Oleate activates phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects

Cancer Research

Volumn 60, Issue 22, 2000, Pages 6353-6358

  Hardy, S ^a   Langelier, Y ^a   Prentki, M ^a  

^a NOTRE DAME HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

OLEIC ACID; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE;

APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; CANCER CELL CULTURE; CANCER RISK; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FAT INTAKE; HUMAN; HUMAN CELL; LIPID METABOLISM; PRIORITY JOURNAL; STARVATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; BREAST NEOPLASMS; CELL DIVISION; CULTURE MEDIA, SERUM-FREE; DRUG INTERACTIONS; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; OLEIC ACID; PALMITIC ACID; TUMOR CELLS, CULTURED;

EID: 0033692758     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Relationship between dietary fat and experimental mammary tumorigenesis: A review and critique
2. Effects of dietary fatty acids on breast and prostate cancers: Evidence from in vitro experiments and animal studies
3. Dietary fat, calorie restriction, ad libitum feeding, and cancer risk
4. A rationale for dietary intervention in postmenopausal breast cancer patients: An update
5. Cohort studies of fat intake and the risk of breast cancer: A pooled analysis
6. Association of dietary intake of fat and fatty acids with risk of breast cancer
7. Effect of different types and amounts of fat on the development of mammary tumors in rodents: A review
8. Fatty acids and breast cancer cell proliferation
9. Human studies on the effects of fatty acids on cancer: Summary, gaps, and future research
10. Stearate inhibition of breast cancer cell proliferation. A mechanism involving epidermal growth factor receptor and G-proteins
11. Eicosanoids and linoleate-enhanced growth of mouse mammary tumor cells. Prostaglandins Leukotrienes Essent
12. Relationship of the uptake and β-oxidation of 18-carbon fatty acids with stimulation of murine mammary tumor cell growth
13. Modulation of mouse mammary tumor growth and linoleate enhanced metastasis by oleate
14. Stearate inhibits human tumor cell invasion
15. Effects of fatty acids and inhibitors of eicosanoid synthesis on the growth of a human breast cancer cell line in culture
16. Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acids
17. Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells
18. Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer
19. Fatty acid synthase (FAS): A target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells
20. Fatty acid synthesis: A potential selective target for antineoplastic therapy
21. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma
22. Activators of the nuclear receptor PPARγ enhance colon polyp formation
23. Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
24. Differentiation and reversal of malignant changes in colon cancer through PPARγ
25. Ligands for peroxisome proliferator-activated receptor γ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
26. Palmitate and oleate induce the immediate-early response genes c-fos and nur-77 in the pancreatic β-cell line INS-1
27. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
28. Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity
29. The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase
30. Phosphatidylinositol 3-kinase: A novel effector
31. Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in β (INS-1)-cells
32. A simple salting out procedure for extracting DNA from human nucleated cells
33. PDGF-mediated activation of phosphatidylinositol 3 kinase in human mesangial cells
34. Serummyocardium gradients of non-esterified fatty acids in dog, rat and man
35. Unbound free fatty acid levels in human serum
36. Interactions of long-chain fatty acids and albumin: Determination of free fatty acid levels using the fluorescent probe ADIFAB
37. Influence of n-3 fatty acids on the growth of human breast cancer cells in vitro: Relationship to peroxides and vitamin-E
38. Diet effects on fatty acid metabolism in lean and obese humans
39. Obesity as a risk factor for certain types of cancer
40. Insulin and colon cancer
41. Association between breast and colorectal cancers
42. Insulin promotion of colon tumors in rats
43. Nutrition and breast cancer risk: Can an effect via insulin resistance be demonstrated?
44. Fatty acid-induced β cell apoptosis: A link between obesity and diabetes
45. Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis
46. Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes
47. An update of the enzymology and regulation of sphingomyelin metabolism
48. Peroxisome proliferator-activated receptors: Nuclear control of metabolism
49. Src-family tyrosine kinases in activation of ERK-1 and p85/p110-phosphatidylinositol 3-kinase by G/CCKB receptors
50. G-protein coupled receptor-mediated activation of PI 3-kinase in neutrophils
51. Activation of epithelial growth factor receptor pathway by unsaturated fatty acids
52. Binding of sulfosuccinimidyl fatty acids to adipocyte membrane proteins: Isolation and amino-terminal sequence of an 88-kD protein implicated in transport of long-chain fatty acids
53. Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets