A toxicologic review of quantum dots: Toxicity depends on physicochemical and environmental factors

Environmental Health Perspectives

Volumn 114, Issue 2, 2006, Pages 165-172

  Hardman, Ron ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

Environment; Human health; Nanomaterials; Nanosized particles; Nanotechnology; Nanotoxicology; Quantum dots; Toxicology

Indexed keywords

3 MERCAPTOPROPIONIC ACID; ACETYLCYSTEINE; CADMIUM; CARBON NANOTUBE; CARBOXYLIC ACID; FULLERENE DERIVATIVE; LEAD; MACROGOL; MERCAPTAMINE; PHOSPHATIDYLCHOLINE; POLYACRYLIC ACID; QUANTUM DOT; SELENIUM; TELLURIUM; TROLOX C; ZINC SULFIDE;

ABSORPTION; CONCENTRATION (PARAMETERS); CORRELATION ANALYSIS; CYTOTOXICITY; DIAGNOSTIC IMAGING; DRUG TARGETING; ECOTOXICOLOGY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; GENOTOXICITY; IN VIVO STUDY; NANOTECHNOLOGY; OXIDATION; PARTICLE SIZE; PHOTOLYSIS; PHYSICAL CHEMISTRY; PREVALENCE; PRIORITY JOURNAL; REVIEW; SOCIOECONOMICS;

ADSORPTION; ENGINEERING; ENVIRONMENTAL HEALTH; ENVIRONMENTAL POLLUTANTS; HUMANS; PARTICLE SIZE; QUANTUM DOTS; RISK ASSESSMENT; TOXICOLOGY;

EID: 32044451341     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.8284     Document Type: Review

References (49)

