Desaturation and interconversion of dietary stearic and palmitic acids in human plasma and lipoproteins

American Journal of Clinical Nutrition

Volumn 65, Issue 2, 1997, Pages 451-458

  Rhee, Sue K ^b   Kayani, Anne J ^b   Ciszek, Aaron ^b   Brenna, J Thomas ^a  

^a Department of Obstetrics Gynecology   (United States)

^b NONE

Author keywords

desaturation; fatty acid interconversion; humans; isotope ratio mass spectrometry; palmitic acid; saturated fat; stable isotope tracer; Stearic acid

Indexed keywords

CHYLOMICRON; PALMITIC ACID; SATURATED FATTY ACID; STEARIC ACID; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; FAT INTAKE; FATTY ACID BLOOD LEVEL; FATTY ACID DESATURATION; FATTY ACID METABOLISM; HUMAN; INTESTINE ABSORPTION; MASS SPECTROMETRY; NORMAL HUMAN; RISK ASSESSMENT;

EID: 0030977243     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/65.2.451     Document Type: Article

References (51)

1. Ahrens EH, Insull W, Blomstrand R, Hirsch J, Tsaltus TT, Peterson AL. The influence of dietary fats on serum-lipid levels in man. Lancet 1957;1:944-53.
2. Keys AJ, Anderson JT, Grande F. Essential fatty acids, degree of unsaturation, and effect of corn (maize) oil on the serum-cholesterol level in man. Lancet 1957;1:66-8.
3. Keys A. Coronary heart disease in seven countries. Circulation 1970;41:I1-211.
4. Grande F, Anderson JT, Keys A. The influence of chain length of the saturated fatty acids on their effect on serum cholesterol concentration in man. J Nutr 1961;74:420-8.
5. Hushim SA, Arteaga A, Van Itallie TB. Effect of saturated mediumchain triglyceride on serum-lipids in man. Lancet 1960;1:1105-9.
6. Keys A, Anderson JT, Grande F. Serum cholesterol response to changes in the diet. IV. Particular saturated fatty acids in the diet. Metabolism 1965;14:776-87.
7. Hegsted DM, McGandy RB, Myers ML, Stare FJ. Quantitative effects of dietary fat on serum cholesterol in man. Am J Clin Nutr 1965;17:281-95.
8. Grande F, Anderson JT, Keys A. Comparison of effects of palmitic acid and stearic acids in the diet on serum cholesterol in man. Am J Clin Nutr 1970;23:1184-93.
9. Bonanome A, Grundy SM. Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels. N Engl J Med 1988;318:1244-8.
10. Haves KC, Pronczuk A, Lindsey S, Diersen-Schade D. Dietary saturated fatty acids (12:0, 14:0, 16:0) differ in their impact on plasma cholesterol and lipoproteins in nonhuman primates. Am J Clin Nutr 1991;53:491-8.
11. Khosla P, Hases KC. Comparison between dietary saturated (16:0), monounsaturated (18:1), and polyunsaturated (18:2) fatty acids on plasma lipoprotein metabolism in cebus and rhesus monkeys fed cholesterol-free diets. Am J Clin Nutr 1992;55:51-62.
12. Sundram K, Haves KC, Siru OH. Dietary palmitic acid results in a lower serum cholesterol than does a lauric-myrislic acid combination in normolipemic humans. Am J Clin Nutr 1994;59:841-6.
13. Pronczuk A, Khosla P, Haves KC. Dietary myristic, palmitic, and linoleic acids modulate eholesterolemia in gerbils. FASEB J 1994;8:1191-200.
14. Denke MA, Grundy SM. Comparison of effects of lauric acid and palmitic acid on plasma lipids and lipoproteins. Am J Clin Nutr 1992;56:895-8.
15. Grundy SM, Denke MA. Dietary influences on serum lipids and lipoproteins. J Lipid Res 1990;31:1149-72.
16. Spady DK, Dietschy JM. Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster. J Clin Invest 1988;81:300-9.
17. Woollett LA, Spady DK, Dietschy JM. Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate. J Lipid Res 1992;33:77-87.
18. Mattson FH. The absorbability of stearic acid when fed as a simple or mixed triglyceride. J Nutr 1959;69:338-42.
19. Hoagland R, Snider GG. Digestibility of some animal and vegetable fats. J Nutr 1943;25:295-301.
20. Carroll KK. Digestibility of individual fatty acids in the rat. J Nutr 1958;64:399-410.
21. Kritchevsky D. Effects of triglyceride structure on lipid-metabolism. Nutr Rev 1988;46:177-81.
22. Emken EA, Adlof RO, Rohwedder WK, Gulley RM. Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans. Biochim Biophys Acta 1993; 1170:173-81.
23. Emken EA. Metabolism of dietary stearic acid relative to other fatty acids in human subjects. Am J Clin Nutr 1994;60(suppl):1023S-8S.
