메뉴 건너뛰기




Volumn 11, Issue 4, 2009, Pages 442-447

Adeno-associated virus vector integration

Author keywords

Adeno associated virus; Gene integration; Homologous recombination; Insertional mutagenesis; Vector

Indexed keywords

PARVOVIRUS VECTOR;

EID: 68649111166     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (178)

References (93)
  • 1
    • 10944269753 scopus 로고    scopus 로고
    • Integration of adeno-associated virus (AAV) and recombinant AAV vectors
    • McCarty DM, Young SM Jr, Samulski RJ: Integration of adeno-associated virus (AAV) and recombinant AAV vectors. Annu Rev Genet (2004) 38:819-845.
    • (2004) Annu Rev Genet , vol.38 , pp. 819-845
    • McCarty, D.M.1    Young Jr, S.M.2    Samulski, R.J.3
  • 2
    • 0033178657 scopus 로고    scopus 로고
    • Adeno-associated virus vectors and hematology
    • Russell DW, Kay MA: Adeno-associated virus vectors and hematology. Blood (1999) 94(3):864-874.
    • (1999) Blood , vol.94 , Issue.3 , pp. 864-874
    • Russell, D.W.1    Kay, M.A.2
  • 3
    • 27744584507 scopus 로고    scopus 로고
    • Characterization of adeno-associated virus genomes isolated from human tissues
    • Schnepp BC, Jensen RL, Chen CL, Johnson PR, Clark KR: Characterization of adeno-associated virus genomes isolated from human tissues. J Virol (2005) 79(23):14793-14803.
    • (2005) J Virol , vol.79 , Issue.23 , pp. 14793-14803
    • Schnepp, B.C.1    Jensen, R.L.2    Chen, C.L.3    Johnson, P.R.4    Clark, K.R.5
  • 7
    • 68649111546 scopus 로고    scopus 로고
    • AAV genomes were detected and isolated by PCR in multiple tissues from non-human primates. Southern blot analysis suggested that the AAV genome can persist in cells as both integrated and non-integrated forms. This paper provided unexpected evidence that AAV infections can spread efficiently throughout the body
    • AAV genomes were detected and isolated by PCR in multiple tissues from non-human primates. Southern blot analysis suggested that the AAV genome can persist in cells as both integrated and non-integrated forms. This paper provided unexpected evidence that AAV infections can spread efficiently throughout the body.
  • 8
  • 11
    • 0027092001 scopus 로고
    • Characterization of a preferred site on human chromosome 19q for integration of adenoassociated virus DNA by non-homologous recombination
    • Kotin RM, Linden RM, Berns KI: Characterization of a preferred site on human chromosome 19q for integration of adenoassociated virus DNA by non-homologous recombination. EMBO J (1992) 11(13):5071-5078.
    • (1992) EMBO J , vol.11 , Issue.13 , pp. 5071-5078
    • Kotin, R.M.1    Linden, R.M.2    Berns, K.I.3
  • 12
    • 0742321699 scopus 로고    scopus 로고
    • Evidence of chromosomal integration of AAV DNA in human testis tissue
    • Mehrle S, Rohde V, Schlehofer JR: Evidence of chromosomal integration of AAV DNA in human testis tissue. Virus Genes (2004) 28(1):61-69.
    • (2004) Virus Genes , vol.28 , Issue.1 , pp. 61-69
    • Mehrle, S.1    Rohde, V.2    Schlehofer, J.R.3
  • 13
    • 68649114945 scopus 로고    scopus 로고
    • Two virus:chromosome junctions were isolated from human testicular tissue by 'genome-walking' PCR. The isolation of these virus:chromosome junctions demonstrated that AAV can integrate in the testes after infection. These findings raise the possibility that AAV vectors can integrate in spermatogonia and perhaps be transferred by germ-line transmission.
    • Two virus:chromosome junctions were isolated from human testicular tissue by 'genome-walking' PCR. The isolation of these virus:chromosome junctions demonstrated that AAV can integrate in the testes after infection. These findings raise the possibility that AAV vectors can integrate in spermatogonia and perhaps be transferred by germ-line transmission.
  • 14
    • 34249790547 scopus 로고    scopus 로고
    • Increased complexity of wild-type adeno-associated virus-chromosomal junctions as determined by analysis of unselected cellular genomes
    • Drew HR, Lockett LJ, Both GW: Increased complexity of wild-type adeno-associated virus-chromosomal junctions as determined by analysis of unselected cellular genomes. J Gen Virol (2007) 88 (Pt 6) :1722-1732.
    • (2007) J Gen Virol , vol.88 , Issue.PART 6 , pp. 1722-1732
    • Drew, H.R.1    Lockett, L.J.2    Both, G.W.3
  • 15
    • 0032506752 scopus 로고    scopus 로고
    • Novel tools for production and purification of recombinant adenoassociated virus vectors
    • Grimm D, Kern A, Rittner K, Kleinschmidt JA: Novel tools for production and purification of recombinant adenoassociated virus vectors. Hum Gene Ther (1998) 9(18):2745-2760.
