hepatic stearoyl-CoA desaturase gene 1 in male and female mice Biochim Biophys Acta 1304 1996 85 88
95. E. Warensjo, M. Ohrvall, and B. Vessby Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women Nutr Metab Cardiovasc Dis 16 2006 128 136
96. N. Stefan, A. Peter, A. Cegan, H. Staiger, J. Machann, and F. Schick Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans Diabetologia 51 2008 648 656
97. M. Enser The role of insulin in the regulation of stearic acid desaturase activity in liver and adipose tissue from obese-hyperglycaemic (ob/ob) and lean mice Biochem J 180 1979 551 558
98. P. Legrand, and D. Hermier Hepatic delta 9 desaturation and plasma VLDL level in genetically lean and fat chickens Int J Obes Relat Metab Disord 16 1992 289 294
99. K.W. Wahle, and J.D. Radcliffe Effect of a diet rich in sunflower oil on aspects of lipid metabolism in the genetically-obese rat Lipids 12 1977 135 139
100. E.J. Giltay, L.J. Gooren, A.W. Toorians, M.B. Katan, and P.L. Zock Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects Am J Clin Nutr 80 2004 1167 1174
101. M.F. Chong, B.A. Fielding, and K.N. Frayn Metabolic interaction of dietary sugars and plasma lipids with a focus on mechanisms and de novo lipogenesis Proc Nutr Soc 66 2007 52 59
102. S.K. Fried, and S.P. Rao Sugars, hypertriglyceridemia, and cardiovascular disease Am J Clin Nutr 78 2003 873S 880S
103. E.J. Parks Dietary carbohydrate's effects on lipogenesis and the relationship of lipogenesis to blood insulin and glucose concentrations Br J Nutr 87 Suppl. 2 2002 S247 S253
104. K.L. Stanhope, and P.J. Havel Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance Curr Opin Lipidol 19 2008 16 24
105. P. Strittmatter, L. Spatz, D. Corcoran, M.J. Rogers, B. Setlow, and R. Redline Purification and properties of rat liver microsomal stearyl coenzyme A desaturase Proc Natl Acad Sci USA 71 1974 4565 4569
106. M.A. Thiede, and P. Strittmatter The induction and characterization of rat liver stearyl-CoA desaturase mRNA J Biol Chem 260 1985 14459 14463
107. I.B. King, R.N. Lemaitre, and M. Kestin Effect of a low-fat diet on fatty acid composition in red cells, plasma phospholipids, and cholesterol esters: investigation of a biomarker of total fat intake Am J Clin Nutr 83 2006 227 236
108. E. Kim, N.C. Liu, I.C. Yu, H.Y. Lin, Y.F. Lee, and J.D. Sparks Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity Diabetes 60 2011 1493 1503
109. M. Miyazaki, A. Dobrzyn, W.C. Man, K. Chu, H. Sampath, and H.J. Kim Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms J Biol Chem 279 2004 25164 25171
110. D. Faeh, K. Minehira, J.M. Schwarz, R. Periasamy, S. Park, and L. Tappy Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy men Diabetes 54 2005 1907 1913
111. K.A. Le, D. Faeh, R. Stettler, C. Debard, E. Loizon, and H. Vidal Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men Diabetes Metab 34 2008 82 85
112. Z.Z. Li, M. Berk, T.M. McIntyre, and A.E. Feldstein Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase J Biol Chem 284 2009 5637 5644
113. M.L. Garg, A.A. Wierzbicki, A.B. Thomson, and M.T. Clandinin Dietary cholesterol and/or n-3 fatty acid modulate delta 9-desaturase activity in rat liver microsomes Biochim Biophys Acta 962 1988 330 336
114. H. Sampath, M. Miyazaki, A. Dobrzyn, and J.M. Ntambi Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat J Biol Chem 282 2007 2483 2493
115. P. Dobrzyn, A. Pyrkowska, M. Jazurek, and A. Dobrzyn Increased availability of endogenous and dietary oleic acid contributes to the upregulation of cardiac fatty acid oxidation Mitochondrion 2011
116. E. Warensjo, U. Riserus, I.B. Gustafsson, R. Mohsen, T. Cederholm, and B. Vessby Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention Nutr Metab Cardiovasc Dis 18 2008 683 690
117. K. Thorn, and P. Bergsten Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cells exposed to oleate compared to palmitate J Cell Biochem 111 2010 497 507
118. Y. Wang, D. Botolin, B. Christian, J. Busik, J. Xu, and D.B. Jump Tissue-specific, nutritional, and developmental regulation of rat fatty acid elongases J Lipid Res 46 2005 706 715
119. G. Kaur, A.J. Sinclair, D. Cameron-Smith, D.P. Barr, J.C. Molero-Navajas, and N. Konstantopoulos Docosapentaenoic acid (22:5n-3) down-regulates the expression of genes involved in fat synthesis in liver cells Prostaglandins Leukot Essent Fatty Acids 85 2011 155 161
