Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy

Molecular Cancer Research

Volumn 9, Issue 11, 2011, Pages 1551-1561

  Roongta, Urvashi V ^a   Pabalan, Jonathan G ^a   Wang, Xinyu ^a   Ryseck, Rolf Peter ^a   Fargnoli, Joseph ^a   Henley, Benjamin J ^a   Yang, Wen Pin ^a   Zhu, Jun ^a   Madireddi, Malavi T ^a   Lawrence, R Michael ^a   Wong, Tai W ^a   Rupnow, Brent A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE 1; ACYL COENZYME A DESATURASE 5; MONOUNSATURATED FATTY ACID; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CATALYSIS; CELL LEVEL; CELL SURVIVAL; CONTROLLED STUDY; CULTURE MEDIUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN INDUCTION; PROTEIN TARGETING; STOMACH CANCER; TUMOR XENOGRAFT;

AMINO ACID SEQUENCE; ANIMALS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL SURVIVAL; FATTY ACIDS, UNSATURATED; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR SEQUENCE DATA; MOLECULAR TARGETED THERAPY; NEOPLASMS; RNA, SMALL INTERFERING; STEAROYL-COA DESATURASE; TRANSFECTION;

EID: 81755173915     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-11-0126     Document Type: Article

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