    • (1998) Hum Gene Ther , vol.9 , Issue.18 , pp. 2745-2760
    • Grimm, D.1    Kern, A.2    Rittner, K.3    Kleinschmidt, J.A.4
  • 16
    • 38649114404 scopus 로고    scopus 로고
    • Single-polarity recombinant adeno-associated virus 2 vector-mediated transgene expression in vitro and in vivo: Mechanism of transduction
    • Zhong L, Zhou X, Li Y, Qing K, Xiao X, Samulski RJ, Srivastava A: Single-polarity recombinant adeno-associated virus 2 vector-mediated transgene expression in vitro and in vivo: Mechanism of transduction. Mol Ther (2008) 16(2):290-295.
    • (2008) Mol Ther , vol.16 , Issue.2 , pp. 290-295
    • Zhong, L.1    Zhou, X.2    Li, Y.3    Qing, K.4    Xiao, X.5    Samulski, R.J.6    Srivastava, A.7
  • 17
    • 1542347741 scopus 로고    scopus 로고
    • Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors
    • Thomas CE, Storm TA, Huang Z, Kay MA: Rapid uncoating of vector genomes is the key to efficient liver transduction with pseudotyped adeno-associated virus vectors. J Virol (2004) 78(6):3110- 3122.
    • (2004) J Virol , vol.78 , Issue.6 , pp. 3110-3122
    • Thomas, C.E.1    Storm, T.A.2    Huang, Z.3    Kay, M.A.4
  • 18
    • 39849103695 scopus 로고    scopus 로고
    • Adeno-associated virus of a single-polarity DNA genome is capable of transduction in vivo
    • Zhou X, Zeng X, Fan Z, Li C, McCown T, Samulski RJ, Xiao X: Adeno-associated virus of a single-polarity DNA genome is capable of transduction in vivo. Mol Ther (2008) 16(3):494-499.
    • (2008) Mol Ther , vol.16 , Issue.3 , pp. 494-499
    • Zhou, X.1    Zeng, X.2    Fan, Z.3    Li, C.4    McCown, T.5    Samulski, R.J.6    Xiao, X.7
  • 19
    • 0033814178 scopus 로고    scopus 로고
    • Recruitment of single-stranded recombinant adeno-associated virus vector genomes and intermolecular recombination are responsible for stable transduction of liver in vivo
    • Nakai H, Storm TA, Kay MA: Recruitment of single-stranded recombinant adeno-associated virus vector genomes and intermolecular recombination are responsible for stable transduction of liver in vivo. J Virol (2000) 74(20):9451-9463.
    • (2000) J Virol , vol.74 , Issue.20 , pp. 9451-9463
    • Nakai, H.1    Storm, T.A.2    Kay, M.A.3
  • 20
    • 0033567129 scopus 로고    scopus 로고
    • Structural analysis of adeno-associated virus transduction circular intermediates
    • Duan D, Yan Z, Yue Y, Engelhardt JF: Structural analysis of adeno-associated virus transduction circular intermediates. Virology (1999) 261(1):8-14.
    • (1999) Virology , vol.261 , Issue.1 , pp. 8-14
    • Duan, D.1    Yan, Z.2    Yue, Y.3    Engelhardt, J.F.4
  • 21
    • 0031691257 scopus 로고    scopus 로고
    • Circular intermediates of recombinant adenoassociated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue
    • Duan D, Sharma P, Yang J, Yue Y, Dudus L, Zhang Y, Fisher KJ, Engelhardt JF: Circular intermediates of recombinant adenoassociated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue. J Virol (1998) 72(11):8568-8577.
    • (1998) J Virol , vol.72 , Issue.11 , pp. 8568-8577
    • Duan, D.1    Sharma, P.2    Yang, J.3    Yue, Y.4    Dudus, L.5    Zhang, Y.6    Fisher, K.J.7    Engelhardt, J.F.8
  • 22
    • 0034960344 scopus 로고    scopus 로고
    • Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo
    • Nakai H, Yant SR, Storm TA, Fuess S, Meuse L, Kay MA: Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo. J Virol (2001) 75(15):6969-6976.
    • (2001) J Virol , vol.75 , Issue.15 , pp. 6969-6976
    • Nakai, H.1    Yant, S.R.2    Storm, T.A.3    Fuess, S.4    Meuse, L.5    Kay, M.A.6
  • 24
    • 33645992763 scopus 로고    scopus 로고
    • Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype
    • Grimm D, Pandey K, Nakai H, Storm TA, Kay MA: Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype. J Virol (2006) 80(1):426-439.
    • (2006) J Virol , vol.80 , Issue.1 , pp. 426-439
    • Grimm, D.1    Pandey, K.2    Nakai, H.3    Storm, T.A.4    Kay, M.A.5
  • 25
    • 0030773872 scopus 로고    scopus 로고
    • Adeno-associated virus vector integration junctions
    • Rutledge EA, Russell DW: Adeno-associated virus vector integration junctions. J Virol (1997) 71(11):8429-8436.
