-
1
-
-
79953304038
-
Retroviral vectors induce epigenetic chromatin modi fications and il-10 production in transduced b cells via activation of toll-like receptor 2
-
Ahangarani RR, Janssens W, Carlier V et al (2011) Retroviral vectors induce epigenetic chromatin modi fications and IL-10 production in transduced B cells via activation of toll-like receptor 2. Mol Ther 19:711-722
-
(2011)
Mol Ther
, vol.19
, pp. 711-722
-
-
Ahangarani, R.R.1
Janssens, W.2
Carlier, V.3
-
2
-
-
28944449341
-
Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel dna targets
-
Arnould S, Chames P, Perez C et al (2006) Engineering of large numbers of highly specific homing endonucleases that induce recombination on novel DNA targets. J Mol Biol 355:443-458
-
(2006)
J Mol Biol
, vol.355
, pp. 443-458
-
-
Arnould, S.1
Chames, P.2
Perez, C.3
-
3
-
-
79951783813
-
Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI
-
Aubert M, Ryu BY, Banks L et al (2011) Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI. PLoS One 6:e16825
-
(2011)
PLoS One
, vol.6
-
-
Aubert, M.1
Ryu, B.Y.2
Banks, L.3
-
4
-
-
33751352744
-
Harnessing a high cargo-capacity transposon for genetic applications in vertebrates
-
Balciunas D, Wangensteen KJ, Wilber A et al (2006) Harnessing a high cargo-capacity transposon for genetic applications in vertebrates. PLoS Genet 2:e169
-
(2006)
PLoS Genet
, vol.2
-
-
Balciunas, D.1
Wangensteen, K.J.2
Wilber, A.3
-
5
-
-
79951679142
-
Innate immune dna sensing pathways: Sting, aimii and the regulation of interferon production and inflammatory responses
-
Barber GN (2011) Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses. Curr Opin Immunol 23:10-20
-
(2011)
Curr Opin Immunol
, vol.23
, pp. 10-20
-
-
Barber, G.N.1
-
6
-
-
34249026300
-
High-resolution pro filing of histone methylations in the human genome
-
Barski A, Cuddapah S, Cui K et al (2007) High-resolution pro filing of histone methylations in the human genome. Cell 29:823-837
-
(2007)
Cell
, vol.29
, pp. 823-837
-
-
Barski, A.1
Cuddapah, S.2
Cui, K.3
-
7
-
-
0026031825
-
Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming transforming gene activate transcription from the normal promoter
-
Bartholomew C, Ihle JN (1991) Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming transforming gene activate transcription from the normal promoter. Mol Cell Biol 11:1820-1828
-
(1991)
Mol Cell Biol
, vol.11
, pp. 1820-1828
-
-
Bartholomew, C.1
Ihle, J.N.2
-
8
-
-
0037443457
-
Side effects of retroviral gene transfer into hematopoietic stem cells
-
Baum C, Düllmann J, Li Z et al (2003) Side effects of retroviral gene transfer into hematopoietic stem cells. Blood 101:2099-2114
-
(2003)
Blood
, vol.101
, pp. 2099-2114
-
-
Baum, C.1
Düllmann, J.2
Li, Z.3
-
9
-
-
33645451483
-
Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors
-
Baum C, Kustikova O, Modlich U et al (2006) Mutagenesis and oncogenesis by chromosomal insertion of gene transfer vectors. Hum Gene Ther 17:252-263
-
(2006)
Hum Gene Ther
, vol.17
, pp. 252-263
-
-
Baum, C.1
Kustikova, O.2
Modlich, U.3
-
10
-
-
0036168937
-
Engineering polydactyl zinc-finger transcription factors
-
Beerli RR, Barbas CF 3rd (2002) Engineering polydactyl zinc-finger transcription factors. Nat Biotechnol 20:135-141
-
(2002)
Nat Biotechnol
, vol.20
, pp. 135-141
-
-
Beerli, R.R.1
Barbas III, C.F.2
-
11
-
-
0345518003
-
Construction of a variability map for eukaryotic large subunit ribosomal RNA
-
Ben Ali A, Wuyts J, De Wachter R et al (1999) Construction of a variability map for eukaryotic large subunit ribosomal RNA. Nucleic Acids Res 27:2825-2831
-
(1999)
Nucleic Acids Res
, vol.27
, pp. 2825-2831
-
-
Ben Ali, A.1
Wuyts, J.2
De Wachter, R.3
-
12
-
-
79551518877
-
Integration pro file of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell
-
Biasco L, Ambrosi A, Pellin D et al (2010) Integration pro file of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell. EMBO Mol Med 3:89-101
-
(2010)
EMBO Mol Med
, vol.3
, pp. 89-101
-
-
Biasco, L.1
Ambrosi, A.2
Pellin, D.3
-
13
-
-
70349257594
-
Site-specific recombinases for manipulation of the mouse genome
-
Birling MC, Gof flot F, Warot X (2009) Site-specific recombinases for manipulation of the mouse genome. Methods Mol Biol 561:245-263
-
(2009)
Methods Mol Biol
, vol.561
, pp. 245-263
-
-
Birling, M.C.1
Gof Flot, F.2
Warot, X.3
-
14
-
-
62949222607
-
Engineering of bacterial strains and vectors for the production of plasmid DNA
-
Bower DM, Prather KL (2009) Engineering of bacterial strains and vectors for the production of plasmid DNA. Appl Microbiol Biotechnol 82:805-813
-
(2009)
Appl Microbiol Biotechnol
, vol.82
, pp. 805-813
-
-
Bower, D.M.1
Prather, K.L.2
-
15
-
-
33947518195
-
RIG-I: Tri-ing to discriminate between self and non-self RNA
-
Bowie AG, Fitzgerald KA (2007) RIG-I: tri-ing to discriminate between self and non-self RNA. Trends Immunol 28:147-150
-
(2007)
Trends Immunol
, vol.28
, pp. 147-150
-
-
Bowie, A.G.1
Fitzgerald, K.A.2
-
16
-
-
77951993592
-
HIV-1 lentiviral vector immunogenicity is mediated by toll-like receptor 3 (tlr3) and TLR7
-
Breckpot K, Escors D, Arce F et al (2010) HIV-1 lentiviral vector immunogenicity is mediated by Toll-like receptor 3 (TLR3) and TLR7. J Virol 84:5627-5636
-
(2010)
J Virol
, vol.84
, pp. 5627-5636
-
-
Breckpot, K.1
Escors, D.2
Arce, F.3
-
18
-
-
34547638572
-
Generation of an inducible and optimized piggyBac transposon system
-
Cadinanos J, Bradley A (2007) Generation of an inducible and optimized piggyBac transposon system. Nucleic Acids Res 35:e87
-
(2007)
Nucleic Acids Res
, vol.35
-
-
Cadinanos, J.1
Bradley, A.2
-
19
-
-
78650213003
-
Plasmid DNA fermentation strain and process-specific effects on vector yield, quality, and transgene expression
-
Carnes AE, Luke JM, Vincent JM et al (2011) Plasmid DNA fermentation strain and process-specific effects on vector yield, quality, and transgene expression. Biotechnol Bioeng 108:354-363
-
(2011)
Biotechnol Bioeng
, vol.108
, pp. 354-363
-
-
Carnes, A.E.1
Luke, J.M.2
Vincent, J.M.3
-
20
-
-
79952110151
-
Mouse models for miRNA expression: The ROSA26 locus
-
Casola S (2010) Mouse models for miRNA expression: the ROSA26 locus. Methods Mol Biol 667:145-163
-
(2010)
Methods Mol Biol
, vol.667
, pp. 145-163
-
-
Casola, S.1
-
21
-
-
34547657665
-
Hot spots of retroviral integration in human CD34+ hematopoietic cells
-
Cattoglio C, Facchini G, Sartori D et al (2007) Hot spots of retroviral integration in human CD34+ hematopoietic cells. Blood 110:1770-1778
-
(2007)
Blood
, vol.110
, pp. 1770-1778
-
-
Cattoglio, C.1
Facchini, G.2
Sartori, D.3
-
22
-
-
78650987483
-
High-de finition mapping of retroviral integration sites de fines the fate of allogeneic T cells after donor lymphocyte infusion
-
Cattoglio C, Maruggi G, Bartholomae C et al (2010a) High-de finition mapping of retroviral integration sites de fines the fate of allogeneic T cells after donor lymphocyte infusion. PLoS One 5:e15688
-
(2010)
PLoS One
, vol.5
-
-
Cattoglio, C.1
Maruggi, G.2
Bartholomae, C.3
-
23
-
-
78650447013
-
High-de finition mapping of retroviral integration sites identi fies active regulatory elements in human multipotent hematopoietic progenitors
-
Cattoglio C, Pellin D, Rizzi E et al (2010b) High-de finition mapping of retroviral integration sites identi fies active regulatory elements in human multipotent hematopoietic progenitors. Blood 116:5507-5517
-
(2010)
Blood
, vol.116
, pp. 5507-5517
-
-
Cattoglio, C.1
Pellin, D.2
Rizzi, E.3
-
24
-
-
80051613693
-
A comparison of exogenous promoter activity at the ROSA26 locus using a PhiC31 integrase mediated cassette exchange approach in mouse ES cells
-
Chen CM, Krohn J, Bhattacharya S et al (2011) A comparison of exogenous promoter activity at the ROSA26 locus using a PhiC31 integrase mediated cassette exchange approach in mouse ES cells. PLoS One 6:e23376
-
(2011)
PLoS One
, vol.6
-
-
Chen, C.M.1
Krohn, J.2
Bhattacharya, S.3
-
25
-
-
34249688206
-
Antitumor effects of hsv-tk-engineered donor lymphocytes after allogeneic stem-cell transplantation
-
Ciceri F, Bonini C, Marktel S et al (2007) Antitumor effects of HSV-TK-engineered donor lymphocytes after allogeneic stem-cell transplantation. Blood 109:4698-4707
-
(2007)
Blood
, vol.109
, pp. 4698-4707
-
-
Ciceri, F.1
Bonini, C.2
Marktel, S.3
-
26
-
-
65349157330
-
Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the tk007 trial): A non-randomised phase i-ii study
-
Ciceri F, Bonini C, Stanghellini MT et al (2009) Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): a non-randomised phase I-II study. Lancet Oncol 10:489-500
