Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men

Journal of Lipid Research

Volumn 39, Issue 6, 1998, Pages 1280-1286

  Aarsland, Asle ^a   Wolfe, Robert R ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

De novo synthesis of fatty acids; Desaturation; Elongation; Linolenic; Oleic; Palmitic; Palmitoleic; St able isotope; Stearic

Indexed keywords

FATTY ACID; LINOLEIC ACID; OLEIC ACID; PALMITIC ACID; STEARIC ACID; VERY LOW DENSITY LIPOPROTEIN;

ARTICLE; CARBOHYDRATE INTAKE; CONTROLLED STUDY; DIETARY INTAKE; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; HUMAN; LIPOGENESIS; LIPOPROTEIN SYNTHESIS; LIVER METABOLISM; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

DIETARY CARBOHYDRATES; ENERGY METABOLISM; FATTY ACIDS, MONOUNSATURATED; FATTY ACIDS, NONESTERIFIED; GLUCOSE; HUMANS; INFUSIONS, INTRAVENOUS; KINETICS; LINOLEIC ACID; LIPOPROTEINS, VLDL; LIVER; MALE; OLEIC ACID; PALMITIC ACID; STEARIC ACIDS; TRIGLYCERIDES;

EID: 0031839599     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Glickman, R. M., and S. M. Sabesin. 1994. Lipoprotein metabolism. In The Liver: Biology and Pathobiology. I. M. Arias, J. L. Boyer, N. Fausto, W. B. Jakoby, D. Schachter, and D. A. Shafrit?, editors. Raven Press, New York. 391-414.
2. Goodridge, A. G. 1991. Fatty acid synthesis in eucaryotes. In Biochemistry of Lipids, Lipoproteins and Membranes. D. E. Vance and J. Vance, editors. Elsevier Science Publishing, Amsterdam. 111-140.
3. Cook, H. W. 1991. Fatty acid desaturation and chain elongation in eucaryotes. In biochemistry of Lipids, Lipoproteins and Membranes. D. E. Vance and J. Vance, editors. Elsevier Science Publishing, Amsterdam. 141-169.
4. Lewis, G. F., K. D. Uffelman, L. Szeto, B. Weller, and G. Steiner. 1995. Interaction between free fatty acids and insulin in the acute control of very low density lipoprotein production in humans. J. Clin. Invest. 95: 158-166.
5. Hughes, T. A., M. Heimberg, X. Wang, H. Wilcox, S. M. Hughes, E. A. Tolley, D. M. Desiderio, and J. T. Dalton. 1996. Comparative lipoprotein metabolism of myristate, palmitate, and stearate in normolipidemic men. Metabolism. 45: 1108-1118.
6. Tijburg, L. B. M., M. J. H. Geelen, and L. M. G. Van Golde. 1989. Regulation of the biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine in the liver. Biochim. Biophys. Acta. 1004: 1-19.
7. Gibbons, G. F. 1990. Assembly and secretion of hepatic very-low-density lipoprotein. Biochem. J. 268: 1-13.
8. Howard, B. V. 1987. Lipoprotein metabolism in diabetes mellitus. J. Lipid Res. 28: 613-628.
9. Gibbons, G. F., and F. J. Burnham. 1991. Effect of nutritional state on the utilization of fatty acids for hepatic triacylglycerol synthesis and secretion as very-low-density lipoprotein. Biochem. J. 275: 87-92.
10. Sparks, J. D., and C. E. Sparks. 1994. Insulin regulation of triacylglycerol rich lipoprotein synthesis and secretion. [Review]. Biochim. Biophys. Acta. 1215: 9-32.
11. Mattson, F. H., and S. M. Grundy. 1985. Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man. J. Lipid. Res. 26: 194-202.
12. Havel, R. J., J. P. Kane, E. O. Balasse, N. Segel, and L. V. Basso. 1970. Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans. J. Clin. Invest. 49: 2017-2035.
13. Boberg, J., L. A. Carlson, U. Freyschuss, B. W. Lassers, and M. L. Wahlqvist. 1972. Splanchnic secretion rate of plasma triglycerides and of total and splanchnic turnover of plasma free fatty acids in man with normo- and hypertriglyceridaemia. Eur. J. Clin. Invest. 2: 454-466.
14. Binnert, C., C. Pachiaudi, M. Beylot, M. Croset, R. Cohen, J. P. Riou, and M. Laville. 1996. Metabolic fate of an oral long-chain triglyceride load in humans. Am. J. Physiol. 270: E445-E450.
15. 2O) and mass isotopomer analysis. Am. J. Physiol. 266: E372-E383.
16. Fukuda, N., and J. A. Ontko. 1984. Interactions between fatty acid synthesis, oxidation, and esterification in the production of triglyceride-rich lipoproteins by the liver. J. Lipid Res. 25: 831-842.
17. Angeletti, C., and M. J. de Alaniz. 1995. Fatty acid uptake and metabolism in HepG2 human-hepatoma cells. Mol. Cell. Biochem. 143: 99-105.
18. Kvilekval, K., J. Lin, W. Cheng, and N. Abumrad. 1994. Fatty acids as determinants of triglyceride and cholesteryl ester synthesis by isolated hepatocytes: kinetics as a function of various fatty acids. J. Lipid Res. 35: 1786-1794.
19. Ajie, H. O., M. J. Connor, W. N. P. Lee, S. Bassilian, E. A. Bergner, and L. O. Byerley. 1995. In vivo study of the biosynthesis of long-chain fatty acids using deuterated water. Am. J. Physiol. 269: E247-E252.
20. Lee, W. N., L. O. Byerley, S. Bassilian, H. O. Ajie, I. Clark, J. Edmond, and E. A. Bergner. 1995. Isotopomer study of lipogenesis in human hepatoma cells in culture: contribution of carbon and hydrogen atoms from glucose. Anal. Biochem. 226: 100-112.
21. Bjornsson, O. G., J. D. Sparks, C. E. Sparks, and G. F. Gibbons. 1994. Regulation of VLDL secretion in primary culture of rat hepatocytes: involvement of cAMP and cAMP-dependent protein kinases. Eur. J. Clin. Invest. 24: 137-148.
22. Aarsland, A., D. Chinkes, and R. R. Wolfe. 1996. Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. J. Clin. Invest. 98: 2008-2017.
23. Wolfe, R. R., T. F. O'Donnel, M. D. Stone, D. A. Richmand, and J. F. Burke. 1980. Investigation of factors determining the optimal glucose infusion rale in total parenteral nutrition. Metabolism. 29: 892-900.
24. Wolfe, R. R., J. R. Allsop, and J. F. Burke. 1979. Glucose metabolism in man: responses to intravenous glucose infusion. Metabolism. 28: 210-220.
25. Grundy, S. M., H. Y. I. Mok, L. Zeck, and D. Steinberg. 1979. Transport of very low density lipoprotein triglycerides in varying degrees of obesity and hypertriglyceridemia. J. Clin. Invest. 63: 1274-1283.
26. Chinkes, D., A. Aarsland, J. Rosenblatt, and R. R. Wolfe. 1996. A comparison of mass isotopomer dilution methods used to compute production of VLDL fatty acids in vivo in human subjects. Am. J. Physiol. 271: E373-E383.
27. Armitage, P., and G. Berry. 1994. Statistical Methods in Medical Research. Blackwell Scientific Publications, Oxford.