Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice

Biochemical and Biophysical Research Communications

Volumn 380, Issue 4, 2009, Pages 818-822

  Miyazaki, Makoto ^a,b   Sampath, Harini ^a   Liu, Xueqing ^a   Flowers, Matthew T ^a   Chu, Kiki ^a   Dobrzyn, Agnieszka ^a,c   Ntambi, James M ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

Author keywords

Hepatic lipids; High fat diet; Leptin resistance

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE 1; INSULIN; LEPTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; ENZYME DEFICIENCY; FAT INTAKE; FEMALE; GENE EXPRESSION; GENE FUNCTION; GLUCOSE TOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID LIVER LEVEL; LIPID STORAGE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; WEIGHT REDUCTION;

ADIPOSITY; AGOUTI SIGNALING PROTEIN; ANIMALS; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN RESISTANCE; LEPTIN; MICE; MICE, MUTANT STRAINS; OBESITY; STEAROYL-COA DESATURASE;

AGOUTI; MUS;

EID: 60849136007     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.01.183     Document Type: Article

References (30)

1. Ntambi J.M., and Miyazaki M. Regulation of stearoyl-CoA desaturases and role in metabolism. Prog. Lipid Res. 43 (2004) 91-104
2. Ntambi J.M., Miyazaki M., Stoehr J.P., Lan H., Kendziorski C.M., Yandell B.S., Song Y., Cohen P., Friedman J.M., and Attie A.D. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc. Natl. Acad. Sci. USA 99 (2002) 11482-11486
3. Miyazaki M., Bruggink S.M., and Ntambi J.M. Identification of mouse palmitoyl-coenzyme A Delta9-desaturase. J. Lipid Res. 47 (2006) 700-704
4. Miyazaki M., Jacobson M.J., Man W.C., Cohen P., Asilmaz E., Friedman J.M., and Ntambi J.M. Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J. Biol. Chem. 278 (2003) 33904-33911
5. Miyazaki M., Dobrzyn A., Elias P.M., and Ntambi J.M. Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development. Proc. Natl. Acad. Sci. USA 102 (2005) 12501-12506
6. Miyazaki M., Dobrzyn A., Man W.C., Chu K., Sampath H., Kim H.J., and Ntambi J.M. Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms. J. Biol. Chem. 279 (2004) 25164-25171
7. Miyazaki M., Kim Y.C., and Ntambi J.M. A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J. Lipid Res. 42 (2001) 1018-1024
8. Jiang G., Li Z., Liu F., Ellsworth K., Dallas-Yang Q., Wu M., Ronan J., Esau C., Murphy C., Szalkowski D., Bergeron R., Doebber T., and Zhang B.B. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. J. Clin. Invest. 115 (2005) 1030-1038
9. Rahman S.M., Dobrzyn A., Dobrzyn P., Lee S.H., Miyazaki M., and Ntambi J.M. Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc. Natl. Acad. Sci. USA 100 (2003) 11110-11115
10. Rahman S.M., Dobrzyn A., Lee S.H., Dobrzyn P., Miyazaki M., and Ntambi J.M. Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue. Am. J. Physiol. Endocrinol. Metab. 288 (2005) E381-E387
11. Flowers J.B., Rabaglia M.E., Schueler K.L., Flowers M.T., Lan H., Keller M.P., Ntambi J.M., and Attie A.D. Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes 56 (2007) 1228-1239
12. Gutierrez-Juarez R., Pocai A., Mulas C., Ono H., Bhanot S., Monia B.P., and Rossetti L. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J. Clin. Invest. 116 (2006) 1686-1695
13. Dobrzyn P., Sampath H., Dobrzyn A., Miyazaki M., and Ntambi J.M. Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart. Am. J. Physiol. Endocrinol. Metab. 294 (2008) E357-E364
14. Cohen P., Miyazaki M., Socci N.D., Hagge-Greenberg A., Liedtke W., Soukas A.A., Sharma R., Hudgins L.C., Ntambi J.M., and Friedman J.M. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297 (2002) 240-243
15. Asilmaz E., Cohen P., Miyazaki M., Dobrzyn P., Ueki K., Fayzikhodjaeva G., Soukas A.A., Kahn C.R., Ntambi J.M., Socci N.D., and Friedman J.M. Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. J. Clin. Invest. 113 (2004) 414-424
16. Cohen P., and Friedman J.M. Leptin and the control of metabolism: role for stearoyl-CoA desaturase-1 (SCD-1). J. Nutr. 134 (2004) 2455S-2463S
17. Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
18. Tschop M., and Heiman M.L. Rodent obesity models: an overview. Exp. Clin. Endocrinol. Diabetes 109 (2001) 307-319
19. Bligh E.G., and Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37 (1959) 911-917
20. Dobrzyn A., Dobrzyn P., Miyazaki M., Sampath H., Chu K., and Ntambi J.M. Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver. J. Biol. Chem. 280 (2005) 23356-23362
21. Chen H.C., Smith S.J., Ladha Z., Jensen D.R., Ferreira L.D., Pulawa L.K., McGuire J.G., Pitas R.E., Eckel R.H., and Farese Jr. R.V. Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J. Clin. Invest. 109 (2002) 1049-1055
22. Sampath H., Miyazaki M., Dobrzyn A., and Ntambi J.M. Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J. Biol. Chem. 282 (2007) 2483-2493
23. Rector R.S., Warner S.O., Liu Y., Hinton P.S., Sun G., Cox R.H., Stump C.S., Laughlin M.H., Dellsperger K.C., and Thomas T.R. Exercise and diet induced weight loss improves measures of oxidative stress and insulin sensitivity in adults with characteristics of the metabolic syndrome. Am. J. Physiol. Endocrinol. Metab. 1 (2007) 1
24. Petersen K.F., and Shulman G.I. Etiology of insulin resistance. Am. J. Med. 119 (2006) S10-S16
25. Fernandez M.L. The metabolic syndrome. Nutr. Rev. 65 (2007) S30-S34
26. Chinookoswong N., Wang J.L., and Shi Z.Q. Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat. Diabetes 48 (1999) 1487-1492
27. Ceddia R.B., Koistinen H.A., Zierath J.R., and Sweeney G. Analysis of paradoxical observations on the association between leptin and insulin resistance. FASEB J. 16 (2002) 1163-1176
28. Steinberg G.R., and Jorgensen S.B. The AMP-activated protein kinase: role in regulation of skeletal muscle metabolism and insulin sensitivity. Mini-Rev. Med. Chem. 7 (2007) 519-526
29. Dobrzyn P., Dobrzyn A., Miyazaki M., Cohen P., Asilmaz E., Hardie D.G., Friedman J.M., and Ntambi J.M. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc. Natl. Acad. Sci. USA 101 (2004) 6409-6414
30. Dobrzyn A., Dobrzyn P., Miyazaki M., and Ntambi J.M. Polyunsaturated fatty acids do not activate AMP-activated protein kinase in mouse tissues. Biochem. Biophys. Res. Commun. 332 (2005) 892-896