24. Bonanome A, Grundy SM. Intestinal absorption of stearic acid after consumption of high fat meals in humans. J Nutr 1989;119:1556-60.
25. Carroll K, Richards J. Factors affecting digestibility of fatty acids in rats. J Nutr 1958;64:411-24.
26. Mattson FH, Nolen GA, Webb MR. The absorbability by rats of various triglycerides of stearic and oleic acid and the effect of dietary calcium and magnesium. J Nutr 1979;109:1682-7.
27. Bracco U. Effect of triglyceride structure on fat absorption. Am J Clin Nutr 1994;60(suppl):1002S-9S.
28. Bonaa KH, Bjerve KS. Norday A. Habitual fish consumption, plasma phospholipid fatty acids, and serum lipids: the Tromso Study. Am J Clin Nutr 1992;55:1126-34.
29. Elovson J. Conversions of palmitic and stearic acid in the intact rat. Biochim Biophys Acta 1965;106:291-303.
30. Bickerstaffe R, Annison EF. Glycerokinase and desaturase activity in pig, chicken and sheep intestinal epithelium. Comp Biochem Physiol 1969;31:47-54.
31. Boucrot P, Clement J. Metabolic conversions of palmitic and stearic acids during their digestion and absorption. Arch Sci Physiol 1965;19:181-96.
32. Chang JHP, Lunt DK, Smith SB. Fatty acid composition and fatty acid elongase and stearoyl-CoA desaturase activities in tissues of steers fed high oleate sunflower seed. J Nutr 1992;122:2074-80.
33. Vazquez CM, Muriana FJG, Ruiz-Gutierrez V. Changes in fatty acid desaturation in hepatic and intestinal tissues induced by intestinal resection. Lipids 1993;28:471-3.
34. Garg ML, Sebokova E, Thomson ABR, Clandinin MT. Delta 6-desalurase activity in liver microsomes of rats fed diets enriched with cholesterol and/or omega-3 fatty acids. Biochem J 1988;249:351-6.
35. Gary ML, Keelan M, Thomson ABR, Clandinin MT. Fatty acid desaturation in the intestinal mucosa. Biochim Biophys Acta 1988;958:139-41.
36. Christie WW. Silver ion chromatography using solid phase extraction columns packed with a bonded-sulfonic acid phase. J Lipid Res 1989;30:1471-3.
37. Hatch FT, Lees RS. Practical methods for plasma lipoprotein analysis. Adv Lipid Res 1968;6:2-68.
38. Thompson JN, Erdody P, Brien R, Murray TK. Fluorometric determination of vitamin A in human blood and liver. Biochem Med 1971;5:67-89.
39. 13C]-labeled precursors. Anal Chem 1992;64:1088-95.
40. Brenna JT. High precision gas isotope ratio mass spectrometry: recent advances in instrumentation and biomedical applications. Ace Chem Res 1994;27:340-6.
41. Elovson J, Olivecrona T, Beitrage P. Metabolism in the rat of chyle obtained after feeding hydrogenated coconut oil labeled with stearic acid. Biochim Biophys Acta 1965;106:34-44.
42. Bonanome A, Bennett M, Grundy SM. Metabolic effects of dietary stearic acid in mice: changes in the fatty acid composition of triglycérides and phospholipids in various tissues. Atherosclerosis 1992;94:119-27.
43. Wang S, Koo SI. Evidence for distinct metabolic utilization of stearic acid in comparison with palmitic and oleic acids in rats. J Nutr Biochem 1993;4:594-601.
44. De Gomez, Dumm NT, Brenner RR. Oxidative desaturation of α-linolenic, linoleic, and stearic acids by human liver microsomes. Lipids 1975;10:315-7.
45. Hangenfeldt L. Turnover of individual free fatty acids in man. Fed Proc 1975;34:2246-9.
46. Ntambi JM, Buhrow SA, Kaestner KH, et al. Differentiation-induced gene expression in 3T3-L1 preadipocytes: characterization of a differentially expressed gene encoding stearoyl-CoA desaturase. J Biol Chem 1988;263:17291-300.
47. Kaestner KH, Ntambi JM, Christy RJ, Kelly TJ, Lene J. Differentiation-induced gene expression in 3T3-L1 preadipocytes: a second differentially expressed gene encoding stearoyl-CoA desaturase. J Biol Chem 1989;264:14755-61.
48. Ntambi JM. Dietary expression of stearoyl-CoA desaturase 1 gene expression in mouse liver. J Biol Chem 1992;267:10925-30.
49. 13C-labeled stearic, oleic, and linoleic acids in humans: application to breath tests. J Lab Clin Med 1985;105:647-52.
50. 13C]palmitic acid in healthy women. Lipids 1995;30:291-8.
51. Beylot M. The use of stable isotopes and mass spectrometry in studying lipid metabolism. Proc Nutr Soc 1994;53:355-62.