Zinc-finger nuclease based genome surgery: It's all about specificity

Current Gene Therapy

Volumn 11, Issue 1, 2011, Pages 28-37

  Händel, Eva Maria ^a   Cathomen, Toni ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cytotoxicity; Gene disruption; Gene targeting; Genome engineering; Genotoxicity; Off target activity; Protein engineering; Zinc finger nuclease

Indexed keywords

CHEMOKINE RECEPTOR CCR5; DNA; NUCLEASE; UNCLASSIFIED DRUG; ZINC FINGER NUCLEASE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CHROMOSOME DELETION; CHROMOSOME TRANSLOCATION; DIMERIZATION; DNA BINDING; DNA MODIFICATION; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENE FREQUENCY; GENE LOCUS; GENE TARGETING; GENE THERAPY; GENETIC ENGINEERING; GENOME SURGERY; GENOTOXICITY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; KNOCKOUT GENE; NONHUMAN;

ANIMALS; DNA DAMAGE; ENDONUCLEASES; GENE THERAPY; GENETIC ENGINEERING; HUMANS; SENSITIVITY AND SPECIFICITY; ZINC FINGERS;

DANIO RERIO; RATTUS;

EID: 79951699566     PISSN: 15665232     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652311794520120     Document Type: Article

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