1. Akerman ME, Chan WCW, Laakkonen P, Bhatia SN, Ruoslahti E. 2002. Nanocrystal targeting in vivo. Proc Natl Acad Sci USA 99(20):12617-12621.
2. Aldana J, Wang YA, Pang X. 2001. Photochemical instability of CdSe nanocrystals coated by hydrophilic thiols. J Am Chem Soc 123:8844-8850.
3. Alivisatos P. 2004. The use of nanocrystals in biological detection. Nat Biotechnol 22:47-52.
4. Ballou B, Lagerholm BC, Ernst LA, Bruchez MP, Waggoner AS. 2004. Noninvasive imaging of quantum dots in mice. Bioconjug Chem 15(1):79-86.
5. Beaurepaire E, Buissette V, Sauviat MP, Giaume D, Lahlil K, Mercuri A, et al. 2004. Functionalized fluorescent oxide nanoparticles: artificial toxins for sodium channel targeting and imaging at the single-molecule level. Nano Lett 4(11):2079-2083.
6. Bruchez M Jr, Moronne M, Gin P, Weiss S, Alivisatos AP. 1998. Semiconductor nanocrystals as fluorescent biological labels. Science 281(5385):2013-2016.
7. Chan WCW, Maxwell DJ, Gao X, Bailey RE, Han M, Nie S. 2002. Luminescent quantum dots for multiplexed biological detection and imaging. Curr Opin Biotechnol 13(1):40-46.
8. Chen FQ, Gerion D. 2004. Fluorescent CdSe/ZnS nanocrystal-peptide conjugates for long-term, nontoxic imaging and nuclear targeting in living cells. Nano Lett 4:1827-1832.
9. Colton HM, Falls JG, Ni H, Kwanyuen P, Creech D, McNeil E, et al. 2004. Visualization and quantitation of peroxisomes using fluorescent nanocrystals: treatment of rats and monkeys with fibrates and detection in the liver. Toxicol Sci 80(1):183-192.
10. Colvin VL. 2003. The potential environmental impact of engineered nanomaterials. Nat Biotechnol 21:1166-1170.
11. Dabbousi BO, RodriguezViejo J, Mikulec FV, Heine JR, Mattoussi H, Ober R, et al. 1997. (CdSe)ZnS core-shell quantum dots: synthesis and characterization of a size series of highly luminescent nanocrystallites. J Phys Chem B 101(46):9463-9475.
12. Dahan M, Levi S, Luccardini C, Rostaing P, Riveau B, Triller A. 2003. Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science 302(5644):442-445.
13. Derfus A. 2004. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett 4:11-18.
14. Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A. 2002. In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science 298(5599):1750-1762.
15. Fan TW, Teh SJ, Hinton DE, Higashi RM. 2002. Selenium biotransformations into proteinaceous forms by foodweb organisms of selenium-laden drainage waters in California. Aquat Toxicol 57(2-2):65-84.
16. Gao X, Cui Y, Levenson RM, Chung LW, Nie S. 2004. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 22:969-976.
17. Hamilton SJ. 2004. Review of selenium toxicity in the aquatic food chain. Sci Total Environ 326(1-3):1-31.
18. Hanaki, K-I, Momo A, Oku T, Komoto A, Maenosono S, Yamaguchi Y, et al. 2003. Semiconductor quantum dot/ albumin complex is a long-life and highly photostable endosome marker. Biochem Biophys Res Commun 302(3):496-501.
19. Henson MC, Chedrese PJ. 2004. Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction. Exp Biol Med (Maywood) 229(5):383-392.
20. Hines MA, Guyot-Sionnest P. 1996. Synthesis and characterization of strongly luminescing ZnS-capped CdSe nanocrystals. J Phys Chem 100:468-471.
21. Hood E. 2004. Nanotechnology: looking as we leap. Environ Health Perspect 112:A740-A749.
22. Hoshino A, Fujioka K, Oku T, Suga M, Sasaki Y, Ohta T, et al. 2004b, Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Lett 4(11):2163-2169.
23. Hoshino A, Hanaki K, Suzuki K, Yamamoto K. 2004a. Applications of T-lymphoma labeled with fluorescent quantum dots to cell tracing markers in mouse body. Biochem Biophys Res Common 314:46-53.
24. Jaiswal JK, Mattoussi H, Mauro JM, Simon SM. 2003. Long-term multiple color imaging of live cells using quantum dot bio-conjugates. Nat Biotechnol 21:47-51.
25. Kim S, Fisher B, Eisler HJ, Bawendi M. 2003. Type-II quantum dots: CdTe/ CdSe(core/shell) and CdSe/ZnTe(core/shell) heterostructures. J Am Chem Soc 125:11466-11467.
26. Kloepfer JA, Mielke RE, Wong MS, Nealson KH, Stucky G, Nadeau JL. 2003. Quantum dots as strain- and metabolism-specific microbiological labels. Appl Environ Microbiol 69(7):4205-4213.
27. Kondoh M, Araragi S, Sato K, Higashimoto M, Takiguchi M, Sato M. 2002. Cadmium induces apoptosis partly via caspase-9 activation in HL-60 cells. Toxicology 170(1-2):111-117.
28. Larson DR, Zipfel WR, Williams RM, Clark SW, Bruchez MP, Wise FW, et al. 2003. Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science 300(5624):1434-1436.
29. Lidke DS, Nagy P, Heintzmann R, Arndt-Jovin DJ, Post JN, Grecco HE, et al. 2004. Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction. Nat Biotechnol 22(2):198-203.
30. Lovric J, Bazzi HS, Cuie Y, Fortin, GRA, Winnik FM, Maysinger D. 2005. Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. J Mol Med 83(5):377-385. Epub 2005 Feb 2.
31. Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, et al. 2005. Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307(5709):538-544.
32. National Science Foundation. 2004. Nanoscale Science and Engineering (NSE). Program Solicitation. Document no. nsf03043. Arlington, VA:National Science Foundation.
33. National Toxicology Program. 2005. Toxicological Evaluation of Nanoscale Materials: Fact Sheet. Research Triangle Park, NC:National Toxicology Program. Available: http://ntp.niehs. nih.gov/ntp/htdocs/liason/ factsheets/nanoscaleFacts.pdf [accessed 20 January 2005]
34. Nordan M, Allard K, Tinker N, Modzelewski M, Kemsley J, Mills S, et al. (2004). The Nanotech Report 2004: Investment Overview and Market Research for Nanotechnology. 3rd ed. New York:Lux Research Inc.
35. Oberdörster G, Oberdörster E, Oberdörster J. 2005. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823-839.
36. Parak WJ, Boudreau R, Le Gros M, Gerion D, Zanchet D, Micheel CM, et al. 2002. Cell motility and metastatic potential studies based on quantum dot imaging of phagokinetic tracks. Adv Mat 14(12):882-885.
37. Poliandri AH, Cabilla JP, Velardez MO, Bodo CC, Duvilanski BH. 2003. Cadmium induces apoptosis in anterior pituitary cells that can be reversed by treatment with antioxidants. Toxicol Appl Pharmacol 190(1):17-24.
38. Roco MC. 2003. Nanotechnology: convergence with modern biology and medicine. Curr Opin Biotechnol 14:337-346.
39. Rudge SR, Kurtz TL, Vessely CR, Catterall LG, Williamson DL. 2000. Preparation, characterization, and performance of magnetic iron-carbon composite microparticles for chemotherapy. Biomaterials 21(14):1411-1420.
40. Satarug S, Moore MR. 2004, Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ Health Perspect 112(10):1099-1103.
41. Scherer F, Anton M, Schillinger U, Henke J, Bergemann C, Krüger A, et al. 2001. Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo. Gene Ther 9(2):102-109.
42. Service RF. 2004. Nanotechnology grows up. Science 304: 1732-1734.
43. Shiohara A, Hoshino A, Hanaki K, Suzuki K, Yamamoto K. 2004. On the cytotoxicity of quantum dots. Microbiol Immunol 48(9): 669-675.
44. Spallholz JE, Hoffman DJ. Selenium toxicity: cause and effects in aquatic birds. Aquat Toxicol 57:27-37(2002).
45. U.S. Environmental Protection Agency. 2003. Research Planning Workshop Report: Vision for Nanotechnology R&D in the Next Decade. Arlington, VA:National Science and Technology Council Committee on Technology Subcommittee on Nanoscale Science, Engineering and Technology. Available: http://es.epa.gov/ncer/nano/ publications/index.html [accessed 12 May 2005].
46. Voura EB, Jaiswal JK, Mattoussi H, Simon SM. 2004. Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy. Nat Med 10:993-998.
47. Wu Y, Li X, Steel D, Gammon D, Sham LJ. 2004. Coherent optical control of semiconductor quantum dots for quantum information processing. Physica E Low Dimen Sys Nanostruct 25(2-3):242-248.
48. Wu X, Liu H, Liu J, Haley KN, Treadway JA, Larson JP, et al. 2003. Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat Biotechnol 21(1):41-46.
49. 2H) functionalized ferrimagnetic iron oxide nanoparticles for potential bio-applications. J Mat Chem 14:2781-2786.