Toxicology of nanomaterials used in nanomedicine

Journal of Toxicology and Environmental Health - Part B: Critical Reviews

Volumn 14, Issue 8, 2011, Pages 593-632

  Zhao, Jinshun ^a   Castranova, Vincent ^b  

^a NINGBO UNIVERSITY   (China)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM OXIDE; CARBON BLACK NANOPARTICLE; CARBON NANOTUBE; CERIUM OXIDE; CHITOSAN; COBALT; COPPER OXIDE; FULLERENE DERIVATIVE; GOLD NANOPARTICLE; MULTI WALLED NANOTUBE; NANOCARRIER; NANOCERAMIC; NANOCOMPOSITE; NANOFIBER; NANOMATERIAL; NANOPARTICLE; NANOROD; NANOSCROLL; NANOTUBE; NANOWIRE; NICKEL NANOPARTICLE; PLATINUM; POLY N ISOPROPYLACRYLAMIDE; POLYMER; QUANTUM DOT; SILICON DIOXIDE NANOPARTICLE; SILVER NANOPARTICLE; SINGLE WALLED NANOTUBE; TITANIUM DIOXIDE; UNCLASSIFIED DRUG; ZINC OXIDE;

ACUTE TOXICITY; ADVERSE OUTCOME; CARCINOGENICITY; CHRONIC TOXICITY; DEVELOPMENTAL TOXICITY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG METABOLISM; GENOTOXICITY; HUMAN; MACROMOLECULE; NANOMEDICINE; NANOTECHNOLOGY; NONHUMAN; PHYSICAL CHEMISTRY; REPRODUCTIVE TOXICITY; REVIEW; TOXICITY;

ANIMALS; HUMANS; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; MOLECULAR TARGETED THERAPY; NANOMEDICINE; NANOSTRUCTURES; TOXICITY TESTS;

EID: 84862908877     PISSN: 10937404     EISSN: 15216950     Source Type: Journal    
DOI: 10.1080/10937404.2011.615113     Document Type: Review

References (251)

1. Ahamed, M., Karns, M., Goodson, M., Rowe, J., Hussain, S. M., Schlager, J. J., and Hong, Y. 2008. DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. Toxicol. Appl. Pharmacol. 233:404-10.
2. Ahamed, M., Siddiqui, M. A., Akhtar, M. J., Ahmad, I., Pant, A. B., and Alhadlaq, H. A. 2010. Genotoxic potential of copper oxide nanoparticles in human lung epithelial cells. Biochem. Biophys. Res. Commun. 396:578-83.
3. Albini, A., Mussi, V., Parodi, A., Ventura, A., Principi, E., Tegami, S., Rocchia, M., Francheschi, E., Sogno, I., Cammarota, R., Cammarota, R., Finzi, G., Sessa, F., Noonan, D. M., and Valbusa, U. 2010. Interactions of single-wall carbon nanotubes with endothelial cells. Nanomedicine 6:277-88.
4. Allen, T. M. 2002. Ligand-targeted therapeutics in anticancer therapy. Nat. Rev. Cancer 2:750-63. (Pubitemid 37328910)
5. Allen, T. M., and Cullis, P. R. 2004. Drug delivery systems: Entering the mainstream. Science 303:1818-22. (Pubitemid 38374867)
6. Applerot, G., Abu-Mukh, R., Irzh, A., Charmet, J., Keppner, H., Laux, E., Guibert, G., and Gedanken, A. 2010. Decorating parylenecoated glass with ZnO nanoparticles for antibacterial applications: A comparative study of sonochemical, microwave, and microwave-plasma coating routes. ACS Appl. Mater. Interfaces 2:1052-59.
7. Asharani, P. V., Lianwu, Y., Gong, Z., and Valiyaveettil, S. 2011. Comparison of the toxicity of silver, gold and platinum nanoparticles in developing zebrafish embryos. Nanotoxicology 5:43-54.
8. Asharani, P. V., Low Kah Mun, G., Hande, M. P., and Valiyaveettil, S. 2009. Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano 3:279-90.
9. Asharani, P. V., Xinyi, N., Hande, M. P., and Valiyaveettil, S. 2010. DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles. Nanomedicine (Lond.) 5:51-64.
10. Baan, R. A. 2007. Carcinogenic hazards from inhaled carbon black, titanium dioxide, and talc not containing asbestos or asbestiform fibers: Recent evaluations by an IARC Monographs Working Group. Inhal. Toxicol. 19 (suppl. 1) : 213-28. (Pubitemid 47450711)
11. Ballou, B., Lagerholm, B. C., Ernst, L. A., Bruchez, M. P., and Waggoner, A. S. 2004. Noninvasive imaging of quantum dots in mice. Bioconj. Chem. 15:79-86. (Pubitemid 38165983)
12. Barillet, S., Jugan, M. L., Laye, M., Leconte, Y., Herlin-Boime, N., Reynaud, C., and Carriere, M. 2010. In vitro evaluation of SiC nanoparticles impact on A549 pulmonary cells: Cyto-, genotoxicity and oxidative stress. Toxicol. Lett. 198:324-30.
13. Barnes, C. A., Elsaesser, A., Arkusz, J., Smok, A., Palus, J., Lesniak, A., Salvati, A., Hanrahan, J. P., Jong, W. H., Dziubaltowska, E., Stepnik, M., Rydzynski, K., McKerr, G., Lynch, I, Dawson, K. A., and Howard, C. V. 2008. Reproducible comet assay of amorphous silica nanoparticles detects no genotoxicity. Nano Lett. 8:3069-74.
14. Barrett, E. G., Johnston, C., Oberdorster, G., and Finkelstein, J. N. 1999. Silica binds serum proteins resulting in a shift of the dose-response for silica-induced chemokine expression in an alveolar type II cell line. Toxicol. Appl. Pharmacol. 161:111-22.
15. Bhattacharya, K., Cramer, H., Albrecht, C., Schins, R., Rahman, Q., Zimmermann, U., and Dopp, E. 2008. Vanadium pentoxidecoated ultrafine titanium dioxide particles induce cellular damage and micronucleus formation in V79 cells. J. Toxicol. Environ. Health A 71:976-80. (Pubitemid 352000702)
16. Bhattacharya, K., Davoren, M., Boertz, J., Schins, R. P., Hoffmann, E., and Dopp, E. 2009. Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells. Part. Fibre Toxicol. 6:17.
17. Bottrill, M., Kwok, L., and Long, N. J. 2006. Lanthanides in magnetic resonance imaging. Chem. Soc. Rev. 35:557-71. (Pubitemid 43815289)
18. Braydich-Stolle, L., Hussain, S., Schlager, J. J., and Hofmann, M. C. 2005. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicol. Sci. 88:412-19. (Pubitemid 41672149)
19. Brooking, J., Davis, S. S., and Illum, L. 2001. Transport of nanoparticles across the rat nasal mucosa. J. Drug Target 9:267-79. (Pubitemid 32776362)
20. Campolongo, M. J., Tan, S. J., Xu, J., and Luo, D. 2010. DNA nanomedicine: Engineering DNA as a polymer for therapeutic and diagnostic applications. Adv. Drug Deliv. Rev. 62:606-16.
21. Casey, A., Herzog, E., Lyng, F. M., Byrne, H. J., Chambers, G., and Davoren, M. 2008. Single walled carbon nanotubes induce indirect cytotoxicity by medium depletion in A549 lung cells. Toxicol. Lett. 179:78-84.
22. Castranova, V., Porter, D, Millecchia, L, Ma, J. Y. C., Hubbs, A. F., and Teass, A. (2002). Effect of inhaled crystalline silica in a rat model: Time course of pulmonary reactions. Mol. Cell Biochem. 234/235:177-84. (Pubitemid 34777855)
23. Castranova, V., Vallyathan, V., and Wallace, W. E. 1996. Silica and silica-induced lung diseases. Boca Raton, FL: CRC Press.
24. Castranova, V., and Vallyathan, V. 2000. Silicosis and coal workers' pneumeconiosis. Environ. Health Perspect. 108 (suppl 4) : 675-84.
