Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome

Diabetes

Volumn 54, Issue 5, 2005, Pages 1314-1323

  Biddinger, Sudha B ^a,b   Almind, Katrine ^a   Miyazaki, Makoto ^c   Kokkotou, Efi ^a   Ntambi, James M ^c   Kahn, C Ronald ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; MONOUNSATURATED FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIETARY INTAKE; ENVIRONMENTAL FACTOR; ENZYME REGULATION; ENZYME SYNTHESIS; FAT INTAKE; FATTY LIVER; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HYPERCHOLESTEROLEMIA; HYPERINSULINEMIA; LIPID ANALYSIS; MALE; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; STRAIN DIFFERENCE; TARGET CELL;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CCAAT-ENHANCER-BINDING PROTEINS; DIET, FAT-RESTRICTED; DIETARY FATS; DNA-BINDING PROTEINS; HYPERCHOLESTEROLEMIA; INSULIN; LEPTIN; LIVER; MALE; METABOLIC SYNDROME X; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; STEAROYL-COA DESATURASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS;

EID: 17844383478     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.5.1314     Document Type: Article

References (40)

1. Ford ES, Giles WH: A comparison of the prevalence of the metabolic syndrome using two proposed definitions. Diabetes Care 26:575-581, 2003
2. Mokdad AH, Ford BS, Bowman BA, Dietz WH, Vinicor F, Bales VS, Marks JS: Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289:76-79, 2003
3. Almind K, Doria A, Kahn CR: Putting the genes for type II diabetes on the map. Nat Med 7:277-279, 2001
4. McGarry JD: What if Minkowski had been ageusic? An alternative angle on diabetes. Science 258:766-770, 1992
5. S. Marchesini G, Brizi M, Bianchi G, Tomassetti S, Bugianesi E, Lenzi M, McCullough AJ, Natale S, Forlani G, Melchionda N: Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 50:1844-1850, 2001
6. Yu AS, Keeffe EB: Nonalcoholic fatty liver disease. Rev Gastroenterol Disord 2:11-19, 2002
7. Clark JM, Diehl AM: Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis. JAMA 289:3000-3004, 2003
8. Ntambi JM, Miyazaki M: Regulation of stearoyl-CoA desaturases and role in metabolism. Prog Lipid Res 43:91-104, 2004
9. Ginsberg HN, Huang LS: The insulin resistance syndrome: impact on lipoprotein metabolism and atherothrombosis. J Cardiovasc Risk 7:325-331, 2000
10. Kulkarni RN, Almind K, Goren HJ, Winnay JN, Ueki K, Okada T, Kahn CR: Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes 52:1028-1534, 2003
11. Almind K, Kulkarni RN, Lannon SM, Kahn CR: Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes 52:1535-1543, 2003
12. Babaev VR, Patel MB, Semenkovich CF, Fazio S, Linton MF: Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice. J Biol Chem 275:26293-26299, 2000
13. Folch J, Lees M, Sloane Stanley GH: A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-509, 1957
14. Morrison WE, Smith LM: Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron flouride-methanol. J Lipid Res 53:600-608, 1964
15. Yechoor VK, Patti ME, Saccone R, Kahn CR: Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice. Proc Natl Acad Sci U S A 99:10587-10592, 2002
16. Yang J, Goldstein JL, Hammer RE, Moon YA, Brown MS, Horton JD: Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene. Proc Natl Acad Sci U S A 98:13607-13612, 2001
17. Sheng Z, Otani H, Brown MS, Goldstein JL: Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc Natl Acad Sci U S A 92:935-938, 1995
18. Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL: Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 98:1575-1584, 1996
19. Cohen P, Miyazaki M, Socci ND, Hagge-Greenberg A, Liedtke W, Soukas AA, Sharma R, Hudgins LC, Ntambi JM, Friedman JM: Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297:240-243, 2002
20. Haluzik M, Colombo C, Gavrilova O, Chua S, Wolf N, Chen M, Stannard B, Dietz KR, Le Roith D, Reitman ML: Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology 145:3258-3264, 2004
21. Colombo C, Haluzik M, Cutson JJ, Dietz KR, Marcus-Samuels B, Vinson C, Gavrilova O, Reitman ML: Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice: role of triglyceride clearance. J Biol Chem 278:3992-3999, 2003
22. Needleman P, Turk J, Jakschik BA, Morrison AR, Lefkowith JB: Arachidonic acid metabolism. Annu Rev Biochem 55:69-102, 1986
23. Horton JD, Goldstein JL, Brown MS: SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109:1125-1131, 2002
24. Shimomura I, Shimano H, Korn BS, Bashmakov Y, Horton JD: Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver. J Biol Chem 273:35299-35306, 1998
25. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM: Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413:131-138, 2001
26. Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM: Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem 277:1645-1648, 2002
27. Krebs DL, Hilton DJ: SOCS: physiological suppressors of cytokine signaling. J Cell Sci 113:2813-2819, 2000
28. Pittas AG, Joseph NA, Greenberg AS: Adipocytokines and insulin resistance. J Clin Endocrinol Metab 89:447-452, 2004
29. Ueki K, Kondo T, Tseng YH, Kahn CR: Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc Natl Acad Sci U S A 101:10422-10427, 2004
30. Dandona P, Aljada A, Bandyopadhyay A: Inflammation: the link between insulin resistance, obesity and diabetes. Trends Immunol 25:4-7, 2004
31. Haffner SM: Pre-diabetes, insulin resistance, inflammation and CVD risk. Diabetes Res Clin Pract 61 (Suppl. 1):S9-S18, 2003
32. Becker W, Huge R, Kantner T, Linnartz K, Korn M, Tschank G, Plum L, Giesen K, Joost HG: Differential hepatic gene expression in a polygenic mouse model with insulin resistance and hyperglycemia: evidence for a combined transcriptional dysregulation of gluconeogenesis and fatty acid synthesis. J Mol Endocrinol 32:195-208, 2004
33. Kakuma T, Lee Y, Unger RH: Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase. Biochem Biophys Res Commun 297:1259-1263, 2002
34. Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL: Isoform 1c of sterol regulatory element binding protein is loss active than isoform 1a in livers of transgenic mice and in cultured cells. J Clin Invest 99:846-854, 1997
35. Yahagi N, Shimano H, Hasty AH, Matsuzaka T, Ide T, Yoshikawa T, Amemiya-Kudo M, Tomita S, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N: Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. J Biol Chem 277:19353-19357, 2002
36. Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS, Song Y, Cohen P, Friedman JM, Attie AD: Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci U S A 99:11482-11486, 2002
37. Shimomura I, Bashmakov Y, Horton JD: Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus. J Biol Chem 274:30028-30032, 1999
38. Asilmaz E, Cohen P, Miyazaki M, Dobrzyn P, Ueki K, Fayzikhodjaeva G, Soukas AA, Kahn CR, Ntambi JM, Socci ND, Friedman JM: Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. J Clin Invest 113:414-424, 2004
39. Goren HJ, Kulkarni RN, Kahn CR: Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57B1/6, C57BLKS/6, DBA/2 and 129X1. Endocrinology 145:3307-3323, 2004
40. Almind K, Kahn CR: Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. Diabetes 53:3274-3285, 2004