-
(2009)
Lancet Oncol
, vol.10
, pp. 489-500
-
-
Ciceri, F.1
Bonini, C.2
Stanghellini, M.T.3
-
27
-
-
28644443483
-
A role for LEDGF/p75 in targeting HIV DNA integration
-
Ciuf fiA, Llano M, Poeschla E et al (2005) A role for LEDGF/p75 in targeting HIV DNA integration. Nat Med 11:1287-1289
-
(2005)
Nat Med
, vol.11
, pp. 1287-1289
-
-
Fia, C.1
Llano, M.2
Poeschla, E.3
-
28
-
-
0031911791
-
I-SceI-induced gene replacement at a natural locus in embryonic stem cells
-
Cohen-Tannoudji M, Robine S, Choulika A et al (1998) I-SceI-induced gene replacement at a natural locus in embryonic stem cells. Mol Cell Biol 18:1444-1448
-
(1998)
Mol Cell Biol
, vol.18
, pp. 1444-1448
-
-
Cohen-Tannoudji, M.1
Robine, S.2
Choulika, A.3
-
29
-
-
58049191558
-
Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation
-
Cui K, Zang C, Roh TY et al (2009) Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell 4:80-93
-
(2009)
Cell Stem Cell
, vol.4
, pp. 80-93
-
-
Cui, K.1
Zang, C.2
Roh, T.Y.3
-
30
-
-
58149265324
-
Shielding of sleeping beauty DNA transposon-delivered transgene cassettes by heterologous insulators in early embryonal cells
-
Dalsgaard T, Moldt B, Sharma N et al (2009) Shielding of sleeping beauty DNA transposon-delivered transgene cassettes by heterologous insulators in early embryonal cells. Mol Ther 17:121-130
-
(2009)
Mol Ther
, vol.17
, pp. 121-130
-
-
Dalsgaard, T.1
Moldt, B.2
Sharma, N.3
-
31
-
-
0024431720
-
Nuclear and nucleolar targeting sequences of c-erb -A, c-myb, n-myc, p53, hsp70, and hiv tat proteins
-
Dang CV, Lee WMF (1989) Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins. J Biol Chem 264:18019-18023
-
(1989)
J Biol Chem
, vol.264
, pp. 18019-18023
-
-
Dang, C.V.1
Wmf, L.2
-
32
-
-
0036728609
-
Polycistronic viral vectors
-
de Felipe P (2002) Polycistronic viral vectors. Curr Gene Ther 2:355-378
-
(2002)
Curr Gene Ther
, vol.2
, pp. 355-378
-
-
De Felipe, P.1
-
33
-
-
77955157281
-
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome
-
DeKelver RC, Choi VM, Moehle EA et al (2010) Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res 20:1133-1142
-
(2010)
Genome Res
, vol.20
, pp. 1133-1142
-
-
Dekelver, R.C.1
Choi, V.M.2
Moehle, E.A.3
-
34
-
-
68649111166
-
Adeno-associated virus vector integration
-
Deyle DR, Russell DW (2009) Adeno-associated virus vector integration. Curr Opin Mol Ther 11:442-447
-
(2009)
Curr Opin Mol Ther
, vol.11
, pp. 442-447
-
-
Deyle, D.R.1
Russell, D.W.2
-
35
-
-
3543100253
-
Characterization of the mouse adeno-associated virus aavs1 ortholog
-
Dutheil N, Yoon-Robarts M, Ward P et al (2004) Characterization of the mouse adeno-associated virus AAVS1 ortholog. J Virol 78:8917-8921
-
(2004)
J Virol
, vol.78
, pp. 8917-8921
-
-
Dutheil, N.1
Yoon-Robarts, M.2
Ward, P.3
-
36
-
-
33750997895
-
Molecular analysis of chromosomal rearrangements in mammalian cells after phiC31-mediated integration
-
Ehrhardt A, Engler JA, Xu H et al (2006) Molecular analysis of chromosomal rearrangements in mammalian cells after phiC31-mediated integration. Hum Gene Ther 17:1077-1094
-
(2006)
Hum Gene Ther
, vol.17
, pp. 1077-1094
-
-
Ehrhardt, A.1
Engler, J.A.2
Xu, H.3
-
37
-
-
0035942736
-
Duplexes of 21-nucleotide rnas mediate rna interference in cultured mammalian cells
-
Elbashir SM, Harborth J, Lendeckel W et al (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494-498
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elbashir, S.M.1
Harborth, J.2
Lendeckel, W.3
-
38
-
-
27744489220
-
Silencing and variegation of gammaretrovirus and lentivirus vectors
-
Ellis J (2005) Silencing and variegation of gammaretrovirus and lentivirus vectors. Hum Gene Ther 16:1241-1246
-
(2005)
Hum Gene Ther
, vol.16
, pp. 1241-1246
-
-
Ellis, J.1
-
39
-
-
79955852358
-
The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors
-
Emery DW (2011) The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors. Hum Gene Ther 22:761-774
-
(2011)
Hum Gene Ther
, vol.22
, pp. 761-774
-
-
Emery, D.W.1
-
40
-
-
33947272049
-
Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector
-
Evans-Galea MV, Wielgosz MM, Hanawa H et al (2007) Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector. Mol Ther 15:801-809
-
(2007)
Mol Ther
, vol.15
, pp. 801-809
-
-
Evans-Galea, M.V.1
Wielgosz, M.M.2
Hanawa, H.3
-
41
-
-
37749029950
-
Insertional mutagenesis and clonal dominance: Biological and statistical considerations
-
Fehse B, Roeder I (2008) Insertional mutagenesis and clonal dominance: biological and statistical considerations. Gene Ther 15:143-153
-
(2008)
Gene Ther
, vol.15
, pp. 143-153
-
-
Fehse, B.1
Roeder, I.2
-
42
-
-
77950961510
-
Transcription factor binding sites are genetic determinants of retroviral integration in the human genome
-
Felice B, Cattoglio C, Cittaro D et al (2009) Transcription factor binding sites are genetic determinants of retroviral integration in the human genome. PLoS One 4:e4571
-
(2009)
PLoS One
, vol.4
-
-
Felice, B.1
Cattoglio, C.2
Cittaro, D.3
-
43
-
-
0032545933
-
Potent and specific genetic interference by doublestranded rna in caenorhabditis elegans
-
Fire A, Xu S, Montgomery MK et al (1998) Potent and specific genetic interference by doublestranded RNA in Caenorhabditis elegans . Nature 391:806-811
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
-
44
-
-
79958148262
-
Liposome-based dna carriers may induce cellular stress response and change gene expression pattern in transfected cells
-
Fiszer-Kierzkowska A, Vydra N, Wysocka-Wycisk A et al (2011) Liposome-based DNA carriers may induce cellular stress response and change gene expression pattern in transfected cells. BMC Mol Biol 10:12-27
-
(2011)
BMC Mol Biol
, vol.10
, pp. 12-27
-
-
Fiszer-Kierzkowska, A.1
Vydra, N.2
Wysocka-Wycisk, A.3
-
45
-
-
70349673723
-
Genome-wide mapping of piggybac transposon integrations in primary human t cells
-
Galvan DL, Nakazawa Y, Kaja A et al (2009) Genome-wide mapping of PiggyBac transposon integrations in primary human T cells. J Immunother 32:837-844
-
(2009)
J Immunother
, vol.32
, pp. 837-844
-
-
Galvan, D.L.1
Nakazawa, Y.2
Kaja, A.3
-
46
-
-
37549059945
-
Postintegrative gene silencing within the Sleeping Beauty transposition system
-
Garrison BS, Yant SR, Mikkelsen JG, Kay MA (2007) Postintegrative gene silencing within the Sleeping Beauty transposition system. Mol Cell Biol 27:8824-8833
-
(2007)
Mol Cell Biol
, vol.27
, pp. 8824-8833
-
-
Garrison, B.S.1
Yant, S.R.2
Mikkelsen, J.G.3
Kay, M.A.4
-
47
-
-
33747453473
-
Insulators: Exploiting transcriptional and epigenetic mechanisms
-
Gaszner M, Felsenfeld G (2006) Insulators: exploiting transcriptional and epigenetic mechanisms. Nat Rev Genet 7:703-713
-
(2006)
Nat Rev Genet
, vol.7
, pp. 703-713
-
-
Gaszner, M.1
Felsenfeld, G.2
-
48
-
-
0035114195
-
Pulmonary cytokine responses associated with pei-dna aerosol gene therapy
-
Gautam A, Densmore CL, Waldrep JC (2001) Pulmonary cytokine responses associated with PEI-DNA aerosol gene therapy. Gene Ther 8:254-257
-
(2001)
Gene Ther
, vol.8
, pp. 254-257
-
-
Gautam, A.1
Densmore, C.L.2
Waldrep, J.C.3
-
49
-
-
68749103477
-
Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood
-
Georgopoulos LJ, Elgue G, Sanchez J et al (2009) Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood. Mol Immunol 46:2911-2917
-
(2009)
Mol Immunol
, vol.46
, pp. 2911-2917
-
-
Georgopoulos, L.J.1
Elgue, G.2
Sanchez, J.3
-
50
-
-
80053218380
-
Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase
-
Gersbach CA, Gaj T, Rm G et al (2011) Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase. Nucleic Acids Res 39:7868-7878
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 7868-7878
-
-
Gersbach, C.A.1
Gaj, T.2
Rm, G.3
-
51
-
-
33749416026
-
Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers
-
Geurts AM, Collier LS, Geurts JL et al (2006) Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. PLoS Genet 2:e156
-
(2006)
PLoS Genet
, vol.2
-
-
Geurts, A.M.1
Collier, L.S.2
Geurts, J.L.3
-
52
-
-
23044473330
-
Ef ficient marking of human cells with rapid but transient repopulating activity in autografted recipients
-
Glimm H, Schmidt M, Fischer M et al (2005) Ef ficient marking of human cells with rapid but transient repopulating activity in autografted recipients. Blood 106:893-898
-
(2005)
Blood
, vol.106
, pp. 893-898
-
-
Glimm, H.1
Schmidt, M.2
Fischer, M.3
-
53
-
-
80051780791
-
A bidirectional promoter architecture enhances lentiviral transgenesis in embryonic and extraembryonic stem cells
