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Volumn 49, Issue 5, 2008, Pages 399-405

Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes

Author keywords

Micronuclei; p53 damage response; ROS; Single cell gel electrophoresis; Titanium dioxide nanoparticles

Indexed keywords

ACETYLCYSTEINE; NANOPARTICLE; PROTEIN BAX; PROTEIN P21; PROTEIN P53; REACTIVE OXYGEN METABOLITE; TITANIUM DIOXIDE; MUTAGENIC AGENT; TITANIUM;

EID: 45849128316     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.20399     Document Type: Article
Times cited : (317)

References (52)
  • 1
    • 0031767712 scopus 로고    scopus 로고
    • Activation of alveolar macrophages and peripheral red blood cells in rats exposed to fibers/ particles
    • Afaq F, Abidi P, Matin R, Rahman Q. 1998. Activation of alveolar macrophages and peripheral red blood cells in rats exposed to fibers/ particles. Toxicol Lett 99:175-182.
    • (1998) Toxicol Lett , vol.99 , pp. 175-182
    • Afaq, F.1    Abidi, P.2    Matin, R.3    Rahman, Q.4
  • 2
    • 0032411599 scopus 로고    scopus 로고
    • Roles for p53 in growth arrest and apoptosis: Putting on the brakes after genotoxic stress
    • Amundson SA, Myers TG, Fornace JAJ. 1998. Roles for p53 in growth arrest and apoptosis: Putting on the brakes after genotoxic stress. Oncogene 17:3287-3299.
    • (1998) Oncogene , vol.17 , pp. 3287-3299
    • Amundson, S.A.1    Myers, T.G.2    Fornace, J.A.J.3
  • 3
    • 0034003005 scopus 로고    scopus 로고
    • Stress signals utilize multiple pathways to stabilize p53
    • Ashcroft M, Taya Y, Vousden KH. 2000. Stress signals utilize multiple pathways to stabilize p53. Mol Cell Biol 20:3224-3233.
    • (2000) Mol Cell Biol , vol.20 , pp. 3224-3233
    • Ashcroft, M.1    Taya, Y.2    Vousden, K.H.3
  • 4
    • 0030697942 scopus 로고    scopus 로고
    • Regression of pulmonary lesions produced by inhaled titanium dioxide in rats
    • Baggs RB, Fern J, Oberdorster G. 1997. Regression of pulmonary lesions produced by inhaled titanium dioxide in rats. Vet Pathol 34:592-597.
    • (1997) Vet Pathol , vol.34 , pp. 592-597
    • Baggs, R.B.1    Fern, J.2    Oberdorster, G.3
  • 5
    • 34548860687 scopus 로고    scopus 로고
    • Carcinogenic hazards from inhaled carbon black, titanium dioxide, and talc not containing asbestos or asbestiform fibers: Recent evaluation by an IARC monographs working group
    • Bann R. 2007. Carcinogenic hazards from inhaled carbon black, titanium dioxide, and talc not containing asbestos or asbestiform fibers: Recent evaluation by an IARC monographs working group. Inhal Toxicol 19:213-228.
    • (2007) Inhal Toxicol , vol.19 , pp. 213-228
    • Bann, R.1
  • 6
    • 0025349238 scopus 로고
    • Toxicology and carcinogenesis studies of dietary titanium dioxide-coated mica in male and female Fischer 344 rats
    • Bernard BK, Osheroff MR, Hofmann A, Mennear JH. 1990. Toxicology and carcinogenesis studies of dietary titanium dioxide-coated mica in male and female Fischer 344 rats. J Toxicol Environ Health 29:417-429.
    • (1990) J Toxicol Environ Health , vol.29 , pp. 417-429
    • Bernard, B.K.1    Osheroff, M.R.2    Hofmann, A.3    Mennear, J.H.4
  • 9
    • 0024232134 scopus 로고
    • Epidemiologic study of workers exposed to titanium dioxide
