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Volumn 23, Issue , 2013, Pages 3-39

Transgene site-specific integration: Problems and solutions

Author keywords

Genotoxicity; Insertional mutagenesis; Safe harbor locus; Site specificity; Transgene silencing; Transgene targeting

Indexed keywords


EID: 84865404755     PISSN: 16102096     EISSN: 16106970     Source Type: Book Series    
DOI: 10.1007/978-94-007-4531-5_1     Document Type: Article
Times cited : (5)

References (225)
  • 1
    • 79953304038 scopus 로고    scopus 로고
    • Retroviral vectors induce epigenetic chromatin modi fications and il-10 production in transduced b cells via activation of toll-like receptor 2
    • Ahangarani RR, Janssens W, Carlier V et al (2011) Retroviral vectors induce epigenetic chromatin modi fications and IL-10 production in transduced B cells via activation of toll-like receptor 2. Mol Ther 19:711-722
    • (2011) Mol Ther , vol.19 , pp. 711-722
    • Ahangarani, R.R.1    Janssens, W.2    Carlier, V.3
  • 2
    • 28944449341 scopus 로고    scopus 로고
    • Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel dna targets
    • Arnould S, Chames P, Perez C et al (2006) Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets. J Mol Biol 355:443-458
    • (2006) J Mol Biol , vol.355 , pp. 443-458
    • Arnould, S.1    Chames, P.2    Perez, C.3
  • 3
    • 79951783813 scopus 로고    scopus 로고
    • Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI
    • Aubert M, Ryu BY, Banks L et al (2011) Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI. PLoS One 6:e16825
    • (2011) PLoS One , vol.6
    • Aubert, M.1    Ryu, B.Y.2    Banks, L.3
  • 4
    • 33751352744 scopus 로고    scopus 로고
    • Harnessing a high cargo-capacity transposon for genetic applications in vertebrates
    • Balciunas D, Wangensteen KJ, Wilber A et al (2006) Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. PLoS Genet 2:e169
    • (2006) PLoS Genet , vol.2
    • Balciunas, D.1    Wangensteen, K.J.2    Wilber, A.3
  • 5
    • 79951679142 scopus 로고    scopus 로고
    • Innate immune dna sensing pathways: Sting, aimii and the regulation of interferon production and inflammatory responses
    • Barber GN (2011) Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses. Curr Opin Immunol 23:10-20
    • (2011) Curr Opin Immunol , vol.23 , pp. 10-20
    • Barber, G.N.1
  • 6
    • 34249026300 scopus 로고    scopus 로고
    • High-resolution pro filing of histone methylations in the human genome
    • Barski A, Cuddapah S, Cui K et al (2007) High-resolution pro filing of histone methylations in the human genome. Cell 29:823-837
    • (2007) Cell , vol.29 , pp. 823-837
    • Barski, A.1    Cuddapah, S.2    Cui, K.3
  • 7
    • 0026031825 scopus 로고
    • Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming transforming gene activate transcription from the normal promoter
    • Bartholomew C, Ihle JN (1991) Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming transforming gene activate transcription from the normal promoter. Mol Cell Biol 11:1820-1828
    • (1991) Mol Cell Biol , vol.11 , pp. 1820-1828
    • Bartholomew, C.1    Ihle, J.N.2
  • 8
    • 0037443457 scopus 로고    scopus 로고
    • Side effects of retroviral gene transfer into hematopoietic stem cells
    • Baum C, Düllmann J, Li Z et al (2003) Side effects of retroviral gene transfer into hematopoietic stem cells. Blood 101:2099-2114
    • (2003) Blood , vol.101 , pp. 2099-2114
    • Baum, C.1    Düllmann, J.2    Li, Z.3
  • 9
    • 33645451483 scopus 로고    scopus 로고
    • Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors
    • Baum C, Kustikova O, Modlich U et al (2006) Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors. Hum Gene Ther 17:252-263
    • (2006) Hum Gene Ther , vol.17 , pp. 252-263
    • Baum, C.1    Kustikova, O.2    Modlich, U.3
  • 10
    • 0036168937 scopus 로고    scopus 로고
    • Engineering polydactyl zinc-finger transcription factors
    • Beerli RR, Barbas CF 3rd (2002) Engineering polydactyl zinc-finger transcription factors. Nat Biotechnol 20:135-141
    • (2002) Nat Biotechnol , vol.20 , pp. 135-141
    • Beerli, R.R.1    Barbas III, C.F.2
  • 11
    • 0345518003 scopus 로고    scopus 로고
    • Construction of a variability map for eukaryotic large subunit ribosomal RNA
    • Ben Ali A, Wuyts J, De Wachter R et al (1999) Construction of a variability map for eukaryotic large subunit ribosomal RNA. Nucleic Acids Res 27:2825-2831
    • (1999) Nucleic Acids Res , vol.27 , pp. 2825-2831
    • Ben Ali, A.1    Wuyts, J.2    De Wachter, R.3
  • 12
    • 79551518877 scopus 로고    scopus 로고
    • Integration pro file of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell
    • Biasco L, Ambrosi A, Pellin D et al (2010) Integration pro file of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell. EMBO Mol Med 3:89-101
    • (2010) EMBO Mol Med , vol.3 , pp. 89-101
    • Biasco, L.1    Ambrosi, A.2    Pellin, D.3
  • 13
    • 70349257594 scopus 로고    scopus 로고
    • Site-specific recombinases for manipulation of the mouse genome
    • Birling MC, Gof flot F, Warot X (2009) Site-specific recombinases for manipulation of the mouse genome. Methods Mol Biol 561:245-263
    • (2009) Methods Mol Biol , vol.561 , pp. 245-263
    • Birling, M.C.1    Gof Flot, F.2    Warot, X.3
  • 14
    • 62949222607 scopus 로고    scopus 로고
    • Engineering of bacterial strains and vectors for the production of plasmid DNA
    • Bower DM, Prather KL (2009) Engineering of bacterial strains and vectors for the production of plasmid DNA. Appl Microbiol Biotechnol 82:805-813
    • (2009) Appl Microbiol Biotechnol , vol.82 , pp. 805-813
    • Bower, D.M.1    Prather, K.L.2
  • 15
    • 33947518195 scopus 로고    scopus 로고
    • RIG-I: Tri-ing to discriminate between self and non-self RNA
    • Bowie AG, Fitzgerald KA (2007) RIG-I: tri-ing to discriminate between self and non-self RNA. Trends Immunol 28:147-150
    • (2007) Trends Immunol , vol.28 , pp. 147-150
    • Bowie, A.G.1    Fitzgerald, K.A.2
  • 16
    • 77951993592 scopus 로고    scopus 로고
    • HIV-1 lentiviral vector immunogenicity is mediated by toll-like receptor 3 (tlr3) and TLR7
    • Breckpot K, Escors D, Arce F et al (2010) HIV-1 lentiviral vector immunogenicity is mediated by Toll-like receptor 3 (TLR3) and TLR7. J Virol 84:5627-5636
    • (2010) J Virol , vol.84 , pp. 5627-5636
    • Breckpot, K.1    Escors, D.2    Arce, F.3
  • 17
  • 18
    • 34547638572 scopus 로고    scopus 로고
    • Generation of an inducible and optimized piggyBac transposon system
    • Cadinanos J, Bradley A (2007) Generation of an inducible and optimized piggyBac transposon system. Nucleic Acids Res 35:e87
    • (2007) Nucleic Acids Res , vol.35
    • Cadinanos, J.1    Bradley, A.2
  • 19
    • 78650213003 scopus 로고    scopus 로고
    • Plasmid DNA fermentation strain and process-specific effects on vector yield, quality, and transgene expression
    • Carnes AE, Luke JM, Vincent JM et al (2011) Plasmid DNA fermentation strain and process-specific effects on vector yield, quality, and transgene expression. Biotechnol Bioeng 108:354-363
    • (2011) Biotechnol Bioeng , vol.108 , pp. 354-363
    • Carnes, A.E.1    Luke, J.M.2    Vincent, J.M.3
  • 20
    • 79952110151 scopus 로고    scopus 로고
    • Mouse models for miRNA expression: The ROSA26 locus
    • Casola S (2010) Mouse models for miRNA expression: the ROSA26 locus. Methods Mol Biol 667:145-163
    • (2010) Methods Mol Biol , vol.667 , pp. 145-163
    • Casola, S.1
  • 21
    • 34547657665 scopus 로고    scopus 로고
    • Hot spots of retroviral integration in human CD34+ hematopoietic cells
    • Cattoglio C, Facchini G, Sartori D et al (2007) Hot spots of retroviral integration in human CD34+ hematopoietic cells. Blood 110:1770-1778
    • (2007) Blood , vol.110 , pp. 1770-1778
    • Cattoglio, C.1    Facchini, G.2    Sartori, D.3
  • 22
    • 78650987483 scopus 로고    scopus 로고
    • High-de finition mapping of retroviral integration sites de fines the fate of allogeneic T cells after donor lymphocyte infusion
    • Cattoglio C, Maruggi G, Bartholomae C et al (2010a) High-de finition mapping of retroviral integration sites de fines the fate of allogeneic T cells after donor lymphocyte infusion. PLoS One 5:e15688
    • (2010) PLoS One , vol.5
    • Cattoglio, C.1    Maruggi, G.2    Bartholomae, C.3
  • 23
    • 78650447013 scopus 로고    scopus 로고
    • High-de finition mapping of retroviral integration sites identi fies active regulatory elements in human multipotent hematopoietic progenitors
    • Cattoglio C, Pellin D, Rizzi E et al (2010b) High-de finition mapping of retroviral integration sites identi fies active regulatory elements in human multipotent hematopoietic progenitors. Blood 116:5507-5517
    • (2010) Blood , vol.116 , pp. 5507-5517
    • Cattoglio, C.1    Pellin, D.2    Rizzi, E.3
  • 24
    • 80051613693 scopus 로고    scopus 로고
    • A comparison of exogenous promoter activity at the ROSA26 locus using a PhiC31 integrase mediated cassette exchange approach in mouse ES cells
    • Chen CM, Krohn J, Bhattacharya S et al (2011) A comparison of exogenous promoter activity at the ROSA26 locus using a PhiC31 integrase mediated cassette exchange approach in mouse ES cells. PLoS One 6:e23376
    • (2011) PLoS One , vol.6
    • Chen, C.M.1    Krohn, J.2    Bhattacharya, S.3
  • 25
    • 34249688206 scopus 로고    scopus 로고
    • Antitumor effects of hsv-tk-engineered donor lymphocytes after allogeneic stem-cell transplantation
    • Ciceri F, Bonini C, Marktel S et al (2007) Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantation. Blood 109:4698-4707
    • (2007) Blood , vol.109 , pp. 4698-4707
    • Ciceri, F.1    Bonini, C.2    Marktel, S.3
  • 26
    • 65349157330 scopus 로고    scopus 로고
    • Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the tk007 trial): A non-randomised phase i-ii study
    • Ciceri F, Bonini C, Stanghellini MT et al (2009) Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study. Lancet Oncol 10:489-500
    • (2009) Lancet Oncol , vol.10 , pp. 489-500
    • Ciceri, F.1    Bonini, C.2    Stanghellini, M.T.3
  • 27
    • 28644443483 scopus 로고    scopus 로고
    • A role for LEDGF/p75 in targeting HIV DNA integration
    • Ciuf fiA, Llano M, Poeschla E et al (2005) A role for LEDGF/p75 in targeting HIV DNA integration. Nat Med 11:1287-1289
    • (2005) Nat Med , vol.11 , pp. 1287-1289