-
Golding MC, Mann MR (2011) A bidirectional promoter architecture enhances lentiviral transgenesis in embryonic and extraembryonic stem cells. Gene Ther 18:817-826
-
(2011)
Gene Ther
, vol.18
, pp. 817-826
-
-
Golding, M.C.1
Mann, M.R.2
-
54
-
-
33744781256
-
Efficient in toto targeted recombination in mouse liver by meganuclease-induced double-strand break
-
Gouble A, Smith J, Bruneau S et al (2006) Efficient in toto targeted recombination in mouse liver by meganuclease-induced double-strand break. J Gene Med 8:616-622
-
(2006)
J Gene Med
, vol.8
, pp. 616-622
-
-
Gouble, A.1
Smith, J.2
Bruneau, S.3
-
55
-
-
0029655849
-
Directed integration of viral dna mediated by fusion proteins consisting of human immunode ficiency virus type 1 integrase and escherichia coli lexa protein
-
Goulaouic H, Chow SA (1996) Directed integration of viral DNA mediated by fusion proteins consisting of human immunode ficiency virus type 1 integrase and Escherichia coli LexA protein. J Virol 70:37-46
-
(1996)
J Virol
, vol.70
, pp. 37-46
-
-
Goulaouic, H.1
Chow, S.A.2
-
56
-
-
77953132759
-
Comparative analysis of transposable element vector systems in human cells
-
Grabundzija I, Irgang M, Mátés L et al (2010) Comparative analysis of transposable element vector systems in human cells. Mol Ther 18:1200-1209
-
(2010)
Mol Ther
, vol.18
, pp. 1200-1209
-
-
Grabundzija, I.1
Irgang, M.2
Mátés, L.3
-
57
-
-
0042528729
-
Heterochromatin and epigenetic control of gene expression
-
Grewal SI, Moazed D (2003) Heterochromatin and epigenetic control of gene expression. Science 301:798-802
-
(2003)
Science
, vol.301
, pp. 798-802
-
-
Grewal, S.I.1
Moazed, D.2
-
58
-
-
70349407359
-
Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease
-
Grizot S, Smith J, Daboussi F et al (2009) Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease. Nucleic Acids Res 37:5405-5419
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 5405-5419
-
-
Grizot, S.1
Smith, J.2
Daboussi, F.3
-
59
-
-
77953702888
-
Directed evolution of an enhanced and highly Efficient FokI cleavage domain for zinc finger nucleases
-
Guo J, Gaj T, Barbas CF (2010) Directed evolution of an enhanced and highly Efficient FokI cleavage domain for zinc finger nucleases. J Mol Biol 400:96-107
-
(2010)
J Mol Biol
, vol.400
, pp. 96-107
-
-
Guo, J.1
Gaj, T.2
Barbas, C.F.3
-
60
-
-
0037448352
-
A serious adverse event after successful gene therapy for X-linked severe combined immunode ficiency
-
Hacein-Bey-Abina S, von Kalle C, Schmidt M et al (2003a) A serious adverse event after successful gene therapy for X-linked severe combined immunode ficiency. N Engl J Med 348:255-256
-
(2003)
N Engl J Med
, vol.348
, pp. 255-256
-
-
Hacein-Bey-Abina, S.1
Von Kalle, C.2
Schmidt, M.3
-
61
-
-
0142084745
-
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
-
Hacein-Bey-Abina S, von Kalle C, Schmidt M et al (2003b) LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302:415-419
-
(2003)
Science
, vol.302
, pp. 415-419
-
-
Hacein-Bey-Abina, S.1
Von Kalle, C.2
Schmidt, M.3
-
62
-
-
40149103278
-
Error-correcting barcoded primers for pyrosequencing hundreds of samples in multiplex
-
Hamady M, Walker JJ, Harris JK et al (2008) Error-correcting barcoded primers for pyrosequencing hundreds of samples in multiplex. Nat Methods 5:235-237
-
(2008)
Nat Methods
, vol.5
, pp. 235-237
-
-
Hamady, M.1
Walker, J.J.2
Harris, J.K.3
-
63
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
64
-
-
79951699566
-
Zinc-finger nuclease based genome surgery: It's all about specificity
-
Händel EM, Cathomen T (2011) Zinc-finger nuclease based genome surgery: it's all about specificity. Curr Gene Ther 11:28-37
-
(2011)
Curr Gene Ther
, vol.11
, pp. 28-37
-
-
Händel, E.M.1
Cathomen, T.2
-
65
-
-
77953768679
-
A method for stabilizing RNA for transfection that allows control of expression duration
-
Hayashi T, Lamba DA, Slowik A et al (2010) A method for stabilizing RNA for transfection that allows control of expression duration. Dev Dyn 239:2034-2040
-
(2010)
Dev Dyn
, vol.239
, pp. 2034-2040
-
-
Hayashi, T.1
Lamba, D.A.2
Slowik, A.3
-
66
-
-
0030610426
-
The structure of I-Crel, a group i intron-encoded homing endonuclease
-
Heath PJ, Stephens KM, Monnat RJ Jr, Stoddard BL (1997) The structure of I-Crel, a group I intron-encoded homing endonuclease. Nat Struct Biol 4:468-476
-
(1997)
Nat Struct Biol
, vol.4
, pp. 468-476
-
-
Heath, P.J.1
Stephens, K.M.2
Monnat Jr., R.J.3
Stoddard, B.L.4
-
67
-
-
20044396722
-
Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells
-
Hematti P, Hong BK, Ferguson C et al (2004) Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells. PLoS Biol 2:e423
-
(2004)
PLoS Biol
, vol.2
-
-
Hematti, P.1
Hong, B.K.2
Ferguson, C.3
-
68
-
-
77957323822
-
Adeno-associated virus: A key to the human genome?
-
Henckaerts E, Linden RM (2010) Adeno-associated virus: a key to the human genome? Future Virol 5:555-574
-
(2010)
Future Virol
, vol.5
, pp. 555-574
-
-
Henckaerts, E.1
Linden, R.M.2
-
69
-
-
4344700911
-
Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides
-
Hodges BL, Taylor KM, Joseph MF et al (2004) Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides. Mol Ther 10:269-278
-
(2004)
Mol Ther
, vol.10
, pp. 269-278
-
-
Hodges, B.L.1
Taylor, K.M.2
Joseph, M.F.3
-
70
-
-
64049098693
-
Innate immune recognition of viruses and viral vectors
-
Huang X, Yang Y (2009) Innate immune recognition of viruses and viral vectors. Hum Gene Ther 20:293-301
-
(2009)
Hum Gene Ther
, vol.20
, pp. 293-301
-
-
Huang, X.1
Yang, Y.2
-
71
-
-
77957579849
-
Gene transfer Efficiency and genome-wide integration pro filing of Sleeping Beauty, Tol2, and piggyBac transposons in human primary T cells
-
Huang X, Guo H, Tammana S et al (2010) Gene transfer Efficiency and genome-wide integration pro filing of Sleeping Beauty, Tol2, and piggyBac transposons in human primary T cells. Mol Ther 18:1803-1813
-
(2010)
Mol Ther
, vol.18
, pp. 1803-1813
-
-
Huang, X.1
Guo, H.2
Tammana, S.3
-
72
-
-
36849012549
-
Identi fication and targeting of the ROSA26 locus in human embryonic stem cells
-
Irion S, Luche H, Gadue P et al (2007) Identi fication and targeting of the ROSA26 locus in human embryonic stem cells. Nat Biotechnol 25:1477-1482
-
(2007)
Nat Biotechnol
, vol.25
, pp. 1477-1482
-
-
Irion, S.1
Luche, H.2
Gadue, P.3
-
73
-
-
23844506121
-
TLR ignores methylated RNA?
-
Ishii KJ, Akira S (2005) TLR ignores methylated RNA? Immunity 23:111-113
-
(2005)
Immunity
, vol.23
, pp. 111-113
-
-
Ishii, K.J.1
Akira, S.2
-
74
-
-
50449205290
-
Potential link between the immune system and metabolism of nucleic acids
-
Ishii KJ, Akira S (2008) Potential link between the immune system and metabolism of nucleic acids. Curr Opin Immunol 20:524-529
-
(2008)
Curr Opin Immunol
, vol.20
, pp. 524-529
-
-
Ishii, K.J.1
Akira, S.2
-
75
-
-
0033962412
-
Split-intron retroviral vectors: Enhanced expression with improved safety
-
Ismail SI, Kingsman SM, Kingsman AJ, Uden M (2000) Split-intron retroviral vectors: enhanced expression with improved safety. J Virol 74:2365-2371
-
(2000)
J Virol
, vol.74
, pp. 2365-2371
-
-
Ismail, S.I.1
Kingsman, S.M.2
Kingsman, A.J.3
Uden, M.4
-
76
-
-
0030662074
-
Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells
-
Ivics Z, Hackett PB, Plasterk RH, Izsvák Z (1997) Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell 91:501-510
-
(1997)
Cell
, vol.91
, pp. 501-510
-
-
Ivics, Z.1
Hackett, P.B.2
Plasterk, R.H.3
Izsvák, Z.4
-
77
-
-
34249339431
-
Targeted sleeping beauty transposition in human cells
-
Ivics Z, Katzer A, Stüwe EE, Fiedler D, Knespel S, Izsvák Z (2007) Targeted sleeping beauty transposition in human cells. Mol Ther 15:1137-1144
-
(2007)
Mol Ther
, vol.15
, pp. 1137-1144
-
-
Ivics, Z.1
Katzer, A.2
Stüwe, E.E.3
Fiedler, D.4
Knespel, S.5
Izsvák, Z.6
-
78
-
-
70350736762
-
Transcriptional effects of transfection: The potential for misinterpretation of gene expression data generated from transiently transfected cells
-
Jacobsen L, Calvin S, Lobenhofer E (2009) Transcriptional effects of transfection: the potential for misinterpretation of gene expression data generated from transiently transfected cells. Biotechniques 47:617-624
-
(2009)
Biotechniques
, vol.47
, pp. 617-624
-
-
Jacobsen, L.1
Calvin, S.2
Lobenhofer, E.3
-
79
-
-
0037372003
-
Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
-
Jaenisch R, Bird A (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33(Suppl):245-254
-
(2003)
Nat Genet
, vol.33
, Issue.SUPPL.