25. Chen, H. H., Yu, C., Ueng, T. H., Chen, S., Chen, B. J., Huang, K. J., and Chiang, L. Y. 1998. Acute and subacute toxicity study of water-soluble polyalkylsulfonated C60 in rats. Toxicol. Pathol. 26:143-51. (Pubitemid 28100699)
26. Chen, H. Q., Luo, F. B., Liu, Y., Liang, A. N., Lin, B., and Wang, L. 2009a. Application of functional CdS nanoparticles in determination of silver ion by resonance light-scattering technique. Spectrochim. Acta A Mol. Biomol. Spectrosc. 71:1701-3.
27. Chen, J., Dong, X., Xin, Y., and Zhao, M. 2011. Effects of titanium dioxide nanoparticles on growth and some histological parameters of zebrafish (Danio rerio) after a long-term exposure. Aquat. Toxicol. 101:493-99.
28. Chen, J. K., Shih, M. H., Peir, J. J., Liu, C. H., Chou, F. I., Lai, W. H., Chang, L. W., Lin, P., Wang, M. Y., Yang, M. H., and Yang, C. S. 2010. The use of radioactive zinc oxide nanoparticles in determination of their tissue concentrations following intravenous administration in mice. Analyst 135:1742-46.
29. Chen, X., and Schluesener, H. J. 2008. Nanosilver: A nanoproduct in medical application. Toxicol. Lett. 176:1-12. (Pubitemid 350251066)
30. Chen, Y. S., Hung, Y. C., Liau, I., and Huang, G. S. 2009b. Assessment of the in vivo toxicity of gold nanoparticles. Nanoscale Res. Lett. 4:858-64.
31. Cheng, J., Flahaut, E., and Cheng, S. H. 2007. Effect of carbon nanotubes on developing zebrafish (Danio rerio) embryos. Environ. Toxicol. Chem. 26:708-16. (Pubitemid 46663271)
32. Cheung, W., Pontoriero, F., Taratula, O., Chen, A. M., and He, H. 2010. DNA and carbon nanotubes as medicine. Adv. Drug Deliv. Rev. 62:633-49.
33. Cho, M., Cho, W. S., Choi, M., Kim, S. J., Han, B. S., Kim, S. H., Kim, H. O., Sheen, Y. Y., and Jeong, J. 2009a. The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles. Toxicol. Lett. 189:177-83.
34. Cho, W. S., Cho, M., Jeong, J., Choi, M., Cho, H. Y., Han, B. S., Kim, S. H., Kim, H. O., Lim, Y. T., and Chung, B. H. 2009b. Acute toxicity and pharmacokinetics of 13 nm-sized PEG-coated gold nanoparticles. Toxicol. Appl. Pharmacol. 236:16-24.
35. Choksi, A. N., Poonawalla, T., and Wilkerson, M. G. 2010. Nanoparticles: A closer look at their dermal effects. J. Drugs Dermatol. 9:475-81.
36. 2 in a tracheal explant system. Am. J. Physiol 274:L81-L86.
37. Colognato, R., Bonelli, A., Ponti, J., Farina, M., Bergamaschi, E., Sabbioni, E., and Migliore, L. 2008. Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro. Mutagenesis 23:377-82.
38. Coyle, P., Philcox, J. C., Carey, L. C., and Rofe, A. M. 2002. Metallothionein: the multipurpose protein. Cell. Mol. Life Sci. 59:627-47. (Pubitemid 34460681)
39. Dasenbrock, C., Peters, L., Creutzenberg, O., and Heinrich, U. 1996. The carcinogenic potency of carbon particles with and without PAH after repeated intratracheal administration in the rat. Toxicol. Lett. 88:15-21. (Pubitemid 26361242)
40. de Lima, R., Feitosa, L., Pereira, A. D., de Moura, M. R., Aouada, F. A., Mattoso, L. H., and Fraceto, L. F. 2010. Evaluation of the genotoxicity of Chitosan nanoparticles for use in food packaging films. J. Food Sci. 75:N89-N96.
41. De Nicola, M., Nuccitelli, S., Gattia, D. M., Traversa, E., Magrini, A., Bergamaschi, A., and Ghibelli, L. 2009. Effects of carbon nanotubes on human monocytes. Ann. NY Acad. Sci. 1171:600-5.
42. Desai, M. P., Labhasetwar, V., Amidon, G. L., and Levy, R. J. 1996. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm. Res. 13:1838-45. (Pubitemid 27034116)
43. Dhawan, A., Taurozzi, J. S., Pandey, A. K., Shan, W., Miller, S. M., Hashsham, S. A., and Tarabara, V. V. 2006. Stable colloidal dispersions of C60 fullerenes in water: evidence for genotoxicity. Environ. Sci. Technol. 40:7394-401. (Pubitemid 44871853)
44. Di Virgilio, A. L., Reigosa, M., Arnal, P. M., and Fernandez Lorenzo de Mele, M. 2010. Comparative study of the cytotoxic and genotoxic effects of titanium oxide and aluminium oxide nanoparticles in Chinese hamster ovary (CHO-K1) cells. J. Hazard. Mater. 177:711-18.
45. Dominic, F., McDermott, A., Daniels, M., Zeger, S. L, and Samet, J. M. 2005. Revised analysis of the national mortality, morbidity and air pollution study: Mortality among residents of 90 cities. J. Toxicol. Environ. Health A 68:1071-92. (Pubitemid 41806199)
46. Donaldson, K., Stone, V., Clouter, A., Renwick, L., and MacNee, W. 2001. Ultrafine particles. Occup. Environ. Med. 58:211-16.
47. Driscoll, K. E., Costa, D. L., Hatch, G., Henderson, R., Oberdorster, G., Salem, H., and Schlesinger, R. B. 2000. Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: Uses and limitations. Toxicol. Sci. 55:24-35. (Pubitemid 30252432)
48. Driscoll, K. E., and Guthrie, G. D. 1997. Crystalline silica and silicosis. In Comprehensive toxicology, Vol. 8, Toxicology of the respiratory system, ed. G. Sipes, C. A. Mc Queen, and A. J. Gandolf, vol. ed. R. A. Roth, 373-391. New York: Pergamon.
49. Dror, I., Baram, D., and Berkowitz, B. 2005. Use of nanosized catalysts for transformation of chloro-organic pollutants. Environ. Sci. Technol. 39:1283-90.
50. Ema, M., Kobayashi, N., Naya, M., Hanai, S., and Nakanishi, J. 2010. Reproductive and developmental toxicity studies of manufactured nanomaterials. Reprod. Toxicol. 30:343-52.
51. 2. Hum. Exp. Toxicol. 28:339-52.
52. Fenske, D. B., MacLachlan, I., and Cullis, P. R. 2001. Long-circulating vectors for the systemic delivery of genes. Curr. Opin. Mol. Ther. 3:153-58. (Pubitemid 32390243)
53. Firme, C. P. 3rd, and Bandaru, P. R. 2010. Toxicity issues in the application of carbon nanotubes to biological systems. Nanomedicine 6:245-56.
54. Florence, A. T. 1997. The oral absorption of micro-and nanoparticulates: neither exceptional nor unusual. Pharm. Res. 14:259-66. (Pubitemid 27160935)
55. Foldvari, M., and Bagonluri, M. 2008. Carbon nanotubes as functional excipients for nanomedicines: II. Drug delivery and biocompatibility issues. Nanomedicine 4:183-200.
56. Folkmann, J. K., Risom, L., Jacobsen, N. R., Wallin, H., Loft, S., and Moller, P. 2009. Oxidatively damaged DNA in rats exposed by oral gavage to C60 fullerenes and singlewalled carbon nanotubes. Environ. Health Perspect. 117:703-8.
57. Foundation, E. E. S. 2004. Nanomedicine, An ESF-European Medical Research Councils (EMRC) forward look report. Strasbourg Cedex, France: ESF.
58. Galagudza, M. M., Korolev, D. V., Sonin, D. L., Postnov, V. N., Papayan, G. V., Uskov, I. S., Belozertseva, A. V., and Shlyakhto, E. V. 2010. Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: Surface functionalization, natural biodistribution, and acute toxicity. Int. J. Nanomedicine 5:231-37.