    • Fia, C.1    Llano, M.2    Poeschla, E.3
  • 28
    • 0031911791 scopus 로고    scopus 로고
    • I-SceI-induced gene replacement at a natural locus in embryonic stem cells
    • Cohen-Tannoudji M, Robine S, Choulika A et al (1998) I-SceI-induced gene replacement at a natural locus in embryonic stem cells. Mol Cell Biol 18:1444-1448
    • (1998) Mol Cell Biol , vol.18 , pp. 1444-1448
    • Cohen-Tannoudji, M.1    Robine, S.2    Choulika, A.3
  • 29
    • 58049191558 scopus 로고    scopus 로고
    • Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation
    • Cui K, Zang C, Roh TY et al (2009) Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell 4:80-93
    • (2009) Cell Stem Cell , vol.4 , pp. 80-93
    • Cui, K.1    Zang, C.2    Roh, T.Y.3
  • 30
    • 58149265324 scopus 로고    scopus 로고
    • Shielding of sleeping beauty DNA transposon-delivered transgene cassettes by heterologous insulators in early embryonal cells
    • Dalsgaard T, Moldt B, Sharma N et al (2009) Shielding of sleeping beauty DNA transposon-delivered transgene cassettes by heterologous insulators in early embryonal cells. Mol Ther 17:121-130
    • (2009) Mol Ther , vol.17 , pp. 121-130
    • Dalsgaard, T.1    Moldt, B.2    Sharma, N.3
  • 31
    • 0024431720 scopus 로고
    • Nuclear and nucleolar targeting sequences of c-erb -A, c-myb, n-myc, p53, hsp70, and hiv tat proteins
    • Dang CV, Lee WMF (1989) Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins. J Biol Chem 264:18019-18023
    • (1989) J Biol Chem , vol.264 , pp. 18019-18023
    • Dang, C.V.1    Wmf, L.2
  • 32
    • 0036728609 scopus 로고    scopus 로고
    • Polycistronic viral vectors
    • de Felipe P (2002) Polycistronic viral vectors. Curr Gene Ther 2:355-378
    • (2002) Curr Gene Ther , vol.2 , pp. 355-378
    • De Felipe, P.1
  • 33
    • 77955157281 scopus 로고    scopus 로고
    • Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome
    • DeKelver RC, Choi VM, Moehle EA et al (2010) Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res 20:1133-1142
    • (2010) Genome Res , vol.20 , pp. 1133-1142
    • Dekelver, R.C.1    Choi, V.M.2    Moehle, E.A.3
  • 34
    • 68649111166 scopus 로고    scopus 로고
    • Adeno-associated virus vector integration
    • Deyle DR, Russell DW (2009) Adeno-associated virus vector integration. Curr Opin Mol Ther 11:442-447
    • (2009) Curr Opin Mol Ther , vol.11 , pp. 442-447
    • Deyle, D.R.1    Russell, D.W.2
  • 35
    • 3543100253 scopus 로고    scopus 로고
    • Characterization of the mouse adeno-associated virus aavs1 ortholog
    • Dutheil N, Yoon-Robarts M, Ward P et al (2004) Characterization of the mouse adeno-associated virus AAVS1 ortholog. J Virol 78:8917-8921
    • (2004) J Virol , vol.78 , pp. 8917-8921
    • Dutheil, N.1    Yoon-Robarts, M.2    Ward, P.3
  • 36
    • 33750997895 scopus 로고    scopus 로고
    • Molecular analysis of chromosomal rearrangements in mammalian cells after phiC31-mediated integration
    • Ehrhardt A, Engler JA, Xu H et al (2006) Molecular analysis of chromosomal rearrangements in mammalian cells after phiC31-mediated integration. Hum Gene Ther 17:1077-1094
    • (2006) Hum Gene Ther , vol.17 , pp. 1077-1094
    • Ehrhardt, A.1    Engler, J.A.2    Xu, H.3
  • 37
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide rnas mediate rna interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W et al (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494-498
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3
  • 38
    • 27744489220 scopus 로고    scopus 로고
    • Silencing and variegation of gammaretrovirus and lentivirus vectors
    • Ellis J (2005) Silencing and variegation of gammaretrovirus and lentivirus vectors. Hum Gene Ther 16:1241-1246
    • (2005) Hum Gene Ther , vol.16 , pp. 1241-1246
    • Ellis, J.1
  • 39
    • 79955852358 scopus 로고    scopus 로고
    • The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors
    • Emery DW (2011) The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors. Hum Gene Ther 22:761-774
    • (2011) Hum Gene Ther , vol.22 , pp. 761-774
    • Emery, D.W.1
  • 40
    • 33947272049 scopus 로고    scopus 로고
    • Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector
    • Evans-Galea MV, Wielgosz MM, Hanawa H et al (2007) Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector. Mol Ther 15:801-809
    • (2007) Mol Ther , vol.15 , pp. 801-809
    • Evans-Galea, M.V.1    Wielgosz, M.M.2    Hanawa, H.3
  • 41
    • 37749029950 scopus 로고    scopus 로고
    • Insertional mutagenesis and clonal dominance: Biological and statistical considerations
    • Fehse B, Roeder I (2008) Insertional mutagenesis and clonal dominance: biological and statistical considerations. Gene Ther 15:143-153
    • (2008) Gene Ther , vol.15 , pp. 143-153
    • Fehse, B.1    Roeder, I.2
  • 42
    • 77950961510 scopus 로고    scopus 로고
    • Transcription factor binding sites are genetic determinants of retroviral integration in the human genome
    • Felice B, Cattoglio C, Cittaro D et al (2009) Transcription factor binding sites are genetic determinants of retroviral integration in the human genome. PLoS One 4:e4571
    • (2009) PLoS One , vol.4
    • Felice, B.1    Cattoglio, C.2    Cittaro, D.3
  • 43
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by doublestranded rna in caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK et al (1998) Potent and specific genetic interference by doublestranded RNA in Caenorhabditis elegans . Nature 391:806-811
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3
  • 44
    • 79958148262 scopus 로고    scopus 로고
    • Liposome-based dna carriers may induce cellular stress response and change gene expression pattern in transfected cells
    • Fiszer-Kierzkowska A, Vydra N, Wysocka-Wycisk A et al (2011) Liposome-based DNA carriers may induce cellular stress response and change gene expression pattern in transfected cells. BMC Mol Biol 10:12-27
    • (2011) BMC Mol Biol , vol.10 , pp. 12-27
    • Fiszer-Kierzkowska, A.1    Vydra, N.2    Wysocka-Wycisk, A.3
  • 45
    • 70349673723 scopus 로고    scopus 로고
    • Genome-wide mapping of piggybac transposon integrations in primary human t cells
    • Galvan DL, Nakazawa Y, Kaja A et al (2009) Genome-wide mapping of PiggyBac transposon integrations in primary human T cells. J Immunother 32:837-844
    • (2009) J Immunother , vol.32 , pp. 837-844
    • Galvan, D.L.1    Nakazawa, Y.2    Kaja, A.3
  • 46
    • 37549059945 scopus 로고    scopus 로고
    • Postintegrative gene silencing within the Sleeping Beauty transposition system
    • Garrison BS, Yant SR, Mikkelsen JG, Kay MA (2007) Postintegrative gene silencing within the Sleeping Beauty transposition system. Mol Cell Biol 27:8824-8833
    • (2007) Mol Cell Biol , vol.27 , pp. 8824-8833
    • Garrison, B.S.1    Yant, S.R.2    Mikkelsen, J.G.3    Kay, M.A.4
  • 47
    • 33747453473 scopus 로고    scopus 로고
    • Insulators: Exploiting transcriptional and epigenetic mechanisms
    • Gaszner M, Felsenfeld G (2006) Insulators: exploiting transcriptional and epigenetic mechanisms. Nat Rev Genet 7:703-713
    • (2006) Nat Rev Genet , vol.7 , pp. 703-713
    • Gaszner, M.1    Felsenfeld, G.2
  • 48
    • 0035114195 scopus 로고    scopus 로고
    • Pulmonary cytokine responses associated with pei-dna aerosol gene therapy
    • Gautam A, Densmore CL, Waldrep JC (2001) Pulmonary cytokine responses associated with PEI-DNA aerosol gene therapy. Gene Ther 8:254-257
    • (2001) Gene Ther , vol.8 , pp. 254-257
    • Gautam, A.1    Densmore, C.L.2    Waldrep, J.C.3
  • 49
    • 68749103477 scopus 로고    scopus 로고
    • Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood
    • Georgopoulos LJ, Elgue G, Sanchez J et al (2009) Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood. Mol Immunol 46:2911-2917
    • (2009) Mol Immunol , vol.46 , pp. 2911-2917
    • Georgopoulos, L.J.1    Elgue, G.2    Sanchez, J.3
  • 50
    • 80053218380 scopus 로고    scopus 로고
    • Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase
    • Gersbach CA, Gaj T, Rm G et al (2011) Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase. Nucleic Acids Res 39:7868-7878
    • (2011) Nucleic Acids Res , vol.39 , pp. 7868-7878
    • Gersbach, C.A.1    Gaj, T.2    Rm, G.3
  • 51
    • 33749416026 scopus 로고    scopus 로고
    • Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers
    • Geurts AM, Collier LS, Geurts JL et al (2006) Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. PLoS Genet 2:e156
    • (2006) PLoS Genet , vol.2
    • Geurts, A.M.1    Collier, L.S.2    Geurts, J.L.3
  • 52
    • 23044473330 scopus 로고    scopus 로고
    • Ef ficient marking of human cells with rapid but transient repopulating activity in autografted recipients
    • Glimm H, Schmidt M, Fischer M et al (2005) Ef ficient marking of human cells with rapid but transient repopulating activity in autografted recipients. Blood 106:893-898
    • (2005) Blood , vol.106 , pp. 893-898
    • Glimm, H.1    Schmidt, M.2    Fischer, M.3
  • 53
    • 80051780791 scopus 로고    scopus 로고
    • A bidirectional promoter architecture enhances lentiviral transgenesis in embryonic and extraembryonic stem cells
    • Golding MC, Mann MR (2011) A bidirectional promoter architecture enhances lentiviral transgenesis in embryonic and extraembryonic stem cells. Gene Ther 18:817-826
    • (2011) Gene Ther , vol.18 , pp. 817-826
    • Golding, M.C.1    Mann, M.R.2
  • 54
    • 33744781256 scopus 로고    scopus 로고
    • Efficient in toto targeted recombination in mouse liver by meganuclease-induced double-strand break
    • Gouble A, Smith J, Bruneau S et al (2006) Efficient in toto targeted recombination in mouse liver by meganuclease-induced double-strand break. J Gene Med 8:616-622
    • (2006) J Gene Med , vol.8 , pp. 616-622
    • Gouble, A.1    Smith, J.2    Bruneau, S.3
  • 55
    • 0029655849 scopus 로고    scopus 로고
    • Directed integration of viral dna mediated by fusion proteins consisting of human immunode ficiency virus type 1 integrase and escherichia coli lexa protein
    • Goulaouic H, Chow SA (1996) Directed integration of viral DNA mediated by fusion proteins consisting of human immunode ficiency virus type 1 integrase and Escherichia coli LexA protein. J Virol 70:37-46
    • (1996) J Virol , vol.70 , pp. 37-46
    • Goulaouic, H.1    Chow, S.A.2
  • 56
    • 77953132759 scopus 로고    scopus 로고
    • Comparative analysis of transposable element vector systems in human cells