, pp. 245-254
-
-
Jaenisch, R.1
Bird, A.2
-
80
-
-
0021816356
-
Chromosomal position and specific demethylation in enhancer sequences of germ line-transmitted retroviral genomes during mouse development
-
Jähner D, Jaenisch R (1985) Chromosomal position and specific demethylation in enhancer sequences of germ line-transmitted retroviral genomes during mouse development. Mol Cell Biol 5:2212-2220
-
(1985)
Mol Cell Biol
, vol.5
, pp. 2212-2220
-
-
Jähner, D.1
Jaenisch, R.2
-
81
-
-
0020048308
-
De novo methylation and expression of retroviral genomes during mouse embryogenesis
-
Jähner D, Stuhlmann H, Stewart CL et al (1982) De novo methylation and expression of retroviral genomes during mouse embryogenesis. Nature 298:623-628
-
(1982)
Nature
, vol.298
, pp. 623-628
-
-
Jähner, D.1
Stuhlmann, H.2
Stewart, C.L.3
-
83
-
-
77951552865
-
An accumulative site-specific gene integration system using cre recombinase-mediated cassette exchange
-
Kameyam Y, Kawabe Y, Ito A, Kamihira M (2010) An accumulative site-specific gene integration system using cre recombinase-mediated cassette exchange. Biotechnol Bioeng 105: 1106-1114
-
(2010)
Biotechnol Bioeng
, vol.105
, pp. 1106-1114
-
-
Kameyam, Y.1
Kawabe, Y.2
Ito, A.3
Kamihira, M.4
-
84
-
-
0036323154
-
Design of a nonviral vector for siteselective, Efficient integration into the human genome
-
Kaminski JM, Huber MR, Summers JB, Ward MB (2002) Design of a nonviral vector for siteselective, Efficient integration into the human genome. FASEB J 6:1242-1247
-
(2002)
FASEB J
, vol.6
, pp. 1242-1247
-
-
Kaminski, J.M.1
Huber, M.R.2
Summers, J.B.3
Ward, M.B.4
-
85
-
-
4644330953
-
Exogenous siRNA mediates sequence-independent gene suppression by signaling through toll-like receptor 3
-
Karikó K, Bhuyan P, Capodici J et al (2004) Exogenous siRNA mediates sequence-independent gene suppression by signaling through toll-like receptor 3. Cells Tissues Organs 177:132-138
-
(2004)
Cells Tissues Organs
, vol.177
, pp. 132-138
-
-
Karikó, K.1
Bhuyan, P.2
Capodici, J.3
-
86
-
-
23844464444
-
Suppression of rna recognition by toll-like receptors: The impact of nucleoside modi fication and the evolutionary origin of rna
-
Karikó K, Buckstein M, Ni H, Weissman D (2005) Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modi fication and the evolutionary origin of RNA. Immunity 23:165-175
-
(2005)
Immunity
, vol.23
, pp. 165-175
-
-
Karikó, K.1
Buckstein, M.2
Ni, H.3
Weissman, D.4
-
87
-
-
34249077041
-
A novel target-specific gene delivery system combining baculovirus and sequence-specific long interspersed nuclear elements
-
Kawashima T, Osanai M, Futahashi R (2007) A novel target-specific gene delivery system combining baculovirus and sequence-specific long interspersed nuclear elements. Virus Res 127:49-60
-
(2007)
Virus Res
, vol.127
, pp. 49-60
-
-
Kawashima, T.1
Osanai, M.2
Futahashi, R.3
-
88
-
-
0035135747
-
Viral vectors for gene therapy: The art of turning infectious agents into vehicles of therapeutics
-
Kay MA, Glorioso JC, Naldini L (2001) Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics. Nat Med 7:33-40
-
(2001)
Nat Med
, vol.7
, pp. 33-40
-
-
Kay, M.A.1
Glorioso, J.C.2
Naldini, L.3
-
89
-
-
0018654088
-
Histone genes and histone messengers
-
Kedes LH (1979) Histone genes and histone messengers. Annu Rev Biochem 48:837-870
-
(1979)
Annu Rev Biochem
, vol.48
, pp. 837-870
-
-
Kedes, L.H.1
-
90
-
-
33846945735
-
Processing of intronic microRNAs
-
Kim YK, Kim VN (2007) Processing of intronic microRNAs. EMBO J 26:775-783
-
(2007)
EMBO J
, vol.26
, pp. 775-783
-
-
Kim, Y.K.1
Kim, V.N.2
-
91
-
-
0037359032
-
Evolution of target specificity in R1 clade non-LTR retrotransposon
-
Kojima KK, Fujiwara H (2003) Evolution of target specificity in R1 clade non-LTR retrotransposon. Mol Biol Evol 20:351-361
-
(2003)
Mol Biol Evol
, vol.20
, pp. 351-361
-
-
Kojima, K.K.1
Fujiwara, H.2
-
92
-
-
1542316940
-
Cross-genome screening of novel sequence-specific non-ltr retrotransposons: Various multicopy rna genes and microsatellites are selected as targets
-
Kojima KK, Fujiwara H (2004) Cross-genome screening of novel sequence-specific non-LTR retrotransposons: various multicopy RNA genes and microsatellites are selected as targets. Mol Biol Evol 21:207-217
-
(2004)
Mol Biol Evol
, vol.21
, pp. 207-217
-
-
Kojima, K.K.1
Fujiwara, H.2
-
93
-
-
22744459066
-
Site-directed genome modi fication: Nucleic acid and protein modules for targeted integration and gene correction
-
Kolb AF, Coates CJ, Kaminski JM et al (2005) Site-directed genome modi fication: nucleic acid and protein modules for targeted integration and gene correction. Trends Biotechnol 23:399-406
-
(2005)
Trends Biotechnol
, vol.23
, pp. 399-406
-
-
Kolb, A.F.1
Coates, C.J.2
Kaminski, J.M.3
-
94
-
-
79751497093
-
Expression of therapeutic proteins after delivery of chemically modi fied mRNA in mice
-
Kormann MS, Hasenpusch G, Aneja MK et al (2011) Expression of therapeutic proteins after delivery of chemically modi fied mRNA in mice. Nat Biotechnol 29:154-157
-
(2011)
Nat Biotechnol
, vol.29
, pp. 154-157
-
-
Kormann, M.S.1
Hasenpusch, G.2
Aneja, M.K.3
-
95
-
-
33847076849
-
Chromatin modi fications and their function
-
Kouzarides T (2007) Chromatin modi fications and their function. Cell 128:693-705
-
(2007)
Cell
, vol.128
, pp. 693-705
-
-
Kouzarides, T.1
-
96
-
-
0142199654
-
Dose finding with retroviral vectors: Correlation of retroviral vector copy numbers in single cells with gene transfer Efficiency in a cell population
-
Kustikova OS, Wahlers A, Kuhlcke K et al (2003) Dose finding with retroviral vectors: Correlation of retroviral vector copy numbers in single cells with gene transfer Efficiency in a cell population. Blood 102:3934-3937
-
(2003)
Blood
, vol.102
, pp. 3934-3937
-
-
Kustikova, O.S.1
Wahlers, A.2
Kuhlcke, K.3
-
97
-
-
21044448037
-
Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking
-
Kustikova OS, Fehse B, Modlich U et al (2005) Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking. Science 308:1171-1174
-
(2005)
Science
, vol.308
, pp. 1171-1174
-
-
Kustikova, O.S.1
Fehse, B.2
Modlich, U.3
-
98
-
-
40549111908
-
Retroviral integration site analysis in hematopoietic stem cells
-
Kustikova OS, Baum C, Fehse B (2008) Retroviral integration site analysis in hematopoietic stem cells. Methods Mol Biol 430:255-267
-
(2008)
Methods Mol Biol
, vol.430
, pp. 255-267
-
-
Kustikova, O.S.1
Baum, C.2
Fehse, B.3
-
100
-
-
77950857472
-
Progress and prospects: Nuclear import of nonviral vectors
-
Lam AP, Dean DA (2010) Progress and prospects: nuclear import of nonviral vectors. Gene Ther 17:439-447
-
(2010)
Gene Ther
, vol.17
, pp. 439-447
-
-
Lam, A.P.1
Dean, D.A.2
-
101
-
-
0033861721
-
Characteristics of the adeno-associated virus preintegration site in human chromosome 19: Open chromatin conformation and transcriptioncompetent environment
-
Lamartina S, Sporeno E, Fattori E, Toniatti C (2000) Characteristics of the adeno-associated virus preintegration site in human chromosome 19: open chromatin conformation and transcriptioncompetent environment. J Virol 74:7671-7677
-
(2000)
J Virol
, vol.74
, pp. 7671-7677
-
-
Lamartina, S.1
Sporeno, E.2
Fattori, E.3
Toniatti, C.4
-
102
-
-
33846976164
-
A B23-interacting sequence as a tool to visualize protein interactions in a cellular context
-
Lechertier T, Sirri V, Hernandez-Verdun D, Roussel P (2007) A B23-interacting sequence as a tool to visualize protein interactions in a cellular context. J Cell Sci 120:265-375
-
(2007)
J Cell Sci
, vol.120
, pp. 265-375
-
-
Lechertier, T.1
Sirri, V.2
Hernandez-Verdun, D.3
Roussel, P.4
-
103
-
-
79952205472
-
Functional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for Efficient in vitro integration into stable nucleosomes
-
Lesbats P, Botbol Y, Chevereau G et al (2011) Functional coupling between HIV-1 integrase and the SWI/SNF chromatin remodeling complex for Efficient in vitro integration into stable nucleosomes. PLoS Pathog 7:e1001280
-
(2011)
PLoS Pathog
, vol.7
-
-
Lesbats, P.1
Botbol, Y.2
Chevereau, G.3
-
104
-
-
33745684269
-
Retroviral DNA integration: Viral and cellular determinants of target-site selection
-
Lewinski MK, Yamashita M, Emerman M et al (2006) Retroviral DNA integration: viral and cellular determinants of target-site selection. PLoS Pathog 2:e60
-
(2006)
PLoS Pathog
, vol.2
-
-
Lewinski, M.K.1
Yamashita, M.2
Emerman, M.3
-
105
-
-
63949083133
-
Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator
-
Li CL, Xiong D, Stamatoyannopoulos G, Emery DW (2009) Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator. Mol Ther 17:716-724
-
(2009)
Mol Ther
, vol.17
, pp. 716-724
-
-
Li, C.L.1
Xiong, D.2
Stamatoyannopoulos, G.3
Emery, D.W.4
-
106
-
-
19944431736
-
Target-site preferences of sleeping beauty transposons
-
Liu G, Geurts AM, Yae K et al (2005) Target-site preferences of Sleeping Beauty transposons. J Mol Biol 346:161-173
-
(2005)
J Mol Biol
, vol.346
, pp. 161-173
-
-
Liu, G.1
Geurts, A.M.2
Yae, K.3
-
107
-
-
33846438660
-
Non-viral ex vivo transduction of human hepatocyte cells to express factor VIII using a human ribosomal DNA-targeting vector
-
Liu X, Liu M, Xue Z et al (2007) Non-viral ex vivo transduction of human hepatocyte cells to express factor VIII using a human ribosomal DNA-targeting vector. J Thromb Haemost 5: 347-351
-
(2007)
J Thromb Haemost
, vol.5
, pp. 347-351
-
-
Liu, X.1
Liu, M.2
Xue, Z.3
-
108
-
-
75649114974
-
HESC engineering by integrase-mediated chromosomal targeting
-
Liu Y, Lakshmipathy U, Ozgenc A et al (2010) hESC engineering by integrase-mediated chromosomal targeting. Methods Mol Biol 584:229-268
-
(2010)
Methods Mol Biol
, vol.584
, pp. 229-268
-
-
Liu, Y.1
Lakshmipathy, U.2
Ozgenc, A.3
-
109
-
-
80053350622
-
Site-specific integration and tailoring of cassette design for sustainable gene transfer
-