    • (1997) J Virol , vol.71 , Issue.11 , pp. 8429-8436
    • Rutledge, E.A.1    Russell, D.W.2
  • 26
    • 0030827586 scopus 로고    scopus 로고
    • Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adenoassociated virus integration in vivo and in vitro
    • Yang CC, Xiao X, Zhu X, Ansardi DC, Epstein ND, Frey MR, Matera AG, Samulski RJ: Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adenoassociated virus integration in vivo and in vitro. J Virol (1997) 71(12):9231-9247.
    • (1997) J Virol , vol.71 , Issue.12 , pp. 9231-9247
    • Yang, C.C.1    Xiao, X.2    Zhu, X.3    Ansardi, D.C.4    Epstein, N.D.5    Frey, M.R.6    Matera, A.G.7    Samulski, R.J.8
  • 28
    • 0028577595 scopus 로고
    • Adeno-associated virus vectors preferentially transduce cells in S phase
    • Russell DW, Miller AD, Alexander IE: Adeno-associated virus vectors preferentially transduce cells in S phase. Proc Natl Acad Sci USA (1994) 91(19):8915-8919.
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.19 , pp. 8915-8919
    • Russell, D.W.1    Miller, A.D.2    Alexander, I.E.3
  • 29
    • 0035989649 scopus 로고    scopus 로고
    • Targeted transgene insertion into human chromosomes by adeno-associated virus vectors
    • Hirata R, Chamberlain J, Dong R, Russell DW: Targeted transgene insertion into human chromosomes by adeno-associated virus vectors. Nat Biotechnol (2002) 20(7):735-738.
    • (2002) Nat Biotechnol , vol.20 , Issue.7 , pp. 735-738
    • Hirata, R.1    Chamberlain, J.2    Dong, R.3    Russell, D.W.4
  • 31
    • 0029836472 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus (AAV-CFTR) vectors do not integrate in a site-specific fashion in an immortalized epithelial cell line
    • Kearns WG, Afione SA, Fulmer SB, Pang MC, Erikson D, Egan M, Landrum MJ, Flotte TR, Cutting GR: Recombinant adeno-associated virus (AAV-CFTR) vectors do not integrate in a site-specific fashion in an immortalized epithelial cell line. Gene Ther (1996) 3(9):748-755.
    • (1996) Gene Ther , vol.3 , Issue.9 , pp. 748-755
    • Kearns, W.G.1    Afione, S.A.2    Fulmer, S.B.3    Pang, M.C.4    Erikson, D.5    Egan, M.6    Landrum, M.J.7    Flotte, T.R.8    Cutting, G.R.9
  • 32
    • 0023889191 scopus 로고
    • Adeno-associated virus general transduction vectors: Analysis of proviral structures
    • McLaughlin SK, Collis P, Hermonat PL, Muzyczka N: Adeno-associated virus general transduction vectors: Analysis of proviral structures. J Virol (1988) 62(6):1963-1973.
    • (1988) J Virol , vol.62 , Issue.6 , pp. 1963-1973
    • McLaughlin, S.K.1    Collis, P.2    Hermonat, P.L.3    Muzyczka, N.4
  • 33
    • 0023731951 scopus 로고
    • Adenoassociated virus: A vector system for efficient introduction and integration of DNA into a variety of mammalian cell types
    • Lebkowski JS, McNally MM, Okarma TB, Lerch LB: Adenoassociated virus: A vector system for efficient introduction and integration of DNA into a variety of mammalian cell types. Mol Cell Biol (1988) 8(10):3988- 3996.
    • (1988) Mol Cell Biol , vol.8 , Issue.10 , pp. 3988-3996
    • Lebkowski, J.S.1    McNally, M.M.2    Okarma, T.B.3    Lerch, L.B.4
  • 34
    • 0024311525 scopus 로고
    • Helper-free stocks of recombinant adeno-associated viruses: Normal integration does not require viral gene expression
    • Samulski RJ, Chang LS, Shenk T: Helper-free stocks of recombinant adeno-associated viruses: Normal integration does not require viral gene expression. J Virol (1989) 63(9):3822-3828.
    • (1989) J Virol , vol.63 , Issue.9 , pp. 3822-3828
    • Samulski, R.J.1    Chang, L.S.2    Shenk, T.3
  • 35
    • 0036478954 scopus 로고    scopus 로고
    • Chromosomal effects of adeno-associated virus vector integration
    • Miller DG, Rutledge EA, Russell DW: Chromosomal effects of adeno-associated virus vector integration. Nat Genet (2002) 30(2):147-148.
