CpG methylation of a plasmid vector results in extended transgene product expression by circumventing induction of immune responses

Molecular Therapy

Volumn 9, Issue 2, 2004, Pages 249-261

  Reyes Sandoval, A ^a,b   Ertl, H C J ^a  

^a WISTAR INSTITUTE   (United States)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

CpG motifs; Gene transfer; Plasmid expression vectors; Tolerance

Indexed keywords

BACTERIAL DNA; GENE PRODUCT; LIPOFECTAMINE; PLASMID DNA; PLASMID VECTOR; VIRUS GLYCOPROTEIN; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANTIGEN RECOGNITION; ARTICLE; B LYMPHOCYTE ACTIVATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA SEQUENCE; EXPRESSION VECTOR; FEMALE; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; HOST; IMMUNE SYSTEM; IMMUNOGENICITY; IMMUNOSTIMULATION; INFLAMMATION; INOCULATION; NONHUMAN; RABIES VIRUS; T LYMPHOCYTE ACTIVATION; TRANSGENE;

BACTERIA (MICROORGANISMS); RABIES VIRUS; VECTORS;

EID: 1342332864     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2003.11.008     Document Type: Article

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