Lombardo A, Cesana D, Genovese P et al (2011) Site-specific integration and tailoring of cassette design for sustainable gene transfer. Nat Methods 8:861-869
-
(2011)
Nat Methods
, vol.8
, pp. 861-869
-
-
Lombardo, A.1
Cesana, D.2
Genovese, P.3
-
110
-
-
34247239206
-
Loss of transgene following ex vivo gene transfer is associated with a dominant Th2 response: Implications for cutaneous gene therapy
-
Lu Z, Ghazizadeh S (2007) Loss of transgene following ex vivo gene transfer is associated with a dominant Th2 response: implications for cutaneous gene therapy. Mol Ther 15:954-961
-
(2007)
Mol Ther
, vol.15
, pp. 954-961
-
-
Lu, Z.1
Ghazizadeh, S.2
-
111
-
-
1842733449
-
HP1 and the dynamics of heterochromatin maintenance
-
Maison C, Almouzni G (2004) HP1 and the dynamics of heterochromatin maintenance. Nat Rev Mol Cell Biol 5:296-304
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 296-304
-
-
Maison, C.1
Almouzni, G.2
-
112
-
-
33644820684
-
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
-
Manno CS, Pierce GF, Arruda VR et al (2006) Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat Med 12:342-347
-
(2006)
Nat Med
, vol.12
, pp. 342-347
-
-
Manno, C.S.1
Pierce, G.F.2
Arruda, V.R.3
-
113
-
-
33845577011
-
Chimeric Mos1 and piggyBac transposases result in site-directed integration
-
Maragathavally KJ, Kaminski JM, Coates CJ (2006) Chimeric Mos1 and piggyBac transposases result in site-directed integration. FASEB J 20:1880-1882
-
(2006)
FASEB J
, vol.20
, pp. 1880-1882
-
-
Maragathavally, K.J.1
Kaminski, J.M.2
Coates, C.J.3
-
114
-
-
77956374120
-
Separating lentiviral vector injection and induction of gene expression in time, does not prevent an immune response to rtTA in rats
-
Markusic DM, de Waart DR, Seppen J (2010) Separating lentiviral vector injection and induction of gene expression in time, does not prevent an immune response to rtTA in rats. PLoS One 5:e9974
-
(2010)
PLoS One
, vol.5
-
-
Markusic, D.M.1
De Waart, D.R.2
Seppen, J.3
-
115
-
-
44349171666
-
Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting
-
Marshall HM, Ronen K, Berry C et al (2007) Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting. PLoS One 2:e1340
-
(2007)
PLoS One
, vol.2
-
-
Marshall, H.M.1
Ronen, K.2
Berry, C.3
-
116
-
-
38449121886
-
Technology transfer from worms and flies to vertebrates: Transposition-based genome manipulations and their future perspectives
-
Mates L, Izsvak Z, Ivics Z (2007) Technology transfer from worms and flies to vertebrates: transposition-based genome manipulations and their future perspectives. Genome Biol 8(Suppl 1):S1
-
(2007)
Genome Biol
, vol.8
, Issue.SUPPL. 1
-
-
Mates, L.1
Izsvak, Z.2
Ivics, Z.3
-
117
-
-
67349250885
-
Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates
-
Mates L, Chuah MK, Belay E et al (2009) Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates. Nat Genet 41:753-761
-
(2009)
Nat Genet
, vol.41
, pp. 753-761
-
-
Mates, L.1
Chuah, M.K.2
Belay, E.3
-
118
-
-
65249139484
-
Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease
-
McConnell Smith A, Takeuchi R, Pellenz S et al (2009) Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease. Proc Natl Acad Sci USA 106:5099-5104
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 5099-5104
-
-
McConnell Smith, A.1
Takeuchi, R.2
Pellenz, S.3
-
119
-
-
39149123507
-
Puri fication and characterization of transcribed RNAs using gel filtration chromatography
-
McKenna SA, Kim I, Puglisi EV et al (2007) Puri fication and characterization of transcribed RNAs using gel filtration chromatography. Nat Protoc 2:3270-3277
-
(2007)
Nat Protoc
, vol.2
, pp. 3270-3277
-
-
McKenna, S.A.1
Kim, I.2
Puglisi, E.V.3
-
120
-
-
79953111808
-
Genome-wide target pro filing of piggyBac and Tol2 in HEK 293: Pros and cons for gene discovery and gene therapy
-
Meir YJ, Weirauch MT, Yang HS et al (2011) Genome-wide target pro filing of piggyBac and Tol2 in HEK 293: pros and cons for gene discovery and gene therapy. BMC Biotechnol 11:28
-
(2011)
BMC Biotechnol
, vol.11
, pp. 28
-
-
Meir, Y.J.1
Weirauch, M.T.2
Yang, H.S.3
-
121
-
-
4644223259
-
Mechanisms of gene silencing by double stranded RNA
-
Meister G, Tuschl T (2004) Mechanisms of gene silencing by double stranded RNA. Nature 431:343-349
-
(2004)
Nature
, vol.431
, pp. 343-349
-
-
Meister, G.1
Tuschl, T.2
-
122
-
-
39849093718
-
The MDS1-EVI1 gene complex as a retrovirus integration site: Impact on behavior of hematopoietic cells and implications for gene therapy
-
Métais JY, Dunbar CE (2008) The MDS1-EVI1 gene complex as a retrovirus integration site: impact on behavior of hematopoietic cells and implications for gene therapy. Mol Ther 6:439-449
-
(2008)
Mol Ther
, vol.6
, pp. 439-449
-
-
Métais, J.Y.1
Dunbar, C.E.2
-
123
-
-
0142213094
-
Helper-independent Sleeping Beauty transposontransposase vectors for Efficient nonviral gene delivery and persistent gene expression in vivo
-
Mikkelsen JG, Yant SR, Meuse L et al (2003) Helper-independent Sleeping Beauty transposontransposase vectors for Efficient nonviral gene delivery and persistent gene expression in vivo . Mol Ther 8:654-665
-
(2003)
Mol Ther
, vol.8
, pp. 654-665
-
-
Mikkelsen, J.G.1
Yant, S.R.2
Meuse, L.3
-
124
-
-
65749110643
-
Tissue-specific and transcription factor-mediated nuclear entry of DNA
-
Miller A, Dean D (2009) Tissue-specific and transcription factor-mediated nuclear entry of DNA. Adv Drug Deliv Rev 61:603-613
-
(2009)
Adv Drug Deliv Rev
, vol.61
, pp. 603-613
-
-
Miller, A.1
Dean, D.2
-
125
-
-
79959932534
-
Immune responses to AAV in clinical trials
-
Mingozzi F, High KA (2011) Immune Responses to AAV in Clinical Trials. Curr Gene Ther 11:321-330
-
(2011)
Curr Gene Ther
, vol.11
, pp. 321-330
-
-
Mingozzi, F.1
High, K.A.2
-
126
-
-
34848911647
-
DNA methylation: The nuts and bolts of repression
-
Miranda TB, Jones PA (2007) DNA methylation: the nuts and bolts of repression. J Cell Physiol 213:384-390
-
(2007)
J Cell Physiol
, vol.213
, pp. 384-390
-
-
Miranda, T.B.1
Jones, P.A.2
-
128
-
-
33750624015
-
Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity
-
Modlich U, Bohne J, Schmidt M et al (2006) Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity. Blood 108:2545-2553
-
(2006)
Blood
, vol.108
, pp. 2545-2553
-
-
Modlich, U.1
Bohne, J.2
Schmidt, M.3
-
129
-
-
70449127230
-
Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors
-
Modlich U, Navarro S, Zychlinski D et al (2009) Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors. Mol Ther 17:1919-1928
-
(2009)
Mol Ther
, vol.17
, pp. 1919-1928
-
-
Modlich, U.1
Navarro, S.2
Zychlinski, D.3
-
130
-
-
37149045293
-
Cis-acting gene regulatory activities in the terminal regions of sleeping beauty DNA transposon-based vectors
-
Moldt B, Yant SR, Andersen PR et al (2007) Cis-acting gene regulatory activities in the terminal regions of sleeping beauty DNA transposon-based vectors. Hum Gene Ther 18:1193-1204
-
(2007)
Hum Gene Ther
, vol.18
, pp. 1193-1204
-
-
Moldt, B.1
Yant, S.R.2
Andersen, P.R.3
-
131
-
-
33745108790
-
Hematopoietic stem cell gene transfer in a tumorprone mouse model uncovers low genotoxicity of lentiviral vector integration
-
Montini E, Cesana D, Schmidt M et al (2006) Hematopoietic stem cell gene transfer in a tumorprone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat Biotechnol 24:687-696
-
(2006)
Nat Biotechnol
, vol.24
, pp. 687-696
-
-
Montini, E.1
Cesana, D.2
Schmidt, M.3
-
132
-
-
65249101260
-
The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy
-
Montini E, Cesana D, Schmidt M et al (2009) The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy. J Clin Invest 119:964-975
-
(2009)
J Clin Invest
, vol.119
, pp. 964-975
-
-
Montini, E.1
Cesana, D.2
Schmidt, M.3
-
133
-
-
34547728699
-
PiggyBac transposon mediated transgenesis of the human blood fluke
-
Morales ME, Mann VH, Kines KJ et al (2007) PiggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni. FASEB J 21:3479-3489
-
(2007)
Schistosoma Mansoni. FASEB J
, vol.21
, pp. 3479-3489
-
-
Morales, M.E.1
Mann, V.H.2
Kines, K.J.3
-
134
-
-
58149469932
-
Transgene optimization signi ficantly improves SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD cells
-
Moreno-Carranza B, Gentsch M, Stein S et al (2009) Transgene optimization signi ficantly improves SIN vector titers, gp91phox expression and reconstitution of superoxide production in X-CGD cells. Gene Ther 16:111-118
-
(2009)
Gene Ther
, vol.16
, pp. 111-118
-
-
Moreno-Carranza, B.1
Gentsch, M.2
Stein, S.3
-
135
-
-
33645728427
-
Inserting optimism into gene therapy
-
Naldini L (2006) Inserting optimism into gene therapy. Nat Med 12:386-388
-
(2006)
Nat Med
, vol.12
, pp. 386-388
-
-
Naldini, L.1
-
136
-
-
77949424429
-
Progress and prospects: Immune responses to viral vectors
-
Nayak S, Herzog RW (2010) Progress and prospects: immune responses to viral vectors. Gene Ther 17:295-304
-
(2010)
Gene Ther
, vol.17
, pp. 295-304
-
-
Nayak, S.1
Herzog, R.W.2
-
137
-
-
0036954247
-
Gene therapy progress and prospects: Nonviral vectors
-
Niidome T, Huang L (2002) Gene therapy progress and prospects: nonviral vectors. Gene Ther 9:1647-1652
-
(2002)
Gene Ther
, vol.9
, pp. 1647-1652
-
-
Niidome, T.1
Huang, L.2
-
138
-
-
49349086561
-
Engineering variants of the ISceI homing endonuclease with strand-specific and site-specific DNA-nicking activity
-
Niu Y, Tenney K, Li H, Gimble FS (2008) Engineering variants of the ISceI homing endonuclease with strand-specific and site-specific DNA-nicking activity. J Mol Biol 382:188-202
-
(2008)
J Mol Biol
, vol.382
, pp. 188-202
-
-
Niu, Y.1
Tenney, K.2
Li, H.3
Gimble, F.S.4
-
139
-
-
0042208122
-
Identification of an insulator in AAVS1, a preferred region for integration of adeno-associated virus DNA
-
Ogata T, Kozuka T, Kanda T (2003) Identification of an insulator in AAVS1, a preferred region for integration of adeno-associated virus DNA. J Virol 77:9000-9007
-
(2003)
