DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles

Nanomedicine

Volumn 5, Issue 1, 2010, Pages 51-64

  Asharani, P V ^a,b   Xinyi, Ng ^a   Hande, M Prakash ^b   Valiyaveettil, Suresh ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Anticancer; Apoptosis; Biodistribution; Cell cycle; Cytotoxicity; DNA damage; Genotoxicity; Nanomedicine; Nanoparticles; Platinum

Indexed keywords

CYCLIN B; CYCLINE; METAL NANOPARTICLE; PLATINUM COMPLEX; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROCASPASE 3; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE S PHASE; CELL TYPE; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG ACTIVITY; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG EXPOSURE; DRUG FORMULATION; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; DRUG UPTAKE; GENE EXPRESSION PROFILING; GENOTOXICITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; METAL NANOPARTICLES; PLATINUM; TUMOR SUPPRESSOR PROTEIN P53;

EID: 75949131173     PISSN: 17435889     EISSN: None     Source Type: Journal    
DOI: 10.2217/nnm.09.85     Document Type: Article

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