120. P.K. Flick, J. Chen, and P.R. Vagelos Effect of dietary linoleate on synthesis and degradation of fatty acid synthetase from rat liver J Biol Chem 252 1977 4242 4249
121. R. Jeffcoat, and A.T. James The control of stearoyl-CoA desaturase by dietary linoleic acid FEBS Lett 85 1978 114 118
122. R. Jeffcoat, and A.T. James Interrelationship between the dietary regulation of fatty acid synthesis and the fatty acyl-CoA desaturases Lipids 12 1977 469 474
123. J.M. Ntambi, A.M. Sessler, and T. Takova A model cell line to study regulation of stearoyl-CoA desaturase gene 1 expression by insulin and polyunsaturated fatty acids Biochem Biophys Res Commun 220 1996 990 995
124. S. Ramanadham, S. Zhang, Z. Ma, M. Wohltmann, A. Bohrer, and F.F. Hsu Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations Biochim Biophys Acta 1580 2002 40 56
125. B.H. Jones, M.A. Maher, W.J. Banz, M.B. Zemel, J. Whelan, and P.J. Smith Adipose tissue stearoyl-CoA desaturase mRNA is increased by obesity and decreased by polyunsaturated fatty acids Am J Physiol 271 1996 E44 E49
126. A.M. Sessler, N. Kaur, J.P. Palta, and J.M. Ntambi Regulation of stearoyl-CoA desaturase 1 mRNA stability by polyunsaturated fatty acids in 3T3-L1 adipocytes J Biol Chem 271 1996 29854 29858
127. R.M. Zulkifli, T. Parr, A.M. Salter, and J.M. Brameld Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols J Anim Sci 88 2010 2565 2575
128. T. Yoshikawa, H. Shimano, N. Yahagi, T. Ide, M. Amemiya-Kudo, and T. Matsuzaka Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements J Biol Chem 277 2002 1705 1711
129. H. Bjermo, D. Iggman, J. Kullberg, I. Dahlman, L. Johansson, and L. Persson Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial Am J Clin Nutr 95 2012 1003 1012
130. Y. Choi, Y. Park, M.W. Pariza, and J.M. Ntambi Regulation of stearoyl-CoA desaturase activity by the trans-10, cis-12 isomer of conjugated linoleic acid in HepG2 cells Biochem Biophys Res Commun 284 2001 689 693
131. L. Bretillon, J.M. Chardigny, S. Gregoire, O. Berdeaux, and J.L. Sebedio Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro Lipids 34 1999 965 969
132. K.N. Lee, M.W. Pariza, and J.M. Ntambi Conjugated linoleic acid decreases hepatic stearoyl-CoA desaturase mRNA expression Biochem Biophys Res Commun 248 1998 817 821
133. Y. Park, J.M. Storkson, J.M. Ntambi, M.E. Cook, C.J. Sih, and M.W. Pariza Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10, cis-12 conjugated linoleic acid and its derivatives Biochim Biophys Acta 1486 2000 285 292
134. M.A. Thijssen, C. Malpuech-Brugere, S. Gregoire, J.M. Chardigny, J.L. Sebedio, and R.P. Mensink Effects of specific CLA isomers on plasma fatty acid profile and expression of desaturases in humans Lipids 40 2005 137 145
135. P.C. Calder The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability Mol Nutr Food Res 56 2012 1073 1080
136. P.C. Calder Mechanisms of action of (n-3) fatty acids J Nutr 142 2012 592S 599S
137. E. Patterson, R. Wall, G.F. Fitzgerald, R.P. Ross, and C. Stanton Health implications of high dietary omega-6 polyunsaturated fatty acids J Nutr Metab 2012 2012 539426
138. J.I. Mann, and C.M. Skeaff Lipids J. Mann, A.S. Truswell, Essentials of human nutrition vol. xxii 2007 Oxford University Press Oxford, New York 599
139. C.L. Marcelo, E.A. Duell, L.M. Rhodes, and W.R. Dunham In vitro model of essential fatty acid deficiency J Invest Dermatol 99 1992 703 708
140. M.T. Nakamura, and T.Y. Nara Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases Annu Rev Nutr 24 2004 345 376
141. J.M. Landau, A. Sekowski, and M.W. Hamm Dietary cholesterol and the activity of stearoyl CoA desaturase in rats: evidence for an indirect regulatory effect Biochim Biophys Acta 1345 1997 349 357
142. Y. Sun, M. Hao, Y. Luo, C.P. Liang, D.L. Silver, and C. Cheng Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure J Biol Chem 278 2003 5813 5820
143. C.M. Paton, and J.M. Ntambi Loss of stearoyl-CoA desaturase activity leads to free cholesterol synthesis through increased Xbp-1 splicing Am J Physiol Endocrinol Metab 299 2010 E1066 E1075
144. M.C. Marin, H.M. Pucciarelli, and M.J. de Alaniz Liver desaturase activities and FA composition in monkeys. Effect of a low-protein diet Lipids 38 2003 525 529
