Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides

Molecular Therapy

Volumn 10, Issue 2, 2004, Pages 269-278

  Hodges, Bradley L ^a   Taylor, Kristin M ^a   Joseph, Macy F ^a   Bourgeois, Sarah A ^a   Scheule, Ronald K ^a  

^a GENZYME CORPORATION   (United States)

Author keywords

Gene therapy; Hemophilia; Hydrodynamics based; Lysosomal storage disease; Methylation; Naked DNA

Indexed keywords

ALPHA GALACTOSIDASE; BLOOD CLOTTING FACTOR 9; DINUCLEOTIDE; GENE PRODUCT; METHYL CPG BINDING PROTEIN; PLASMID DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DNA SUPERCOILING; FABRY DISEASE; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE VECTOR; HEMOPHILIA B; HYDRODYNAMICS; IMMUNE RESPONSE; LIVER; LYSOSOME STORAGE DISEASE; MEDICAL DECISION MAKING; MOUSE; MOUSE STRAIN; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; TRANSGENE;

ALPHA-GALACTOSIDASE; ANIMALS; CPG ISLANDS; CYTOMEGALOVIRUS; DNA METHYLATION; DNA, SUPERHELICAL; FACTOR IX; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HEMOPHILIA A; HUMANS; LIVER; LYSOSOMAL STORAGE DISEASES; MICE; PLASMIDS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; TRANSDUCTION, GENETIC; TRANSGENES;

CUCUMBER MOSAIC VIRUS;

EID: 4344700911     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.04.018     Document Type: Article

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