    • (2002) Nat Genet , vol.30 , Issue.2 , pp. 147-148
    • Miller, D.G.1    Rutledge, E.A.2    Russell, D.W.3
  • 36
    • 23844556421 scopus 로고    scopus 로고
    • Large-scale analysis of adeno-associated virus vector integration sites in normal human cells
    • Miller DG, Trobridge GD, Petek LM, Jacobs MA, Kaul R, Russell DW: Large-scale analysis of adeno-associated virus vector integration sites in normal human cells. J Virol (2005) 79(17):11434-11442.
    • (2005) J Virol , vol.79 , Issue.17 , pp. 11434-11442
    • Miller, D.G.1    Trobridge, G.D.2    Petek, L.M.3    Jacobs, M.A.4    Kaul, R.5    Russell, D.W.6
  • 37
    • 68649092454 scopus 로고    scopus 로고
    • Reported the analysis of 977 AAV vector:chromosome junctions and integration sites in human fibroblasts. This study was the first large-scale analysis of provirus integration sites in human cells and characterization of these junctions provided a representation of insertional mutagenesis by AAV vectors and an improved knowledge of AAV integration.
    • Reported the analysis of 977 AAV vector:chromosome junctions and integration sites in human fibroblasts. This study was the first large-scale analysis of provirus integration sites in human cells and characterization of these junctions provided a representation of insertional mutagenesis by AAV vectors and an improved knowledge of AAV integration.
  • 38
    • 0032990410 scopus 로고    scopus 로고
    • Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver
    • Nakai H, Iwaki Y, Kay MA, Couto LB: Isolation of recombinant adeno-associated virus vector-cellular DNA junctions from mouse liver. J Virol (1999) 73(7):5438-5447.
    • (1999) J Virol , vol.73 , Issue.7 , pp. 5438-5447
    • Nakai, H.1    Iwaki, Y.2    Kay, M.A.3    Couto, L.B.4
  • 39
    • 0038054338 scopus 로고    scopus 로고
    • AAV serotype 2 vectors preferentially integrate into active genes in mice
    • Nakai H, Montini E, Fuess S, Storm TA, Grompe M, Kay MA: AAV serotype 2 vectors preferentially integrate into active genes in mice. Nat Genet (2003) 34(3):297-302.
    • (2003) Nat Genet , vol.34 , Issue.3 , pp. 297-302
    • Nakai, H.1    Montini, E.2    Fuess, S.3    Storm, T.A.4    Grompe, M.5    Kay, M.A.6
  • 40
    • 14744268153 scopus 로고    scopus 로고
    • Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver
    • Nakai H, Wu X, Fuess S, Storm TA, Munroe D, Montini E, Burgess SM, Grompe M, Kay MA: Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver. J Virol (2005) 79(6):3606-3614.
    • (2005) J Virol , vol.79 , Issue.6 , pp. 3606-3614
    • Nakai, H.1    Wu, X.2    Fuess, S.3    Storm, T.A.4    Munroe, D.5    Montini, E.6    Burgess, S.M.7    Grompe, M.8    Kay, M.A.9
  • 41
    • 68649098889 scopus 로고    scopus 로고
    • An analysis of 347 AAV vector:chromosome junctions from mouse livers provided definitive evidence for significant in vivo integration by AAV vectors. Integration site preferences were described and integration occurred preferentially in transcribed genes in this study
    • An analysis of 347 AAV vector:chromosome junctions from mouse livers provided definitive evidence for significant in vivo integration by AAV vectors. Integration site preferences were described and integration occurred preferentially in transcribed genes in this study.
  • 42
    • 35148872604 scopus 로고    scopus 로고
    • DNA palindromes with a modest arm length of greater, similar 20 base pairs are a significant target for recombinant adeno-associated virus vector integration in the liver, muscles, and heart in mice
    • Inagaki K, Lewis SM, Wu X, Ma C, Munroe DJ, Fuess S, Storm TA, Kay MA, Nakai H: DNA palindromes with a modest arm length of greater, similar 20 base pairs are a significant target for recombinant adeno-associated virus vector integration in the liver, muscles, and heart in mice. J Virol (2007) 81(20):11290-11303.
    • (2007) J Virol , vol.81 , Issue.20 , pp. 11290-11303
    • Inagaki, K.1    Lewis, S.M.2    Wu, X.3    Ma, C.4    Munroe, D.J.5    Fuess, S.6    Storm, T.A.7    Kay, M.A.8    Nakai, H.9
  • 43
    • 68649093898 scopus 로고    scopus 로고
    • Reported the isolation of multiple independent vector:chromosome junctions from different mouse tissues. An analysis of the integration sites showed that AAV vectors integrate near DNA palindromes. This was the first demonstration of integration in tissues other than the liver after vector delivery
    • Reported the isolation of multiple independent vector:chromosome junctions from different mouse tissues. An analysis of the integration sites showed that AAV vectors integrate near DNA palindromes. This was the first demonstration of integration in tissues other than the liver after vector delivery.
