Preclinical evaluation of innate immunity to baculovirus gene therapy vectors in whole human blood

Molecular Immunology

Volumn 46, Issue 15, 2009, Pages 2911-2917

  Georgopoulos, Lindsay J ^b   Elgue, Graciela ^a   Sanchez, Javier ^a   Dussupt, Vincent ^b   Magotti, Paola ^c   Lambris, John D ^c   Tötterman, Thomas H ^a   Maitland, Norman J ^b   Nilsson, Bo ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF YORK   (United Kingdom)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Autographa californica; Baculovirus; C5a receptor antagonist; Complement; Compstatin; Gene therapy

Indexed keywords

BACULOVIRUS VECTOR; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C5 INHIBITOR; COMPLEMENT INHIBITOR; COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPSTATIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; OPSONIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTICOAGULATION; ANTIGEN BINDING; ARTICLE; BACULOVIRUS; COMPLEMENT ACTIVATION; COMPLEMENT INHIBITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ERYTHROCYTE; EX VIVO STUDY; HUMAN; HUMAN CELL; INFLAMMATION; INNATE IMMUNITY; OPSONIZATION; PRIORITY JOURNAL; PROTEIN INTERACTION; VIRAL GENE DELIVERY SYSTEM; VIRUS INFECTIVITY; VIRUS PARTICLE;

BACULOVIRIDAE; COMPLEMENT C3B; COMPLEMENT C5A; COMPLEMENT MEMBRANE ATTACK COMPLEX; CYTOKINES; GENE THERAPY; GENETIC VECTORS; HUMANS; IMMUNITY, INNATE; IMMUNOASSAY; IMMUNOGLOBULIN M; PEPTIDES, CYCLIC;

AUTOGRAPHA CALIFORNICA;

EID: 68749103477     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.07.008     Document Type: Article

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