Site-specific integration of retroviral DNA in human cells using fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc-finger protein E2C

Methods

Volumn 47, Issue 4, 2009, Pages 269-276

  Su, Kunkai ^a   Wang, Dan ^a   Ye, Jian ^a   Kim, Yun C ^b   Chow, Samson A ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Designed polydactyl zinc finger protein; E2C; Gene therapy; HIV 1 integrase; IN fusion proteins; Insertional mutagenesis; Quantitative PCR; Retroviral DNA integration; Retroviral vectors; Site directed integration

Indexed keywords

AMINO ACID; DNA BINDING PROTEIN; HYBRID PROTEIN; INTEGRASE; RETROVIRUS VECTOR; SITE SPECIFIC DNA METHYLTRANSFERASE (ADENINE SPECIFIC); UNCLASSIFIED DRUG; VIRUS DNA; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN E2C; P31 INTEGRASE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; VIRUS FUSION PROTEIN;

CATALYSIS; CONTROLLED STUDY; DNA BINDING; DNA SEQUENCE; GENE CONSTRUCT; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; IN VIVO STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; ANIMAL; ENZYMOLOGY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; PHYSIOLOGY; PROCEDURES; SITE DIRECTED MUTAGENESIS; VIRUS DNA CELL DNA INTERACTION;

ANIMALS; DNA, VIRAL; DNA-BINDING PROTEINS; HIV INTEGRASE; HIV-1; HUMANS; MUTAGENESIS, SITE-DIRECTED; VIRAL FUSION PROTEINS; VIRUS INTEGRATION; ZINC FINGERS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 64649102398     PISSN: 10462023     EISSN: 10959130     Source Type: Journal    
DOI: 10.1016/j.ymeth.2009.01.001     Document Type: Review

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