메뉴 건너뛰기




Volumn 23, Issue 1, 2011, Pages 10-20

Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses

Author keywords

[No Author keywords available]

Indexed keywords

ABSENT IN MELANOMA 2; BETA INTERFERON; DEOXYRIBONUCLEASE; DNA DIRECTED RNA POLYMERASE III; EXTRACHROMOSOMAL DNA; INTERFERON; STIMULATOR OF INTEREFERON GENE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 9; TREX 1; UNCLASSIFIED DRUG;

EID: 79951679142     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2010.12.015     Document Type: Review
Times cited : (209)

References (56)
  • 1
    • 74549167783 scopus 로고    scopus 로고
    • Regulation of adaptive immunity by the innate immune system
    • Iwasaki A., Medzhitov R. Regulation of adaptive immunity by the innate immune system. Science 2010, 327:291-295.
    • (2010) Science , vol.327 , pp. 291-295
    • Iwasaki, A.1    Medzhitov, R.2
  • 2
    • 77949940198 scopus 로고    scopus 로고
    • Intracellular toll-like receptors
    • Blasius A.L., Beutler B. Intracellular toll-like receptors. Immunity 2010, 32:305-315.
    • (2010) Immunity , vol.32 , pp. 305-315
    • Blasius, A.L.1    Beutler, B.2
  • 3
    • 63649108380 scopus 로고    scopus 로고
    • The roles of TLRs RLRs and NLRs in pathogen recognition
    • Kawai T., Akira S. The roles of TLRs RLRs and NLRs in pathogen recognition. Int Immunol 2009, 21:317-337.
    • (2009) Int Immunol , vol.21 , pp. 317-337
    • Kawai, T.1    Akira, S.2
  • 4
    • 77649152255 scopus 로고    scopus 로고
    • Autoimmunity and the clearance of dead cells
    • Nagata S., Hanayama R., Kawane K. Autoimmunity and the clearance of dead cells. Cell 2010, 140:619-630.
    • (2010) Cell , vol.140 , pp. 619-630
    • Nagata, S.1    Hanayama, R.2    Kawane, K.3
  • 5
    • 46249115827 scopus 로고    scopus 로고
    • Interferon-inducible antiviral effectors
    • Sadler A.J., Williams B.R. Interferon-inducible antiviral effectors. Nat Rev Immunol 2008, 8:559-568.
    • (2008) Nat Rev Immunol , vol.8 , pp. 559-568
    • Sadler, A.J.1    Williams, B.R.2
  • 6
    • 48749085127 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
    • Gilliet M., Cao W., Liu Y.J. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat Rev Immunol 2008, 8:594-606.
    • (2008) Nat Rev Immunol , vol.8 , pp. 594-606
    • Gilliet, M.1    Cao, W.2    Liu, Y.J.3
  • 7
    • 58049217490 scopus 로고    scopus 로고
    • RNA recognition and signal transduction by RIG-I-like receptors
    • Yoneyama M., Fujita T. RNA recognition and signal transduction by RIG-I-like receptors. Immunol Rev 2009, 227:54-65.
    • (2009) Immunol Rev , vol.227 , pp. 54-65
    • Yoneyama, M.1    Fujita, T.2
  • 10
    • 63649145255 scopus 로고    scopus 로고
    • AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    • Fernandes-Alnemri T., Yu J.W., Datta P., Wu J., Alnemri E.S. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 2009, 458:509-513.
    • (2009) Nature , vol.458 , pp. 509-513
    • Fernandes-Alnemri, T.1    Yu, J.W.2    Datta, P.3    Wu, J.4    Alnemri, E.S.5
  • 13
    • 53349178089 scopus 로고    scopus 로고
    • STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
    • Ishikawa H., Barber G.N. STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature 2008, 455:674-678.
    • (2008) Nature , vol.455 , pp. 674-678
    • Ishikawa, H.1    Barber, G.N.2
  • 14
    • 70349943834 scopus 로고    scopus 로고
    • STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    • Ishikawa H., Ma Z., Barber G.N. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 2009, 461:788-792.
    • (2009) Nature , vol.461 , pp. 788-792
    • Ishikawa, H.1    Ma, Z.2    Barber, G.N.3
  • 15
  • 16
  • 18
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    • Lund J., Sato A., Akira S., Medzhitov R., Iwasaki A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 2003, 198:513-520.
    • (2003) J Exp Med , vol.198 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, R.4    Iwasaki, A.5
  • 21
    • 37849002321 scopus 로고    scopus 로고