    • Grabundzija I, Irgang M, Mátés L et al (2010) Comparative analysis of transposable element vector systems in human cells. Mol Ther 18:1200-1209
    • (2010) Mol Ther , vol.18 , pp. 1200-1209
    • Grabundzija, I.1    Irgang, M.2    Mátés, L.3
  • 57
    • 0042528729 scopus 로고    scopus 로고
    • Heterochromatin and epigenetic control of gene expression
    • Grewal SI, Moazed D (2003) Heterochromatin and epigenetic control of gene expression. Science 301:798-802
    • (2003) Science , vol.301 , pp. 798-802
    • Grewal, S.I.1    Moazed, D.2
  • 58
    • 70349407359 scopus 로고    scopus 로고
    • Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease
    • Grizot S, Smith J, Daboussi F et al (2009) Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease. Nucleic Acids Res 37:5405-5419
    • (2009) Nucleic Acids Res , vol.37 , pp. 5405-5419
    • Grizot, S.1    Smith, J.2    Daboussi, F.3
  • 59
    • 77953702888 scopus 로고    scopus 로고
    • Directed evolution of an enhanced and highly Efficient FokI cleavage domain for zinc finger nucleases
    • Guo J, Gaj T, Barbas CF (2010) Directed evolution of an enhanced and highly Efficient FokI cleavage domain for zinc finger nucleases. J Mol Biol 400:96-107
    • (2010) J Mol Biol , vol.400 , pp. 96-107
    • Guo, J.1    Gaj, T.2    Barbas, C.F.3
  • 60
    • 0037448352 scopus 로고    scopus 로고
    • A serious adverse event after successful gene therapy for X-linked severe combined immunode ficiency
    • Hacein-Bey-Abina S, von Kalle C, Schmidt M et al (2003a) A serious adverse event after successful gene therapy for X-linked severe combined immunode ficiency. N Engl J Med 348:255-256
    • (2003) N Engl J Med , vol.348 , pp. 255-256
    • Hacein-Bey-Abina, S.1    Von Kalle, C.2    Schmidt, M.3
  • 61
    • 0142084745 scopus 로고    scopus 로고
    • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    • Hacein-Bey-Abina S, von Kalle C, Schmidt M et al (2003b) LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302:415-419
    • (2003) Science , vol.302 , pp. 415-419
    • Hacein-Bey-Abina, S.1    Von Kalle, C.2    Schmidt, M.3
  • 62
    • 40149103278 scopus 로고    scopus 로고
    • Error-correcting barcoded primers for pyrosequencing hundreds of samples in multiplex
    • Hamady M, Walker JJ, Harris JK et al (2008) Error-correcting barcoded primers for pyrosequencing hundreds of samples in multiplex. Nat Methods 5:235-237
    • (2008) Nat Methods , vol.5 , pp. 235-237
    • Hamady, M.1    Walker, J.J.2    Harris, J.K.3
  • 63
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 64
    • 79951699566 scopus 로고    scopus 로고
    • Zinc-finger nuclease based genome surgery: It's all about specificity
    • Händel EM, Cathomen T (2011) Zinc-finger nuclease based genome surgery: it's all about specificity. Curr Gene Ther 11:28-37
    • (2011) Curr Gene Ther , vol.11 , pp. 28-37
    • Händel, E.M.1    Cathomen, T.2
  • 65
    • 77953768679 scopus 로고    scopus 로고
    • A method for stabilizing RNA for transfection that allows control of expression duration
    • Hayashi T, Lamba DA, Slowik A et al (2010) A method for stabilizing RNA for transfection that allows control of expression duration. Dev Dyn 239:2034-2040
    • (2010) Dev Dyn , vol.239 , pp. 2034-2040
    • Hayashi, T.1    Lamba, D.A.2    Slowik, A.3
  • 67
    • 20044396722 scopus 로고    scopus 로고
    • Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells
    • Hematti P, Hong BK, Ferguson C et al (2004) Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells. PLoS Biol 2:e423
    • (2004) PLoS Biol , vol.2
    • Hematti, P.1    Hong, B.K.2    Ferguson, C.3
  • 68
    • 77957323822 scopus 로고    scopus 로고
    • Adeno-associated virus: A key to the human genome?
    • Henckaerts E, Linden RM (2010) Adeno-associated virus: a key to the human genome? Future Virol 5:555-574
    • (2010) Future Virol , vol.5 , pp. 555-574
    • Henckaerts, E.1    Linden, R.M.2
  • 69
    • 4344700911 scopus 로고    scopus 로고
    • Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides
    • Hodges BL, Taylor KM, Joseph MF et al (2004) Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides. Mol Ther 10:269-278
    • (2004) Mol Ther , vol.10 , pp. 269-278
    • Hodges, B.L.1    Taylor, K.M.2    Joseph, M.F.3
  • 70
    • 64049098693 scopus 로고    scopus 로고
    • Innate immune recognition of viruses and viral vectors
    • Huang X, Yang Y (2009) Innate immune recognition of viruses and viral vectors. Hum Gene Ther 20:293-301
    • (2009) Hum Gene Ther , vol.20 , pp. 293-301
    • Huang, X.1    Yang, Y.2
  • 71
    • 77957579849 scopus 로고    scopus 로고
    • Gene transfer Efficiency and genome-wide integration pro filing of Sleeping Beauty, Tol2, and piggyBac transposons in human primary T cells
    • Huang X, Guo H, Tammana S et al (2010) Gene transfer Efficiency and genome-wide integration pro filing of Sleeping Beauty, Tol2, and piggyBac transposons in human primary T cells. Mol Ther 18:1803-1813
    • (2010) Mol Ther , vol.18 , pp. 1803-1813
    • Huang, X.1    Guo, H.2    Tammana, S.3
  • 72
    • 36849012549 scopus 로고    scopus 로고
    • Identi fication and targeting of the ROSA26 locus in human embryonic stem cells
    • Irion S, Luche H, Gadue P et al (2007) Identi fication and targeting of the ROSA26 locus in human embryonic stem cells. Nat Biotechnol 25:1477-1482
    • (2007) Nat Biotechnol , vol.25 , pp. 1477-1482
    • Irion, S.1    Luche, H.2    Gadue, P.3
  • 73
    • 23844506121 scopus 로고    scopus 로고
    • TLR ignores methylated RNA?
    • Ishii KJ, Akira S (2005) TLR ignores methylated RNA? Immunity 23:111-113
    • (2005) Immunity , vol.23 , pp. 111-113
    • Ishii, K.J.1    Akira, S.2
  • 74
    • 50449205290 scopus 로고    scopus 로고
    • Potential link between the immune system and metabolism of nucleic acids
    • Ishii KJ, Akira S (2008) Potential link between the immune system and metabolism of nucleic acids. Curr Opin Immunol 20:524-529
    • (2008) Curr Opin Immunol , vol.20 , pp. 524-529
    • Ishii, K.J.1    Akira, S.2
  • 75
    • 0033962412 scopus 로고    scopus 로고
    • Split-intron retroviral vectors: Enhanced expression with improved safety
    • Ismail SI, Kingsman SM, Kingsman AJ, Uden M (2000) Split-intron retroviral vectors: enhanced expression with improved safety. J Virol 74:2365-2371
    • (2000) J Virol , vol.74 , pp. 2365-2371
    • Ismail, S.I.1    Kingsman, S.M.2    Kingsman, A.J.3    Uden, M.4
  • 76
    • 0030662074 scopus 로고    scopus 로고
    • Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells
    • Ivics Z, Hackett PB, Plasterk RH, Izsvák Z (1997) Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell 91:501-510
    • (1997) Cell , vol.91 , pp. 501-510
    • Ivics, Z.1    Hackett, P.B.2    Plasterk, R.H.3    Izsvák, Z.4
  • 78
    • 70350736762 scopus 로고    scopus 로고
    • Transcriptional effects of transfection: The potential for misinterpretation of gene expression data generated from transiently transfected cells
    • Jacobsen L, Calvin S, Lobenhofer E (2009) Transcriptional effects of transfection: the potential for misinterpretation of gene expression data generated from transiently transfected cells. Biotechniques 47:617-624
    • (2009) Biotechniques , vol.47 , pp. 617-624
    • Jacobsen, L.1    Calvin, S.2    Lobenhofer, E.3
  • 79
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch R, Bird A (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33(Suppl):245-254
    • (2003) Nat Genet , vol.33 , Issue.SUPPL. , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 80
    • 0021816356 scopus 로고
    • Chromosomal position and specific demethylation in enhancer sequences of germ line-transmitted retroviral genomes during mouse development
    • Jähner D, Jaenisch R (1985) Chromosomal position and specific demethylation in enhancer sequences of germ line-transmitted retroviral genomes during mouse development. Mol Cell Biol 5:2212-2220
    • (1985) Mol Cell Biol , vol.5 , pp. 2212-2220
    • Jähner, D.1    Jaenisch, R.2
  • 81
    • 0020048308 scopus 로고
    • De novo methylation and expression of retroviral genomes during mouse embryogenesis
    • Jähner D, Stuhlmann H, Stewart CL et al (1982) De novo methylation and expression of retroviral genomes during mouse embryogenesis. Nature 298:623-628
    • (1982) Nature , vol.298 , pp. 623-628
    • Jähner, D.1    Stuhlmann, H.2    Stewart, C.L.3
  • 83
    • 77951552865 scopus 로고    scopus 로고
    • An accumulative site-specific gene integration system using cre recombinase-mediated cassette exchange
    • Kameyam Y, Kawabe Y, Ito A, Kamihira M (2010) An accumulative site-specific gene integration system using cre recombinase-mediated cassette exchange. Biotechnol Bioeng 105: 1106-1114
    • (2010) Biotechnol Bioeng , vol.105 , pp. 1106-1114
    • Kameyam, Y.1    Kawabe, Y.2    Ito, A.3    Kamihira, M.4
  • 84
    • 0036323154 scopus 로고    scopus 로고
    • Design of a nonviral vector for siteselective, Efficient integration into the human genome
    • Kaminski JM, Huber MR, Summers JB, Ward MB (2002) Design of a nonviral vector for siteselective, Efficient integration into the human genome. FASEB J 6:1242-1247
    • (2002) FASEB J , vol.6 , pp. 1242-1247
    • Kaminski, J.M.1    Huber, M.R.2    Summers, J.B.3    Ward, M.B.4
  • 85
    • 4644330953 scopus 로고    scopus 로고
    • Exogenous siRNA mediates sequence-independent gene suppression by signaling through toll-like receptor 3
    • Karikó K, Bhuyan P, Capodici J et al (2004) Exogenous siRNA mediates sequence-independent gene suppression by signaling through toll-like receptor 3. Cells Tissues Organs 177:132-138
    • (2004) Cells Tissues Organs , vol.177 , pp. 132-138
    • Karikó, K.1    Bhuyan, P.2    Capodici, J.3
  • 86
    • 23844464444 scopus 로고    scopus 로고
    • Suppression of rna recognition by toll-like receptors: The impact of nucleoside modi fication and the evolutionary origin of rna
    • Karikó K, Buckstein M, Ni H, Weissman D (2005) Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modi fication and the evolutionary origin of RNA. Immunity 23:165-175
    • (2005) Immunity , vol.23 , pp. 165-175
    • Karikó, K.1    Buckstein, M.2    Ni, H.3    Weissman, D.4
  • 87
    • 34249077041 scopus 로고    scopus 로고
    • A novel target-specific gene delivery system combining baculovirus and sequence-specific long interspersed nuclear elements
