The role of stearoyl-CoA desaturase in obesity, insulin resistance, and inflammation

Annals of the New York Academy of Sciences

Volumn 1243, Issue 1, 2011, Pages 47-53

  Sampath, Harini ^a   Ntambi, James M ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Fatty acid oxidation; Leptin resistance; Lipogenesis; Skin barrier; Thermogenesis

Indexed keywords

ACYL COENZYME A DESATURASE; ACYL COENZYME A DESATURASE 1; ADIPONECTIN; FATTY ACID SYNTHASE; FISH OIL; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MONOUNSATURATED FATTY ACID; OMEGA 3 FATTY ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR;

ACYL COENZYME A DESATURASE 1 DEFICIENCY; ADIPOSE TISSUE; ATHEROSCLEROSIS; CELL METABOLISM; DIET SUPPLEMENTATION; DYSLIPIDEMIA; ENZYME DEFICIENCY; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; FATTY LIVER; GENE CONTROL; GENE DELETION; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HYPERTRIGLYCERIDEMIA; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; LIPOGENESIS; LIVER; LIVER CELL CARCINOMA; MACROPHAGE; NEOPLASM; NONHUMAN; NONSHIVERING THERMOGENESIS; OBESITY; PHENOTYPE; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; REVIEW; SCID MOUSE; SKIN; SKIN INFLAMMATION; ULCERATIVE COLITIS;

EID: 84255163040     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2011.06303.x     Document Type: Review

References (75)