    • Toll-like receptor 9 (TLR9) agonists in the treatment of cancer
    • Krieg A.M. Toll-like receptor 9 (TLR9) agonists in the treatment of cancer. Oncogene 2008, 27:161-167.
    • (2008) Oncogene , vol.27 , pp. 161-167
    • Krieg, A.M.1
  • 22
    • 71649101226 scopus 로고    scopus 로고
    • Emerging roles of TLR7 and TLR9 in murine SLE
    • Santiago-Raber M.L., Baudino L., Izui S. Emerging roles of TLR7 and TLR9 in murine SLE. J Autoimmun 2009, 33:231-238.
    • (2009) J Autoimmun , vol.33 , pp. 231-238
    • Santiago-Raber, M.L.1    Baudino, L.2    Izui, S.3
  • 23
    • 34249707811 scopus 로고    scopus 로고
    • TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
    • Baccala R., Hoebe K., Kono D.H., Beutler B., Theofilopoulos A.N. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat Med 2007, 13:543-551.
    • (2007) Nat Med , vol.13 , pp. 543-551
    • Baccala, R.1    Hoebe, K.2    Kono, D.H.3    Beutler, B.4    Theofilopoulos, A.N.5
  • 24
    • 33645076274 scopus 로고    scopus 로고
    • TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE
    • Ehlers M., Fukuyama H., McGaha T.L., Aderem A., Ravetch J.V. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med 2006, 203:553-561.
    • (2006) J Exp Med , vol.203 , pp. 553-561
    • Ehlers, M.1    Fukuyama, H.2    McGaha, T.L.3    Aderem, A.4    Ravetch, J.V.5
  • 25
    • 29244450802 scopus 로고    scopus 로고
    • Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
    • Barton G.M., Kagan J.C., Medzhitov R. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol 2006, 7:49-56.
    • (2006) Nat Immunol , vol.7 , pp. 49-56
    • Barton, G.M.1    Kagan, J.C.2    Medzhitov, R.3
  • 26
    • 0345447639 scopus 로고    scopus 로고
    • Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice
    • Spies B., Hochrein H., Vabulas M., Huster K., Busch D.H., Schmitz F., Heit A., Wagner H. Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice. J Immunol 2003, 171:5908-5912.
    • (2003) J Immunol , vol.171 , pp. 5908-5912
    • Spies, B.1    Hochrein, H.2    Vabulas, M.3    Huster, K.4    Busch, D.H.5    Schmitz, F.6    Heit, A.7    Wagner, H.8
  • 27
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • Stetson D.B., Medzhitov R. Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 2006, 24:93-103.
    • (2006) Immunity , vol.24 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 28
    • 27944453599 scopus 로고    scopus 로고
    • Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation
    • Okabe Y., Kawane K., Akira S., Taniguchi T., Nagata S. Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation. J Exp Med 2005, 202:1333-1339.
    • (2005) J Exp Med , vol.202 , pp. 1333-1339
    • Okabe, Y.1    Kawane, K.2    Akira, S.3    Taniguchi, T.4    Nagata, S.5
  • 29
    • 53349168904 scopus 로고    scopus 로고
    • The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
    • Zhong B., Yang Y., Li S., Wang Y.Y., Li Y., Diao F., Lei C., He X., Zhang L., Tien P., et al. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity 2008, 29:538-550.
    • (2008) Immunity , vol.29 , pp. 538-550
    • Zhong, B.1    Yang, Y.2    Li, S.3    Wang, Y.Y.4    Li, Y.5    Diao, F.6    Lei, C.7    He, X.8    Zhang, L.9    Tien, P.10
  • 31
    • 49449115516 scopus 로고    scopus 로고
    • MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals
    • Jin L., Waterman P.M., Jonscher K.R., Short C.M., Reisdorph N.A., Cambier J.C. MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Mol Cell Biol 2008, 28:5014-5026.
    • (2008) Mol Cell Biol , vol.28 , pp. 5014-5026
    • Jin, L.1    Waterman, P.M.2    Jonscher, K.R.3    Short, C.M.4    Reisdorph, N.A.5    Cambier, J.C.6
  • 34
    • 0442292211 scopus 로고    scopus 로고
    • The exocyst meets the translocon: a regulatory circuit for secretion and protein synthesis?
    • Guo W., Novick P. The exocyst meets the translocon: a regulatory circuit for secretion and protein synthesis?. Trends Cell Biol 2004, 14:61-63.