145. J. Turyn, M. Stojek, and J. Swierczynski Up-regulation of stearoyl-CoA desaturase 1 and elongase 6 genes expression in rat lipogenic tissues by chronic food restriction and chronic food restriction/refeeding Mol Cell Biochem 345 2010 181 188
146. D. Mainieri, S. Summermatter, J. Seydoux, J.P. Montani, S. Rusconi, and A.P. Russell A role for skeletal muscle stearoyl-CoA desaturase 1 in control of thermogenesis FASEB J 20 2006 1751 1753
147. L.M. Mangravite, K. Dawson, R.R. Davis, J.P. Gregg, and R.M. Krauss Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol response Am J Clin Nutr 86 2007 759 767
148. P.K. Raju, and R. Reiser Inhibition of fatty acyl desaturase by cyclopropene fatty acids J Biol Chem 242 1967 379 384
149. P.K. Raju, and R. Reiser Inhibition of stearoyl coenzyme A desaturase by sterculate in mouse liver microsomes J Biol Chem 247 1972 3700 3701
150. P.K. Raju, and R. Reiser Hepatic stearoyl-CoA desaturase activity in mice as affected by early postnatal dietary cyclopropene fatty acids J Nutr 103 1973 904 907
151. C.C. Cunningham, S. Filus, R.E. Bottenus, and P.I. Spach Effect of ethanol consumption on the phospholipid composition of rat liver microsomes and mitochondria Biochim Biophys Acta 712 1982 225 233
152. K. Tomita, T. Azuma, N. Kitamura, J. Nishida, G. Tamiya, and A. Oka Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met Gastroenterology 126 2004 873 885
153. S. Wada, T. Yamazaki, Y. Kawano, S. Miura, and O. Ezaki Fish oil fed prior to ethanol administration prevents acute ethanol-induced fatty liver in mice J Hepatol 49 2008 441 450
154. S. Umeki, H. Shiojiri, and Y. Nozawa Chronic ethanol administration decreases fatty acyl-CoA desaturase activities in rat liver microsomes FEBS Lett 169 1984 274 278
155. D. Mozaffarian, H. Cao, I.B. King, R.N. Lemaitre, X. Song, and D.S. Siscovick Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes Am J Clin Nutr 92 2010 1350 1358
156. M.I. Gurr, J.L. Harwood, and K.N. Frayn Lipid biochemistry vol. xvi 2002 Blackwell Oxford p. 320
157. C.M. Pond The fats of life 1998 Cambridge University Press Cambridge p. 337
158. F. Cambien, J.M. Warnet, V. Vernier, P. Ducimetiere, A. Jacqueson, and C. Flament An epidemiologic appraisal of the associations between the fatty acids esterifying serum cholesterol and some cardiovascular risk factors in middle-aged men Am J Epidemiol 127 1988 75 86
159. F.L. Crowe, C.M. Skeaff, T.J. Green, and A.R. Gray Serum fatty acids as biomarkers of fat intake predict serum cholesterol concentrations in a population-based survey of New Zealand adolescents and adults Am J Clin Nutr 83 2006 887 894
160. G.C. Leng, F.B. Smith, F.G. Fowkes, D.F. Horrobin, K. Ells, and N. Morse-Fisher Relationship between plasma essential fatty acids and smoking, serum lipids, blood pressure and haemostatic and rheological factors Prostaglandins Leukot Essent Fatty Acids 51 1994 101 108
161. J.A. Simon, J. Fong, J.T. Bernert Jr., and W.S. Browner Relation of smoking and alcohol consumption to serum fatty acids Am J Epidemiol 144 1996 325 334
162. X. Qin, J. Tian, P. Zhang, Y. Fan, L. Chen, and Y. Guan Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells Cardiovasc Res 74 2007 506 514
163. S.B. Biddinger, K. Almind, M. Miyazaki, E. Kokkotou, J.M. Ntambi, and C.R. Kahn Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome Diabetes 54 2005 1314 1323
164. A. Dobrzyn, P. Dobrzyn, S.H. Lee, M. Miyazaki, P. Cohen, and E. Asilmaz Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle Am J Physiol Endocrinol Metab 288 2005 E599 E607
165. A. Dobrzyn, P. Dobrzyn, M. Miyazaki, and J.M. Ntambi Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues Biochem Biophys Res Commun 332 2005 892 896
166. A. Dobrzyn, P. Dobrzyn, M. Miyazaki, H. Sampath, K. Chu, and J.M. Ntambi
167. M. Miyazaki, A. Dobrzyn, H. Sampath, S.H. Lee, W.C. Man, and K. Chu Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha J Biol Chem 279 2004 35017 35024
168. M. Miyazaki, H. Sampath, X. Liu, M.T. Flowers, K. Chu, and A. Dobrzyn Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice Biochem Biophys Res Commun 380 2009 818 822
