Characteristics of the adeno-associated virus preintegration site in human chromosome 19: Open chromatin conformation and transcription-competent environment

Journal of Virology

Volumn 74, Issue 16, 2000, Pages 7671-7677

  Lamartina, S ^a   Sporeno, E ^a   Fattori, E ^a   Toniatti, C ^a  

^a IRBM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE; VIRUS PROTEIN;

ADENO ASSOCIATED VIRUS; ANIMAL CELL; ARTICLE; BINDING SITE; CHROMATIN STRUCTURE; CHROMOSOME 19; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENHANCER REGION; GENE ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT; VIRUS CHARACTERIZATION; VIRUS DNA CELL DNA INTERACTION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL LINE; CHROMATIN; CHROMOSOMES, HUMAN, PAIR 19; DEPENDOVIRUS; DNA-BINDING PROTEINS; GENE THERAPY; HELA CELLS; HUMANS; RATS; TRANSCRIPTION, GENETIC; VIRAL PROTEINS; VIRUS INTEGRATION;

EID: 0033861721     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.74.16.7671-7677.2000     Document Type: Article

References (62)

1. Current protocols in molecular biology
2. Adeno-associated virus Rep78 protein and terminal repeats enhance integration of DNA sequences into the cellular genome
3. The cryptic life style of adeno-associated virus
4. Going the distance: A current view of enhancer action
5. Tissue-specific factors additively increase the probability of the all-or-none formation of hypersensitive site
6. Rep-mediated nicking of the adeno-associated virus origin requires two biochemical activities, DNA helicase activity and transesterification
7. Looping versus linking: Toward a model of long-distance gene activation
8. Hypersensitive site 2 specifies a unique function within the human β-globin locus control region to stimulate globin gene transcription
9. Analysis of Drosophila chromatin structure in vivo
10. Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats
11. A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human β-globin locus control region
12. Chromatin structure and gene expression
13. Locus control region function and heterochromatin-induced position variegation effect
14. Position- and orientation-independent activity of the Schizosaccharomyces pombe meiotic recombination hot spot M26
15. A cell specific enhancer far upstream of the mouse tyrosinase gene confers high level and copy number-related expression in transgenic mice
16. Status of the transcription factor database (TFD)
17. Site-specific integration by adeno-associated virus is directed by a cellular DNA sequence
18. Nuclease hypersensitive sites in chromatin
19. Core hystone hyperacetylation co-maps with generalized DNAse I sensitivity in the chicken β-globin chromosomal domain
20. The AAV origin-binding protein Rep68 is an ATP dependent site-specific endonuclease with DNA helicase activity
21. Partial purification of adeno-associated virus Rep78, Rep52, and Rep40 and their biochemical characterization
22. The immunoglobulin μ enhancer core establishes local factor access in nuclear protein independent of transcriptional stimulation
23. Extension of chromatin accessibility by nuclear matrix attachment regions
24. Transcription factor Mts1/Mts2 (Atf1/Pcr1, Gad7/Pcr1) activates the M26 meiotic recombination hotspot in Schizosaccharomyces pombe
25. Prospects for the use of adeno-associated virus as a vector for human gene therapy
26. Site-specific integration by adeno-associated virus
27. Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination
28. Lipofection of purified adeno-associated virus Rep68 protein: Toward a chromosome-targeting nonviral particle
29. Locus control regions: Coming of age at a decade plus
30. Site-specific integration by adeno-associated virus: A basis for a potential gene-therapy vector
31. The recombination signals for adeno-associated virus site-specific integration
32. Site-specific integration by adeno-associated virus
33. The meiotic recombination hot spot created by the single-base substitution ade6-M26 results in remodeling of chromatin structure in fission yeast
34. Relationship between transcription and initiation of meiotic recombination: Toward chromatin accessibility
35. Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues
36. A new element within the T-cell receptor α locus required for tissue-specific locus control region activity
37. Site-specific integration in mammalian cells mediated by a new hybrid baculovirus-adeno-associated virus vector
38. What's up and down with histone deacetylation and transcription
39. Targeted integration of adeno-associated virus-derived plasmid in transfected human cells
40. Site-specific integration mediated by a hybrid adenovirus/adenoassociated virus vector
41. Conditional site-specific integration into human chromosome 19 using a ligand-dependent chimeric AAV/rep protein
42. Development of animal models for adeno-associated virus site-specific integration
43. Meiotic chromosomes: It takes two to tango
44. Sequence requirements for binding of Rep68 to the adeno-associated virus terminal repeats
45. Adeno-associated virus: Integration at a specific chromosomal locus
46. Targeted integration of adeno-associated virus (AAV) into human chromosome 19
47. Targeted integration of transfected and infected adeno-associated virus vectors containing the neomycin resistance gene
48. Features of the adeno-associated virus origin involved in substrate recognition by the viral Rep protein
49. Nucleotide sequence and organization of the adeno-associated virus 2 genome
50. Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome
51. The polyoma virus enhancer cannot substitute for DNAseI core hypersensitive sites 2-4 in the human beta-globin region
52. Mapping of DNAse I-hypersensitive sites in the upstream DNA of human embryonic ε-globin gene in K562 leukemia cells
53. Dividing the empire: Boundary chomatin elements delimit the territory of enhancers
54. Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein
55. A heterodimeric protein that binds to a meiotic homologous recombination hot spot: Correlation of binding and hot spot activity
56. Enhancers increase the probability but not the level of gene expression
57. Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA
58. Interaction of wild-type and mutant adeno-associated virus (AAV) Rep proteins on AAV hairpin DNA
59. A maltose-binding protein/adeno-associated virus Rep68 fusion protein has DNA-RNA helicase and ATPase activities
60. Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro
61. In vivo analysis of chromatin structure
62. Biochemical characterization of adeno-associated virus Rep68 DNA helicase and ATPase activity