J Virol
, vol.77
, pp. 9000-9007
-
-
Ogata, T.1
Kozuka, T.2
Kanda, T.3
-
140
-
-
33645734405
-
Correction of x-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1
-
Ott MG, Schmidt M, Schwarzwaelder K et al (2006) Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med 12:401-409
-
(2006)
Nat Med
, vol.12
, pp. 401-409
-
-
Ott, M.G.1
Schmidt, M.2
Schwarzwaelder, K.3
-
141
-
-
66149102465
-
Targeted transgenesis at the HPRT locus: An Efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system
-
Palais G, Nguyen Dinh Cat A, Friedman H et al (2009) Targeted transgenesis at the HPRT locus: an Efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system. Physiol Genomics 37:140-146
-
(2009)
Physiol Genomics
, vol.37
, pp. 140-146
-
-
Palais, G.1
Nguyen Dinh Cat, A.2
Friedman, H.3
-
142
-
-
79960206845
-
Landscape of chromatin control element patents: Positioning effects in pharmaceutical bioproduction
-
Palazzoli F, Bire S, Bigot Y, Bonnin-Rouleux F (2011) Landscape of chromatin control element patents: positioning effects in pharmaceutical bioproduction. Nat Biotechnol 29:593-597
-
(2011)
Nat Biotechnol
, vol.29
, pp. 593-597
-
-
Palazzoli, F.1
Bire, S.2
Bigot, Y.3
Bonnin-Rouleux, F.4
-
143
-
-
80052405826
-
Generation of transgene-free human induced pluripotent stem cells with an excisable single polycistronic vector
-
Papapetrou EP, Sadelain M (2011) Generation of transgene-free human induced pluripotent stem cells with an excisable single polycistronic vector. Nat Protoc 6:1251-1273
-
(2011)
Nat Protoc
, vol.6
, pp. 1251-1273
-
-
Papapetrou, E.P.1
Sadelain, M.2
-
144
-
-
78651337233
-
Genomic safe harbors permit high b-globin transgene expression in thalassemia induced pluripotent stem cells
-
Papapetrou EP, Lee G, Malani N et al (2011) Genomic safe harbors permit high b-globin transgene expression in thalassemia induced pluripotent stem cells. Nat Biotechnol 29:73-78
-
(2011)
Nat Biotechnol
, vol.29
, pp. 73-78
-
-
Papapetrou, E.P.1
Lee, G.2
Malani, N.3
-
145
-
-
33745950160
-
Sleeping Beauty transposition in the mouse genome is associated with changes in DNA methylation at the site of insertion
-
Park CW, Park J, Kren BT, Steer CJ (2006) Sleeping Beauty transposition in the mouse genome is associated with changes in DNA methylation at the site of insertion. Genomics 88:204-213
-
(2006)
Genomics
, vol.88
, pp. 204-213
-
-
Park, C.W.1
Park, J.2
Kren, B.T.3
Steer, C.J.4
-
146
-
-
77955220225
-
Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing
-
Paruzynski A, Arens A, Gabriel R et al (2010) Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing. Nat Protoc 5:1379-1395
-
(2010)
Nat Protoc
, vol.5
, pp. 1379-1395
-
-
Paruzynski, A.1
Arens, A.2
Gabriel, R.3
-
147
-
-
0025773296
-
Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2 1 A
-
Pavletich NP, Pabo CO (1991) Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2 1 A. Science 252:809-817
-
(1991)
Science
, vol.252
, pp. 809-817
-
-
Pavletich, N.P.1
Pabo, C.O.2
-
148
-
-
0742290164
-
Transgene expression after rep-mediated sitespecific integration into chromosome 19
-
Philpott NJ, Gomos J, Falck-Pedersen E (2004) Transgene expression after rep-mediated sitespecific integration into chromosome 19. Hum Gene Ther 15:47-61
-
(2004)
Hum Gene Ther
, vol.15
, pp. 47-61
-
-
Philpott, N.J.1
Gomos, J.2
Falck-Pedersen, E.3
-
149
-
-
77957343707
-
Chemical vectors for gene delivery: Uptake and intracellular traf ficking
-
Pichon C, Billiet L, Midoux P (2010) Chemical vectors for gene delivery: uptake and intracellular traf ficking. Curr Opin Biotechnol 21:640-645
-
(2010)
Curr Opin Biotechnol
, vol.21
, pp. 640-645
-
-
Pichon, C.1
Billiet, L.2
Midoux, P.3
-
150
-
-
33646722147
-
Emergent properties of reduced genome Escherichia coli
-
Posfai G, Plunkett G III, Feher T et al (2006) Emergent properties of reduced genome Escherichia coli . Science 312:1044-1046
-
(2006)
Science
, vol.312
, pp. 1044-1046
-
-
Posfai, G.1
Plunkett III, G.2
Feher, T.3
-
151
-
-
38949107300
-
Analysis of factor VIII mediated suppression of lentiviral vector titres
-
Radcliffe PA, Sion CJ, Wilkes FJ et al (2008) Analysis of factor VIII mediated suppression of lentiviral vector titres. Gene Ther 15:289-297
-
(2008)
Gene Ther
, vol.15
, pp. 289-297
-
-
Radcliffe, P.A.1
Sion, C.J.2
Wilkes, F.J.3
-
152
-
-
80052468612
-
Efficient recombinase-mediated cassette exchange at the AAVS1 locus in human embryonic stem cells using baculoviral vectors
-
Ramachandra CJ, Shahbazi M, Kwang TW et al (2011) Efficient recombinase-mediated cassette exchange at the AAVS1 locus in human embryonic stem cells using baculoviral vectors. Nucleic Acids Res 39:e107
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Ramachandra, C.J.1
Shahbazi, M.2
Kwang, T.W.3
-
153
-
-
31944440000
-
Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells
-
Recchia A, Bonini C, Magnani Z et al (2006) Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells. Proc Natl Acad Sci USA 103:1457-1462
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 1457-1462
-
-
Recchia, A.1
Bonini, C.2
Magnani, Z.3
-
154
-
-
1342332864
-
CpG methylation of a plasmid vector results in extended transgene product expression by circumventing induction of immune responses
-
Reyes-Sandoval A, Ertl HC (2004) CpG methylation of a plasmid vector results in extended transgene product expression by circumventing induction of immune responses. Mol Ther 9:249-261
-
(2004)
Mol Ther
, vol.9
, pp. 249-261
-
-
Reyes-Sandoval, A.1
Ertl, H.C.2
-
155
-
-
79951840580
-
HIV-1-derived lentiviral vectors directly activate plasmacytoid dendritic cells, which in turn induce the maturation of myeloid dendritic cells
-
Rossetti M, Gregori S, Hauben E et al (2011) HIV-1-derived lentiviral vectors directly activate plasmacytoid dendritic cells, which in turn induce the maturation of myeloid dendritic cells. Hum Gene Ther 22:177-188
-
(2011)
Hum Gene Ther
, vol.22
, pp. 177-188
-
-
Rossetti, M.1
Gregori, S.2
Hauben, E.3
-
156
-
-
0029053229
-
Human ribosomal RNA gene cluster: Identification of the proximal end containing a novel tandem repeat sequence
-
Sakai K, Ohta T, Minoshima S et al (1995) Human ribosomal RNA gene cluster: Identification of the proximal end containing a novel tandem repeat sequence. Genomics 26:521-526
-
(1995)
Genomics
, vol.26
, pp. 521-526
-
-
Sakai, K.1
Ohta, T.2
Minoshima, S.3
-
157
-
-
40849104849
-
Innate immune response induced by gene delivery vectors
-
Sakurai H, Kawabata K, Sakurai F et al (2008) Innate immune response induced by gene delivery vectors. Int J Pharm 354:9-15
-
(2008)
Int J Pharm
, vol.354
, pp. 9-15
-
-
Sakurai, H.1
Kawabata, K.2
Sakurai, F.3
-
158
-
-
0038286220
-
Integration by design
-
Sandmeyer S (2003) Integration by design. Proc Natl Acad Sci USA 100:5586-5588
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 5586-5588
-
-
Sandmeyer, S.1
-
159
-
-
0037007010
-
Directed evolution of the site specificity of Cre recombinase
-
Santoro SW, Schultz PG (2002) Directed evolution of the site specificity of Cre recombinase. Proc Natl Acad Sci USA 99:4185-4190
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 4185-4190
-
-
Santoro, S.W.1
Schultz, P.G.2
-
160
-
-
34249298695
-
Improving transcriptional termination of selfinactivating gamma-retroviral and lentiviral vectors
-
Schambach A, Galla M, Maetzig T et al (2007) Improving transcriptional termination of selfinactivating gamma-retroviral and lentiviral vectors. Mol Ther 15:1167-73
-
(2007)
Mol Ther
, vol.15
, pp. 1167-1173
-
-
Schambach, A.1
Galla, M.2
Maetzig, T.3
-
161
-
-
0345144017
-
Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-de ficient SCID neonates
-
Schmidt M, Carbonaro DA, Speckmann C et al (2003) Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-de ficient SCID neonates. Nat Med 9:463-468
-
(2003)
Nat Med
, vol.9
, pp. 463-468
-
-
Schmidt, M.1
Carbonaro, D.A.2
Speckmann, C.3
-
162
-
-
36749052217
-
High-resolution insertion-site analysis by linear ampli fication-mediated PCR (LAM-PCR)
-
Schmidt M, Schwarzwaelder K, Bartholomae C et al (2007) High-resolution insertion-site analysis by linear ampli fication-mediated PCR (LAM-PCR). Nat Methods 4:1051-1057
-
(2007)
Nat Methods
, vol.4
, pp. 1051-1057
-
-
Schmidt, M.1
Schwarzwaelder, K.2
Bartholomae, C.3
-
163
-
-
0037162715
-
HIV-1 integration in the human genome favors active genes and local hotspots
-
Schroder AR, Shinn P, Chen H et al (2002) HIV-1 integration in the human genome favors active genes and local hotspots. Cell 110:521-529
-
(2002)
Cell
, vol.110
, pp. 521-529
-
-
Schroder, A.R.1
Shinn, P.2
Chen, H.3
-
164
-
-
33846874141
-
Construction and characterization of new piggyBac vectors for constitutive or inducible expression of heterologous gene pairs and the Identification of a previously unrecognized activator sequence in piggyBac
-
Shi X, Harrison RL, Hollister JR et al (2007) Construction and characterization of new piggyBac vectors for constitutive or inducible expression of heterologous gene pairs and the Identification of a previously unrecognized activator sequence in piggyBac . BMC Biotechnol 7:5
-
(2007)
BMC Biotechnol
, vol.7
, pp. 5
-
-
Shi, X.1
Harrison, R.L.2
Hollister, J.R.3
-
165
-
-
33646049347
-
Innate sensing of self and non-self rnas by toll-like receptors
-
Sioud M (2006) Innate sensing of self and non-self RNAs by Toll-like receptors. Trends Mol Med 12:167-176
-
(2006)
Trends Mol Med
, vol.12
, pp. 167-176
-
-
Sioud, M.1
-
166
-
-
84860390327
-
B-globin matrix attachment region improves stable genomic expression of the Sleeping Beauty transposon
-
Sjeklocha L, Chen Y, Daly MC et al (2011) b-globin matrix attachment region improves stable genomic expression of the Sleeping Beauty transposon. J Cell Biochem 112:2361-2375
-
(2011)
J Cell Biochem
, vol.112
, pp. 2361-2375
-
-
Sjeklocha, L.1
Chen, Y.2
Daly, M.C.3
-
167
-
-
33845914020
-