169. J.M. Ntambi, M. Miyazaki, J.P. Stoehr, H. Lan, C.M. Kendziorski, and B.S. Yandell Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity Proc Natl Acad Sci USA 99 2002 11482 11486
170. S.M. Rahman, A. Dobrzyn, P. Dobrzyn, S.H. Lee, M. Miyazaki, and J.M. Ntambi Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle Proc Natl Acad Sci USA 100 2003 11110 11115
171. S.M. Rahman, A. Dobrzyn, S.H. Lee, P. Dobrzyn, M. Miyazaki, and J.M. Ntambi Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue Am J Physiol Endocrinol Metab 288 2005 E381 E387
172. B. Cannon, and J. Nedergaard Nonshivering thermogenesis and its adequate measurement in metabolic studies J Exp Biol 214 2011 242 253
173. S.H. Lee, A. Dobrzyn, P. Dobrzyn, S.M. Rahman, M. Miyazaki, and J.M. Ntambi Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment J Lipid Res 45 2004 1674 1682
174. M.T. Flowers, M.P. Keller, Y. Choi, H. Lan, C. Kendziorski, and J.M. Ntambi Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet Physiol Genomics 33 2008 361 372
175. X. Liu, M. Miyazaki, M.T. Flowers, H. Sampath, M. Zhao, and K. Chu Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate Arterioscler Thromb Vasc Biol 30 2010 31 38
176. P. Dobrzyn, A. Dobrzyn, M. Miyazaki, P. Cohen, E. Asilmaz, and D.G. Hardie Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver Proc Natl Acad Sci USA 101 2004 6409 6414
177. C. Moreau, P. Froment, L. Tosca, V. Moreau, and J. Dupont Expression and regulation of the SCD2 desaturase in the rat ovary Biol Reprod 74 2006 75 87
178. B. Garbay, F. Boiron-Sargueil, M. Shy, T. Chbihi, H. Jiang, and J. Kamholz Regulation of oleoyl-CoA synthesis in the peripheral nervous system: demonstration of a link with myelin synthesis J Neurochem 71 1998 1719 1726
179. M. Miyazaki, M.T. Flowers, H. Sampath, K. Chu, C. Otzelberger, and X. Liu Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis Cell Metab 6 2007 484 496
180. H. Sampath, M.T. Flowers, X. Liu, C.M. Paton, R. Sullivan, and K. Chu Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity J Biol Chem 284 2009 19961 19973
181. M.T. Flowers, C.M. Paton, S.M. O'Byrne, K. Schiesser, J.A. Dawson, and W.S. Blaner Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism PLoS One 6 2011 e19734
182. C.K. Hyun, E.D. Kim, M.T. Flowers, X. Liu, E. Kim, and M. Strable Adipose-specific deletion of stearoyl-CoA desaturase 1 up-regulates the glucose transporter GLUT1 in adipose tissue Biochem Biophys Res Commun 399 2010 480 486
183. M.T. Flowers, L. Ade, M.S. Strable, and J.M. Ntambi Combined deletion of SCD1 from adipose tissue and liver does not protect mice from obesity J Lipid Res 53 2012 1646 1653
184. P. Lindstrom The physiology of obese-hyperglycemic mice [ob/ob mice] ScientificWorldJournal 7 2007 666 685
185. A.H. Gates, and M. Karasek Hereditary absence of sebaceous glands in the mouse Science 148 1965 1471 1473
186. Y. Zheng, K.J. Eilertsen, L. Ge, L. Zhang, J.P. Sundberg, and S.M. Prouty Scd1 is expressed in sebaceous glands and is disrupted in the asebia mouse Nat Genet 23 1999 268 270
187. A.D. Attie, R.M. Krauss, M.P. Gray-Keller, A. Brownlie, M. Miyazaki, and J.J. Kastelein Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia J Lipid Res 43 2002 1899 1907
188. P. Cohen, and J.M. Friedman Leptin and the control of metabolism: role for stearoyl-CoA desaturase-1 (SCD-1) J Nutr 134 2004 2455S 2463S
189. C. Fernandez, M. Lindholm, M. Krogh, S. Lucas, S. Larsson, and P. Osmark Disturbed cholesterol homeostasis in hormone-sensitive lipase-null mice Am J Physiol Endocrinol Metab 295 2008 E820 E831
190. C. Fernandez, K. Schuhmann, R. Herzog, B. Fielding, K. Frayn, and A. Shevchenko Altered desaturation and elongation of fatty acids in hormone-sensitive lipase null mice PLoS One 6 2011 e21603
191. D.J. Peet, S.D. Turley, W. Ma, B.A. Janowski, J.M. Lobaccaro, and R.E. Hammer Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha Cell 93 1998 693 704
192. K. Maeda, H. Cao, K. Kono, C.Z. Gorgun, M. Furuhashi, and K.T. Uysal Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes Cell Metab 1 2005 107 119
193. H. Cao, K. Maeda, C.Z. Gorgun, H.J. Kim, S.Y. Park, and G.I. Shulman Regulation of metabolic responses by adipocyte/macrophage fatty acid-binding proteins in leptin-deficient mice Diabetes 55 2006 1915 1922
194. S. Kersten, B. Desvergne, and W. Wahli Roles of PPARs in health and disease Nature 405 2000 421 424