59. Gamer, A. O., Leibold, E., and van Ravenzwaay, B. 2006. The in vitro absorption of microfine zinc oxide and titanium dioxide through porcine skin. Toxicol. In Vitro 20:301-7. (Pubitemid 43343759)
60. Geiser, M., Rothen-Rutishauser, B., Kapp, N., Schurch, S., Kreyling, W., Schulz, H., Semmler, M., Im Hof, V., Heyder, J., and Gehr, P. 2005. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ. Health Perspect. 113:1555-60. (Pubitemid 41614911)
61. Gharbi, N., Pressac, M., Hadchouel, M., Szwarc, H., Wilson, S. R., and Moussa, F. 2005. [60]Fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity. Nano Lett. 5:2578-85. (Pubitemid 43088916)
62. Goldberg, M. S., Burnett, R. T., Bailar, J. C. III, Tamblyn, R., Ernst, R., Flegel, K., Brook, J., Bonvalot, J., Singh, R., Valois, M. F., and Vincent, R. 2001. Identification of persons with cardiorespiratory conditions who are at risk of dying from the acute effects of ambient air particles. Environ. Health Perspect. 109 (suppl. 4) : 487-94. (Pubitemid 32834559)
63. Goodman, C. M., McCusker, C. D., Yilmaz, T., and Rotello, V. M. 2004. Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconj. Chem. 15:897-900. (Pubitemid 38981966)
64. Gref, R., Minamitake, Y., Peracchia, M. T., Trubetskoy, V., Torchilin, V., and Langer, R. 1994. Biodegradable long-circulating polymeric nanospheres. Science 263:1600-3. (Pubitemid 24128361)
65. Grose, M., Sakurai, H., Savstrom, J., Stolzenburg, M. R., Watts, W. F., Jr., Morgan, C. G., Murray, I. P., Twigg, M. V., Kittelson, D. B., and McMurry, P. H. 2006. Chemical and physical properties of ultrafine diesel exhaust particles sampled downstream of a catalytic trap. Environ. Sci. Technol. 40:5502-7. (Pubitemid 44373119)
66. Gulson, B., McCall, M., Korsch, M., Gomez, L., Casey, P., Oytam, Y., Taylor, A., McCulloch, M., Trotter, J., Kinsley, L., and Greenoak, G. 2010. Small amounts of zinc from zinc oxide particles in sunscreens applied outdoors are absorbed through human skin. Toxicol. Sci. 118:140-49.
67. Gulumian, M., and Vallyathan, V. 2010. Nanoparticles and potential human health implications: Past and future directions. Preface. J. Toxicol. Environ. Health A 73:339-40.
68. Hackenberg, S., Friehs, G., Froelich, K., Ginzkey, C., Koehler, C., Scherzed, A., Burghartz, M., Hagen, R., and Kleinsasser, N. 2010. Intracellular distribution, geno-and cytotoxic effects of nanosized titanium dioxide particles in the anatase crystal phase on human nasal mucosa cells. Toxicol. Lett. 195:9-14.
69. Hagens, W. I., Oomen, A. G., de Jong, W. H., Cassee, F. R., and Sips, A. J. 2007. What do we (need to) know about the kinetic properties of nanoparticles in the body? Regul. Toxicol. Pharmacol. 49:217-29. (Pubitemid 350087396)
70. Han, S. G., Andrews, R., and Gairola, C. G. 2010. Acute pulmonary response of mice to multi-wall carbon nanotubes. Inhal. Toxicol. 22:340-47.
71. Hardman, R. 2006. A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors. Environ. Health Perspect. 114:165-72. (Pubitemid 43193634)
72. Heinrich, U. F. R., Rittinghausen, S., Creutzenberg, O., Bellmann, B., Koch, W., and Levsen, K. 1995. Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide. Inhal. Toxicol. 7:533-56.
73. Hillyer, J. F., and Albrecht, R. M. 2001. Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J. Pharm. Sci. 90:1927-36. (Pubitemid 33144438)
74. Ho, D., Garcia, D., and Ho, C. M. 2006. Nanomanufacturing and characterization modalities for bio-nano-informatics systems. J. Nanosci. Nanotechnol. 6:875-91. (Pubitemid 44578011)
75. Hoet, P. H., Bruske-Hohlfeld, I., and Salata, O. V. 2004. Nanoparticles-Known and unknown health risks. J. Nanobiotechnol. 2:12.
76. Hu, X., Cook, S., Wang, P., Hwang, H. M., Liu, X., and Williams, Q. L. 2010. In vitro evaluation of cytotoxicity of engineered carbon nanotubes in selected human cell lines. Sci. Total Environ. 408:1812-17.
77. 2 long-term exposure. Toxicol. Appl. Pharmacol. 241:182-94.
78. Hussain, N., Jaitley, V., and Florence, A. T. 2001. Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics. Adv. Drug Deliv. Rev. 50:107-42. (Pubitemid 32727279)
79. Inoue, K., Takano, H., Yanagisawa, R., Hirano, S., Sakurai, M., Shimada, A., and Yoshikawa, T. 2006. Effects of airway exposure to nanoparticles on lung inflammation induced by bacterial endotoxin in mice. Environ. Health Perspect. 114:1325-30. (Pubitemid 44314752)
80. Jacobsen, N. R., Moller, P., Jensen, K. A., Vogel, U., Ladefoged, O., Loft, S., and Wallin, H. 2009. Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/-mice. Part. Fibre Toxicol. 6:2.
81. Jacobsen, N. R., Pojana, G., White, P., Moller, P., Cohn, C. A., Korsholm, K. S., Vogel, U., Marcomini, A., Loft, S., and Wallin, H. 2008. Genotoxicity, cytotoxicity, and reactive oxygen species induced by single-walled carbon nanotubes and C (60) fullerenes in the FE1-Mutatrade markMouse lung epithelial cells. Environ. Mol. Mutagen. 49:476-87.
82. Janes, K. A., Fresneau, M. P., Marazuela, A., Fabra, A., and Alonso, M. J. 2001. Chitosan nanoparticles as delivery systems for doxorubicin. J. Controlled Release 73:255-67. (Pubitemid 32539254)
83. Jani, P., Halbert, G. W., Langridge, J., and Florence, A. T. 1990. Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency. J. Pharm. Pharmacol. 42:821-26.
84. Javier, D., Nitin, N., Roblye, D., and Richards-Kortumd, R. 2008. Metal-based nanorods as molecule-specific contrast agents for reflectance imaging in 3D tissues. Nanophotonics 2:23506.
85. Jin, Y., Kannan, S., Wu, M., and Zhao, J. X. 2007. Toxicity of luminescent silica nanoparticles to living cells. Chem. Res. Toxicol. 20:1126-33. (Pubitemid 47372991)
86. John, S., Marpu, S., Li, J., Omary, M., Hu, Z., Fujita, Y., and Neogi, A. 2010. Hybrid zinc oxide nanoparticles for biophotonics. J. Nanosci. Nanotechnol. 10:1707-12.
87. Kagan, V. E., Konduru, N. V., Feng, W., Allen, B. L., Conroy, J., Volkov, Y., Vlasova, II, Belikova, N. A., Yanamala, N., Kapralov, A., Tyurina, Y. Y., Shi, J., Kisin, E. R., Murray, A. R., Franks, J., Stolz, D., Gou, P., Klein-Seetharaman, J. Fadeel, B., Star, A., and Shvedova, A. A. 2010. Carbon nanotubes degraded by neutrophil myeloperoxidase induce less pulmonary inflammation. Nat. Nanotechnol. 5:354-59.
88. Kaida, T., Kobayashi, K., Adachi, M., and Suzuki, F. 2004. Optical characteristics of titanium oxide interference film and the film laminated with oxides and their applications for cosmetics. J. Cosmet. Sci. 55:219-20. (Pubitemid 38758804)
89. Kalita, S. J., Bhardwaja, A., and Bhatta, H. A. 2007. Nanocrystalline calcium phosphate ceramics in biomedical engineering. Mater. Sci. Eng. C 27:441-49. (Pubitemid 46281624)
90. Kang, S. J., Kim, B. M., Lee, Y. J., and Chung, H. W. 2008. Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes. Environ. Mol. Mutagen. 49:399-405.
91. Karlsson, H. L., Cronholm, P., Gustafsson, J., and Moller, L. 2008. Copper oxide nanoparticles are highly toxic: A comparison between metal oxide nanoparticles and carbon nanotubes. Chem. Res. Toxicol. 21:1726-32.
92. Karlsson, H. L., Gustafsson, J., Cronholm, P., and Moller, L. 2009. Size-dependent toxicity of metal oxide particles-A comparison between nano-and micrometer size. Toxicol. Lett. 188:112-18.
