Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

Nature Genetics

Volumn 41, Issue 6, 2009, Pages 753-761

  Mátés, Lajos ^a   Chuah, Marinee K L ^b   Belay, Eyayu ^b   Jerchow, Boris ^a   Manoj, Namitha ^a   Acosta Sanchez, Abel ^b   Grzela, Dawid P ^a   Schmitt, Andrea ^a   Becker, Katja ^a   Matrai, Janka ^b   Ma, Ling ^b   Samara Kuko, Ermira ^b   Gysemans, Conny ^b   Pryputniewicz, Diana ^a   Miskey, Csaba ^a   Fletcher, Bradley ^c   Vandendriessche, Thierry ^b   Ivics, Zoltán ^a   Izsvák, Zsuzsanna ^a,d  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSPOSASE; SLEEPING BEAUTY TRANSPOSASE, HUMAN; TRANSPOSON;

ANIMAL EXPERIMENT; ARTICLE; FEMALE; FUNCTIONAL GENOMICS; GENE INSERTION; GENE THERAPY; GENE TRANSFER; MALE; MOLECULAR EVOLUTION; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; TRANSGENICS; TRANSPOSON; VERTEBRATE; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; GENETICS; HUMAN; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYLOGENY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; TRANSGENIC MOUSE;

AMINO ACID SEQUENCE; ANIMALS; CONSERVED SEQUENCE; DNA TRANSPOSABLE ELEMENTS; EVOLUTION, MOLECULAR; HUMANS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PHYLOGENY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; TRANSPOSASES; VERTEBRATES;

MAMMALIA; MUS; VERTEBRATA;

EID: 67349250885     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.343     Document Type: Article

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