195. C.F. Liew, C.J. Groves, S. Wiltshire, E. Zeggini, T.M. Frayling, and K.R. Owen Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism Diabetologia 47 2004 2168 2175
196. E. Warensjo, E. Ingelsson, P. Lundmark, L. Lannfelt, A.C. Syvanen, and B. Vessby Polymorphisms in the SCD1 gene: associations with body fat distribution and insulin sensitivity Obesity (Silver Spring) 15 2007 1732 1740
197. F. Paillard, D. Catheline, F.L. Duff, M. Bouriel, Y. Deugnier, and M. Pouchard Plasma palmitoleic acid, a product of stearoyl-coA desaturase activity, is an independent marker of triglyceridemia and abdominal adiposity Nutr Metab Cardiovasc Dis 18 2008 436 440
198. T. Okada, N. Furuhashi, Y. Kuromori, M. Miyashita, F. Iwata, and K. Harada Plasma palmitoleic acid content and obesity in children Am J Clin Nutr 82 2005 747 750
199. S. Virtue, and A. Vidal-Puig Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome-an allostatic perspective Biochim Biophys Acta 1801 2010 338 349
200. M. Cnop, J.C. Hannaert, A. Hoorens, D.L. Eizirik, and D.G. Pipeleers Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation Diabetes 50 2001 1771 1777
201. J.E. de Vries, M.M. Vork, T.H. Roemen, Y.F. de Jong, J.P. Cleutjens, and G.J. van der Vusse Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes J Lipid Res 38 1997 1384 1394
202. S. Hardy, Y. Langelier, and M. Prentki Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects Cancer Res 60 2000 6353 6358
203. L.L. Listenberger, X. Han, S.E. Lewis, S. Cases, R.V. Farese Jr., and D.S. Ory Triglyceride accumulation protects against fatty acid-induced lipotoxicity Proc Natl Acad Sci USA 100 2003 3077 3082
204. L.L. Listenberger, D.S. Ory, and J.E. Schaffer Palmitate-induced apoptosis can occur through a ceramide-independent pathway J Biol Chem 276 2001 14890 14895
205. K. Maedler, G.A. Spinas, D. Dyntar, W. Moritz, N. Kaiser, and M.Y. Donath Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function Diabetes 50 2001 69 76
206. M.B. Paumen, Y. Ishida, M. Muramatsu, M. Yamamoto, and T. Honjo Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis J Biol Chem 272 1997 3324 3329
207. J.N. Lee, H. Kim, H. Yao, Y. Chen, K. Weng, and J. Ye Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis Proc Natl Acad Sci USA 107 2010 21424 21429
208. J. Gong, H. Campos, S. McGarvey, Z. Wu, R. Goldberg, and A. Baylin Adipose tissue palmitoleic acid and obesity in humans: does it behave as a lipokine? Am J Clin Nutr 93 2011 186 191
209. L. Hodson, S.E. McQuaid, S.M. Humphreys, R. Milne, B.A. Fielding, and K.N. Frayn Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation? Am J Physiol Endocrinol Metab 299 2010 E584 E592
210. B. Vessby, B. Ahren, E. Warensjo, and F. Lindgarde Plasma lipid fatty acid composition, desaturase activities and insulin sensitivity in Amerindian women Nutr Metab Cardiovasc Dis 2010
211. A. Kotronen, T. Seppanen-Laakso, J. Westerbacka, T. Kiviluoto, J. Arola, and A.L. Ruskeepaa Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver Diabetes 58 2009 203 208
212. H. Petersson, J. Arnlov, B. Zethelius, and U. Riserus Serum fatty acid composition and insulin resistance are independently associated with liver fat markers in elderly men Diabetes Res Clin Pract 87 2010 379 384
213. R. Mar-Heyming, M. Miyazaki, D. Weissglas-Volkov, N.A. Kolaitis, N. Sadaat, and C. Plaisier Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia Arterioscler Thromb Vasc Biol 28 2008 1193 1199
214. K. Shiwaku, M. Hashimoto, K. Kitajima, A. Nogi, E. Anuurad, and B. Enkhmaa Triglyceride levels are ethnic-specifically associated with an index of stearoyl-CoA desaturase activity and n-3 PUFA levels in Asians J Lipid Res 45 2004 914 922
215. S.K. Pinnamaneni, R.J. Southgate, M.A. Febbraio, and M.J. Watt Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro Diabetologia 49 2006 3027 3037
216. S. Schenk, and J.F. Horowitz Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance J Clin Invest 117 2007 1690 1698
217. P. Dobrzyn, A. Pyrkowska, M. Jazurek, K. Szymanski, J. Langfort, and A. Dobrzyn Endurance training-induced accumulation of muscle triglycerides is coupled to upregulation of stearoyl-CoA desaturase 1 J Appl Physiol 109 2010 1653 1661