    • Chen JL, Fayerweather WE. 1988. Epidemiologic study of workers exposed to titanium dioxide. J Occup Med 30:937-942.
    • (1988) J Occup Med , vol.30 , pp. 937-942
    • Chen, J.L.1    Fayerweather, W.E.2
  • 11
    • 0030876498 scopus 로고    scopus 로고
    • The importance of oxidative stress in apoptosis
    • Clutton S. 1997. The importance of oxidative stress in apoptosis. Br Med Bull 53:662-668.
    • (1997) Br Med Bull , vol.53 , pp. 662-668
    • Clutton, S.1
  • 12
    • 0141594997 scopus 로고    scopus 로고
    • The potential environmental impacts of engineered nanomaterials
    • Colvin V. 2003. The potential environmental impacts of engineered nanomaterials. Nature Biotechnol 21:1166-1170.
    • (2003) Nature Biotechnol , vol.21 , pp. 1166-1170
    • Colvin, V.1
  • 13
    • 0034621555 scopus 로고    scopus 로고
    • Effect of ionic strength and hydrogen peroxide on the photocatalytic degradation of 4-chlorobenzoic acid in water
    • Dionysiou DD, Suidan MT, Bekoua E, Baudin I, Laîné JM. 2000. Effect of ionic strength and hydrogen peroxide on the photocatalytic degradation of 4-chlorobenzoic acid in water. Appl Catal B 26:153-171.
    • (2000) Appl Catal B , vol.26 , pp. 153-171
    • Dionysiou, D.D.1    Suidan, M.T.2    Bekoua, E.3    Baudin, I.4    Laîné, J.M.5
  • 14
    • 0034837969 scopus 로고    scopus 로고
    • Ambient particle inhalation and the cardiovascular system: Potential mechanisms
    • Donaldson K, Stone V, Seaton A, MacNee W. 2001. Ambient particle inhalation and the cardiovascular system: Potential mechanisms. Environ Health Perspect 109:523-527.
    • (2001) Environ Health Perspect , vol.109 , pp. 523-527
    • Donaldson, K.1    Stone, V.2    Seaton, A.3    MacNee, W.4
  • 15
    • 0026323213 scopus 로고
    • Cytokine and growth factor release by alveolar macrophages: Potential biomarkers of pulmonary toxicity
    • Driscoll KE, Maurer JK. 1991. Cytokine and growth factor release by alveolar macrophages: Potential biomarkers of pulmonary toxicity. Toxicol Pathol 19:398-405.
    • (1991) Toxicol Pathol , vol.19 , pp. 398-405
    • Driscoll, K.E.1    Maurer, J.K.2
  • 17
    • 0027497435 scopus 로고
    • The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations
    • Fenech M. 1993. The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations. Mutat Res 285:35-44.
    • (1993) Mutat Res , vol.285 , pp. 35-44
    • Fenech, M.1
  • 18
    • 0034693730 scopus 로고    scopus 로고
    • The in vitro micronucleus technique
    • Fenech M. 2000. The in vitro micronucleus technique. Mutat Res 455:81-95.
    • (2000) Mutat Res , vol.455 , pp. 81-95
    • Fenech, M.1
  • 19
    • 0141849021 scopus 로고    scopus 로고
    • Assessment of the skin photoprotective capacities of an organo-mineral broad-spectrum sunblock on two ex vivo skin models
    • Gelis C, Girard S, Mavon A, Delverdier M, Paillous N, Vicendo P. 2003. Assessment of the skin photoprotective capacities of an organo-mineral broad-spectrum sunblock on two ex vivo skin models. Photodermatol Photoimmunol Photomed 19:242-253.
    • (2003) Photodermatol Photoimmunol Photomed , vol.19 , pp. 242-253
    • Gelis, C.1    Girard, S.2    Mavon, A.3    Delverdier, M.4    Paillous, N.5    Vicendo, P.6
  • 20
    • 23944463473 scopus 로고    scopus 로고
    • Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells
    • Gurr JR, Wang AS, Chen CH, Jan KY. 2005. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 213:66-73.
    • (2005) Toxicology , vol.213 , pp. 66-73
    • Gurr, J.R.1    Wang, A.S.2    Chen, C.H.3    Jan, K.Y.4
  • 21
    • 0031914450 scopus 로고    scopus 로고
    • In vitro toxicity of respirable-size particles of diatomaceous earth and crystalline silica compared with asbestos and titanium dioxide
    • Hart GA, Hesterberg TW. 1998. In vitro toxicity of respirable-size particles of diatomaceous earth and crystalline silica compared with asbestos and titanium dioxide. J Occup Environ Med 40:29-42.
    • (1998) J Occup Environ Med , vol.40 , pp. 29-42
    • Hart, G.A.1    Hesterberg, T.W.2
  • 24
    • 14544286557 scopus 로고    scopus 로고
    • Photocatalytic oxidation of n-butanol under fluorescent visible light lamp over commercial TiO2 (Hombicat UV100 and Degussa P25)
    • Kirchnerova J, Herrera Cohen ML, Guy C, Klvana D. 2005. Photocatalytic oxidation of n-butanol under fluorescent visible light lamp over commercial TiO2 (Hombicat UV100 and Degussa P25). Appl Catal A 282:321-332.
    • (2005) Appl Catal A , vol.282 , pp. 321-332
    • Kirchnerova, J.1    Herrera Cohen, M.L.2    Guy, C.3    Klvana, D.4
  • 25
    • 0022264004 scopus 로고
    • Pulmonary response of rats exposed to titanium dioxide (TiO2) by inhalation for two years
    • Lee KP, Trochimowicz HJ, Reinhardt CF. 1985. Pulmonary response of rats exposed to titanium dioxide (TiO2) by inhalation for two years. Toxicol Appl Pharmacol 79:179-192.
    • (1985) Toxicol Appl Pharmacol , vol.79 , pp. 179-192
    • Lee, K.P.1    Trochimowicz, H.J.2    Reinhardt, C.F.3
  • 26
    • 0029945231 scopus 로고    scopus 로고
    • Analysis of genomic instability in Li-Fraumeni fibroblast with germline p53 mutations
    • Liu PK, Kraus E, Wu TA, Strong LC, Tainsky MA. 1996. Analysis of genomic instability in Li-Fraumeni fibroblast with germline p53 mutations. Oncogene 12:2267-2278.
    • (1996) Oncogene , vol.12 , pp. 2267-2278
    • Liu, P.K.1    Kraus, E.2    Wu, T.A.3    Strong, L.C.4    Tainsky, M.A.5
  • 27
    • 0036183331 scopus 로고    scopus 로고
    • Fine and ultrafine particles of the diet: Influence on the mucosal immune response and association with Crohn's disease
    • Lomer MC, Thompson RP, Powell JJ. 2002. Fine and ultrafine particles of the diet: Influence on the mucosal immune response and association with Crohn's disease. Proc Nutr Soc 61:123-130.
    • (2002) Proc Nutr Soc , vol.61 , pp. 123-130
    • Lomer, M.C.1    Thompson, R.P.2    Powell, J.J.3
  • 28
    • 33746255334 scopus 로고    scopus 로고
    • Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): Implications for nanoparticle neurotoxicity
    • Long TC, Saleh N, Tilton RD, Lowry GV, Veronesi B. 2006. Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): Implications for nanoparticle neurotoxicity. Environ Sci Technol 40:4346-4352.
    • (2006) Environ Sci Technol , vol.40 , pp. 4346-4352
    • Long, T.C.1    Saleh, N.2    Tilton, R.D.3    Lowry, G.V.4    Veronesi, B.5
  • 30
    • 0343776197 scopus 로고    scopus 로고
    • Role of reactive oxygen species in apoptosis: Implications for cancer therapy