  • 45
    • 0346433831 scopus 로고    scopus 로고
    • Potential for germ line transmission after intramyocardial gene delivery by adeno-associated virus
    • Pachori AS, Melo LG, Zhang L, Loda M, Pratt RE, Dzau VJ: Potential for germ line transmission after intramyocardial gene delivery by adeno-associated virus. Biochem Biophys Res Commun (2004) 313(3):528-533.
    • (2004) Biochem Biophys Res Commun , vol.313 , Issue.3 , pp. 528-533
    • Pachori, A.S.1    Melo, L.G.2    Zhang, L.3    Loda, M.4    Pratt, R.E.5    Dzau, V.J.6
  • 46
    • 0031779697 scopus 로고    scopus 로고
    • Adeno-associated virus vector-mediated transgene integration into neurons and other nondividing cell targets
    • Wu P, Phillips MI, Bui J, Terwilliger EF: Adeno-associated virus vector-mediated transgene integration into neurons and other nondividing cell targets. J Virol (1998) 72(7):5919-5926.
    • (1998) J Virol , vol.72 , Issue.7 , pp. 5919-5926
    • Wu, P.1    Phillips, M.I.2    Bui, J.3    Terwilliger, E.F.4
  • 49
    • 0037841763 scopus 로고    scopus 로고
    • Transcription start regions in the human genome are favored targets for MLV integration
    • Wu X, Li Y, Crise B, Burgess SM: Transcription start regions in the human genome are favored targets for MLV integration. Science (2003) 300 (5626):1749-1751.
    • (2003) Science , vol.300 , Issue.5626 , pp. 1749-1751
    • Wu, X.1    Li, Y.2    Crise, B.3    Burgess, S.M.4
  • 50
    • 3042728872 scopus 로고    scopus 로고
    • Adeno-associated virus vectors integrate at chromosome breakage sites
    • Miller DG, Petek LM, Russell DW: Adeno-associated virus vectors integrate at chromosome breakage sites. Nat Genet (2004) 36(7):767-773.
    • (2004) Nat Genet , vol.36 , Issue.7 , pp. 767-773
    • Miller, D.G.1    Petek, L.M.2    Russell, D.W.3
  • 51
    • 68649111754 scopus 로고    scopus 로고
    • AAV vectors integrated at induced chromosome double-strand breaks. The sequences of vector proviruses in relation to the location of the doublestrand breaks were consistent with integration via the non-homologous end-joining repair pathway. This paper provided direct evidence that AAV vectors integrate at pre-existing chromosomal breaks
    • AAV vectors integrated at induced chromosome double-strand breaks. The sequences of vector proviruses in relation to the location of the doublestrand breaks were consistent with integration via the non-homologous end-joining repair pathway. This paper provided direct evidence that AAV vectors integrate at pre-existing chromosomal breaks.
  • 52
    • 0031668970 scopus 로고    scopus 로고
    • Transition mutations at CpG dinucleotides are the most frequent in vivo spontaneous single-based substitution mutation in the human HPRT gene
    • O'Neill JP, Finette BA: Transition mutations at CpG dinucleotides are the most frequent in vivo spontaneous single-based substitution mutation in the human HPRT gene. Environ Mol Mutagen (1998) 32(2):188-191.
    • (1998) Environ Mol Mutagen , vol.32 , Issue.2 , pp. 188-191
    • O'Neill, J.P.1    Finette, B.A.2
  • 53
    • 0025266610 scopus 로고
    • Alternative chromatin structure at CpG islands
    • Tazi J, Bird A: Alternative chromatin structure at CpG islands. Cell (1990) 60(6):909-920.
    • (1990) Cell , vol.60 , Issue.6 , pp. 909-920
    • Tazi, J.1    Bird, A.2
  • 54
    • 0021996682 scopus 로고
    • Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes
    • Wolf SF, Migeon BR: Clusters of CpG dinucleotides implicated by nuclease hypersensitivity as control elements of housekeeping genes. Nature (1985) 314 (6010):467-469.
    • (1985) Nature , vol.314 , Issue.6010 , pp. 467-469
    • Wolf, S.F.1    Migeon, B.R.2
  • 55
    • 33747156656 scopus 로고    scopus 로고
    • Strategies to maintain the stability of the ribosomal RNA gene repeats - Collaboration of recombination, cohesion, and condensation
    • Kobayashi T: Strategies to maintain the stability of the ribosomal RNA gene repeats - Collaboration of recombination, cohesion, and condensation. Genes Genet Syst (2006) 81(3):155-161.
    • (2006) Genes Genet Syst , vol.81 , Issue.3 , pp. 155-161
    • Kobayashi, T.1
  • 56
    • 33745373606 scopus 로고    scopus 로고
    • Primate segmental duplications: Crucibles of evolution, diversity and disease
    • Bailey JA, Eichler EE: Primate segmental duplications: Crucibles of evolution, diversity and disease. Nat Rev Genet (2006) 7(7):552-564.