    • Kawashima T, Osanai M, Futahashi R (2007) A novel target-specific gene delivery system combining baculovirus and sequence-specific long interspersed nuclear elements. Virus Res 127:49-60
    • (2007) Virus Res , vol.127 , pp. 49-60
    • Kawashima, T.1    Osanai, M.2    Futahashi, R.3
  • 88
    • 0035135747 scopus 로고    scopus 로고
    • Viral vectors for gene therapy: The art of turning infectious agents into vehicles of therapeutics
    • Kay MA, Glorioso JC, Naldini L (2001) Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat Med 7:33-40
    • (2001) Nat Med , vol.7 , pp. 33-40
    • Kay, M.A.1    Glorioso, J.C.2    Naldini, L.3
  • 89
    • 0018654088 scopus 로고
    • Histone genes and histone messengers
    • Kedes LH (1979) Histone genes and histone messengers. Annu Rev Biochem 48:837-870
    • (1979) Annu Rev Biochem , vol.48 , pp. 837-870
    • Kedes, L.H.1
  • 90
    • 33846945735 scopus 로고    scopus 로고
    • Processing of intronic microRNAs
    • Kim YK, Kim VN (2007) Processing of intronic microRNAs. EMBO J 26:775-783
    • (2007) EMBO J , vol.26 , pp. 775-783
    • Kim, Y.K.1    Kim, V.N.2
  • 91
    • 0037359032 scopus 로고    scopus 로고
    • Evolution of target specificity in R1 clade non-LTR retrotransposon
    • Kojima KK, Fujiwara H (2003) Evolution of target specificity in R1 clade non-LTR retrotransposon. Mol Biol Evol 20:351-361
    • (2003) Mol Biol Evol , vol.20 , pp. 351-361
    • Kojima, K.K.1    Fujiwara, H.2
  • 92
    • 1542316940 scopus 로고    scopus 로고
    • Cross-genome screening of novel sequence-specific non-ltr retrotransposons: Various multicopy rna genes and microsatellites are selected as targets
    • Kojima KK, Fujiwara H (2004) Cross-genome screening of novel sequence-specific non-LTR retrotransposons: various multicopy RNA genes and microsatellites are selected as targets. Mol Biol Evol 21:207-217
    • (2004) Mol Biol Evol , vol.21 , pp. 207-217
    • Kojima, K.K.1    Fujiwara, H.2
  • 93
    • 22744459066 scopus 로고    scopus 로고
    • Site-directed genome modi fication: Nucleic acid and protein modules for targeted integration and gene correction
    • Kolb AF, Coates CJ, Kaminski JM et al (2005) Site-directed genome modi fication: nucleic acid and protein modules for targeted integration and gene correction. Trends Biotechnol 23:399-406
    • (2005) Trends Biotechnol , vol.23 , pp. 399-406
    • Kolb, A.F.1    Coates, C.J.2    Kaminski, J.M.3
  • 94
    • 79751497093 scopus 로고    scopus 로고
    • Expression of therapeutic proteins after delivery of chemically modi fied mRNA in mice
    • Kormann MS, Hasenpusch G, Aneja MK et al (2011) Expression of therapeutic proteins after delivery of chemically modi fied mRNA in mice. Nat Biotechnol 29:154-157
    • (2011) Nat Biotechnol , vol.29 , pp. 154-157
    • Kormann, M.S.1    Hasenpusch, G.2    Aneja, M.K.3
  • 95
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modi fications and their function
    • Kouzarides T (2007) Chromatin modi fications and their function. Cell 128:693-705
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 96
    • 0142199654 scopus 로고    scopus 로고
    • Dose finding with retroviral vectors: Correlation of retroviral vector copy numbers in single cells with gene transfer Efficiency in a cell population
    • Kustikova OS, Wahlers A, Kuhlcke K et al (2003) Dose finding with retroviral vectors: Correlation of retroviral vector copy numbers in single cells with gene transfer Efficiency in a cell population. Blood 102:3934-3937
    • (2003) Blood , vol.102 , pp. 3934-3937
    • Kustikova, O.S.1    Wahlers, A.2    Kuhlcke, K.3
  • 97
    • 21044448037 scopus 로고    scopus 로고
    • Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking
    • Kustikova OS, Fehse B, Modlich U et al (2005) Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking. Science 308:1171-1174
    • (2005) Science , vol.308 , pp. 1171-1174
    • Kustikova, O.S.1    Fehse, B.2    Modlich, U.3
  • 98
    • 40549111908 scopus 로고    scopus 로고
    • Retroviral integration site analysis in hematopoietic stem cells
    • Kustikova OS, Baum C, Fehse B (2008) Retroviral integration site analysis in hematopoietic stem cells. Methods Mol Biol 430:255-267
    • (2008) Methods Mol Biol , vol.430 , pp. 255-267
    • Kustikova, O.S.1    Baum, C.2    Fehse, B.3
  • 100
    • 77950857472 scopus 로고    scopus 로고
    • Progress and prospects: Nuclear import of nonviral vectors
    • Lam AP, Dean DA (2010) Progress and prospects: nuclear import of nonviral vectors. Gene Ther 17:439-447
    • (2010) Gene Ther , vol.17 , pp. 439-447
    • Lam, A.P.1    Dean, D.A.2
  • 101
    • 0033861721 scopus 로고    scopus 로고
    • Characteristics of the adeno-associated virus preintegration site in human chromosome 19: Open chromatin conformation and transcriptioncompetent environment
    • Lamartina S, Sporeno E, Fattori E, Toniatti C (2000) Characteristics of the adeno-associated virus preintegration site in human chromosome 19: open chromatin conformation and transcriptioncompetent environment. J Virol 74:7671-7677
    • (2000) J Virol , vol.74 , pp. 7671-7677
    • Lamartina, S.1    Sporeno, E.2    Fattori, E.3    Toniatti, C.4
  • 102
    • 33846976164 scopus 로고    scopus 로고
    • A B23-interacting sequence as a tool to visualize protein interactions in a cellular context
    • Lechertier T, Sirri V, Hernandez-Verdun D, Roussel P (2007) A B23-interacting sequence as a tool to visualize protein interactions in a cellular context. J Cell Sci 120:265-375
    • (2007) J Cell Sci , vol.120 , pp. 265-375
    • Lechertier, T.1    Sirri, V.2    Hernandez-Verdun, D.3    Roussel, P.4
  • 103
    • 79952205472 scopus 로고    scopus 로고
    • Functional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for Efficient in vitro integration into stable nucleosomes
    • Lesbats P, Botbol Y, Chevereau G et al (2011) Functional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for Efficient in vitro integration into stable nucleosomes. PLoS Pathog 7:e1001280
    • (2011) PLoS Pathog , vol.7
    • Lesbats, P.1    Botbol, Y.2    Chevereau, G.3
  • 104
    • 33745684269 scopus 로고    scopus 로고
    • Retroviral DNA integration: Viral and cellular determinants of target-site selection
    • Lewinski MK, Yamashita M, Emerman M et al (2006) Retroviral DNA integration: viral and cellular determinants of target-site selection. PLoS Pathog 2:e60
    • (2006) PLoS Pathog , vol.2
    • Lewinski, M.K.1    Yamashita, M.2    Emerman, M.3
  • 105
    • 63949083133 scopus 로고    scopus 로고
    • Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator
    • Li CL, Xiong D, Stamatoyannopoulos G, Emery DW (2009) Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator. Mol Ther 17:716-724
    • (2009) Mol Ther , vol.17 , pp. 716-724
    • Li, C.L.1    Xiong, D.2    Stamatoyannopoulos, G.3    Emery, D.W.4
  • 106
    • 19944431736 scopus 로고    scopus 로고
    • Target-site preferences of sleeping beauty transposons
    • Liu G, Geurts AM, Yae K et al (2005) Target-site preferences of Sleeping Beauty transposons. J Mol Biol 346:161-173
    • (2005) J Mol Biol , vol.346 , pp. 161-173
    • Liu, G.1    Geurts, A.M.2    Yae, K.3
  • 107
    • 33846438660 scopus 로고    scopus 로고
    • Non-viral ex vivo transduction of human hepatocyte cells to express factor VIII using a human ribosomal DNA-targeting vector
    • Liu X, Liu M, Xue Z et al (2007) Non-viral ex vivo transduction of human hepatocyte cells to express factor VIII using a human ribosomal DNA-targeting vector. J Thromb Haemost 5: 347-351
    • (2007) J Thromb Haemost , vol.5 , pp. 347-351
    • Liu, X.1    Liu, M.2    Xue, Z.3
  • 108
    • 75649114974 scopus 로고    scopus 로고
    • HESC engineering by integrase-mediated chromosomal targeting
    • Liu Y, Lakshmipathy U, Ozgenc A et al (2010) hESC engineering by integrase-mediated chromosomal targeting. Methods Mol Biol 584:229-268
    • (2010) Methods Mol Biol , vol.584 , pp. 229-268
    • Liu, Y.1    Lakshmipathy, U.2    Ozgenc, A.3
  • 109
    • 80053350622 scopus 로고    scopus 로고
    • Site-specific integration and tailoring of cassette design for sustainable gene transfer
    • Lombardo A, Cesana D, Genovese P et al (2011) Site-specific integration and tailoring of cassette design for sustainable gene transfer. Nat Methods 8:861-869
    • (2011) Nat Methods , vol.8 , pp. 861-869
    • Lombardo, A.1    Cesana, D.2    Genovese, P.3
  • 110
    • 34247239206 scopus 로고    scopus 로고
    • Loss of transgene following ex vivo gene transfer is associated with a dominant Th2 response: Implications for cutaneous gene therapy
    • Lu Z, Ghazizadeh S (2007) Loss of transgene following ex vivo gene transfer is associated with a dominant Th2 response: implications for cutaneous gene therapy. Mol Ther 15:954-961
    • (2007) Mol Ther , vol.15 , pp. 954-961
    • Lu, Z.1    Ghazizadeh, S.2
  • 111
    • 1842733449 scopus 로고    scopus 로고
    • HP1 and the dynamics of heterochromatin maintenance
    • Maison C, Almouzni G (2004) HP1 and the dynamics of heterochromatin maintenance. Nat Rev Mol Cell Biol 5:296-304
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 296-304
    • Maison, C.1    Almouzni, G.2
  • 112
    • 33644820684 scopus 로고    scopus 로고
    • Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
    • Manno CS, Pierce GF, Arruda VR et al (2006) Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat Med 12:342-347
    • (2006) Nat Med , vol.12 , pp. 342-347
    • Manno, C.S.1    Pierce, G.F.2    Arruda, V.R.3
  • 113
    • 33845577011 scopus 로고    scopus 로고
    • Chimeric Mos1 and piggyBac transposases result in site-directed integration
    • Maragathavally KJ, Kaminski JM, Coates CJ (2006) Chimeric Mos1 and piggyBac transposases result in site-directed integration. FASEB J 20:1880-1882
    • (2006) FASEB J , vol.20 , pp. 1880-1882
    • Maragathavally, K.J.1    Kaminski, J.M.2    Coates, C.J.3
  • 114
    • 77956374120 scopus 로고    scopus 로고
    • Separating lentiviral vector injection and induction of gene expression in time, does not prevent an immune response to rtTA in rats
    • Markusic DM, de Waart DR, Seppen J (2010) Separating lentiviral vector injection and induction of gene expression in time, does not prevent an immune response to rtTA in rats. PLoS One 5:e9974
    • (2010) PLoS One , vol.5
    • Markusic, D.M.1    De Waart, D.R.2    Seppen, J.3
  • 115
    • 44349171666 scopus 로고    scopus 로고
    • Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting
    • Marshall HM, Ronen K, Berry C et al (2007) Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting. PLoS One 2:e1340
    • (2007) PLoS One , vol.2
    • Marshall, H.M.1    Ronen, K.2    Berry, C.3
  • 116
    • 38449121886 scopus 로고    scopus 로고
    • Technology transfer from worms and flies to vertebrates: Transposition-based genome manipulations and their future perspectives
    • Mates L, Izsvak Z, Ivics Z (2007) Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives. Genome Biol 8(Suppl 1):S1
    • (2007) Genome Biol , vol.8 , Issue.SUPPL. 1
    • Mates, L.1    Izsvak, Z.2    Ivics, Z.3
  • 117
    • 67349250885 scopus 로고    scopus 로고
    • Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates
    • Mates L, Chuah MK, Belay E et al (2009) Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates. Nat Genet 41:753-761
    • (2009) Nat Genet , vol.41 , pp. 753-761
    • Mates, L.1    Chuah, M.K.2    Belay, E.3
  • 118
    • 65249139484 scopus 로고    scopus 로고
    • Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease
    • McConnell Smith A, Takeuchi R, Pellenz S et al (2009) Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease. Proc Natl Acad Sci USA 106:5099-5104
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 5099-5104
    • McConnell Smith, A.1    Takeuchi, R.2    Pellenz, S.3
  • 119
    • 39149123507 scopus 로고    scopus 로고
    • Puri fication and characterization of transcribed RNAs using gel filtration chromatography
    • McKenna SA, Kim I, Puglisi EV et al (2007) Puri fication and characterization of transcribed RNAs using gel filtration chromatography. Nat Protoc 2:3270-3277
    • (2007) Nat Protoc , vol.2 , pp. 3270-3277
    • McKenna, S.A.1    Kim, I.2    Puglisi, E.V.3
  • 120
    • 79953111808 scopus 로고    scopus 로고
    • Genome-wide target pro filing of piggyBac and Tol2 in HEK 293: Pros and cons for gene discovery and gene therapy
    • Meir YJ, Weirauch MT, Yang HS et al (2011) Genome-wide target pro filing of piggyBac and Tol2 in HEK 293: pros and cons for gene discovery and gene therapy. BMC Biotechnol 11:28
    • (2011) BMC Biotechnol , vol.11 , pp. 28
    • Meir, Y.J.1    Weirauch, M.T.2    Yang, H.S.3
  • 121
    • 4644223259 scopus 로고    scopus 로고
    • Mechanisms of gene silencing by double stranded RNA
    • Meister G, Tuschl T (2004) Mechanisms of gene silencing by double stranded RNA. Nature 431:343-349
    • (2004) Nature , vol.431 , pp. 343-349
    • Meister, G.1    Tuschl, T.2
  • 122
    • 39849093718 scopus 로고    scopus 로고
    • The MDS1-EVI1 gene complex as a retrovirus integration site: Impact on behavior of hematopoietic cells and implications for gene therapy
    • Métais JY, Dunbar CE (2008) The MDS1-EVI1 gene complex as a retrovirus integration site: impact on behavior of hematopoietic cells and implications for gene therapy. Mol Ther 6:439-449
    • (2008) Mol Ther , vol.6 , pp. 439-449
    • Métais, J.Y.1    Dunbar, C.E.2
  • 123
    • 0142213094 scopus 로고    scopus 로고
    • Helper-independent Sleeping Beauty transposontransposase vectors for Efficient nonviral gene delivery and persistent gene expression in vivo
    • Mikkelsen JG, Yant SR, Meuse L et al (2003) Helper-independent Sleeping Beauty transposontransposase vectors for Efficient nonviral gene delivery and persistent gene expression in vivo . Mol Ther 8:654-665
    • (2003) Mol Ther , vol.8 , pp. 654-665
    • Mikkelsen, J.G.1    Yant, S.R.2    Meuse, L.3
  • 124
    • 65749110643 scopus 로고    scopus 로고
    • Tissue-specific and transcription factor-mediated nuclear entry of DNA
    • Miller A, Dean D (2009) Tissue-specific and transcription factor-mediated nuclear entry of DNA. Adv Drug Deliv Rev 61:603-613
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 603-613
    • Miller, A.1    Dean, D.2
  • 125
    • 79959932534 scopus 로고    scopus 로고
    • Immune responses to AAV in clinical trials
    • Mingozzi F, High KA (2011) Immune Responses to AAV in Clinical Trials. Curr Gene Ther 11:321-330
    • (2011) Curr Gene Ther , vol.11 , pp. 321-330
    • Mingozzi, F.1    High, K.A.2
  • 126
    • 34848911647 scopus 로고    scopus 로고
    • DNA methylation: The nuts and bolts of repression
    • Miranda TB, Jones PA (2007) DNA methylation: the nuts and bolts of repression. J Cell Physiol 213:384-390
    • (2007) J Cell Physiol , vol.213 , pp. 384-390
    • Miranda, T.B.1    Jones, P.A.2
  • 128
    • 33750624015 scopus 로고    scopus 로고
    • Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity
    • Modlich U, Bohne J, Schmidt M et al (2006) Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity. Blood 108:2545-2553
    • (2006) Blood , vol.108 , pp. 2545-2553
    • Modlich, U.1    Bohne, J.2    Schmidt, M.3
  • 129
    • 70449127230 scopus 로고    scopus 로고
    • Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors
    • Modlich U, Navarro S, Zychlinski D et al (2009) Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors. Mol Ther 17:1919-1928
    • (2009) Mol Ther , vol.17 , pp. 1919-1928
    • Modlich, U.1    Navarro, S.2    Zychlinski, D.3
  • 130
    • 37149045293 scopus 로고    scopus 로고
    • Cis-acting gene regulatory activities in the terminal regions of sleeping beauty DNA transposon-based vectors
    • Moldt B, Yant SR, Andersen PR et al (2007) Cis-acting gene regulatory activities in the terminal regions of sleeping beauty DNA transposon-based vectors. Hum Gene Ther 18:1193-1204
    • (2007) Hum Gene Ther , vol.18 , pp. 1193-1204
    • Moldt, B.1    Yant, S.R.2    Andersen, P.R.3
  • 131
    • 33745108790 scopus 로고    scopus 로고
    • Hematopoietic stem cell gene transfer in a tumorprone mouse model uncovers low genotoxicity of lentiviral vector integration
    • Montini E, Cesana D, Schmidt M et al (2006) Hematopoietic stem cell gene transfer in a tumorprone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat Biotechnol 24:687-696
    • (2006) Nat Biotechnol , vol.24 , pp. 687-696
    • Montini, E.1    Cesana, D.2    Schmidt, M.3
  • 132
    • 65249101260 scopus 로고    scopus 로고
    • The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
    • Montini E, Cesana D, Schmidt M et al (2009) The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy. J Clin Invest 119:964-975
    • (2009) J Clin Invest , vol.119 , pp. 964-975
    • Montini, E.1    Cesana, D.2    Schmidt, M.3
  • 133
    • 34547728699 scopus 로고    scopus 로고
    • PiggyBac transposon mediated transgenesis of the human blood fluke
    • Morales ME, Mann VH, Kines KJ et al (2007) PiggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni. FASEB J 21:3479-3489
    • (2007) Schistosoma Mansoni. FASEB J , vol.21 , pp. 3479-3489
    • Morales, M.E.1    Mann, V.H.2    Kines, K.J.3
  • 134
    • 58149469932 scopus 로고    scopus 로고
    • Transgene optimization signi ficantly improves SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD cells
    • Moreno-Carranza B, Gentsch M, Stein S et al (2009) Transgene optimization signi ficantly improves SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD cells. Gene Ther 16:111-118
    • (2009) Gene Ther , vol.16 , pp. 111-118
    • Moreno-Carranza, B.1    Gentsch, M.2    Stein, S.3
  • 135
    • 33645728427 scopus 로고    scopus 로고
    • Inserting optimism into gene therapy
    • Naldini L (2006) Inserting optimism into gene therapy. Nat Med 12:386-388
    • (2006) Nat Med , vol.12 , pp. 386-388
    • Naldini, L.1
  • 136
    • 77949424429 scopus 로고    scopus 로고
    • Progress and prospects: Immune responses to viral vectors
    • Nayak S, Herzog RW (2010) Progress and prospects: immune responses to viral vectors. Gene Ther 17:295-304
    • (2010) Gene Ther , vol.17 , pp. 295-304
    • Nayak, S.1    Herzog, R.W.2
  • 137
    • 0036954247 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Nonviral vectors
    • Niidome T, Huang L (2002) Gene therapy progress and prospects: nonviral vectors. Gene Ther 9:1647-1652
    • (2002) Gene Ther , vol.9 , pp. 1647-1652
    • Niidome, T.1    Huang, L.2
  • 138
    • 49349086561 scopus 로고    scopus 로고
    • Engineering variants of the ISceI homing endonuclease with strand-specific and site-specific DNA-nicking activity
    • Niu Y, Tenney K, Li H, Gimble FS (2008) Engineering variants of the ISceI homing endonuclease with strand-specific and site-specific DNA-nicking activity. J Mol Biol 382:188-202
    • (2008) J Mol Biol , vol.382 , pp. 188-202
    • Niu, Y.1    Tenney, K.2    Li, H.3    Gimble, F.S.4
  • 139
    • 0042208122 scopus 로고    scopus 로고
    • Identification of an insulator in AAVS1, a preferred region for integration of adeno-associated virus DNA
    • Ogata T, Kozuka T, Kanda T (2003) Identification of an insulator in AAVS1, a preferred region for integration of adeno-associated virus DNA. J Virol 77:9000-9007
    • (2003) J Virol , vol.77 , pp. 9000-9007
    • Ogata, T.1    Kozuka, T.2    Kanda, T.3
  • 140
    • 33645734405 scopus 로고    scopus 로고
    • Correction of x-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
    • Ott MG, Schmidt M, Schwarzwaelder K et al (2006) Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med 12:401-409
    • (2006) Nat Med , vol.12 , pp. 401-409
    • Ott, M.G.1    Schmidt, M.2    Schwarzwaelder, K.3
  • 141
    • 66149102465 scopus 로고    scopus 로고
    • Targeted transgenesis at the HPRT locus: An Efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system
    • Palais G, Nguyen Dinh Cat A, Friedman H et al (2009) Targeted transgenesis at the HPRT locus: an Efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system. Physiol Genomics 37:140-146
    • (2009) Physiol Genomics , vol.37 , pp. 140-146
    • Palais, G.1    Nguyen Dinh Cat, A.2    Friedman, H.3
  • 142
    • 79960206845 scopus 로고    scopus 로고
    • Landscape of chromatin control element patents: Positioning effects in pharmaceutical bioproduction
    • Palazzoli F, Bire S, Bigot Y, Bonnin-Rouleux F (2011) Landscape of chromatin control element patents: positioning effects in pharmaceutical bioproduction. Nat Biotechnol 29:593-597
    • (2011) Nat Biotechnol , vol.29 , pp. 593-597
    • Palazzoli, F.1    Bire, S.2    Bigot, Y.3    Bonnin-Rouleux, F.4
  • 143
    • 80052405826 scopus 로고    scopus 로고
    • Generation of transgene-free human induced pluripotent stem cells with an excisable single polycistronic vector