1. Nakamura, M.T. & T.Y. Nara. 2004. Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. Annu. Rev. Nutr. 24: 345-376.
2. Sampath, H. & J.M. Ntambi. 2006. Stearoyl-coenzyme A desaturase 1, sterol regulatory element binding protein-1c and peroxisome proliferator-activated receptor-alpha: independent and interactive roles in the regulation of lipid metabolism. Curr. Opin. Clin. Nutr. Metab. Care 9: 84-88.
3. Man, W.C. et al. 2006. Membrane topology of mouse stearoyl-CoA desaturase 1. J. Biol. Chem. 281: 1251-1260.
4. Shanklin, J. & E.B. Cahoon. 1998. Desaturation and related modifications of fatty acids. Annu. Rev. Plant Physiol. Plant Mol. Biol. 49: 611-641.
5. Miyazaki, M., S.M. Bruggink & J.M. Ntambi. 2006. Identification of mouse palmitoyl-coenzyme A Delta9-desaturase. J. Lipid Res. 47: 700-704.
6. Kaestner, K.H. et al. 1989. Differentiation-induced gene expression in 3T3-L1 preadipocytes. A second differentially expressed gene encoding stearoyl-CoA desaturase. J. Biol. Chem. 264: 14755-14761.
7. Miyazaki, M. et al. 2005. Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development. Proc. Natl. Acad. Sci. USA 102: 12501-12506.
8. Miyazaki, M. et al. 2003. Identification and characterization of murine SCD4, a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors. J. Biol. Chem. 278: 33904-33911.
9. Zheng, Y. et al. 2001. Scd3-a novel gene of the stearoyl-CoA desaturase family with restricted expression in skin. Genomics 71: 182-191.
10. Ntambi, J.M. et al. 2002. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc. Natl. Acad. Sci. USA 99: 11482-11486.
11. Miyazaki, M. et al. 2001. Oleoyl-CoA is the major de novo product of stearoyl-CoA desaturase 1 gene isoform and substrate for the biosynthesis of the Harderian gland 1-alkyl-2, 3-diacylglycerol. J. Biol. Chem. 276: 39455-39461.
12. Dobrzyn, P. et al. 2008. Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart. Am. J. Physiol. Endocrinol. Metab. 294: E357-E364.
13. Sampath, H.N. & M. James. 2008. Role of stearoyl-CoA desaturase in human metabolic disease. Future Lipidology 3: 163-173.
14. Miyazaki, M. et al. 2004. Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms. J. Biol. Chem. 279: 25164-25171.
15. Miyazaki, M. et al. 2007. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell. Metab. 6: 484-496.
16. Miyazaki, M., Y.C. Kim & J.M. Ntambi. 2001. A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis. J. Lipid Res. 42: 1018-1024.
17. Sampath, H. et al. 2007. Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J. Biol. Chem. 282: 2483-2493.
18. Sampath, H. et al. 2009. Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity. J. Biol. Chem. 284: 19961-19973.
19. Sundberg, J.P. et al. 2000. Asebia-2J (Scd1(ab2J)): a new allele and a model for scarring alopecia. Am. J. Pathol. 156: 2067-2075.
20. Sampath, H. & J.M. Ntambi. 2005. Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu. Rev. Nutr. 25: 317-340.
21. Heinemann, F.S., G. Korza & J. Ozols. 2003. A plasminogen-like protein selectively degrades stearoyl-CoA desaturase in liver microsomes. J. Biol. Chem. 278: 42966-42975.
22. Heinemann, F.S. et al. 2003. A microsomal endopeptidase from liver that preferentially degrades stearoyl-CoA desaturase. Biochemistry 42: 6929-6937.
23. Heinemann, F.S. & J. Ozols. 1998. Degradation of stearoyl-coenzyme A desaturase: endoproteolytic cleavage by an integral membrane protease. Mol. Biol. Cell 9: 3445-3453.
24. Kato, H., K. Sakaki & K. Mihara. 2006. Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase. J. Cell Sci. 119: 2342-2353.
25. Biddinger, S.B. et al. 2006. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes 55: 2032-2041.
26. Dobrzyn, P. et al. 2010. Loss of stearoyl-CoA desaturase 1 rescues cardiac function in obese leptin-deficient mice. J. Lipid Res. 51: 2202-2210.
27. Flowers, J.B. et al. 2007. Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice. Diabetes 56: 1228-1239.
28. Miyazaki, M. et al. 2009. Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice. Biochem. Biophys. Res. Commun. 380: 818-822.
29. Rahman, S.M. et al. 2003. Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc. Natl. Acad. Sci. USA 100: 11110-11115.
30. Rahman, S.M. et al. 2005. Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue. Am. J. Physiol. Endocrinol. Metab. 288: E381-E387.
31. MacDonald, M.L. et al. 2009. Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis. Arterioscler. Thromb Vasc. Biol. 29: 341-347.
32. Brown, J.M. et al. 2008. Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis. Circulation 118: 1467-1475.
33. Feingold, K.R. 2009. The outer frontier: the importance of lipid metabolism in the skin. J. Lipid Res. 50 Suppl: S417-S422.
34. Fluhr, J.W. et al. 2003. Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice. J. Invest. Dermatol. 120: 728-737.
35. Lee, S.H. et al. 2004. Lack of stearoyl-CoA desaturase 1 upregulates basal thermogenesis but causes hypothermia in a cold environment. J. Lipid Res. 45: 1674-1682.
36. Cohen, P. et al. 2002. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297: 240-243.
37. Brown, J.M. et al. 2010. Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis. Arterioscler. Thromb Vasc. Biol. 30: 24-30.