93. Katiyar, A., Yadav, S., Smirniotis, P. G., and Pinto, N. G. 2006. Synthesis of ordered large pore SBA-15 spherical particles for adsorption of biomolecules. J. Chromatogr. A 1122:13-20. (Pubitemid 44041353)
94. Kawata, K., Osawa, M., and Okabe, S. 2009. In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cells. Environ. Sci. Technol. 43:6046-51.
95. Ken, T., Ken-ichiro, S., Aki, I., Miyoko, K.-I., Rie, F., Masako, T., Shigeru, O., Yoshimasa, N., Tomomi, I., and Masao, S. 2009. Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems. Health Sci. 55:95-102.
96. 2 and ZnO nanoparticles to human lung cells. J. Nanosci. Nanotechnol. 10:3453-58.
97. Kim, S., Seong, K., Kim, O., Seo, H., Lee, M., Khang, G., and Lee, D. 2010b. Polyoxalate nanoparticles as a biodegradable and biocompatible drug delivery vehicle. Biomacromolecules 11:555-60.
98. Kim, J.-E., Lim, H.-T., Minai-Tehrani, A., Kwon, J.-T., Shin, J.-Y., Woo, C.-G., Choi, M., Back, J. Jeong, D. J., Ha, Y-C., Chae, C-H., Song, K.-S., Ahn, K.-H., Lee, J.-H., Sung, H.-J., Yu, I.-J., Beck, G. R, and Cho, M.-H. 2010c. Toxicity and clearence of intratracheally administrered multiwalled carbon nanotubes from muine lung. J. Toxicol Environ. Health A 73:1530-43.
99. Kim, W. Y., Kim, J., Park, J. D., Ryu, H. Y., and Yu, I. J. 2009. Histological study of gender differences in accumulation of silver nanoparticles in kidneys of Fischer 344 rats. J. Toxicol. Environ. Health A 72:1279-84.
100. Kim, Y. S., Kim, J. S., Cho, H. S., Rha, D. S., Kim, J. M., Park, J. D., Choi, B. S., Lim, R., Chang, H. K., Chung, Y. H., Kwon, I. H., Jeong, J., Han, B. S., and Yu, I. J. 2008. Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats. Inhal. Toxicol. 20:575-83. (Pubitemid 351601408)
101. Kisin, E. R., Murray, A. R., Keane, M. J., Shi, X. C., Schwegler-Berry, D., Gorelik, O., Arepalli, S., Castranova, V., Wallace, W. E., Kagan, V. E., and Shvedova, A. A. 2007. Single-walled carbon nanotubes: geno-and cytotoxic effects in lung fibroblast V79 cells. J. Toxicol. Environ. Health A 70:2071-79. (Pubitemid 350207578)
102. Kisin, E. R., Murray, A. R., Sargent, L., Lowry, D., Chirila, M., Siegrist, K. J., Schwegler-Berry, D., Leonard, S., Castranova, V., Fadeel, B., Kagan, V. E., and Shvedova, A. A. 2011. Genotoxicity of carbon nanofibers: Are they potentially more or less dangerous than carbon nanotubes or asbestos? Toxicol. Appl. Pharmacol. 252:1-10.
103. Kohli, A. K., and Alpar, H. O. 2004. Potential use of nanoparticles for transcutaneous vaccine delivery: effect of particle size and charge. Int. J. Pharm. 275:13-17. (Pubitemid 38481516)
104. Kolosnjaj, J., Szwarc, H., and Moussa, F. 2007. Toxicity studies of fullerenes and derivatives. Adv. Exp. Med. Biol. 620:168-80.
105. Koyama, S., Haniu, H., Osaka, K., Koyama, H., Kuroiwa, N., Endo, M., Kim, Y. A., and Hayashi, T. 2006. Medical application of carbon-nanotube-filled nanocomposites: The microcatheter. Small 2:1406-11. (Pubitemid 44786880)
106. Kreyling, W. G., Semmler, M., Erbe, F., Mayer, P., Takenaka, S., Oberdorster, G., and Ziesenis, A. 2002. Minute translocation of inhaled ultrafine insoluble iridium particles from lung epithelium to extrapulmonary tissues. J. Toxicol. Environ. Health A 65:1513-30. (Pubitemid 35217498)
107. Kumari, M., Mukherjee, A., and Chandrasekaran, N. 2009. Genotoxicity of silver nanoparticles in Allium cepa. Sci. Total Environ. 407:5243-46.
108. Landsiedel, R., Kapp, M. D., Schulz, M., Wiench, K., and Oesch, F. 2009. Genotoxicity investigations on nanomaterials: Methods, preparation and characterization of test material, potential artifacts and limitations-Many questions, some answers. Mutat. Res. 681:241-58.
109. Landsiedel, R., Ma-Hock, L., Van Ravenzwaay, B., Schulz, M., Wiench, K., Champ, S., Schulte, S., Wohlleben, W., and Oesch, F. 2010. Gene toxicity studies on titanium dioxide and zinc oxide nanomaterials used for UV-protection in cosmetic formulations. Nanotoxicology 4:364-81.
110. Lam, C. W., James, J. T., McCluskey, R., and Hunter, R. L. 2004. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol. Sci. 77:126-134. (Pubitemid 38128652)
111. Lasagna-Reeves, C., Gonzalez-Romero, D., Barria, M. A., Olmedo, I., Clos, A., Sadagopa Ramanujam, V. M., Urayama, A., Vergara, L., Kogan, M. J., and Soto, C. 2010. Bioaccumulation and toxicity of gold nanoparticles after repeated administration in mice. Biochem. Biophys. Res. Commun. 393:649-55.
112. Le Blanc, A. J., Crumpston, J. L., Chen, B. T., Frazer, D., Castranova, V., and Nurkiewicz, T. R. 2009. Nanoparticle inhalation impairs endothelium-dependent vasodilation in subepicardial arterioles. J. Toxicol. Environ. Health A 72:1576-84.
113. Lee, H. J., Yeo, S. Y., and Jeong, S. H. 2003. Antibacterial effect of nanosized silver colloidal solution on textile fabrics. J. Mater. Sci. 38:2199-204.
114. Lee, K. J., Nallathamby, P. D., Browning, L. M., Osgood, C. J., and Xu, X. H. 2007. In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos. ACS Nano 1:133-43.
115. 2) by inhalation for two years. Toxicol. Appl. Pharmacol. 79:179-92. (Pubitemid 15013722)
116. Le Geros, R. Z. 1993. Biodegradation and bioresorption of calcium phosphate ceramics. Clin. Mater. 14:65-88.
117. Levi, N., Hantgan, R. R., Lively, M. O., Carroll, D. L., and Prasad, G. L. 2006. C60-fullerenes: Detection of intracellular photoluminescence and lack of cytotoxic effects. J. Nanobiotechnol. 4:14.
118. Liang, F., and Chen, B. 2010. A review on biomedical applications of single-walled carbon nanotubes. Curr. Med. Chem. 17:10-24.
119. Linkov, I., Satterstrom, F. K., and Corey, L. M. 2008. Nanotoxicology and nanomedicine: making hard decisions. Nanomedicine 4:167-71.
120. Liu, M., Zhang, H., and Slutsky, A. S. 2009a. Acute lung injury: A yellow card for engineered nanoparticles? J. Mol. Cell Biol. 1:6-7.
121. Liu, Y., Gao, Y. X., Zhang, L. L., Wang, T. C., Wang, J. X., Jiao, F., Li, W., Liu, Y., Li, Y. F., Li, B., Chai, Z. F., Wu, G., and Chen, C. Y. 2009b. Potential health impact on mice after nasal instillation of nano-sized copper particles and their translocation in mice. J. Nanosci. Nanotechnol. 9:6335-43.
122. Liu, Y., Miyoshi, H., and Nakamura, M. 2007. Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles. Int. J. Cancer 120:2527-37. (Pubitemid 46651272)
123. Lomer, M. C., Thompson, R. P., and Powell, J. J. 2002. Fine and ultrafine particles of the diet: Influence on the mucosal immune response and association with Crohn's disease. Proc. Nutr. Soc. 61:123-30. (Pubitemid 34173020)
124. Long, T. C., Tajuba, J., Sama, P., Saleh, N., Swartz, C., Parker, J., Hester, S., Lowry, G. V., and Veronesi, B. 2007. Nanosize titanium dioxide stimulates reactive oxygen species in brain microglia and damages neurons in vitro. Environ. Health Perspect. 115:1631-37.