218. B.C. Bergman, L. Perreault, D.M. Hunerdosse, M.C. Koehler, A.M. Samek, and R.H. Eckel Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes J Appl Physiol 108 2010 1134 1141
219. C. Thamer, J. Machann, O. Bachmann, M. Haap, D. Dahl, and B. Wietek Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity J Clin Endocrinol Metab 88 2003 1785 1791
220. M.W. Hulver, J.R. Berggren, R.N. Cortright, R.W. Dudek, R.P. Thompson, and W.J. Pories Skeletal muscle lipid metabolism with obesity Am J Physiol Endocrinol Metab 284 2003 E741 E747
221. M.W. Hulver, J.R. Berggren, M.J. Carper, M. Miyazaki, J.M. Ntambi, and E.P. Hoffman Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans Cell Metab 2 2005 251 261
222. A. Peter, C. Weigert, H. Staiger, F. Machicao, F. Schick, and J. Machann Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo Diabetes 58 2009 1757 1765
223. P. Dobrzyn, A. Dobrzyn, M. Miyazaki, and J.M. Ntambi Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice J Lipid Res 51 2010 2202 2210
224. A. Peter, C. Weigert, H. Staiger, K. Rittig, A. Cegan, and P. Lutz Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity Am J Physiol Endocrinol Metab 295 2008 E339 E349
225. E. Warensjo, J. Sundstrom, B. Vessby, T. Cederholm, and U. Riserus Markers of dietary fat quality and fatty acid desaturation as predictors of total and cardiovascular mortality: a population-based prospective study Am J Clin Nutr 88 2008 203 209
226. A.K. Busch, E. Gurisik, D.V. Cordery, M. Sudlow, G.S. Denyer, and D.R. Laybutt Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis Diabetes 54 2005 2917 2924
227. K. Thorn, M. Hovsepyan, and P. Bergsten Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing beta-cells Lipids Health Dis 9 2010 108
228. R. Roberts, L. Hodson, A.L. Dennis, M.J. Neville, S.M. Humphreys, and K.E. Harnden Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans Diabetologia 52 2009 882 890
229. P. Sjogren, J. Sierra-Johnson, K. Gertow, M. Rosell, B. Vessby, and U. de Faire Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance Diabetologia 51 2008 328 335
230. E. Warensjo, U. Riserus, and B. Vessby Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men Diabetologia 48 2005 1999 2005
231. E. Warensjo, J. Sundstrom, L. Lind, and B. Vessby Factor analysis of fatty acids in serum lipids as a measure of dietary fat quality in relation to the metabolic syndrome in men Am J Clin Nutr 84 2006 442 448
232. E. Corpeleijn, E.J. Feskens, E.H. Jansen, M. Mensink, W.H. Saris, and T.W. de Bruin Improvements in glucose tolerance and insulin sensitivity after lifestyle intervention are related to changes in serum fatty acid profile and desaturase activities: the SLIM study Diabetologia 49 2006 2392 2401
233. E. Warensjo, M. Rosell, M.L. Hellenius, B. Vessby, U. De Faire, and U. Riserus Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance Lipids Health Dis 8 2009 37
234. D.J. Baer, J.T. Judd, B.A. Clevidence, and R.P. Tracy Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized crossover study Am J Clin Nutr 79 2004 969 973
235. P.C. Calder Does early exposure to long chain polyunsaturated fatty acids provide immune benefits? J Pediatr 156 2010 869 871
236. H. Petersson, S. Basu, T. Cederholm, and U. Riserus Serum fatty acid composition and indices of stearoyl-CoA desaturase activity are associated with systemic inflammation: longitudinal analyses in middle-aged men Br J Nutr 99 2008 1186 1189
237. H. Petersson, L. Lind, J. Hulthe, A. Elmgren, T. Cederholm, and U. Riserus Relationships between serum fatty acid composition and multiple markers of inflammation and endothelial function in an elderly population Atherosclerosis 203 2009 298 303
238. H. Melhus, U. Riserus, E. Warensjo, L. Wernroth, K. Jensevik, and L. Berglund A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men Osteoporos Int 19 2008 929 934
239. T. Akune, S. Ohba, S. Kamekura, M. Yamaguchi, U.I. Chung, and N. Kubota PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors J Clin Invest 113 2004 846 855
240. F. Elefteriou, J.D. Ahn, S. Takeda, M. Starbuck, X. Yang, and X. Liu Leptin regulation of bone resorption by the sympathetic nervous system and CART Nature 434 2005 514 520
241. S. Takeda, F. Elefteriou, R. Levasseur, X. Liu, L. Zhao, and K.L. Parker Leptin regulates bone formation via the sympathetic nervous system Cell 111 2002 305 317