    • (2006) Nat Rev Genet , vol.7 , Issue.7 , pp. 552-564
    • Bailey, J.A.1    Eichler, E.E.2
  • 57
    • 1842526843 scopus 로고    scopus 로고
    • Implications of human genome architecture for rearrangement-based disorders: The genomic basis of disease
    • Shaw CJ, Lupski JR: Implications of human genome architecture for rearrangement-based disorders: The genomic basis of disease. Hum Mol Genet (2004) 13 (Suppl 1) :R57-R64.
    • (2004) Hum Mol Genet , vol.13 , Issue.SUPPL. 1
    • Shaw, C.J.1    Lupski, J.R.2
  • 58
    • 0036469913 scopus 로고    scopus 로고
    • The connection between transcription and genomic instability
    • Aguilera A: The connection between transcription and genomic instability. EMBO J (2002) 21(3):195-201.
    • (2002) EMBO J , vol.21 , Issue.3 , pp. 195-201
    • Aguilera, A.1
  • 60
    • 41149139448 scopus 로고    scopus 로고
    • AAV vectors do not increase the risk of tumor formation in p53 deficient models
    • Schuettrumpf J, Baila S, Khazi F, Liu JH, Bunte R, Arruda V: AAV vectors do not increase the risk of tumor formation in p53 deficient models. Mol Ther (2007) 15 (Suppl 1) :S1.
    • (2007) Mol Ther , vol.15 , Issue.SUPPL. 1
    • Schuettrumpf, J.1    Baila, S.2    Khazi, F.3    Liu, J.H.4    Bunte, R.5    Arruda, V.6
  • 61
    • 34548792469 scopus 로고    scopus 로고
    • Long term portal vein administration of AAV-WPRE vector results in increased incidence of neoplastic disease and hepatic pathology
    • Abs 216
    • Embury JE, Charron CC, Poirier AE, Zori A, Carmichael R, Flotte TR, Laipis PJ: Long term portal vein administration of AAV-WPRE vector results in increased incidence of neoplastic disease and hepatic pathology. Mol Ther (2006) 13 (Suppl 1) :Abs 216.
    • (2006) Mol Ther , vol.13 , Issue.SUPPL. 1
    • Embury, J.E.1    Charron, C.C.2    Poirier, A.E.3    Zori, A.4    Carmichael, R.5    Flotte, T.R.6    Laipis, P.J.7
  • 66
    • 68649108280 scopus 로고    scopus 로고
    • Newborn mice injected with an AAV vector developed hepatocellular carcinoma. The region of chromosome 12 where the four integrated proviruses were observed in tumors contains multiple maternally and paternally imprinted genes. Microarray analysis showed upregulation of nearby transcripts. These data provide compelling evidence that AAV integration can be associated with tumorigenesis.
    • Newborn mice injected with an AAV vector developed hepatocellular carcinoma. The region of chromosome 12 where the four integrated proviruses were observed in tumors contains multiple maternally and paternally imprinted genes. Microarray analysis showed upregulation of nearby transcripts. These data provide compelling evidence that AAV integration can be associated with tumorigenesis.
  • 68
    • 37549069296 scopus 로고    scopus 로고
    • Gene targeting of mutant COL1A2 alleles in mesenchymal stem cells from individuals with osteogenesis imperfecta
    • Chamberlain JR, Deyle DR, Schwarze U, Wang P, Hirata RK, Li Y, Byers PH, Russell DW: Gene targeting of mutant COL1A2 alleles in mesenchymal stem cells from individuals with osteogenesis imperfecta. Mol Ther (2008) 16(1):187-193.
    • (2008) Mol Ther , vol.16 , Issue.1 , pp. 187-193
    • Chamberlain, J.R.1    Deyle, D.R.2    Schwarze, U.3    Wang, P.4    Hirata, R.K.5    Li, Y.6    Byers, P.H.7    Russell, D.W.8
  • 70
    • 68649101349 scopus 로고    scopus 로고
    • Mesenchymal stem cells from patients with osteogenesis imperfecta were infected with an AAV gene-targeting vector designed to disrupt the COL1A1 gene. After selection, Southern blot analysis demonstrated that 31 to 90% of cells were targeted at the COL1A1 gene. This was the first demonstration of gene targeting in adult human stem cells
    • Mesenchymal stem cells from patients with osteogenesis imperfecta were infected with an AAV gene-targeting vector designed to disrupt the COL1A1 gene. After selection, Southern blot analysis demonstrated that 31 to 90% of cells were targeted at the COL1A1 gene. This was the first demonstration of gene targeting in adult human stem cells.
  • 71
    • 0034991469 scopus 로고    scopus 로고
    • Introduction of single base substitutions at homologous chromosomal sequences by adeno-associated virus vectors
    • Inoue N, Dong R, Hirata RK, Russell DW: Introduction of single base substitutions at homologous chromosomal sequences by adeno-associated virus vectors. Mol Ther (2001) 3(4):526-530.