    • Papapetrou EP, Sadelain M (2011) Generation of transgene-free human induced pluripotent stem cells with an excisable single polycistronic vector. Nat Protoc 6:1251-1273
    • (2011) Nat Protoc , vol.6 , pp. 1251-1273
    • Papapetrou, E.P.1    Sadelain, M.2
  • 144
    • 78651337233 scopus 로고    scopus 로고
    • Genomic safe harbors permit high b-globin transgene expression in thalassemia induced pluripotent stem cells
    • Papapetrou EP, Lee G, Malani N et al (2011) Genomic safe harbors permit high b-globin transgene expression in thalassemia induced pluripotent stem cells. Nat Biotechnol 29:73-78
    • (2011) Nat Biotechnol , vol.29 , pp. 73-78
    • Papapetrou, E.P.1    Lee, G.2    Malani, N.3
  • 145
    • 33745950160 scopus 로고    scopus 로고
    • Sleeping Beauty transposition in the mouse genome is associated with changes in DNA methylation at the site of insertion
    • Park CW, Park J, Kren BT, Steer CJ (2006) Sleeping Beauty transposition in the mouse genome is associated with changes in DNA methylation at the site of insertion. Genomics 88:204-213
    • (2006) Genomics , vol.88 , pp. 204-213
    • Park, C.W.1    Park, J.2    Kren, B.T.3    Steer, C.J.4
  • 146
    • 77955220225 scopus 로고    scopus 로고
    • Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing
    • Paruzynski A, Arens A, Gabriel R et al (2010) Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing. Nat Protoc 5:1379-1395
    • (2010) Nat Protoc , vol.5 , pp. 1379-1395
    • Paruzynski, A.1    Arens, A.2    Gabriel, R.3
  • 147
    • 0025773296 scopus 로고
    • Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2 1 A
    • Pavletich NP, Pabo CO (1991) Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2 1 A. Science 252:809-817
    • (1991) Science , vol.252 , pp. 809-817
    • Pavletich, N.P.1    Pabo, C.O.2
  • 148
    • 0742290164 scopus 로고    scopus 로고
    • Transgene expression after rep-mediated sitespecific integration into chromosome 19
    • Philpott NJ, Gomos J, Falck-Pedersen E (2004) Transgene expression after rep-mediated sitespecific integration into chromosome 19. Hum Gene Ther 15:47-61
    • (2004) Hum Gene Ther , vol.15 , pp. 47-61
    • Philpott, N.J.1    Gomos, J.2    Falck-Pedersen, E.3
  • 149
    • 77957343707 scopus 로고    scopus 로고
    • Chemical vectors for gene delivery: Uptake and intracellular traf ficking
    • Pichon C, Billiet L, Midoux P (2010) Chemical vectors for gene delivery: uptake and intracellular traf ficking. Curr Opin Biotechnol 21:640-645
    • (2010) Curr Opin Biotechnol , vol.21 , pp. 640-645
    • Pichon, C.1    Billiet, L.2    Midoux, P.3
  • 150
    • 33646722147 scopus 로고    scopus 로고
    • Emergent properties of reduced genome Escherichia coli
    • Posfai G, Plunkett G III, Feher T et al (2006) Emergent properties of reduced genome Escherichia coli . Science 312:1044-1046
    • (2006) Science , vol.312 , pp. 1044-1046
    • Posfai, G.1    Plunkett III, G.2    Feher, T.3
  • 151
    • 38949107300 scopus 로고    scopus 로고
    • Analysis of factor VIII mediated suppression of lentiviral vector titres
    • Radcliffe PA, Sion CJ, Wilkes FJ et al (2008) Analysis of factor VIII mediated suppression of lentiviral vector titres. Gene Ther 15:289-297
    • (2008) Gene Ther , vol.15 , pp. 289-297
    • Radcliffe, P.A.1    Sion, C.J.2    Wilkes, F.J.3
  • 152
    • 80052468612 scopus 로고    scopus 로고
    • Efficient recombinase-mediated cassette exchange at the AAVS1 locus in human embryonic stem cells using baculoviral vectors
    • Ramachandra CJ, Shahbazi M, Kwang TW et al (2011) Efficient recombinase-mediated cassette exchange at the AAVS1 locus in human embryonic stem cells using baculoviral vectors. Nucleic Acids Res 39:e107
    • (2011) Nucleic Acids Res , vol.39
    • Ramachandra, C.J.1    Shahbazi, M.2    Kwang, T.W.3
  • 153
    • 31944440000 scopus 로고    scopus 로고
    • Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells
    • Recchia A, Bonini C, Magnani Z et al (2006) Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells. Proc Natl Acad Sci USA 103:1457-1462
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1457-1462
    • Recchia, A.1    Bonini, C.2    Magnani, Z.3
  • 154
    • 1342332864 scopus 로고    scopus 로고
    • CpG methylation of a plasmid vector results in extended transgene product expression by circumventing induction of immune responses
    • Reyes-Sandoval A, Ertl HC (2004) CpG methylation of a plasmid vector results in extended transgene product expression by circumventing induction of immune responses. Mol Ther 9:249-261
    • (2004) Mol Ther , vol.9 , pp. 249-261
    • Reyes-Sandoval, A.1    Ertl, H.C.2
  • 155
    • 79951840580 scopus 로고    scopus 로고
    • HIV-1-derived lentiviral vectors directly activate plasmacytoid dendritic cells, which in turn induce the maturation of myeloid dendritic cells
    • Rossetti M, Gregori S, Hauben E et al (2011) HIV-1-derived lentiviral vectors directly activate plasmacytoid dendritic cells, which in turn induce the maturation of myeloid dendritic cells. Hum Gene Ther 22:177-188
    • (2011) Hum Gene Ther , vol.22 , pp. 177-188
    • Rossetti, M.1    Gregori, S.2    Hauben, E.3
  • 156
    • 0029053229 scopus 로고
    • Human ribosomal RNA gene cluster: Identification of the proximal end containing a novel tandem repeat sequence
    • Sakai K, Ohta T, Minoshima S et al (1995) Human ribosomal RNA gene cluster: Identification of the proximal end containing a novel tandem repeat sequence. Genomics 26:521-526
    • (1995) Genomics , vol.26 , pp. 521-526
    • Sakai, K.1    Ohta, T.2    Minoshima, S.3
  • 157
    • 40849104849 scopus 로고    scopus 로고
    • Innate immune response induced by gene delivery vectors
    • Sakurai H, Kawabata K, Sakurai F et al (2008) Innate immune response induced by gene delivery vectors. Int J Pharm 354:9-15
    • (2008) Int J Pharm , vol.354 , pp. 9-15
    • Sakurai, H.1    Kawabata, K.2    Sakurai, F.3
  • 158
    • 0038286220 scopus 로고    scopus 로고
    • Integration by design
    • Sandmeyer S (2003) Integration by design. Proc Natl Acad Sci USA 100:5586-5588
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5586-5588
    • Sandmeyer, S.1
  • 159
    • 0037007010 scopus 로고    scopus 로고
    • Directed evolution of the site specificity of Cre recombinase
    • Santoro SW, Schultz PG (2002) Directed evolution of the site specificity of Cre recombinase. Proc Natl Acad Sci USA 99:4185-4190
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 4185-4190
    • Santoro, S.W.1    Schultz, P.G.2
  • 160
    • 34249298695 scopus 로고    scopus 로고
    • Improving transcriptional termination of selfinactivating gamma-retroviral and lentiviral vectors
    • Schambach A, Galla M, Maetzig T et al (2007) Improving transcriptional termination of selfinactivating gamma-retroviral and lentiviral vectors. Mol Ther 15:1167-73
    • (2007) Mol Ther , vol.15 , pp. 1167-1173
    • Schambach, A.1    Galla, M.2    Maetzig, T.3
  • 161
    • 0345144017 scopus 로고    scopus 로고
    • Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-de ficient SCID neonates
    • Schmidt M, Carbonaro DA, Speckmann C et al (2003) Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-de ficient SCID neonates. Nat Med 9:463-468
    • (2003) Nat Med , vol.9 , pp. 463-468
    • Schmidt, M.1    Carbonaro, D.A.2    Speckmann, C.3
  • 162
    • 36749052217 scopus 로고    scopus 로고
    • High-resolution insertion-site analysis by linear ampli fication-mediated PCR (LAM-PCR)
    • Schmidt M, Schwarzwaelder K, Bartholomae C et al (2007) High-resolution insertion-site analysis by linear ampli fication-mediated PCR (LAM-PCR). Nat Methods 4:1051-1057
    • (2007) Nat Methods , vol.4 , pp. 1051-1057
    • Schmidt, M.1    Schwarzwaelder, K.2    Bartholomae, C.3
  • 163
    • 0037162715 scopus 로고    scopus 로고
    • HIV-1 integration in the human genome favors active genes and local hotspots
    • Schroder AR, Shinn P, Chen H et al (2002) HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110:521-529
    • (2002) Cell , vol.110 , pp. 521-529
    • Schroder, A.R.1    Shinn, P.2    Chen, H.3
  • 164
    • 33846874141 scopus 로고    scopus 로고
    • Construction and characterization of new piggyBac vectors for constitutive or inducible expression of heterologous gene pairs and the Identification of a previously unrecognized activator sequence in piggyBac
    • Shi X, Harrison RL, Hollister JR et al (2007) Construction and characterization of new piggyBac vectors for constitutive or inducible expression of heterologous gene pairs and the Identification of a previously unrecognized activator sequence in piggyBac . BMC Biotechnol 7:5
    • (2007) BMC Biotechnol , vol.7 , pp. 5
    • Shi, X.1    Harrison, R.L.2    Hollister, J.R.3
  • 165
    • 33646049347 scopus 로고    scopus 로고
    • Innate sensing of self and non-self rnas by toll-like receptors
    • Sioud M (2006) Innate sensing of self and non-self RNAs by Toll-like receptors. Trends Mol Med 12:167-176
    • (2006) Trends Mol Med , vol.12 , pp. 167-176
    • Sioud, M.1
  • 166
    • 84860390327 scopus 로고    scopus 로고
    • B-globin matrix attachment region improves stable genomic expression of the Sleeping Beauty transposon
    • Sjeklocha L, Chen Y, Daly MC et al (2011) b-globin matrix attachment region improves stable genomic expression of the Sleeping Beauty transposon. J Cell Biochem 112:2361-2375
    • (2011) J Cell Biochem , vol.112 , pp. 2361-2375
    • Sjeklocha, L.1    Chen, Y.2    Daly, M.C.3
  • 167
    • 33845914020 scopus 로고    scopus 로고
    • A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences
    • Smith J, Grizot S, Arnould S et al (2006) A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences. Nucleic Acids Res 34:e149
    • (2006) Nucleic Acids Res , vol.34
    • Smith, J.1    Grizot, S.2    Arnould, S.3
  • 168
    • 24944583478 scopus 로고    scopus 로고
    • Targeted modification of mammalian genomes
    • Sorrell DA, Kolb AF (2005) Targeted modification of mammalian genomes. Biotechnol Adv 23:431-469
    • (2005) Biotechnol Adv , vol.23 , pp. 431-469
    • Sorrell, D.A.1    Kolb, A.F.2
  • 169
    • 35548970476 scopus 로고    scopus 로고
    • Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent
    • Strathdee D, Ibbotson H, Grant SG (2006) Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent. PLoS One 1:e4
    • (2006) PLoS One , vol.1
    • Strathdee, D.1    Ibbotson, H.2    Grant, S.G.3
  • 170
    • 64649102398 scopus 로고    scopus 로고