242. R.A. Igal Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer Carcinogenesis 31 2010 1509 1515
243. U.V. Roongta, J.G. Pabalan, X. Wang, R.P. Ryseck, J. Fargnoli, and B.J. Henley Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy Mol Cancer Res 9 2011 1551 1561
244. N. Scaglia, J.M. Caviglia, and R.A. Igal High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts Biochim Biophys Acta 1687 2005 141 151
245. N. Scaglia, and R.A. Igal Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells J Biol Chem 280 2005 25339 25349
246. N. Scaglia, and R.A. Igal Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis Int J Oncol 33 2008 839 850
247. D. Hess, J.W. Chisholm, and R.A. Igal Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells PLoS One 5 2010 e11394
248. V. Chajes, V. Joulin, and F. Clavel-Chapelon The fatty acid desaturation index of blood lipids, as a biomarker of hepatic stearoyl-CoA desaturase expression, is a predictive factor of breast cancer risk Curr Opin Lipidol 22 2011 6 10
249. J. Li, S.F. Ding, N.A. Habib, B.F. Fermor, C.B. Wood, and R.S. Gilmour Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues Int J Cancer 57 1994 348 352
250. N. Yahagi, H. Shimano, K. Hasegawa, K. Ohashi, T. Matsuzaka, and Y. Najima Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma Eur J Cancer 41 2005 1316 1322
251. S. Moore, B. Knudsen, L.D. True, S. Hawley, R. Etzioni, and C. Wade Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma Int J Cancer 114 2005 563 571
252. V. Chajes, K. Hulten, A.L. Van Kappel, A. Winkvist, R. Kaaks, and G. Hallmans Fatty-acid composition in serum phospholipids and risk of breast cancer: an incident case-control study in Sweden Int J Cancer 83 1999 585 590
253. V. Chajes, A.C. Thiebaut, M. Rotival, E. Gauthier, V. Maillard, and M.C. Boutron-Ruault Association between serum trans-monounsaturated fatty acids and breast cancer risk in the E3N-EPIC Study Am J Epidemiol 167 2008 1312 1320
254. V. Pala, V. Krogh, P. Muti, V. Chajes, E. Riboli, and A. Micheli Erythrocyte membrane fatty acids and subsequent breast cancer: a prospective Italian study J Natl Cancer Inst 93 2001 1088 1095
255. J. Shannon, I.B. King, R. Moshofsky, J.W. Lampe, D.L. Gao, and R.M. Ray Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai China Am J Clin Nutr 85 2007 1090 1097
256. D. Hess, and R.A. Igal Genistein downregulates de novo lipid synthesis and impairs cell proliferation in human lung cancer cells Exp Biol Med (Maywood) 236 2011 707 713
257. M. Minville-Walz, A.S. Pierre, L. Pichon, S. Bellenger, C. Fevre, and J. Bellenger Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells PLoS One 5 2010 e14363
258. N. Scaglia, J.W. Chisholm, and R.A. Igal Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK PLoS One 4 2009 e6812
259. Y. Choi, Y. Park, J.M. Storkson, M.W. Pariza, and J.M. Ntambi Inhibition of stearoyl-CoA desaturase activity by the cis-9, trans-11 isomer and the trans-10, cis-12 isomer of conjugated linoleic acid in MDA-MB-231 and MCF-7 human breast cancer cells Biochem Biophys Res Commun 294 2002 785 790
260. Y.K. Ramtohul, C. Black, C.C. Chan, S. Crane, J. Guay, and S. Guiral SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors Bioorg Med Chem Lett 20 2010 1593 1597
261. R.M. Oballa, L. Belair, W.C. Black, K. Bleasby, C.C. Chan, and C. Desroches Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia J Med Chem 54 2011 5082 5096
262. U. Riserus, G.D. Tan, B.A. Fielding, M.J. Neville, J. Currie, and D.B. Savage Rosiglitazone increases indexes of stearoyl-CoA desaturase activity in humans: link to insulin sensitization and the role of dominant-negative mutation in peroxisome proliferator-activated receptor-gamma Diabetes 54 2005 1379 1384
263. Y. Kawashima, N. Uy-Yu, and H. Kozuka Sex-related differences in the enhancing effects of perfluoro-octanoic acid on stearoyl-CoA desaturase and its influence on the acyl composition of phospholipid in rat liver. Comparison with clofibric acid and tiadenol Biochem J 263 1989 897 904
264. C.W. Miller, and J.M. Ntambi Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression Proc Natl Acad Sci USA 93 1996 9443 9448