    • (2001) Mol Ther , vol.3 , Issue.4 , pp. 526-530
    • Inoue, N.1    Dong, R.2    Hirata, R.K.3    Russell, D.W.4
  • 72
    • 0032874343 scopus 로고    scopus 로고
    • High-fidelity correction of mutations at multiple chromosomal positions by adenoassociated virus vectors
    • Inoue N, Hirata RK, Russell DW: High-fidelity correction of mutations at multiple chromosomal positions by adenoassociated virus vectors. J Virol (1999) 73(9):7376-7380.
    • (1999) J Virol , vol.73 , Issue.9 , pp. 7376-7380
    • Inoue, N.1    Hirata, R.K.2    Russell, D.W.3
  • 73
    • 17444434208 scopus 로고    scopus 로고
    • Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses
    • Kohli M, Rago C, Lengauer C, Kinzler KW, Vogelstein B: Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses. Nucleic Acids Res (2004) 32(1) :e3.
    • (2004) Nucleic Acids Res , vol.32 , Issue.1
    • Kohli, M.1    Rago, C.2    Lengauer, C.3    Kinzler, K.W.4    Vogelstein, B.5
  • 74
    • 0345599102 scopus 로고    scopus 로고
    • Chromosomal integration and homologous gene targeting by replication-incompetent vectors based on the autonomous parvovirus minute virus of mice
    • Hendrie PC, Hirata RK, Russell DW: Chromosomal integration and homologous gene targeting by replication-incompetent vectors based on the autonomous parvovirus minute virus of mice. J Virol (2003) 77(24):13136-13145.
    • (2003) J Virol , vol.77 , Issue.24 , pp. 13136-13145
    • Hendrie, P.C.1    Hirata, R.K.2    Russell, D.W.3
  • 75
    • 0038076102 scopus 로고    scopus 로고
    • Human gene targeting by adenoassociated virus vectors is enhanced by DNA double-strand breaks
    • Miller DG, Petek LM, Russell DW: Human gene targeting by adenoassociated virus vectors is enhanced by DNA double-strand breaks. Mol Cell Biol (2003) 23(10):3550-3557.
    • (2003) Mol Cell Biol , vol.23 , Issue.10 , pp. 3550-3557
    • Miller, D.G.1    Petek, L.M.2    Russell, D.W.3
  • 76
    • 0037627488 scopus 로고    scopus 로고
    • Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks
    • Porteus MH, Cathomen T, Weitzman MD, Baltimore D: Efficient gene targeting mediated by adeno-associated virus and DNA double-strand breaks. Mol Cell Biol (2003) 23(10):3558-3565.
    • (2003) Mol Cell Biol , vol.23 , Issue.10 , pp. 3558-3565
    • Porteus, M.H.1    Cathomen, T.2    Weitzman, M.D.3    Baltimore, D.4
  • 77
    • 33746198006 scopus 로고    scopus 로고
    • Homologous recombination is required for AAV-mediated gene targeting
    • Vasileva A, Linden RM, Jessberger R: Homologous recombination is required for AAV-mediated gene targeting. Nucleic Acids Res (2006) 34(11):3345-3360.
    • (2006) Nucleic Acids Res , vol.34 , Issue.11 , pp. 3345-3360
    • Vasileva, A.1    Linden, R.M.2    Jessberger, R.3
  • 78
    • 68649090373 scopus 로고    scopus 로고
    • The reduction of the non-homologous end-joining DNA-dependent protein kinase catalytic subunit by RNAi had no effect on gene targeting, while the reduction of homologous recombination proteins RAD54B, RAD54L and XRCC3 decreased or eliminated vector targeting. These results demonstrate which homologous recombination proteins are involved in targeting and a strategy for determining the cellular mechanisms involved
    • The reduction of the non-homologous end-joining DNA-dependent protein kinase catalytic subunit by RNAi had no effect on gene targeting, while the reduction of homologous recombination proteins RAD54B, RAD54L and XRCC3 decreased or eliminated vector targeting. These results demonstrate which homologous recombination proteins are involved in targeting and a strategy for determining the cellular mechanisms involved.
  • 79
    • 34247332735 scopus 로고    scopus 로고
    • Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation
    • Hurley PJ, Wilsker D, Bunz F: Human cancer cells require ATR for cell cycle progression following exposure to ionizing radiation. Oncogene (2006) 26(18):2535-2542.
    • (2006) Oncogene , vol.26 , Issue.18 , pp. 2535-2542
    • Hurley, P.J.1    Wilsker, D.2    Bunz, F.3
  • 80
    • 34247211554 scopus 로고    scopus 로고
    • The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage
    • Wang P, Yu J, Zhang L: The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage. Proc Natl Acad Sci USA (2007) 104(10):4054-4059.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.10 , pp. 4054-4059
    • Wang, P.1    Yu, J.2    Zhang, L.3
  • 81
    • 34548735435 scopus 로고    scopus 로고
    • Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers
    • Arena S, Isella C, Martini M, de Marco A, Medico E, Bardelli A: Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers. Cancer Res (2007) 67(18):8468-8476.