38. Savransky, V. et al. 2008. Dyslipidemia and atherosclerosis induced by chronic intermittent hypoxia are attenuated by deficiency of stearoyl coenzyme A desaturase. Circ. Res. 103: 1173-1180.
39. Dobrzyn, A. et al. 2005. Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 288: E599-E607.
40. Dobrzyn, P. et al. 2004. Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc. Natl. Acad. Sci. USA 101: 6409-6414.
41. Miyazaki, M. et al. 2004. Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha. J. Biol. Chem. 279: 35017-35024.
42. Flowers, M.T. et al. 2011. Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism. PLoS One 6: e19734.
43. Smith, S.J. et al. 2000. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat. Genet. 25: 87-90.
44. Chen, H.C. et al. 2003. Analysis of energy expenditure at different ambient temperatures in mice lacking DGAT1. Am. J. Physiol. Endocrinol. Metab. 284: E213-E218.
45. Shih, M.Y. et al. 2009. Retinol esterification by DGAT1 is essential for retinoid homeostasis in murine skin. J. Biol. Chem. 284: 4292-4299.
46. Cannon, B. & J. Nedergaard. 2011. Nonshivering thermogenesis and its adequate measurement in metabolic studies. J. Exp. Biol. 214: 242-253.
47. Ahmad, F. et al. 1997. Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes. J. Clin. Invest. 100: 449-458.
48. Kenner, K.A. et al. 1993. Regulation of protein tyrosine phosphatases by insulin and insulin-like growth factor I. J. Biol. Chem. 268: 25455-25462.
49. Summers, S.A. et al. 1998. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Mol. Cell. Biol. 18: 5457-5464.
50. Chavez, J.A. et al. 2005. Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling. J. Biol. Chem. 280: 20148-20153.
51. Bruce, C.R. et al. 2006. Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content. Am. J. Physiol. Endocrinol. Metab. 291: E99-E107.
52. Gutierrez-Juarez, R. et al. 2006. Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance. J. Clin. Invest. 116: 1686-1695.
53. Jiang, G. et al. 2005. Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1. J. Clin. Invest. 115: 1030-1038.
54. Hyun, C.K. et al. 2010. Adipose-specific deletion of stearoyl-CoA desaturase 1 up-regulates the glucose transporter GLUT1 in adipose tissue. Biochem. Biophys. Res. Commun. 399: 480-486.
55. Liu, X., M.S. Strable & J.M. Ntambi. 2011. Stearoyl CoA desaturase 1: role in cellular inflammation and stress. Adv. Nutr. 2: 15-22.
56. Liu, X. et al. 2010. Loss of stearoyl-CoA desaturase-1 attenuates adipocyte inflammation. Arterioscler. Thromb Vasc. Biol. 30: 31-38.
57. Chen, C. et al. 2008. Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis. Cell. Metab. 7: 135-147.
58. MacDonald, M.L. et al. 2009. Absence of stearoyl-CoA desaturase-1 does not promote DSS-induced acute colitis. Biochim. Biophys. Acta 1791: 1166-1172.
59. Brown, W.R. & M.H. Hardy. 1988. A hypothesis on the cause of chronic epidermal hyperproliferation in asebia mice. Clin. Exp. Dermatol. 13: 74-77.
60. Oran, A. et al. 1997. Cyclosporin inhibits intercellular adhesion molecule-1 expression and reduces mast cell numbers in the asebia mouse model of chronic skin inflammation. Br. J. Dermatol. 136: 519-526.
61. Peter, A. et al. 2009. Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. Diabetes 58: 1757-1765.
62. Peter, A. et al. 2008. Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity. Am. J. Physiol. Endocrinol. Metab. 295: E339-E349.
63. Qin, X. et al. 2007. Laminar shear stress up-regulates the expression of stearoyl-CoA desaturase-1 in vascular endothelial cells. Cardiovasc. Res. 74: 506-514.
64. Park, E.J. et al. 2010. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140: 197-208.
65. Li, N., S.I. Grivennikov & M. Karin. 2011. The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment. Cancer Cell 19: 429-431.
66. Calle, E.E. & R. Kaaks. 2004. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat. Rev. Cancer 4: 579-591.
67. Igal, R.A. 2010. Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer. Carcinogenesis 31: 1509-1515.
68. Scaglia, N., J.M. Caviglia & R.A. Igal. 2005. High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts. Biochim. Biophys. Acta 1687: 141-151.
69. Scaglia, N. & R.A. Igal. 2005. Stearoyl-CoA desaturase is involved in the control of proliferation, anchorage-independent growth, and survival in human transformed cells. J. Biol. Chem. 280: 25339-25349.
70. Scaglia, N., J.W. Chisholm & R.A. Igal. 2009. Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK. PLoS One 4: e6812.
71. Hess, D., J.W. Chisholm & R.A. Igal. 2010. Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One 5: e11394.
72. Fritz, V. et al. 2010. Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol. Cancer Ther. 9: 1740-1754.
73. Morgan-Lappe, S.E. et al. 2007. Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen. Cancer Res. 67: 4390-4398.
74. Brown, J.M. & L.L. Rudel. 2010. Stearoyl-coenzyme A desaturase 1 inhibition and the metabolic syndrome: considerations for future drug discovery. Curr. Opin. Lipidol. 21: 192-197.
75. Moore, S. et al. 2005. Loss of stearoyl-CoA desaturase expression is a frequent event in prostate carcinoma. Int. J. Cancer 114: 563-571.