    • (2004) Trends Cell Biol , vol.14 , pp. 61-63
    • Guo, W.1    Novick, P.2
  • 37
  • 38
    • 79951672460 scopus 로고    scopus 로고
    • The ENU-induced Goldenticket (Gt) mouse mutant reveals an essential function of Sting (Tmem173, Mita, Mpys Eris) in the in vivo interferon response to Listeria monocytogenes and cyclic-di-nucleotides
    • Sauer J.D., Sotelo-Troha K., von Moltke J., Monroe K.M., Rae C.S., Brubaker S.W., Hyodo M., Hayakawa Y., Woodward J.J., Portnoy D.A., et al. The ENU-induced Goldenticket (Gt) mouse mutant reveals an essential function of Sting (Tmem173, Mita, Mpys Eris) in the in vivo interferon response to Listeria monocytogenes and cyclic-di-nucleotides. Infect Immun 2010.
    • (2010) Infect Immun
    • Sauer, J.D.1    Sotelo-Troha, K.2    von Moltke, J.3    Monroe, K.M.4    Rae, C.S.5    Brubaker, S.W.6    Hyodo, M.7    Hayakawa, Y.8    Woodward, J.J.9    Portnoy, D.A.10
  • 39
    • 62049084519 scopus 로고    scopus 로고
    • The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA
    • Zhong B., Zhang L., Lei C., Li Y., Mao A.P., Yang Y., Wang Y.Y., Zhang X.L., Shu H.B. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity 2009, 30:397-407.
    • (2009) Immunity , vol.30 , pp. 397-407
    • Zhong, B.1    Zhang, L.2    Lei, C.3    Li, Y.4    Mao, A.P.5    Yang, Y.6    Wang, Y.Y.7    Zhang, X.L.8    Shu, H.B.9
  • 40
    • 77953724278 scopus 로고    scopus 로고
    • Regulation of dsDNA-induced innate immune responses by membrane trafficking
    • Saitoh T., Fujita N., Yoshimori T., Akira S. Regulation of dsDNA-induced innate immune responses by membrane trafficking. Autophagy 2010, 6:430-432.
    • (2010) Autophagy , vol.6 , pp. 430-432
    • Saitoh, T.1    Fujita, N.2    Yoshimori, T.3    Akira, S.4
  • 42
    • 12344290452 scopus 로고    scopus 로고
    • Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA
    • Yoshida H., Okabe Y., Kawane K., Fukuyama H., Nagata S. Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA. Nat Immunol 2005, 6:49-56.
    • (2005) Nat Immunol , vol.6 , pp. 49-56
    • Yoshida, H.1    Okabe, Y.2    Kawane, K.3    Fukuyama, H.4    Nagata, S.5
  • 48
    • 36248988008 scopus 로고    scopus 로고
    • Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease
    • Yang Y.G., Lindahl T., Barnes D.E. Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 2007, 131:873-886.
    • (2007) Cell , vol.131 , pp. 873-886
    • Yang, Y.G.1    Lindahl, T.2    Barnes, D.E.3
  • 49
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • Stetson D.B., Ko J.S., Heidmann T., Medzhitov R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 2008, 134:587-598.
    • (2008) Cell , vol.134 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 50
    • 36849045915 scopus 로고    scopus 로고
    • The inflammasome: a danger sensing complex triggering innate immunity
    • Petrilli V., Dostert C., Muruve D.A., Tschopp J. The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol 2007, 19:615-622.
    • (2007) Curr Opin Immunol , vol.19 , pp. 615-622
    • Petrilli, V.1    Dostert, C.2    Muruve, D.A.3    Tschopp, J.4
  • 51
    • 68049092912 scopus 로고    scopus 로고
    • RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway
    • Chiu Y.H., Macmillan J.B., Chen Z.J. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 2009, 138:576-591.
    • (2009) Cell , vol.138 , pp. 576-591
    • Chiu, Y.H.1    Macmillan, J.B.2    Chen, Z.J.3
  • 56
    • 77957009390 scopus 로고    scopus 로고
    • Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
    • Kim T., Pazhoor S., Bao M., Zhang Z., Hanabuchi S., Facchinetti V., Bover L., Plumas J., Chaperot L., Qin J., et al. Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells. Proc Natl Acad Sci U S A 2010, 107:15181-15186.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 15181-15186
    • Kim, T.1    Pazhoor, S.2    Bao, M.3    Zhang, Z.4    Hanabuchi, S.5    Facchinetti, V.6    Bover, L.7    Plumas, J.8    Chaperot, L.9    Qin, J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.