125. 2 nanoparticles on soybean (Glycine max) plants. Environ. Sci. Technol. 44:7315-20.
126. Losic, D., and Simovic, S. 2009. Self-ordered nanopore and nanotube platforms for drug delivery applications. Expert Opin. Drug Deliv. 6:1363-81.
127. Maenosono, S., Suzuki, T., and Saita, S. 2007. Mutagenicity of water-soluble FePt nanoparticles in Ames test. J. Toxicol. Sci. 32:575-79.
128. Ma-Hock, L., Treumann, S., Strauss, V., Brill, S., Luizi, F., Mertler, M., Wiench, K., Gamer, A. O., van Ravenzwaay, B., and Landsiedel, R. 2009. Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months. Toxicol. Sci. 112:468-81.
129. Mansour, H. M., Rhee, Y. S., and Wu, X. 2009. Nanomedicine in pulmonary delivery. Int. J. Nanomedicine 4:299-319.
130. Maynard, A. D., Baron, P. A., Foley, M., Shvedova, A. A., Kisin, E. R., and Castranova, V. 2004. Exposure to carbon nanotube material: Aerosol release during the handling of unrefined single-walled carbon nanotube material. J. Toxicol. Environ. Health A 67:87-107. (Pubitemid 38117533)
131. Mercer, R. R., Scabilloni, J., Wang, L., Kisin, E., Murray, A. R., Schwegler-Berry, D., Shvedova, A. A., and Castranova, V. 2008. Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single walled carbon nantoubes in a mouse model. Am. J. Physiol. Lung Cell Mol. Physiol. 294:L87-L97. (Pubitemid 351380321)
132. Mercer, R. R., Hubbs, A. F., Scabilloni, J. F., Wang, L., Battelli, L. A., Friend, S., Castranova, V., and Porter, D. W. 2011. Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes. Part. Fibre Toxicol. 8:21.
133. Michalet, X., Pinaud, F. F., Bentolila, L. A., Tsay, J. M., Doose, S., Li, J. J., Sundaresan, G., Wu, A. M., Gambhir, S. S., and Weiss, S. 2005. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307:538-44. (Pubitemid 40165671)
134. Moghimi, S. M., Hunter, A. C., and Murray, J. C. 2005. Nanomedicine: Current status and future prospects. FASEB J. 19:311-30. (Pubitemid 40316520)
135. Mori, T., Takada, H., Ito, S., Matsubayashi, K., Miwa, N., and Sawaguchi, T. 2006. Preclinical studies on safety of fullerene upon acute oral administration and evaluation for no mutagenesis. Toxicology 225:48-54.
136. Mortelmans, K., and Zeiger, E. 2000. The Ames Salmonella/microsome mutagenicity assay. Mutat. Res. 455:29-60.
137. 24 on the frequency of micronuclei and chromosome aberrations in CHO-K1 cells. Mutat. Res. 680:25-30.
138. Mroz, R. M., Schins, R. P., Li, H., Drost, E. M., Macnee, W., and Donaldson, K. 2007. Nanoparticle carbon black driven DNA damage induces growth arrest and AP-1 and NFkappaB DNA binding in lung epithelial A549 cell line. J. Physiol. Pharmacol. 58 (suppl. 5) : 461-70. (Pubitemid 351346695)
139. Muller, J., Delos, M., Panin, N., Rabolli, V., Huaux, F., and Lison, D. 2009. Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat. Toxicol. Sci. 110:442-48.
140. Nagender, R. P., Pena-Mendez, E. M., and Havel, J. 2009. Gold and nano-gold in medicine: Overview, toxicology and perspectives. J. Appl. Biomed. 7:75-91.
141. Naha, P. C., Bhattacharya, K., Tenuta, T., Dawson, K. A., Lynch, I., Gracia, A., Lyng, F. M., and Byrne, H. J. 2010. Intracellular localisation, geno-and cytotoxic response of polyN-isopropylacrylamide (PNIPAM) nanoparticles to human keratinocyte (HaCaT) and colon cells (SW 480). Toxicol Lett. 19:134-43.
142. Nemmar, A., Hoet, P. H., Vanquickenborne, B., Dinsdale, D., Thomeer, M., Hoylaerts, M. F., Vanbilloen, H., Mortelmans, L., and Nemery, B. 2002a. Passage of inhaled particles into the blood circulation in humans. Circulation 105:411-14. (Pubitemid 34141694)
143. Nemmar, A., Hoylaerts, M. F., Hoet, P. H., Dinsdale, D., Smith, T., Xu, H., Vermylen, J., and Nemery, B. 2002b. Ultrafine particles affect experimental thrombosis in an in vivo hamster model. Am. J. Respir. Crit. Care Med 166:998-1004. (Pubitemid 35193233)
144. Nemmar, A., Hoylaerts, M. F., Hoet, P. H., Vermylen, J., and Nemery, B. 2003. Size effect of intratracheally instilled particles on pulmonary inflammation and vascular thrombosis. Toxicol. Appl. Pharmacol. 186:38-45. (Pubitemid 36262947)
145. Nemmar, A., Vanbilloen, H., Hoylaerts, M. F., Hoet, P. H., Verbruggen, A., and Nemery, B. 2001. Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. Am. J. Respir. Crit. Care Med 164:1665-68. (Pubitemid 33124156)
146. Nishimori, H., Kondoh, M., Isoda, K., Tsunoda, S., Tsutsumi, Y., and Yagi, K. 2009. Silica nanoparticles as hepatotoxicants. Eur. J. Pharm. Biopharm. 72:496-501.
147. National Insitute for Occupational Safety and Health. 2011. Current intelligence bulletin 63: Occupational exposure to titanium dioxide. DHHS (NIOSH) Publication number 2011-160. http://www.cdc.gov/niosh/docs/2011-160/
148. Nygaard, U. C., Hansen, J. S., Samuelsen, M., Alberg, T., Marioara, C. D., and Lovik, M. 2009. Single-walled and multi-walled carbon nanotubes promote allergic immune responses in mice. Toxicol. Sci. 109:113-23.
149. Oberdorster, G. 2010. Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology. J. Intern. Med. 267:89-105.
150. Oberdorster, G., Oberdorster, E., and Oberdorster, J. 2005. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 113:823-39. (Pubitemid 40984181)
151. Oberdorster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Kreyling, W., and Cox, C. 2004. Translocation of inhaled ultrafine particles to the brain. Inhal. Toxicol. 16:437-45. (Pubitemid 38685135)
152. Oberdorster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Lunts, A., Kreyling, W., and Cox, C. 2002. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J. Toxicol. Environ. Health A 65:1531-43. (Pubitemid 35217499)
153. Ogawara, K., Yoshida, M., Furumoto, K., Takakura, Y., Hashida, M., Higaki, K., and Kimura, T. 1999. Uptake by hepatocytes and biliary excretion of intravenously administered polystyrene microspheres in rats. J. Drug Target. 7:213-21. (Pubitemid 30028965)
154. Pauluhn, J. 2010. Multi-walled carbon nanotubes (Baytubes) : Approach for derivation of occupational exposure limit. Regul. Toxicol. Pharmacol. 57:78-89.
155. Panyam, J., and Labhasetwar, V. 2003. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev. 55:329-47. (Pubitemid 36297053)
156. Park, M. V., Annema, W., Salvati, A., Lesniak, A., Elsaesser, A., Barnes, C., McKerr, G., Howard, C. V., Lynch, I., Dawson, K. A., Piersma, A. H., and de Jong, W. H. 2009. In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles. Toxicol. Appl. Pharmacol. 240:108-16.
157. Partidos, C. D. 2003. Delivering vaccines into the skin without needles and syringes. Expert Rev. Vaccines 2:753-61. (Pubitemid 37541562)
158. Patlolla, A., Knighten, B., and Tchounwou, P. 2010. Multi-walled carbon nanotubes induce cytotoxicity, genotoxicity and apoptosis in normal human dermal fibroblast cells. Ethnicity Dis. 20:S1-65-72.
159. Patton, J. S., and Byron, P. R. 2007. Inhaling medicines: delivering drugs to the body through the lungs. Nat. Rev. Drug Discov. 6:67-74. (Pubitemid 46020287)
160. 2-DNA oligonucleotide nanoconjugates show prolonged intracellular retention period and T1-weighted contrast enhancement in magnetic resonance images. Nanomedicine 4:201-7.