    • (2007) Cancer Res , vol.67 , Issue.18 , pp. 8468-8476
    • Arena, S.1    Isella, C.2    Martini, M.3    de Marco, A.4    Medico, E.5    Bardelli, A.6
  • 84
    • 68649084130 scopus 로고    scopus 로고
    • AAV vectors were used to knockout both alleles of the HAUSP gene in human cells by homologous recombination. This study demonstrated that AAV-mediated gene targeting can be a powerful technique for human somatic cell genetics, and that double knockouts can be produced in human cells to determine gene function
    • AAV vectors were used to knockout both alleles of the HAUSP gene in human cells by homologous recombination. This study demonstrated that AAV-mediated gene targeting can be a powerful technique for human somatic cell genetics, and that double knockouts can be produced in human cells to determine gene function.
  • 85
    • 33846160505 scopus 로고    scopus 로고
    • Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA
    • Kim J-S, Lee C, Bonifant CL, Ressom H, Waldman T: Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA. Mol Cell Biol (2007) 27(2): 662-677.
    • (2007) Mol Cell Biol , vol.27 , Issue.2 , pp. 662-677
    • Kim, J.-S.1    Lee, C.2    Bonifant, C.L.3    Ressom, H.4    Waldman, T.5
  • 87
    • 33645743572 scopus 로고    scopus 로고
    • CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48
    • Dang LH, Chen F, Ying C, Chun SY, Knock SA, Appelman HD, Dang DT: CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48. Oncogene (2005) 25(15):2264-2272.
    • (2005) Oncogene , vol.25 , Issue.15 , pp. 2264-2272
    • Dang, L.H.1    Chen, F.2    Ying, C.3    Chun, S.Y.4    Knock, S.A.5    Appelman, H.D.6    Dang, D.T.7
  • 88
    • 32944477859 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1α promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts
    • Dang DT, Chen F, Gardner LB, Cummins JM, Rago C, Bunz F, Kantsevoy SV, Dang LH: Hypoxia-inducible factor-1α promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts. Cancer Res (2006) 66(3):1684-1693.
    • (2006) Cancer Res , vol.66 , Issue.3 , pp. 1684-1693
    • Dang, D.T.1    Chen, F.2    Gardner, L.B.3    Cummins, J.M.4    Rago, C.5    Bunz, F.6    Kantsevoy, S.V.7    Dang, L.H.8
  • 89
    • 33646814635 scopus 로고    scopus 로고
    • Targeted deletion of MKK4 in cancer cells: A detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss
    • Cunningham SC, Gallmeier E, Hucl T, Dezentje DA, Calhoun ES, Falco G, Abdelmohsen K, Gorospe M, Kern SE: Targeted deletion of MKK4 in cancer cells: A detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss. Cancer Res (2006) 66(11):5560-5564.
    • (2006) Cancer Res , vol.66 , Issue.11 , pp. 5560-5564
    • Cunningham, S.C.1    Gallmeier, E.2    Hucl, T.3    Dezentje, D.A.4    Calhoun, E.S.5    Falco, G.6    Abdelmohsen, K.7    Gorospe, M.8    Kern, S.E.9
  • 90
    • 27144492939 scopus 로고    scopus 로고
    • Glutathione S-transferase π1 promotes tumorigenicity in HCT116 human colon cancer cells
    • Dang DT, Chen F, Kohli M, Rago C, Cummins JM, Dang LH: Glutathione S-transferase π1 promotes tumorigenicity in HCT116 human colon cancer cells. Cancer Res (2005) 65(20):9485-9494.
    • (2005) Cancer Res , vol.65 , Issue.20 , pp. 9485-9494
    • Dang, D.T.1    Chen, F.2    Kohli, M.3    Rago, C.4    Cummins, J.M.5    Dang, L.H.6
  • 91
    • 2342615480 scopus 로고    scopus 로고
    • X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells
    • Cummins JM, Kohli M, Rago C, Kinzler KW, Vogelstein B, Bunz F: X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells. Cancer Res (2004) 64(9):3006-3008.
    • (2004) Cancer Res , vol.64 , Issue.9 , pp. 3006-3008
    • Cummins, J.M.1    Kohli, M.2    Rago, C.3    Kinzler, K.W.4    Vogelstein, B.5    Bunz, F.6
  • 93
    • 68649100101 scopus 로고    scopus 로고
    • In vivo correction of a metabolic liver disease by AAV8-mediated homologous recombination
    • Abs 804
    • Wursthorn K, Storm T, Kay MA, Finegold M, Grompe M: In vivo correction of a metabolic liver disease by AAV8-mediated homologous recombination. Mol Ther (2006) 13 (Suppl 1): Abs 804.
    • (2006) Mol Ther , vol.13 , Issue.SUPPL. 1
    • Wursthorn, K.1    Storm, T.2    Kay, M.A.3    Finegold, M.4    Grompe, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.