265. M.H. Oosterveer, A. Grefhorst, T.H. van Dijk, R. Havinga, B. Staels, and F. Kuipers Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice J Biol Chem 284 2009 34036 34044
266. R. Shiri-Sverdlov, K. Wouters, P.J. van Gorp, M.J. Gijbels, B. Noel, and L. Buffat Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates J Hepatol 44 2006 732 741
267. O. Kuda, B. Stankova, E. Tvrzicka, M. Hensler, T. Jelenik, and M. Rossmeisl Prominent role of liver in elevated plasma palmitoleate levels in response to rosiglitazone in mice fed high-fat diet J Physiol Pharmacol 60 2009 135 140
268. A.K. Wong, J. Howie, J.R. Petrie, and C.C. Lang AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease Clin Sci (Lond) 116 2009 607 620
269. G. Jiang, Z. Li, F. Liu, K. Ellsworth, Q. Dallas-Yang, and M. Wu Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1 J Clin Invest 115 2005 1030 1038
270. R. Gutierrez-Juarez, A. Pocai, C. Mulas, H. Ono, S. Bhanot, and B.P. Monia Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance J Clin Invest 116 2006 1686 1695
271. J.M. Brown, S. Chung, J.K. Sawyer, C. Degirolamo, H.M. Alger, and T. Nguyen Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis Circulation 118 2008 1467 1475
272. L.S. Maguire, S.M. O'Sullivan, K. Galvin, T.P. O'Connor, and N.M. O'Brien Fatty acid profile, tocopherol, squalene and phytosterol content of walnuts, almonds, peanuts, hazelnuts and the macadamia nut Int J Food Sci Nutr 55 2004 171 178
273. Y. Wu, R. Li, and D.F. Hildebrand Biosynthesis and metabolic engineering of palmitoleate production, an important contributor to human health and sustainable industry Prog Lipid Res 51 2012 340 349
274. M.S. Wilke, M.A. French, Y.K. Goh, E.A. Ryan, P.J. Jones, and M.T. Clandinin Synthesis of specific fatty acids contributes to VLDL-triacylglycerol composition in humans with and without type 2 diabetes Diabetologia 52 2009 1628 1637
275. L. Hagenfeldt, J. Wahren, B. Pernow, and L. Raf Uptake of individual free fatty acids by skeletal muscle and liver in man J Clin Invest 51 1972 2324 2330
276. K.J. Halliwell, B.A. Fielding, J.S. Samra, S.M. Humphreys, and K.N. Frayn Release of individual fatty acids from human adipose tissue in vivo after an overnight fast J Lipid Res 37 1996 1842 1848
277. J. Westerbacka, A. Kotronen, B.A. Fielding, J. Wahren, L. Hodson, and J. Perttila Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease Gastroenterology 139 2010 1961-1971e1
278. W.E. Connor, D.S. Lin, and C. Colvis Differential mobilization of fatty acids from adipose tissue J Lipid Res 37 1996 290 298
279. G. Mamalakis, A. Kafatos, Y. Manios, N. Kalogeropoulos, and N. Andrikopoulos Abdominal vs buttock adipose fat: relationships with children's serum lipid levels Eur J Clin Nutr 56 2002 1081 1086
280. X. Guo, H. Li, H. Xu, V. Halim, W. Zhang, and H. Wang Palmitoleate induces hepatic steatosis but suppresses liver inflammatory response in mice PLoS One 7 2012 e39286
281. E. Fabbrini, F. Magkos, X. Su, N.A. Abumrad, N. Nejedly, and C.C. Coughlin Insulin sensitivity is not associated with palmitoleate availability in obese humans J Lipid Res 52 2011 808 812
282. N. Stefan, K. Kantartzis, N. Celebi, H. Staiger, J. Machann, and F. Schick Circulating palmitoleate strongly and independently predicts insulin sensitivity in humans Diabetes Care 33 2010 405 407
283. P. Puri, M.M. Wiest, O. Cheung, F. Mirshahi, C. Sargeant, and H.K. Min The plasma lipidomic signature of nonalcoholic steatohepatitis Hepatology 50 2009 1827 1838
284. B. Vessby, S. Tengblad, and H. Lithell Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men Diabetologia 37 1994 1044 1050
285. A.M. Hodge, D.R. English, K. O'Dea, A.J. Sinclair, M. Makrides, and R.A. Gibson Plasma phospholipid and dietary fatty acids as predictors of type 2 diabetes: interpreting the role of linoleic acid Am J Clin Nutr 86 2007 189 197
286. S. Nielsen, Z. Guo, C.M. Johnson, D.D. Hensrud, and M.D. Jensen Splanchnic lipolysis in human obesity J Clin Invest 113 2004 1582 1588
287. D. Iggman, J. Arnlov, B. Vessby, T. Cederholm, P. Sjogren, and U. Riserus Adipose tissue fatty acids and insulin sensitivity in elderly men Diabetologia 53 2010 850 857
288. T. Matsuzaka, H. Shimano, N. Yahagi, T. Kato, A. Atsumi, and T. Yamamoto Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance Nat Med 13 2007 1193 1202