161. Pelka, J., Gehrke, H., Esselen, M., Turk, M., Crone, M., Brase, S., Muller, T., Blank, H., Send, W., Zibat, V., Brenner, P., Schneider, R., Gerthsen, D., and Marko, D. 2009. Cellular uptake of platinum nanoparticles in human colon carcinoma cells and their impact on cellular redox systems and DNA integrity. Chem. Res. Toxicol. 22:649-59.
162. Phillips, J. I., Green, F. Y., Davies, J. C., and Murray, J. 2010. Pulmonary and systemic toxicity following exposure to nickel nanoparticles. Am. J. Ind. Med. 53:763-67.
163. Piddubnyak, V., Kurcok, P., Matuszowicz, A., Glowala, M., Fiszer-Kierzkowska, A., Jedlinski, Z., Juzwa, M., and Krawczyk, Z. 2004. Oligo-3-hydroxybutyrates as potential carriers for drug delivery. Biomaterials 25:5271-79. (Pubitemid 38521166)
164. Pierscionek, B. K., Li, Y., Yasseen, A. A., Colhoun, L. M., Schachar, R. A., and Chen, W. 2010. Nanoceria have no genotoxic effect on human lens epithelial cells. Nanotechnology 21:035102.
165. Pitard, B., Bello-Roufai, M., Lambert, O., Richard, P., Desigaux, L., Fernandes, S., Lanctin, C., Pollard, H., Zeghal, M., Rescan, P. Y., and Escande, D. 2004. Negatively charged self-assembling DNA/poloxamine nanospheres for in vivo gene transfer. Nucleic Acids Res. 32:e159.
166. Pokharkar, V., Dhar, S., Bhumkar, D., Mali, V., Bodhankar, S., and Prasad, B. L. 2009. Acute and subacute toxicity studies of chitosan reduced gold nanoparticles: a novel carrier for therapeutic agents. J. Biomed. Nanotechnol. 5:233-39.
167. Ponti, J., Sabbioni, E., Munaro, B., Broggi, F., Marmorato, P., Franchini, F., Colognato, R., and Rossi, F. 2009. Genotoxicity and morphological transformation induced by cobalt nanoparticles and cobalt chloride: An in vitro study in Balb/3T3 mouse fibroblasts. Mutagenesis 24:439-45.
168. Pope, C. A. III, Burnett, R. T., Thun, M. J., Calle, E. E., Krewski, D., Ito, K., and Thurston, G. D. 2002. Lung cancer, cardiopulmonary motality, and long-term exposure to fine particulate air pollution. J. Am. Med. Assoc. 287:1132-41. (Pubitemid 34252082)
169. Porter, D. W., Hubbs, A., Mercer, R., Wu, N., Wolfarth, M. G., Sriram, K., Leonard, S., Battelli, L., Schwegler-Berry, D., Friend, S., Andrew, M., Chen, B. T., Tsuruoko, S., Endo, M., and Castranova, V. 2010. Mouse pulmonary dose-and time course-response induced by exposure to multi-walled carbon nanotubes. Toxicology 269:136-147.
170. Pott, F., and Roller, M. 2005. Carcinogenicity study with nineteen granular dusts in rats. Eur. J. Oncol. 10:249-82.
171. Prausnitz, M. R., Mitragotri, S., and Langer, R. 2004. Current status and future potential of transdermal drug delivery. Nat. Rev. Drug Discov. 3:115-24. (Pubitemid 38239773)
172. Price, H., Arthur, R., Sexton, K., Gregory, C., Hoogendoorn, B., Matthews, I., Jones, T., and Beru Be, K. 2010. Airborne particles in Swansea, UK: Their collection and characterization. J. Toxicol. Environ. Health A 73:355-67.
173. Rahman, Q., Lohani, M., Dopp, E., Pemsel, H., Jonas, L., Weiss, D. G., and Schiffmann, D. 2002. Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts. Environ. Health Perspect. 110:797-800.
174. Rao, G. V., Kumar, G. S., and Ahuja, Y. R. 1997. Single cell gel electrophoresis on peripheral blood leukocytes of patients with oral squamous cell carcinoma. J. Oral Pathol. Med. 26:377-80. (Pubitemid 27415847)
175. Ravichandran, P., Periyakaruppan, A., Sadanandan, B., Ramesh, V., Hall, J. C., Jejelowo, O., and Ramesh, G. T. 2009. Induction of apoptosis in rat lung epithelial cells by multiwalled carbon nanotubes. J. Biochem. Mol. Toxicol. 23:333-44.
176. Rittinghausen, S., Mohr, U., and Dungworth, D. L. 1997. Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles. Exp. Toxicol. Pathol. 49:433-46. (Pubitemid 28064607)
177. Roberts, J. R., Chapman, R. S., Young, S., Kenyon, A., Schwegler-Berry, D., Stefaniak, A. B., Chen, B. T., and Antonini, J. M. 2011. Pulmonary toxicity following intratracheal instillation of dispersed silver nanoparticles in rats. Toxicologist 120:A1759.
178. Roller, M. 2009. Carcinogenicity of inhaled nanoparticles. Inhal. Toxicol. 21 (suppl. 1) : 144-57.
179. Rothen-Rutishauser, B. M., Schurch, S., Haenni, B., Kapp, N., and Gehr, P. 2006. Interaction of fine particles and nanoparticles with red blood cells visualized with advanced microscopic techniques. Environ. Sci. Technol. 40:4353-59. (Pubitemid 44092367)
180. Rouse, J. G., Yang, J., Ryman-Rasmussen, J. P., Barron, A. R., and Monteiro-Riviere, N. A. 2007. Effects of mechanical flexion on the penetration of fullerene amino acidderivatized peptide nanoparticles through skin. Nano Lett. 7:155-60. (Pubitemid 46225845)
181. Ryman-Rasmussen, J. P., Riviere, J. E., and Monteiro-Riviere, N. A. 2006. Penetration of intact skin by quantum dots with diverse physicochemical properties. Toxicol. Sci. 91:159-65.
182. Sabbioni, E., Fortaner, S., Bosisio, S., Farina, M., Del Torchio, R., Edel, J., and Fischbach, M. 2010. Metabolic fate of ultratrace levels of GeCl (4) in the rat and in vitro studies on its basal cytotoxicity and carcinogenic potential in Balb/3T3 and HaCaT cell lines dagger. J. Appl. Toxicol. 30:34-41.
183. 2 particles. Toxicol. Sci. 115:156-66.
184. Sahoo, S. K., and Labhasetwar, V. 2003. Nanotech approaches to drug delivery and imaging. Drug Discov. Today 8:1112-1120. (Pubitemid 37547917)
185. Sajja, H. K., East, M. P., Mao, H., Wang, Y. A., Nie, S., and Yang, L. 2009. Development of multifunctional nanoparticles for targeted drug delivery and noninvasive imaging of therapeutic effect. Curr. Drug Discov. Technol. 6:43-51.
186. Sakamoto, Y., Nakae, D., Fukumori, N., Tayama, K., Maekawa, A., Imai, K., Hirose, A., Nishimura, T., Ohashi, N., and Ogata, A. 2009. Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats. J. Toxicol. Sci. 34:65-76.
187. Samet, J. M., Dominici, F., Carriero, F. C., Coursac, I., and Zeger, S. L. 2000. Fine particulate air pollution and mortality in 20 U. S. Cities, 1987-1994. N. Engl. J. Med. 343:1742-1749. (Pubitemid 32369215)
188. Sarlo, K., Blackburn, K. L., Clark, E. D., Grothaus, J., Chaney, J., Neu, S., Flood, J., Abbott, D., Bohne, C., Casey, K., et al. 2009. Tissue distribution of 20 nm, 100 nm and 1000 nm fluorescent polystyrene latex nanospheres following acute systemic or acute and repeat airway exposure in the rat. Toxicology 263:117-26.