    • Site-specific integration of retroviral DNA in human cells using fusion proteins consisting of human immunode ficiency virus type 1 integrase and the designed polydactyl zinc-finger protein E2C
    • Su K, Wang D, Ye J et al (2009) Site-specific integration of retroviral DNA in human cells using fusion proteins consisting of human immunode ficiency virus type 1 integrase and the designed polydactyl zinc-finger protein E2C. Methods 47:269-276
    • (2009) Methods , vol.47 , pp. 269-276
    • Su, K.1    Wang, D.2    Ye, J.3
  • 171
    • 74549114206 scopus 로고    scopus 로고
    • DB Stable transgene expression in primitive human cd34+ hematopoietic stem/progenitor cells using the sleeping beauty transposon system
    • Sumiyoshi T, Holt NG, Hollis RP et al (2009) DB Stable transgene expression in primitive human CD34+ hematopoietic stem/progenitor cells using the Sleeping Beauty transposon system. Hum Gene Ther 20:1607-1626
    • (2009) Hum Gene Ther , vol.20 , pp. 1607-1626
    • Sumiyoshi, T.1    Holt, N.G.2    Hollis, R.P.3
  • 172
    • 78651256000 scopus 로고    scopus 로고
    • Progress in the development of ultrasoundmediated gene delivery systems utilizing nanoand microbubbles
    • Suzuki R, Oda Y, Utoguchi N, Maruyama K (2011) Progress in the development of ultrasoundmediated gene delivery systems utilizing nanoand microbubbles. J Control Release 149: 36-41
    • (2011) J Control Release , vol.149 , pp. 36-41
    • Suzuki, R.1    Oda, Y.2    Utoguchi, N.3    Maruyama, K.4
  • 173
    • 34447323568 scopus 로고    scopus 로고
    • Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases
    • Szczepek M, Brondani V, Büchel J et al (2007) Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nature Biotech 25:786-793
    • (2007) Nature Biotech , vol.25 , pp. 786-793
    • Szczepek, M.1    Brondani, V.2    Büchel, J.3
  • 174
    • 0033135797 scopus 로고    scopus 로고
    • Transcription analysis of the telomeric repeat-specific retrotransposons TRAS1 and SART1 of the silkworm Bombyx mori
    • Takahashi H, Fujiwara H (1999) Transcription analysis of the telomeric repeat-specific retrotransposons TRAS1 and SART1 of the silkworm Bombyx mori. Nucleic Acids Res 27:2015-2021
    • (1999) Nucleic Acids Res , vol.27 , pp. 2015-2021
    • Takahashi, H.1    Fujiwara, H.2
  • 175
    • 0036470563 scopus 로고    scopus 로고
    • Transplantation of target site specificity by swapping the endonuclease domains of two LINEs
    • Takahashi H, Fujiwara H (2002) Transplantation of target site specificity by swapping the endonuclease domains of two LINEs. EMBO J 21:408-417
    • (2002) EMBO J , vol.21 , pp. 408-417
    • Takahashi, H.1    Fujiwara, H.2
  • 176
    • 79955579208 scopus 로고    scopus 로고
    • Positive correlation between the generation of reactive oxygen species and activation/reactivation of transgene expression after hydrodynamic injections into mice
    • Takiguchi N, Takahashi Y, Nishikawa M et al (2011) Positive correlation between the generation of reactive oxygen species and activation/reactivation of transgene expression after hydrodynamic injections into mice. Pharm Res 28:702-711
    • (2011) Pharm Res , vol.28 , pp. 702-711
    • Takiguchi, N.1    Takahashi, Y.2    Nishikawa, M.3
  • 177
    • 0037148368 scopus 로고    scopus 로고
    • Transcriptional silencing at Saccharomyces telomeres: Implications for other organisms
    • Tham WH, Zakian VA (2002) Transcriptional silencing at Saccharomyces telomeres: implications for other organisms. Oncogene 21:512-521
    • (2002) Oncogene , vol.21 , pp. 512-521
    • Tham, W.H.1    Zakian, V.A.2
  • 178
    • 0026437552 scopus 로고
    • Nested chromosomal fragmentation in yeast using the meganuclease I-Sce I: A new method for physical mapping of eukaryotic genomes
    • Thierry A, Dujon B (1992) Nested chromosomal fragmentation in yeast using the meganuclease I-Sce I: a new method for physical mapping of eukaryotic genomes. Nucleic Acids Res 20: 5625-5631
    • (1992) Nucleic Acids Res , vol.20 , pp. 5625-5631
    • Thierry, A.1    Dujon, B.2
  • 179
    • 0035008830 scopus 로고    scopus 로고
    • Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase
    • Thyagarajan B, Olivares EC, Hollis RP et al (2001) Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase. Mol Cell Biol 21:3926-3934
    • (2001) Mol Cell Biol , vol.21 , pp. 3926-3934
    • Thyagarajan, B.1    Olivares, E.C.2    Hollis, R.P.3
  • 180
    • 74549206662 scopus 로고    scopus 로고
    • Retroviral vectors encoding ADA regulatory locus control region provide enhanced T-cell-specific transgene expression
    • Trinh AT, Ball BG, Weber E et al (2009) Retroviral vectors encoding ADA regulatory locus control region provide enhanced T-cell-specific transgene expression. Genet Vaccines Ther 30:7-13
    • (2009) Genet Vaccines Ther , vol.30 , pp. 7-13
    • Trinh, A.T.1    Ball, B.G.2    Weber, E.3
  • 181
    • 79952310557 scopus 로고    scopus 로고
    • Recombinase-mediated cassette exchange (RMCE): Traditional concepts and current challenges
    • Turan S, Galla M, Ernst E et al (2011) Recombinase-mediated cassette exchange (RMCE): traditional concepts and current challenges. J Mol Biol 407:193-221
    • (2011) J Mol Biol , vol.407 , pp. 193-221
    • Turan, S.1    Galla, M.2    Ernst, E.3
  • 182
    • 8644231282 scopus 로고    scopus 로고
    • Human cell proteins and human immunode ficiency virus DNA integration
    • Turlure F, Devroe E, Silver PA et al (2004) Human cell proteins and human immunode ficiency virus DNA integration. Front Biosci 9:3187-3208
    • (2004) Front Biosci , vol.9 , pp. 3187-3208
    • Turlure, F.1    Devroe, E.2    Silver, P.A.3
  • 183
    • 79953809082 scopus 로고    scopus 로고
    • Suppression of melanoma growth and metastasis by DNA vaccination using an ultrasound-responsive and mannose-modified gene carrier
    • Un K, Kawakami S, Suzuki R et al (2011) Suppression of melanoma growth and metastasis by DNA vaccination using an ultrasound-responsive and mannose-modified gene carrier. Mol Pharm 8:543-554
    • (2011) Mol Pharm , vol.8 , pp. 543-554
    • Un, K.1    Kawakami, S.2    Suzuki, R.3
  • 186
    • 0036404918 scopus 로고    scopus 로고
    • Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements
    • Vigdal TJ, Kaufman CD, Izsvak Z et al (2002) Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements. J Mol Biol 323:441-452
    • (2002) J Mol Biol , vol.323 , pp. 441-452
    • Vigdal, T.J.1    Kaufman, C.D.2    Izsvak, Z.3
  • 187
    • 0242492858 scopus 로고    scopus 로고
    • The human polycomb group EED protein interacts with the integrase of human immunode ficiency virus type 1
    • Violot S, Hong SS, Rakotobe D et al (2003) The human polycomb group EED protein interacts with the integrase of human immunode ficiency virus type 1. J Virol 77:12507-12522
    • (2003) J Virol , vol.77 , pp. 12507-12522
    • Violot, S.1    Hong, S.S.2    Rakotobe, D.3
  • 188
    • 54249090643 scopus 로고    scopus 로고
    • Targeted gene insertion for molecular medicine
    • Voigt K, Izsvák Z, Ivics Z (2008) Targeted gene insertion for molecular medicine. J Mol Med 86:1205-1219
    • (2008) J Mol Med , vol.86 , pp. 1205-1219
    • Voigt, K.1    Izsvák, Z.2    Ivics, Z.3
  • 189
    • 0037423742 scopus 로고    scopus 로고
    • Stepwise manipulation of DNA specificity in Flp recombinase: Progressively adapting Flp to individual and combinatorial mutations in its target site
    • Voziyanov Y, Konieczka JH, Stewart AF, Jayaram M (2003) Stepwise manipulation of DNA specificity in Flp recombinase: progressively adapting Flp to individual and combinatorial mutations in its target site. J Mol Biol 326:65-76
    • (2003) J Mol Biol , vol.326 , pp. 65-76
    • Voziyanov, Y.1    Konieczka, J.H.2    Stewart, A.F.3    Jayaram, M.4
  • 190
    • 79960912431 scopus 로고    scopus 로고
    • Developing extrachromosomal gene expression vector technologies: An overview
    • Wade-Martins R (2011) Developing extrachromosomal gene expression vector technologies: an overview. Methods Mol Biol 738:1-17
    • (2011) Methods Mol Biol , vol.738 , pp. 1-17
    • Wade-Martins, R.1
  • 191
    • 0035070944 scopus 로고    scopus 로고
    • In fluence of multiplicity of infection and protein stability on retroviral vector mediated gene expression in hematopoietic cells
    • Wahlers A, Schwieger M, Li Z et al (2001) In fluence of multiplicity of infection and protein stability on retroviral vector mediated gene expression in hematopoietic cells. Gene Ther 8:477-486
    • (2001) Gene Ther , vol.8 , pp. 477-486
    • Wahlers, A.1    Schwieger, M.2    Li, Z.3
  • 192
    • 33645232339 scopus 로고    scopus 로고
    • Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1
    • Walisko O, Izsvák Z, Szabó K et al (2006) Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1. Proc Natl Acad Sci USA 103:4062-4067
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4062-4067
    • Walisko, O.1    Izsvák, Z.2    Szabó, K.3
  • 193
    • 78751681902 scopus 로고    scopus 로고
    • Codon optimization of human factor VIII cDNAs leads to high-level expression
    • Ward NJ, Buckley SM, Waddington SN (2011) Codon optimization of human factor VIII cDNAs leads to high-level expression. Blood 117:798-807
    • (2011) Blood , vol.117 , pp. 798-807
    • Ward, N.J.1    Buckley, S.M.2    Waddington, S.N.3
  • 194
    • 27944486578 scopus 로고    scopus 로고
    • Gene activation and deactivation related changes in the three-dimensional structure of chromatin
    • Wegel E, Shaw P (2005) Gene activation and deactivation related changes in the three-dimensional structure of chromatin. Chromosoma 114:331-337
    • (2005) Chromosoma , vol.114 , pp. 331-337
    • Wegel, E.1    Shaw, P.2
  • 195
    • 58149214356 scopus 로고    scopus 로고
    • Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
    • Wei G, Wei L, Zhu J (2009) Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30:155-167
    • (2009) Immunity , vol.30 , pp. 155-167
    • Wei, G.1    Wei, L.2    Zhu, J.3
  • 197
    • 32944463921 scopus 로고    scopus 로고
    • RNA as a source of transposase for Sleeping Beautymediated gene insertion and expression in somatic cells and tissues
    • Wilber A, Frandsen JL, Geurts JL et al (2006) RNA as a source of transposase for Sleeping Beautymediated gene insertion and expression in somatic cells and tissues. Mol Ther 13:625-630
    • (2006) Mol Ther , vol.13 , pp. 625-630
    • Wilber, A.1    Frandsen, J.L.2    Geurts, J.L.3
