Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: Links to obesity and insulin resistance

Lipids in Health and Disease

Volumn 8, Issue , 2009, Pages

  Warensjö, Eva ^a   Rosell, Magdalena ^b   Hellenius, Mai Lis ^b   Vessby, Bengt ^a   De Faire, Ulf ^b   Risérus, Ulf ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; DELTA5 DESATURASE; FATTY ACID; LINOLEOYL COENZYME A DESATURASE; OXYGENASE; PHOSPHOLIPID; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; LONG CHAIN FATTY ACID COENZYME A LIGASE; STEAROYL COA SYNTHETASE; STEAROYL-COA SYNTHETASE;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; LIPID BLOOD LEVEL; MALE; NORMAL HUMAN; OBESITY; RISK FACTOR; BLOOD; ENZYMOLOGY; FEMALE; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADIPOSE TISSUE; BODY MASS INDEX; COENZYME A LIGASES; FATTY ACID DESATURASES; FATTY ACIDS, NONESTERIFIED; FEMALE; HUMANS; INSULIN RESISTANCE; LINOLEOYL-COA DESATURASE; MALE; MIDDLE AGED; OBESITY; PHOSPHOLIPIDS; TRIGLYCERIDES;

EID: 70349417898     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-8-37     Document Type: Article

References (27)

1. The use of fatty acid biomarkers to reflect dietary intake. A Baylin H Campos, Curr Opin Lipidol 2006 17 1 22 27 10.1097/01.mol.0000199814.46720.83 16407712
2. Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. MB Katan JP Deslypere AP van Birgelen M Penders M Zegwaard, J Lipid Res 1997 38 10 2012 2022 9374124
3. Plasma fatty acid composition as an indicator of habitual dietary fat intake in middle-aged adults. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. J Ma AR Folsom E Shahar JH Eckfeldt, Am J Clin Nutr 1995 62 3 564 571 7661118
4. Fatty acid composition of serum cholesteryl esters and erythrocyte membranes as indicators of linoleic acid intake in man. JF Glatz AE Soffers MB Katan, Am J Clin Nutr 1989 49 2 269 276 2916448
5. Desaturation and elongation of Fatty acids and insulin action. B Vessby IB Gustafsson S Tengblad M Boberg A Andersson, Ann N Y Acad Sci 2002 967 183 195 12079847
6. Adipose tissue: a key target for diabetes pathophysiology and treatment? KN Frayn GD Tan F Karpe, Horm Metab Res 2007 39 10 739 742 10.1055/s-2007-990270 17952837
7. Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women. E Warensjö M hrvall B Vessby, Nutr Metab Cardiovasc Dis 2006 16 2 128 136 10.1016/j.numecd.2005.06. 001 16487913
8. Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men. B Vessby S Tengblad H Lithell, Diabetologia 1994 37 10 1044 1050 10.1007/BF00400468 7851683
9. Plasma fatty acid composition and incidence of diabetes in middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) Study. L Wang AR Folsom ZJ Zheng JS Pankow JH Eckfeldt, Am J Clin Nutr 2003 78 1 91 98 12816776 (Pubitemid 39655252)
10. Fatty acid composition of serum lipids predicts the development of the metabolic syndrome in men. E Warensjö U Riserus B Vessby, Diabetologia 2005 48 10 1999 2005 10.1007/s00125-005-1897-x 16132958
11. Associations between diet and the metabolic syndrome vary with the validity of dietary intake data. MS Rosell ML Hellenius UH de Faire GK Johansson, Am J Clin Nutr 2003 78 1 84 90 12816775
12. Associations between the intake of dairy fat and calcium and abdominal obesity. M Rosell G Johansson L Berglund B Vessby U de Faire ML Hellenius, Int J Obes Relat Metab Disord 2004 28 11 1427 1434 10.1038/sj.ijo.0802769 15326466
13. Rapid sampling and long-term storage of subcutaneous adipose-tissue biopsies for determination of fatty acid composition. AC Beynen MB Katan, Am J Clin Nutr 1985 42 2 317 322 4025201
14. Platelet fatty acid composition in relation to fatty acid composition in plasma and to serum lipoprotein lipids in healthy subjects with special reference to the linoleic acid pathway. M Boberg LB Croon IB Gustafsson B Vessby, Clin Sci (Lond) 1985 68 5 581 587 3919990
15. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. DR Matthews JP Hosker AS Rudenski BA Naylor DF Treacher RC Turner, Diabetologia 1985 28 7 412 419 10.1007/BF00280883 3899825
16. Physiological regulation of NEFA availability: lipolysis pathway. V Stich M Berlan, Proc Nutr Soc 2004 63 2 369 374 10.1079/PNS2004350 15294057
17. Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. L Hodson CM Skeaff BA Fielding, Prog Lipid Res 2008 47 5 348 380 10.1016/j.plipres.2008.03.003 18435934
18. Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity. LK Summers BA Fielding HA Bradshaw V Ilic C Beysen ML Clark NR Moore KN Frayn, Diabetologia 2002 45 3 369 377 10.1007/s00125-001-0768-3 11914742
19. Dietary stearic acid and risk of cardiovascular disease: intake, sources, digestion, and absorption. PM Kris-Etherton AE Griel TL Psota SK Gebauer J Zhang TD Etherton, Lipids 2005 40 12 1193 1200 10.1007/s11745-005-1485-y 16477802
20. Structure, Function, And Dietary Regulation of Delta6, Delta5, and Delta9 Desaturases. MT Nakamura TY Nara, Annu Rev Nutr 2004 24 345 376 10.1146/annurev.nutr.24.121803.063211 15189125
21. Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study. B Vessby M Uusitupa K Hermansen G Riccardi AA Rivellese LC Tapsell C Nalsen L Berglund A Louheranta BM Rasmussen, et al. Diabetologia 2001 44 3 312 319 10.1007/s001250051620 11317662
22. Dietary fat, fatty acid composition in plasma and the metabolic syndrome. B Vessby, Curr Opin Lipidol 2003 14 1 15 19 10.1097/00041433-200302000-00004 12544656
23. Fatty acid desaturases in human adipose tissue: relationships between gene expression, desaturation indexes and insulin resistance. P Sjogren J Sierra-Johnson K Gertow M Rosell B Vessby U de Faire A Hamsten ML Hellenius RM Fisher, Diabetologia 2008 51 2 328 335 10.1007/s00125-007-0876-9 18030445
24. Skeletal muscle membrane lipid composition is related to adiposity and insulin action. DA Pan S Lillioja MR Milner AD Kriketos LA Baur C Bogardus LH Storlien, J Clin Invest 1995 96 6 2802 2808 10.1172/JCI118350 8675650
25. The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. M Borkman LH Storlien DA Pan AB Jenkins DJ Chisholm LV Campbell, N Engl J Med 1993 328 4 238 244 10.1056/ NEJM199301283280404 8418404
26. Metabolic Regulation -A human perspective. KN Frayn, Oxford, UK: Blackwell Science Ltd Second 2003
27. Parallel activation of de novo lipogenesis and stearoyl-CoA desaturase activity after 3 d of high-carbohydrate feeding. MF Chong L Hodson AS Bickerton R Roberts M Neville F Karpe KN Frayn BA Fielding, Am J Clin Nutr 2008 87 4 817 823 18400702