Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 5, 2006, Pages 1457-1462

  Recchia, Alessandra ^a,b   Bonini, Chiara ^a   Magnani, Zulma ^a   Urbinati, Fabrizia ^b   Sartori, Daniela ^a,c   Muraro, Sara ^a   Tagliafico, Enrico ^b   Bondanza, Attilio ^a,d   Stanghellini, Maria Teresa Lupo ^a   Bernardi, Massimo ^a   Pescarollo, Alessandra ^a   Ciceri, Fabio ^a   Bordignon, Claudio ^c,d   Mavilio, Fulvio ^b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c MOLMED S P A   (Italy)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

Donor lymphocyte infusion; Gene therapy; Graft versus host disease; Insertional mutagenesis; Retroviral integration

Indexed keywords

RETROVIRUS VECTOR;

ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; CELL FUNCTION; CELL TRANSPLANTATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA MODIFICATION; GENE EXPRESSION REGULATION; GENETIC ANALYSIS; GENETIC RISK; GENOTOXICITY; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKEMIA CELL; MOLECULAR BIOLOGY; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; RETROVIRUS VECTOR INTEGRATION; RISK ASSESSMENT; SAFETY; SIGNAL TRANSDUCTION; SUICIDE GENE; T LYMPHOCYTE; TREATMENT OUTCOME; VIRAL GENE THERAPY;

ADOLESCENT; ADULT; CELL TRANSPLANTATION; CLINICAL TRIALS; CLONING, MOLECULAR; DNA, COMPLEMENTARY; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, VIRAL; GENE THERAPY; GENETIC VECTORS; GENOME; GRAFT VS HOST DISEASE; HUMANS; IMMUNE SYSTEM; IMMUNOPHENOTYPING; LEUKEMIA; LEUKEMIA, MYELOID, CHRONIC; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTES; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; MODELS, GENETIC; MUTAGENESIS; PHENOTYPE; PROVIRUSES; RETROVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEM CELL TRANSPLANTATION; T-LYMPHOCYTES; TIME FACTORS;

EID: 31944440000     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0507496103     Document Type: Article

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