A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences
-
Smith J, Grizot S, Arnould S et al (2006) A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences. Nucleic Acids Res 34:e149
-
(2006)
Nucleic Acids Res
, vol.34
-
-
Smith, J.1
Grizot, S.2
Arnould, S.3
-
168
-
-
24944583478
-
Targeted modification of mammalian genomes
-
Sorrell DA, Kolb AF (2005) Targeted modification of mammalian genomes. Biotechnol Adv 23:431-469
-
(2005)
Biotechnol Adv
, vol.23
, pp. 431-469
-
-
Sorrell, D.A.1
Kolb, A.F.2
-
169
-
-
35548970476
-
Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent
-
Strathdee D, Ibbotson H, Grant SG (2006) Expression of transgenes targeted to the Gt(ROSA)26Sor locus is orientation dependent. PLoS One 1:e4
-
(2006)
PLoS One
, vol.1
-
-
Strathdee, D.1
Ibbotson, H.2
Grant, S.G.3
-
170
-
-
64649102398
-
Site-specific integration of retroviral DNA in human cells using fusion proteins consisting of human immunode ficiency virus type 1 integrase and the designed polydactyl zinc-finger protein E2C
-
Su K, Wang D, Ye J et al (2009) Site-specific integration of retroviral DNA in human cells using fusion proteins consisting of human immunode ficiency virus type 1 integrase and the designed polydactyl zinc-finger protein E2C. Methods 47:269-276
-
(2009)
Methods
, vol.47
, pp. 269-276
-
-
Su, K.1
Wang, D.2
Ye, J.3
-
171
-
-
74549114206
-
DB Stable transgene expression in primitive human cd34+ hematopoietic stem/progenitor cells using the sleeping beauty transposon system
-
Sumiyoshi T, Holt NG, Hollis RP et al (2009) DB Stable transgene expression in primitive human CD34+ hematopoietic stem/progenitor cells using the Sleeping Beauty transposon system. Hum Gene Ther 20:1607-1626
-
(2009)
Hum Gene Ther
, vol.20
, pp. 1607-1626
-
-
Sumiyoshi, T.1
Holt, N.G.2
Hollis, R.P.3
-
172
-
-
78651256000
-
Progress in the development of ultrasoundmediated gene delivery systems utilizing nanoand microbubbles
-
Suzuki R, Oda Y, Utoguchi N, Maruyama K (2011) Progress in the development of ultrasoundmediated gene delivery systems utilizing nanoand microbubbles. J Control Release 149: 36-41
-
(2011)
J Control Release
, vol.149
, pp. 36-41
-
-
Suzuki, R.1
Oda, Y.2
Utoguchi, N.3
Maruyama, K.4
-
173
-
-
34447323568
-
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases
-
Szczepek M, Brondani V, Büchel J et al (2007) Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nature Biotech 25:786-793
-
(2007)
Nature Biotech
, vol.25
, pp. 786-793
-
-
Szczepek, M.1
Brondani, V.2
Büchel, J.3
-
174
-
-
0033135797
-
Transcription analysis of the telomeric repeat-specific retrotransposons TRAS1 and SART1 of the silkworm Bombyx mori
-
Takahashi H, Fujiwara H (1999) Transcription analysis of the telomeric repeat-specific retrotransposons TRAS1 and SART1 of the silkworm Bombyx mori. Nucleic Acids Res 27:2015-2021
-
(1999)
Nucleic Acids Res
, vol.27
, pp. 2015-2021
-
-
Takahashi, H.1
Fujiwara, H.2
-
175
-
-
0036470563
-
Transplantation of target site specificity by swapping the endonuclease domains of two LINEs
-
Takahashi H, Fujiwara H (2002) Transplantation of target site specificity by swapping the endonuclease domains of two LINEs. EMBO J 21:408-417
-
(2002)
EMBO J
, vol.21
, pp. 408-417
-
-
Takahashi, H.1
Fujiwara, H.2
-
176
-
-
79955579208
-
Positive correlation between the generation of reactive oxygen species and activation/reactivation of transgene expression after hydrodynamic injections into mice
-
Takiguchi N, Takahashi Y, Nishikawa M et al (2011) Positive correlation between the generation of reactive oxygen species and activation/reactivation of transgene expression after hydrodynamic injections into mice. Pharm Res 28:702-711
-
(2011)
Pharm Res
, vol.28
, pp. 702-711
-
-
Takiguchi, N.1
Takahashi, Y.2
Nishikawa, M.3
-
177
-
-
0037148368
-
Transcriptional silencing at Saccharomyces telomeres: Implications for other organisms
-
Tham WH, Zakian VA (2002) Transcriptional silencing at Saccharomyces telomeres: implications for other organisms. Oncogene 21:512-521
-
(2002)
Oncogene
, vol.21
, pp. 512-521
-
-
Tham, W.H.1
Zakian, V.A.2
-
178
-
-
0026437552
-
Nested chromosomal fragmentation in yeast using the meganuclease I-Sce I: A new method for physical mapping of eukaryotic genomes
-
Thierry A, Dujon B (1992) Nested chromosomal fragmentation in yeast using the meganuclease I-Sce I: a new method for physical mapping of eukaryotic genomes. Nucleic Acids Res 20: 5625-5631
-
(1992)
Nucleic Acids Res
, vol.20
, pp. 5625-5631
-
-
Thierry, A.1
Dujon, B.2
-
179
-
-
0035008830
-
Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase
-
Thyagarajan B, Olivares EC, Hollis RP et al (2001) Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase. Mol Cell Biol 21:3926-3934
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3926-3934
-
-
Thyagarajan, B.1
Olivares, E.C.2
Hollis, R.P.3
-
180
-
-
74549206662
-
Retroviral vectors encoding ADA regulatory locus control region provide enhanced T-cell-specific transgene expression
-
Trinh AT, Ball BG, Weber E et al (2009) Retroviral vectors encoding ADA regulatory locus control region provide enhanced T-cell-specific transgene expression. Genet Vaccines Ther 30:7-13
-
(2009)
Genet Vaccines Ther
, vol.30
, pp. 7-13
-
-
Trinh, A.T.1
Ball, B.G.2
Weber, E.3
-
181
-
-
79952310557
-
Recombinase-mediated cassette exchange (RMCE): Traditional concepts and current challenges
-
Turan S, Galla M, Ernst E et al (2011) Recombinase-mediated cassette exchange (RMCE): traditional concepts and current challenges. J Mol Biol 407:193-221
-
(2011)
J Mol Biol
, vol.407
, pp. 193-221
-
-
Turan, S.1
Galla, M.2
Ernst, E.3
-
182
-
-
8644231282
-
Human cell proteins and human immunode ficiency virus DNA integration
-
Turlure F, Devroe E, Silver PA et al (2004) Human cell proteins and human immunode ficiency virus DNA integration. Front Biosci 9:3187-3208
-
(2004)
Front Biosci
, vol.9
, pp. 3187-3208
-
-
Turlure, F.1
Devroe, E.2
Silver, P.A.3
-
183
-
-
79953809082
-
Suppression of melanoma growth and metastasis by DNA vaccination using an ultrasound-responsive and mannose-modified gene carrier
-
Un K, Kawakami S, Suzuki R et al (2011) Suppression of melanoma growth and metastasis by DNA vaccination using an ultrasound-responsive and mannose-modified gene carrier. Mol Pharm 8:543-554
-
(2011)
Mol Pharm
, vol.8
, pp. 543-554
-
-
Un, K.1
Kawakami, S.2
Suzuki, R.3
-
184
-
-
77955867185
-
Genome editing with engineered zinc finger nucleases
-
Urnov FD, Rebar EJ, Holmes MC, Zhang HS, Gregory PD (2010) Genome editing with engineered zinc finger nucleases. Nat Rev Genet 11:636-646
-
(2010)
Nat Rev Genet
, vol.11
, pp. 636-646
-
-
Urnov, F.D.1
Rebar, E.J.2
Holmes, M.C.3
Zhang, H.S.4
Gregory, P.D.5
-
186
-
-
0036404918
-
Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements
-
Vigdal TJ, Kaufman CD, Izsvak Z et al (2002) Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements. J Mol Biol 323:441-452
-
(2002)
J Mol Biol
, vol.323
, pp. 441-452
-
-
Vigdal, T.J.1
Kaufman, C.D.2
Izsvak, Z.3
-
187
-
-
0242492858
-
The human polycomb group EED protein interacts with the integrase of human immunode ficiency virus type 1
-
Violot S, Hong SS, Rakotobe D et al (2003) The human polycomb group EED protein interacts with the integrase of human immunode ficiency virus type 1. J Virol 77:12507-12522
-
(2003)
J Virol
, vol.77
, pp. 12507-12522
-
-
Violot, S.1
Hong, S.S.2
Rakotobe, D.3
-
188
-
-
54249090643
-
Targeted gene insertion for molecular medicine
-
Voigt K, Izsvák Z, Ivics Z (2008) Targeted gene insertion for molecular medicine. J Mol Med 86:1205-1219
-
(2008)
J Mol Med
, vol.86
, pp. 1205-1219
-
-
Voigt, K.1
Izsvák, Z.2
Ivics, Z.3
-
189
-
-
0037423742
-
Stepwise manipulation of DNA specificity in Flp recombinase: Progressively adapting Flp to individual and combinatorial mutations in its target site
-
Voziyanov Y, Konieczka JH, Stewart AF, Jayaram M (2003) Stepwise manipulation of DNA specificity in Flp recombinase: progressively adapting Flp to individual and combinatorial mutations in its target site. J Mol Biol 326:65-76
-
(2003)
J Mol Biol
, vol.326
, pp. 65-76
-
-
Voziyanov, Y.1
Konieczka, J.H.2
Stewart, A.F.3
Jayaram, M.4
-
190
-
-
79960912431
-
Developing extrachromosomal gene expression vector technologies: An overview
-
Wade-Martins R (2011) Developing extrachromosomal gene expression vector technologies: an overview. Methods Mol Biol 738:1-17
-
(2011)
Methods Mol Biol
, vol.738
, pp. 1-17
-
-
Wade-Martins, R.1
-
191
-
-
0035070944
-
In fluence of multiplicity of infection and protein stability on retroviral vector mediated gene expression in hematopoietic cells
-
Wahlers A, Schwieger M, Li Z et al (2001) In fluence of multiplicity of infection and protein stability on retroviral vector mediated gene expression in hematopoietic cells. Gene Ther 8:477-486
-
(2001)
Gene Ther
, vol.8
, pp. 477-486
-
-
Wahlers, A.1
Schwieger, M.2
Li, Z.3
-
192
-
-
33645232339
-
Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1
-
Walisko O, Izsvák Z, Szabó K et al (2006) Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1. Proc Natl Acad Sci USA 103:4062-4067
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 4062-4067
-
-
Walisko, O.1
Izsvák, Z.2
Szabó, K.3
-
193
-
-
78751681902
-
Codon optimization of human factor VIII cDNAs leads to high-level expression
-
Ward NJ, Buckley SM, Waddington SN (2011) Codon optimization of human factor VIII cDNAs leads to high-level expression. Blood 117:798-807
-
(2011)
Blood
, vol.117
, pp. 798-807
-
-
Ward, N.J.1
Buckley, S.M.2
Waddington, S.N.3
-
194
-
-
27944486578
-
Gene activation and deactivation related changes in the three-dimensional structure of chromatin
-
Wegel E, Shaw P (2005) Gene activation and deactivation related changes in the three-dimensional structure of chromatin. Chromosoma 114:331-337
-
(2005)
Chromosoma
, vol.114
, pp. 331-337
-
-
Wegel, E.1