189. Schipper, M. L., Nakayama-Ratchford, N., Davis, C. R., Kam, N. W., Chu, P., Liu, Z., Sun, X., Dai, H., and Gambhir, S. S. 2008. A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice. Nat. Nanotechnol. 3:216-21. (Pubitemid 351506336)
190. Schulz, J., Hohenberg, H., Pflucker, F., Gartner, E., Will, T., Pfeiffer, S., Wepf, R., Wendel, V., Gers-Barlag, H., and Wittern, K. P. 2002. Distribution of sunscreens on skin. Adv. Drug Deliv. Rev. 54 (suppl. 1) : S157-S163. (Pubitemid 35379960)
191. Schwarz, F., Bieling, K., Latz, T., Nuesry, E., and Becker, J. 2006. Healing of intrabony periimplantitis defects following application of a nanocrystalline hydroxyapatite (Ostim) or a bovine-derived xenograft (Bio-Oss) in combination with a collagen membrane (Bio-Gide). A case series. J. Clin. Periodontol. 33:491-99. (Pubitemid 43941206)
192. Schwarz, F., Sahm, N., Bieling, K., and Becker, J. 2009. Surgical regenerative treatment of peri-implantitis lesions using a nanocrystalline hydroxyapatite or a natural bone mineral in combination with a collagen membrane: A four-year clinical follow-up report. J. Clin. Periodontol. 36:807-14.
193. Scott-Fordsmand, J. J., Krogh, P. H., Schaefer, M., and Johansen, A. 2008. The toxicity testing of double-walled nanotubescontaminated food to Eisenia veneta earthworms. Ecotoxicol. Environ. Safety 71:616-19.
194. Scuri, M., Chen, B. T., Castranova, V., Reynolds, J. S., Johnson, V. J., Samsell, L., Watson, C., and Piedimonte, G. 2010. Effects of titanium dioxide nanoparticle exposure on neuro immune responses in rat airways. J. Toxicol Enviorn Health A 73:1353-69.
195. Semete, B., Booysen, L., Lemmer, Y., Kalombo, L., Katata, L., Verschoor, J., and Swai, H. S. 2010. In vivo evaluation of the biodistribution and safety of PLGA nanoparticles as drug delivery systems. Nanomedicine 6:662-71.
196. Sharma, V., Shukla, R. K., Saxena, N., Parmar, D., Das, M., and Dhawan, A. 2009. DNA damaging potential of zinc oxide nanoparticles in human epidermal cells. Toxicol. Lett. 185:211-18.
197. Shavandi, Z., Ghazanfari, T., and Moghaddam, K. N. 2010. In vitro toxicity of silver nanoparticles on murine peritoneal macrophages. Immunopharmacol. Immunotoxicol. doi:10.3109/08923973.2010.487489.
198. Shen, X. S., Wang, G. Z., Hong, X., and Zhu, W. 2009. Nanospheres of silver nanoparticles: Agglomeration, surface morphology control and application as SERS substrates. Phys. Chem. Chem. Phys. 11:7450-54.
199. Shi, X., Castranova, V., Halliwell, B, and Vallyathan, V. 1998. Reactive oxygen species and silica - induced carcinogenesis. J. Toxicol. Environ. Health B 1:181-97. (Pubitemid 128693558)
200. Shi, Y., Yadav, S., Wang, F., and Wang, H. 2010. Endotoxin promotes adverse effects of amorphous silica nanoparticles on lung epithelial cells in vitro. J. Toxicol. Environ. Health A 73:748-56.
201. Shimizu, M., Tainaka, H., Oba, T., Mizuo, K., Umezawa, M., and Takeda, K. 2009. Maternal exposure to nanoparticulate titanium dioxide during the prenatal period alters gene expression related to brain development in the mouse. Part. Fibre Toxicol. 6:20.
202. Shinohara, N., Matsumoto, K., Endoh, S., Maru, J., and Nakanishi, J. 2009. In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles. Toxicol. Lett. 191:289-96.
203. Shvedova, A. A., Castranova, V., Kisin, E. R., Schwegler-Berry, D., Murray, A. R., Gandelsman, V. Z., Maynard, A., and Baron, P. 2003. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J. Toxicol. Environ. Health A 66:1909-1926. (Pubitemid 37352634)
204. Shvedova, A. A., Kisin, E. R. Mercer, R., Murray, A. R., Johnson, V. J., Potapovich, A. F., Tyurina, Y. Y., Gorelik, O., Arepalli, S., Schwegler-Berry, D., Hubbs, A. F., Antonini, J., Evans, D. E., Ku, B.-K., Ramsey, D., Maynard, A., Kagan, V. E., Castranova, V., and Baron, P. 2005. Unusual inflammatory and fibrogenic pulmonary, response to single walled carbon nanotubes in mice. Am. J. Physiol. Lung Cell Mol. Physiol. 289:L698-L708. (Pubitemid 41504399)
205. Shvedova, A. A., and Kagan, V. E. 2010. The role of nanotoxicology in realizing the 'helping without harm' paradigm of nanomedicine: Lessons from studies of pulmonary effects of single-walled carbon nanotubes. J. Intern. Med. 267:106-18.
206. Shvedova, A. A., Kisin, E., Murray, A. R., Johnson, V. J., Gorelik, O., Arepalli, S., Hubbs, A. F., Mercer, R. R., Keohavong, P., Sussman, N. Jin, J., Yin, J., Stone, S., Chen, B. T., Deye, G., Maynard, A., Castranova, V., Baron, P. A., and Kagan, V. E. 2008a. Inhalation vs. aspiration of singlewalled carbon nanotubes in C57BL/6 mice: Inflammation, fibrosis, oxidative stress, and mutagenesis. Am. J. Physiol. Lung Cell Mol. Physiol. 295:L552-L565.
207. Shvedova, A. A., Fabisiak, J. P., Kisin, E. R., Murray, A. R., Roberts, J. R., Antonini, J. A., Kommineni, C., Reynolds, J., Barchowsky, A., Castranova, V., and Kagan, V. 2008b. Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. Am. J. Respir. Cell Mol. Biol. 38:579-90. (Pubitemid 351758677)
208. Shvedova, A. A., Kisin, E. R., Porter, D., Schulte, P., Kagan, V. E., Fadeel, B., and Castranova, V. 2009. Mechanisms of toxicity and medical applications of carbon nanotubes: Two faces of Janus? J. Pharmacol. Ther. 121:192-204.
209. Stueckle, T. A., Mishra, A., Derk, R., Rojanasakul, Y., Castranova, V., and Wang, L. 2011. In vitro assessment of potential tumorgenicity of chronic SWCNT and MWCNT exposure to lung epithelium. Toxicologist 120:A1182.
210. Sudimack, J., and Lee, R. J. 2000. Targeted drug delivery via the folate receptor. Adv. Drug Deliv. Rev. 41:147-62. (Pubitemid 30122955)
211. Sumner, S. C., Fennell, T. R., Snyder, R. W., Taylor, G. F., and Lewin, A. H. 2010. Distribution of carbon-14 labeled C60 ([14C]C60) in the pregnant and in the lactating dam and the effect of C60 exposure on the biochemical profile of urine. J. Appl. Toxicol. 30:354-60.
212. Tabet, L., Bussy, C., Amara, N., Setyan, A., Grodet, A., Rossi, M. J., Pairon, J. C., Boczkowski, J., and Lanone, S. 2009. Adverse effects of industrial multiwalled carbon nanotubes on human pulmonary cells. J. Toxicol. Environ. Health A 72:60-73.
213. Takagi, A., Hirose, A., Nishimura, T., Fukumori, N., Ogata, A., Ohashi, N., Kitajima, S., and Kanno, J. 2008. Induction of mesothelioma in p53+/-mouse by intraperitoneal application of multi-wall carbon nanotube. J. Toxicol. Sci. 33:105-16. (Pubitemid 351340768)
214. Tang, X., Choo, E. S., Li, L., Ding, J., and Xue, J. 2009. One-pot synthesis of water-stable ZnO nanoparticles via a polyol hydrolysis route and their cell labeling applications. Langmuir 25:5271-75.
215. Teli, M. K., Mutalik, S., and Rajanikant, G. K. 2010. Nanotechnology and nanomedicine: Going small means aiming big. Curr. Pharm. Des. 16:1882-92.
216. Thian, E. S., Huang, J., Best, S. M., Barber, Z. H., Brooks, R. A., Rushton, N., and Bonfield, W. 2006. The response of osteoblasts to nanocrystalline siliconsubstituted hydroxyapatite thin films. Biomaterials 27:2692-98. (Pubitemid 43122072)
217. Ting, G., Chang, C. H., and Wang, H. E. 2009. Cancer nanotargeted radiopharmaceuticals for tumor imaging and therapy. Anticancer Res. 29:4107-18.