  • 198
    • 79955994750 scopus 로고    scopus 로고
    • Designing and testing chimeric zinc finger transposases
    • Wilson MH, George AL Jr (2010) Designing and testing chimeric zinc finger transposases. Methods Mol Biol 649:353-363
    • (2010) Methods Mol Biol , vol.649 , pp. 353-363
    • Wilson, M.H.1    George Jr., A.L.2
  • 199
    • 36148961543 scopus 로고    scopus 로고
    • Road to precision: Recombinase-based targeting technologies for genome engineering
    • Wirth D, Gama-Norton L, Riemer P et al (2007) Road to precision: recombinase-based targeting technologies for genome engineering. Curr Opin Biotechnol 18:411-419
    • (2007) Curr Opin Biotechnol , vol.18 , pp. 411-419
    • Wirth, D.1    Gama-Norton, L.2    Riemer, P.3
  • 200
    • 64749083939 scopus 로고    scopus 로고
    • PiggyBac transposition reprograms fIbroblasts to induced pluripotent stem cells
    • Woltjen K, Mickael IP, Mohseni P et al (2009) piggyBac transposition reprograms fIbroblasts to induced pluripotent stem cells. Nature 458:766-770
    • (2009) Nature , vol.458 , pp. 766-770
    • Woltjen, K.1    Mickael, I.P.2    Mohseni, P.3
  • 201
    • 0037841763 scopus 로고    scopus 로고
    • Transcription start regions in the human genome are favored targets for MLV integration
    • Wu X, Li Y, Crise B, Burgess SM (2003) Transcription start regions in the human genome are favored targets for MLV integration. Science 300:1749-1751
    • (2003) Science , vol.300 , pp. 1749-1751
    • Wu, X.1    Li, Y.2    Crise, B.3    Burgess, S.M.4
  • 202
    • 33750060436 scopus 로고    scopus 로고
    • PiggyBac is a flexible and highly active transposon as compared to sleeping beauty, Tol2, and Mos1 in mammalian cells
    • Wu SC, Meir YJ, Coates CJ et al (2006) PiggyBac is a flexible and highly active transposon as compared to sleeping beauty, Tol2, and Mos1 in mammalian cells. Proc Natl Acad Sci USA 103:15008-15013
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15008-15013
    • Wu, S.C.1    Meir, Y.J.2    Coates, C.J.3
  • 203
    • 38649139896 scopus 로고    scopus 로고
    • Optimization of self-complementary AAV vectors for liverdirected expression results in sustained correction of hemophilia B at low vector dose
    • Wu Z, Sun J, Zhang T et al (2008) Optimization of self-complementary AAV vectors for liverdirected expression results in sustained correction of hemophilia B at low vector dose. Mol Ther 16:280-289
    • (2008) Mol Ther , vol.16 , pp. 280-289
    • Wu, Z.1    Sun, J.2    Zhang, T.3
  • 204
    • 0034816496 scopus 로고    scopus 로고
    • Targeting of the yeast Ty5 retrotransposon to silent chromatin is mediated by interactions between integrase and Sir4p
    • Xie W, Gai X, Zhu Y (2001) Targeting of the yeast Ty5 retrotransposon to silent chromatin is mediated by interactions between integrase and Sir4p. Mol Cell Biol 21:6606-6614
    • (2001) Mol Cell Biol , vol.21 , pp. 6606-6614
    • Xie, W.1    Gai, X.2    Zhu, Y.3
  • 205
    • 70349320475 scopus 로고    scopus 로고
    • Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system
    • Xue X, Huang X, Nodland SE et al (2009) Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system. Blood 114:1319-1330
    • (2009) Blood , vol.114 , pp. 1319-1330
    • Xue, X.1    Huang, X.2    Nodland, S.E.3
  • 207
    • 0242721679 scopus 로고    scopus 로고
    • Nonhomologous-end-joining factors regulate DNA repair fidelity during Sleeping Beauty element transposition in mammalian cells
    • Yant SR, Kay MA (2003) Nonhomologous-end-joining factors regulate DNA repair fidelity during Sleeping Beauty element transposition in mammalian cells. Mol Cell Biol 23:8505-8518
    • (2003) Mol Cell Biol , vol.23 , pp. 8505-8518
    • Yant, S.R.1    Kay, M.A.2
  • 208
    • 14844355218 scopus 로고    scopus 로고
    • High-resolution genome-wide mapping of transposon integration in mammals
    • Yant SR, Wu X, Huang Y et al (2005) High-resolution genome-wide mapping of transposon integration in mammals. Mol Cell Biol 25:2085-2094
    • (2005) Mol Cell Biol , vol.25 , pp. 2085-2094
    • Yant, S.R.1    Wu, X.2    Huang, Y.3
  • 210
    • 3042732990 scopus 로고    scopus 로고
    • Retrovirus silencing, variegation, extinction, and memory are controlled by a dynamic interplay of multiple epigenetic modifications
    • Yao S, Sukonnik T, Kean T, Bharadwaj RR, Pasceri P, Ellis J (2004) Retrovirus silencing, variegation, extinction, and memory are controlled by a dynamic interplay of multiple epigenetic modifications. Mol Ther 10:27-36
    • (2004) Mol Ther , vol.10 , pp. 27-36
    • Yao, S.1    Sukonnik, T.2    Kean, T.3    Bharadwaj, R.R.4    Pasceri, P.5    Ellis, J.6
  • 211
    • 14744301443 scopus 로고    scopus 로고
    • Controlling the kinetics of transgene expression by plasmid design
    • Yew NS (2005) Controlling the kinetics of transgene expression by plasmid design. Adv Drug Deliv Rev 57:769-780
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 769-780
    • Yew, N.S.1
  • 212
    • 0035989006 scopus 로고    scopus 로고
    • CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo
    • Yew NS, Zhao H, Przybylska M et al (2002) CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo . Mol Ther 5:731-738
    • (2002) Mol Ther , vol.5 , pp. 731-738
    • Yew, N.S.1    Zhao, H.2    Przybylska, M.3
  • 213
    • 0030840954 scopus 로고    scopus 로고
    • Cytosine methylation and the ecology of intragenomic parasites
    • Yoder JA, Walsh CP, Bestor TH (1997) Cytosine methylation and the ecology of intragenomic parasites. Trends Genet 13:335-340
    • (1997) Trends Genet , vol.13 , pp. 335-340
    • Yoder, J.A.1    Walsh, C.P.2    Bestor, T.H.3
  • 214
    • 79952957934 scopus 로고    scopus 로고
    • The base excision repair pathway is required for Efficient lentivirus integration
    • Yoder KE, Espeseth A, Wang XH et al (2011) The base excision repair pathway is required for Efficient lentivirus integration. PLoS One 6:e17862
    • (2011) PLoS One , vol.6
    • Yoder, K.E.1    Espeseth, A.2    Wang, X.H.3
  • 215
    • 1942453798 scopus 로고    scopus 로고
    • Enhancement of Sleeping Beauty transposition by CpG methylation: Possible role of heterochromatin formation
    • Yusa K, Takeda J, Horie K (2004) Enhancement of Sleeping Beauty transposition by CpG methylation: possible role of heterochromatin formation. Mol Cell Biol 24:4004-4018
    • (2004) Mol Cell Biol , vol.24 , pp. 4004-4018
    • Yusa, K.1    Takeda, J.2    Horie, K.3
  • 216
    • 65449154892 scopus 로고    scopus 로고
    • Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon
    • Yusa K, Rad R, Takeda J, Bradley A (2009) Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods 6:363-369
    • (2009) Nat Methods , vol.6 , pp. 363-369
    • Yusa, K.1    Rad, R.2    Takeda, J.3    Bradley, A.4
  • 217
    • 38949104082 scopus 로고    scopus 로고
    • How not to be seen: Immune-evasion strategies in gene therapy
    • Zaldumbide A, Hoeben RC (2008) How not to be seen: immune-evasion strategies in gene therapy. Gene Ther 15:239-246
    • (2008) Gene Ther , vol.15 , pp. 239-246
    • Zaldumbide, A.1    Hoeben, R.C.2
  • 218
    • 0030990991 scopus 로고    scopus 로고
    • Disruption of overlapping transcripts in the ROSA b geo 26 gene trap strain leads to widespread expression of b-galactosidase in mouse embryos and hematopoietic cells
    • Zambrowicz BP, Imamoto A, Fiering S et al (1997) Disruption of overlapping transcripts in the ROSA b geo 26 gene trap strain leads to widespread expression of b-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci USA 94:3789-3794
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3789-3794
    • Zambrowicz, B.P.1    Imamoto, A.2    Fiering, S.3
  • 219
    • 0038412815 scopus 로고    scopus 로고
    • The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition
    • Zayed H, Izsvaak S, Khare D et al (2003) The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition. Nucleic Acids Res 31:2313-2322
    • (2003) Nucleic Acids Res , vol.31 , pp. 2313-2322
    • Zayed, H.1    Izsvaak, S.2    Khare, D.3
  • 220
    • 70349323106 scopus 로고    scopus 로고
    • Transposable elements and an epigenetic basis for punctuated equilibria
    • Zeh DW, Zeh JA, Ishida Y (2009) Transposable elements and an epigenetic basis for punctuated equilibria. Bioessays 31:715-726
    • (2009) Bioessays , vol.31 , pp. 715-726
    • Zeh, D.W.1    Zeh, J.A.2    Ishida, Y.3
  • 221
    • 72449197565 scopus 로고    scopus 로고
    • Novel functions for small RNA molecules 1
    • Zhang C (2009) Novel functions for small RNA molecules 1. Curr Opin Mol Ther 11:641-651
    • (2009) Curr Opin Mol Ther , vol.11 , pp. 641-651
    • Zhang, C.1
  • 222
    • 34247168672 scopus 로고    scopus 로고
    • Electroporation-mediated transfer of plasmids to the lung results in reduced TLR9 signaling and in flammation
    • Zhou R, Norton JE, Zhang N, Dean DA (2007) Electroporation-mediated transfer of plasmids to the lung results in reduced TLR9 signaling and in flammation. Gene Ther 14:775-780
    • (2007) Gene Ther , vol.14 , pp. 775-780
    • Zhou, R.1    Norton, J.E.2    Zhang, N.3    Dean, D.A.4
  • 223
    • 77952580874 scopus 로고    scopus 로고
    • Generation of stable cell lines by site-specific integration of transgenes into engineered Chinese hamster ovary strains using an FLP-FRT system
    • Zhou H, Liu ZG, Sun ZW et al (2010) Generation of stable cell lines by site-specific integration of transgenes into engineered Chinese hamster ovary strains using an FLP-FRT system. J Biotechnol 147:122-129
    • (2010) J Biotechnol , vol.147 , pp. 122-129
    • Zhou, H.1    Liu, Z.G.2    Sun, Z.W.3
  • 224
    • 77449156754 scopus 로고    scopus 로고
    • High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene
    • Zhu J, Park CW, Sjeklocha L et al (2010) High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene. Biochemistry 49:1507-1521
    • (2010) Biochemistry , vol.49 , pp. 1507-1521
    • Zhu, J.1    Park, C.W.2    Sjeklocha, L.3
  • 225
    • 41149133413 scopus 로고    scopus 로고
    • Physiological promoters reduce the genotoxic risk of integrating gene vectors
    • Zychlinski D, Schambach A, Modlich U et al (2008) Physiological promoters reduce the genotoxic risk of integrating gene vectors. Mol Ther 16:718-725
    • (2008) Mol Ther , vol.16 , pp. 718-725
    • Zychlinski, D.1    Schambach, A.2    Modlich, U.3


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