Shaw, P.2
-
195
-
-
58149214356
-
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
-
Wei G, Wei L, Zhu J (2009) Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30:155-167
-
(2009)
Immunity
, vol.30
, pp. 155-167
-
-
Wei, G.1
Wei, L.2
Zhu, J.3
-
197
-
-
32944463921
-
RNA as a source of transposase for Sleeping Beautymediated gene insertion and expression in somatic cells and tissues
-
Wilber A, Frandsen JL, Geurts JL et al (2006) RNA as a source of transposase for Sleeping Beautymediated gene insertion and expression in somatic cells and tissues. Mol Ther 13:625-630
-
(2006)
Mol Ther
, vol.13
, pp. 625-630
-
-
Wilber, A.1
Frandsen, J.L.2
Geurts, J.L.3
-
198
-
-
79955994750
-
Designing and testing chimeric zinc finger transposases
-
Wilson MH, George AL Jr (2010) Designing and testing chimeric zinc finger transposases. Methods Mol Biol 649:353-363
-
(2010)
Methods Mol Biol
, vol.649
, pp. 353-363
-
-
Wilson, M.H.1
George Jr., A.L.2
-
199
-
-
36148961543
-
Road to precision: Recombinase-based targeting technologies for genome engineering
-
Wirth D, Gama-Norton L, Riemer P et al (2007) Road to precision: recombinase-based targeting technologies for genome engineering. Curr Opin Biotechnol 18:411-419
-
(2007)
Curr Opin Biotechnol
, vol.18
, pp. 411-419
-
-
Wirth, D.1
Gama-Norton, L.2
Riemer, P.3
-
200
-
-
64749083939
-
PiggyBac transposition reprograms fIbroblasts to induced pluripotent stem cells
-
Woltjen K, Mickael IP, Mohseni P et al (2009) piggyBac transposition reprograms fIbroblasts to induced pluripotent stem cells. Nature 458:766-770
-
(2009)
Nature
, vol.458
, pp. 766-770
-
-
Woltjen, K.1
Mickael, I.P.2
Mohseni, P.3
-
201
-
-
0037841763
-
Transcription start regions in the human genome are favored targets for MLV integration
-
Wu X, Li Y, Crise B, Burgess SM (2003) Transcription start regions in the human genome are favored targets for MLV integration. Science 300:1749-1751
-
(2003)
Science
, vol.300
, pp. 1749-1751
-
-
Wu, X.1
Li, Y.2
Crise, B.3
Burgess, S.M.4
-
202
-
-
33750060436
-
PiggyBac is a flexible and highly active transposon as compared to sleeping beauty, Tol2, and Mos1 in mammalian cells
-
Wu SC, Meir YJ, Coates CJ et al (2006) PiggyBac is a flexible and highly active transposon as compared to sleeping beauty, Tol2, and Mos1 in mammalian cells. Proc Natl Acad Sci USA 103:15008-15013
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 15008-15013
-
-
Wu, S.C.1
Meir, Y.J.2
Coates, C.J.3
-
203
-
-
38649139896
-
Optimization of self-complementary AAV vectors for liverdirected expression results in sustained correction of hemophilia B at low vector dose
-
Wu Z, Sun J, Zhang T et al (2008) Optimization of self-complementary AAV vectors for liverdirected expression results in sustained correction of hemophilia B at low vector dose. Mol Ther 16:280-289
-
(2008)
Mol Ther
, vol.16
, pp. 280-289
-
-
Wu, Z.1
Sun, J.2
Zhang, T.3
-
204
-
-
0034816496
-
Targeting of the yeast Ty5 retrotransposon to silent chromatin is mediated by interactions between integrase and Sir4p
-
Xie W, Gai X, Zhu Y (2001) Targeting of the yeast Ty5 retrotransposon to silent chromatin is mediated by interactions between integrase and Sir4p. Mol Cell Biol 21:6606-6614
-
(2001)
Mol Cell Biol
, vol.21
, pp. 6606-6614
-
-
Xie, W.1
Gai, X.2
Zhu, Y.3
-
205
-
-
70349320475
-
Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system
-
Xue X, Huang X, Nodland SE et al (2009) Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system. Blood 114:1319-1330
-
(2009)
Blood
, vol.114
, pp. 1319-1330
-
-
Xue, X.1
Huang, X.2
Nodland, S.E.3
-
207
-
-
0242721679
-
Nonhomologous-end-joining factors regulate DNA repair fidelity during Sleeping Beauty element transposition in mammalian cells
-
Yant SR, Kay MA (2003) Nonhomologous-end-joining factors regulate DNA repair fidelity during Sleeping Beauty element transposition in mammalian cells. Mol Cell Biol 23:8505-8518
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8505-8518
-
-
Yant, S.R.1
Kay, M.A.2
-
208
-
-
14844355218
-
High-resolution genome-wide mapping of transposon integration in mammals
-
Yant SR, Wu X, Huang Y et al (2005) High-resolution genome-wide mapping of transposon integration in mammals. Mol Cell Biol 25:2085-2094
-
(2005)
Mol Cell Biol
, vol.25
, pp. 2085-2094
-
-
Yant, S.R.1
Wu, X.2
Huang, Y.3
-
210
-
-
3042732990
-
Retrovirus silencing, variegation, extinction, and memory are controlled by a dynamic interplay of multiple epigenetic modifications
-
Yao S, Sukonnik T, Kean T, Bharadwaj RR, Pasceri P, Ellis J (2004) Retrovirus silencing, variegation, extinction, and memory are controlled by a dynamic interplay of multiple epigenetic modifications. Mol Ther 10:27-36
-
(2004)
Mol Ther
, vol.10
, pp. 27-36
-
-
Yao, S.1
Sukonnik, T.2
Kean, T.3
Bharadwaj, R.R.4
Pasceri, P.5
Ellis, J.6
-
211
-
-
14744301443
-
Controlling the kinetics of transgene expression by plasmid design
-
Yew NS (2005) Controlling the kinetics of transgene expression by plasmid design. Adv Drug Deliv Rev 57:769-780
-
(2005)
Adv Drug Deliv Rev
, vol.57
, pp. 769-780
-
-
Yew, N.S.1
-
212
-
-
0035989006
-
CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo
-
Yew NS, Zhao H, Przybylska M et al (2002) CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo . Mol Ther 5:731-738
-
(2002)
Mol Ther
, vol.5
, pp. 731-738
-
-
Yew, N.S.1
Zhao, H.2
Przybylska, M.3
-
213
-
-
0030840954
-
Cytosine methylation and the ecology of intragenomic parasites
-
Yoder JA, Walsh CP, Bestor TH (1997) Cytosine methylation and the ecology of intragenomic parasites. Trends Genet 13:335-340
-
(1997)
Trends Genet
, vol.13
, pp. 335-340
-
-
Yoder, J.A.1
Walsh, C.P.2
Bestor, T.H.3
-
214
-
-
79952957934
-
The base excision repair pathway is required for Efficient lentivirus integration
-
Yoder KE, Espeseth A, Wang XH et al (2011) The base excision repair pathway is required for Efficient lentivirus integration. PLoS One 6:e17862
-
(2011)
PLoS One
, vol.6
-
-
Yoder, K.E.1
Espeseth, A.2
Wang, X.H.3
-
215
-
-
1942453798
-
Enhancement of Sleeping Beauty transposition by CpG methylation: Possible role of heterochromatin formation
-
Yusa K, Takeda J, Horie K (2004) Enhancement of Sleeping Beauty transposition by CpG methylation: possible role of heterochromatin formation. Mol Cell Biol 24:4004-4018
-
(2004)
Mol Cell Biol
, vol.24
, pp. 4004-4018
-
-
Yusa, K.1
Takeda, J.2
Horie, K.3
-
216
-
-
65449154892
-
Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon
-
Yusa K, Rad R, Takeda J, Bradley A (2009) Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods 6:363-369
-
(2009)
Nat Methods
, vol.6
, pp. 363-369
-
-
Yusa, K.1
Rad, R.2
Takeda, J.3
Bradley, A.4
-
217
-
-
38949104082
-
How not to be seen: Immune-evasion strategies in gene therapy
-
Zaldumbide A, Hoeben RC (2008) How not to be seen: immune-evasion strategies in gene therapy. Gene Ther 15:239-246
-
(2008)
Gene Ther
, vol.15
, pp. 239-246
-
-
Zaldumbide, A.1
Hoeben, R.C.2
-
218
-
-
0030990991
-
Disruption of overlapping transcripts in the ROSA b geo 26 gene trap strain leads to widespread expression of b-galactosidase in mouse embryos and hematopoietic cells
-
Zambrowicz BP, Imamoto A, Fiering S et al (1997) Disruption of overlapping transcripts in the ROSA b geo 26 gene trap strain leads to widespread expression of b-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci USA 94:3789-3794
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3789-3794
-
-
Zambrowicz, B.P.1
Imamoto, A.2
Fiering, S.3
-
219
-
-
0038412815
-
The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition
-
Zayed H, Izsvaak S, Khare D et al (2003) The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition. Nucleic Acids Res 31:2313-2322
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 2313-2322
-
-
Zayed, H.1
Izsvaak, S.2
Khare, D.3
-
220
-
-
70349323106
-
Transposable elements and an epigenetic basis for punctuated equilibria
-
Zeh DW, Zeh JA, Ishida Y (2009) Transposable elements and an epigenetic basis for punctuated equilibria. Bioessays 31:715-726
-
(2009)
Bioessays
, vol.31
, pp. 715-726
-
-
Zeh, D.W.1
Zeh, J.A.2
Ishida, Y.3
-
221
-
-
72449197565
-
Novel functions for small RNA molecules 1
-
Zhang C (2009) Novel functions for small RNA molecules 1. Curr Opin Mol Ther 11:641-651
-
(2009)
Curr Opin Mol Ther
, vol.11
, pp. 641-651
-
-
Zhang, C.1
-
222
-
-
34247168672
-
Electroporation-mediated transfer of plasmids to the lung results in reduced TLR9 signaling and in flammation
-
Zhou R, Norton JE, Zhang N, Dean DA (2007) Electroporation-mediated transfer of plasmids to the lung results in reduced TLR9 signaling and in flammation. Gene Ther 14:775-780
-
(2007)
Gene Ther
, vol.14
, pp. 775-780
-
-
Zhou, R.1
Norton, J.E.2
Zhang, N.3
Dean, D.A.4
-
223
-
-
77952580874
-
Generation of stable cell lines by site-specific integration of transgenes into engineered Chinese hamster ovary strains using an FLP-FRT system
-
Zhou H, Liu ZG, Sun ZW et al (2010) Generation of stable cell lines by site-specific integration of transgenes into engineered Chinese hamster ovary strains using an FLP-FRT system. J Biotechnol 147:122-129
-
(2010)
J Biotechnol
, vol.147
, pp. 122-129
-
-
Zhou, H.1
Liu, Z.G.2
Sun, Z.W.3
-
224
-
-
77449156754
-
High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene
-
Zhu J, Park CW, Sjeklocha L et al (2010) High-level genomic integration, epigenetic changes, and expression of sleeping beauty transgene. Biochemistry 49:1507-1521
-
(2010)
Biochemistry
, vol.49
, pp. 1507-1521
-
-
Zhu, J.1
Park, C.W.2
Sjeklocha, L.3
-
225
-
-
41149133413
-
Physiological promoters reduce the genotoxic risk of integrating gene vectors
-
Zychlinski D, Schambach A, Modlich U et al (2008) Physiological promoters reduce the genotoxic risk of integrating gene vectors. Mol Ther 16:718-725
-
(2008)
Mol Ther
, vol.16
, pp. 718-725
-
-
Zychlinski, D.1
Schambach, A.2
Modlich, U.3
|