218. Tinkle, S. S., Antonini, J. M., Rich, B. A., Roberts, J. R., Salmen, R., De Pree, K., and Adkins, E. J. 2003. Skin as a route of exposure and sensitization in chronic beryllium disease. Environ. Health Perspect. 111:1202-8. (Pubitemid 36939402)
219. Tsuchiya, T., Oguri, I., Yamakoshi, Y. N., and Miyata, N. 1996. Novel harmful effects of [60]fullerene on mouse embryos in vitro and in vivo. FEBS Lett. 393:139-45. (Pubitemid 26298248)
220. Tsuda, H., Xu, J., Sakai, Y., Futakuchi, M., and Fukamachi, K. 2009. Toxicology of engineered nanomaterials-A review of carcinogenic potential. Asian Pacific J. Cancer Prev. 10:975-80.
221. Tsuji, J. S., Maynard, A. D., Howard, P. C., James, J. T., Lam, C. W., Warheit, D. B., and Santamaria, A. B. 2006. Research strategies for safety evaluation of nanomaterials, part IV: risk assessment of nanoparticles. Toxicol. Sci. 89:42-50. (Pubitemid 43013753)
222. Vermylen, J., Nemmar, A., Nemery, B., and Hoylaerts, M. F. 2005. Ambient air pollution and acute myocardial infarction. J. Thromb. Haemost. 3:1955-61. (Pubitemid 43086052)
223. Videira, M. A., Gano, L., Santos, C., Neves, M., and Almeida, A. J. 2006. Lymphatic uptake of lipid nanoparticles following endotracheal administration. J. Microencapsul. 23:855-62. (Pubitemid 46332097)
224. Wahab, R., Mishra, A., Yun, S. I., Kim, Y. S., and Shin, H. S. 2010. Antibacterial activity of ZnO nanoparticles prepared via nonhydrolytic solution route. Appl. Microbiol. Biotechnol. 87:1917-25.
225. Wang, J., Liu, Y., Jiao, F., Lao, F., Li, W., Gu, Y., Li, Y., Ge, C., Zhou, G., Li, B., Zhao, Y., Chai, Z., and Chen, C. 2008. Time-dependent translocation and potential impairment on central nervous system by intranasally instilled TiO (2) nanoparticles. Toxicology 254:82-90.
226. 2 particles in cultured human lymphoblastoid cells. Mutat. Res. 628:99-106. (Pubitemid 46330879)
227. Wang, L., Mercer, R. R., Rojanasakul, Y., Qiu, A., Lu, Y., Scabilloni, J. F., Wu, N., and Castranova, V. 2010. Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts. J. Toxicol. Environ. Health A 73:410-22.
228. Wang, M., and Thanou, M. 2010. Targeting nanoparticles to cancer. Pharmacol. Res. 62:90-99.
229. Warheit, D. B., Laurence, B. R., Reed, K. L., Roach, D. H., Reynolds, G. A., and Webb, T. R. 2004. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol. Sci. 77:117-25. (Pubitemid 38128651)
230. Wiench, K., Wohlleben, W., Hisgen, V., Radke, K., Salinas, E., Zok, S., and Landsiedel, R. 2009. Acute and chronic effects of nano-and non-nano-scale TiO (2) and ZnO particles on mobility and reproduction of the freshwater invertebrate Daphnia magna. Chemosphere 76:1356-65.
231. Williams, J. H., Schray, R. C., Sirsi, S. R., and Lutz, G. J. 2008. Nanopolymers improve delivery of exon skipping oligonucleotides and concomitant dystrophin expression in skeletal muscle of mdx mice. BMC Biotechnol. 8:35.
232. Wirnitzer, U., Herbold, B., Voetz, M., and Ragot, J. 2009. Studies on the in vitro genotoxicity of baytubes, agglomerates of engineered multi-walled carbon-nanotubes (MWCNT). Toxicol. Lett. 186:160-65.
233. Wise, J. P., Sr., Goodale, B. C., Wise, S. S., Craig, G. A., Pongan, A. F., Walter, R. B., Thompson, W. D., Ng, A. K., Aboueissa, A. M., Mitani, H., Spalding, M. J., and Mason, M. D. 2010. Silver nanospheres are cytotoxic and genotoxic to fish cells. Aquat. Toxicol. 97:34-41.
234. Wiwanitkit, V., Sereemaspun, A., and Rojanathanes, R. 2009. Effect of gold nanoparticles on spermatozoa: The first world report. Fertil. Steril. 91:e7-e8.
235. Wolf, R., Matz, H., Orion, E., and Lipozencic, J. 2003. Sunscreens-The ultimate cosmetic. Acta Dermatovenerol. Croat. 11:158-62.
236. Wolfarth, M. G., McKinney, W., Chen, B. T., Castranova, V., and Porter, D. W. 2011. Acute pulmonary responses to MWCNT inhalation. Toxicologist 120:A53.
237. Xia, T., Zhao, Y., Sager, T., George, S., Pokhrel, S., Li, N., Schoenfield, D., Meng, H., Lin, S., Wang, X., Wang, M., Ji, Z., Zink, J. I., Madler, L., Castranova, V., and Nel, A. E. 2011. Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos. ACS Nano 5:1223-35.
238. 2 ceramics in grinding by the aid of ultrasonic vibration. Key Eng. Mater. 190:315-16.
239. Xu, A., Chai, Y., Nohmi, T., and Hei, T. K. 2009. Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells. Part. Fibre Toxicol. 6:3.
240. Ye, X., and Yang, D. 2009. Recent advances in biological strategies for targeted drug delivery. Cardiovasc. Hematol. Disord. Drug Targets 9:206-21.
241. Yoshida, R., Kitamura, D., and Maenosono, S. 2009. Mutagenicity of water-soluble ZnO nanoparticles in Ames test. J. Toxicol. Sci. 34:119-22.
242. Yoshida, S., Hiyoshi, K., Oshio, S., Takano, H., Takeda, K., and Ichinose, T. 2010. Effects of fetal exposure to carbon nanoparticles on reproductive function in male offspring. Fertil. Steril. 93:1695-99.
243. Yudoh, K., Karasawa, R., Masuko, K., and Kato, T. 2009. Water-soluble fullerene (C60) inhibits the osteoclast differentiation and bone destruction in arthritis. Int. J. Nanomed. 4:233-39.
244. Zakharenko, L. P., Zakharov, I. K., Vasiunina, E. A., Karamysheva, T. V., Danilenko, A. M., and Nikiforov, A. A. 1997. Determination of the genotoxicity of fullerene C60 and fullerol using the method of somatic mosaics on cells of Drosophila melanogaster wing and SOS-chromotest. Genetika 33:405-9. (Pubitemid 127755552)
245. Zelikin, A. N. 2010. Drug releasing polymer thin films: new era of surface-mediated drug delivery. ACS Nano 4:2494-509.
246. 2) nanoparticles induce JB6 cell apoptosis through activation of the caspase-8/Bid and mitochondrial pathways. J. Toxicol. Environ. Health A 72:1141-49.
247. Zhao, J., Shi, X., Castranova, V., and Ding, M. 2009b. Occupational toxicology of nickel and nickel compounds. J. Environ. Pathol. Toxicol. Oncol. 28:177-208.
248. Zheng, J., Wu, X., Wang, M., Ran, D., Xu, W., and Yang, J. 2008. Study on the interaction between silver nanoparticles and nucleic acids in the presence of cetyltrimethylammonium bromide and its analytical application. Talanta 74:526-32.
249. Zhou, W., Gao, P., Shao, L., Caruntu, D., Yu, M., Chen, J., and O'Connor, C. J. 2005. Drug-loaded, magnetic, hollow silica nanocomposites for nanomedicine. Nanomedicine 1:233-37. (Pubitemid 43963633)
250. Zhu, M. T., Feng, W. Y., Wang, Y., Wang, B., Wang, M., Ouyang, H., Zhao, Y. L., and Chai, Z. F. 2009. Particokinetics and extrapulmonary translocation of intratracheally instilled ferric oxide nanoparticles in rats and the potential health risk assessment. Toxicol. Sci. 107:342-51.
251. 2 nanoparticle aggregates in Daphnia magna. Chemosphere 78:209-15.