    • Mates JM, Sanchez-Jimenez FM. 2000. Role of reactive oxygen species in apoptosis: Implications for cancer therapy. Int J Biochem Cell Biol 32:157-170.
    • (2000) Int J Biochem Cell Biol , vol.32 , pp. 157-170
    • Mates, J.M.1    Sanchez-Jimenez, F.M.2
  • 31
    • 0036260697 scopus 로고    scopus 로고
    • Cellular response to oxidative stress: Signaling for suicide and survival
    • Martindale JL, Holbrook NJ. 2002. Cellular response to oxidative stress: Signaling for suicide and survival. J Cell Physiol 192:1-15.
    • (2002) J Cell Physiol , vol.192 , pp. 1-15
    • Martindale, J.L.1    Holbrook, N.J.2
  • 32
    • 0037033005 scopus 로고    scopus 로고
    • FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer
    • Modur V, Nagarajan R, Evers BM, Milbrandt J. 2002. FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer. J Biol Chem 277:47928-47937.
    • (2002) J Biol Chem , vol.277 , pp. 47928-47937
    • Modur, V.1    Nagarajan, R.2    Evers, B.M.3    Milbrandt, J.4
  • 35
    • 3543146722 scopus 로고    scopus 로고
    • Manufactured nanomaterials (Fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass
    • Oberdorster E. 2004. Manufactured nanomaterials (Fullerenes, C60) induce oxidative stress in the brain of juvenile largemouth bass. Environ Health Perspect 112:1058-1062.
    • (2004) Environ Health Perspect , vol.112 , pp. 1058-1062
    • Oberdorster, E.1
  • 36
    • 0025949440 scopus 로고
    • Enhanced lipid peroxidation in lung lavage of rats after inhalation of asbestos
    • Petruska JM, Leslie KO, Mossmann BT. 1991. Enhanced lipid peroxidation in lung lavage of rats after inhalation of asbestos. Free Rad Biol Med 11:425-432.
    • (1991) Free Rad Biol Med , vol.11 , pp. 425-432
    • Petruska, J.M.1    Leslie, K.O.2    Mossmann, B.T.3
  • 37
    • 0031587381 scopus 로고    scopus 로고
    • Evidence that exposure of particulate air pollutants to human and rat alveolar macrophages leads to different oxidative stress
    • Rahman Q, Narwood J, Hatch G. 2002. Evidence that exposure of particulate air pollutants to human and rat alveolar macrophages leads to different oxidative stress. Biochem Biophys Res Commun 240:669-672.
    • (2002) Biochem Biophys Res Commun , vol.240 , pp. 669-672
    • Rahman, Q.1    Narwood, J.2    Hatch, G.3
  • 38
    • 0035875977 scopus 로고    scopus 로고
    • The influence of titianium hydroxypatite composite coatings on vitro oseoblast behaviour
    • Ramires PA, Romito A, Cosentino F, Milella E. 2001. The influence of titianium hydroxypatite composite coatings on vitro oseoblast behaviour. Biomaterials 22:1467-474.
    • (2001) Biomaterials , vol.22 , pp. 1467-1474
    • Ramires, P.A.1    Romito, A.2    Cosentino, F.3    Milella, E.4
  • 39
    • 2442475378 scopus 로고    scopus 로고
    • Do airborne particles induce heritable mutations?
    • Samet JM, DeMarini DW, Malling HV. 2004. Do airborne particles induce heritable mutations? Science 304:971-972.
    • (2004) Science , vol.304 , pp. 971-972
    • Samet, J.M.1    DeMarini, D.W.2    Malling, H.V.3
  • 40
    • 0037067656 scopus 로고    scopus 로고
    • Sharpless NE, DePinho RA. 2002. p53: Good cop/bad cop. Cell 110:9-12.
    • Sharpless NE, DePinho RA. 2002. p53: Good cop/bad cop. Cell 110:9-12.
  • 42
    • 0023919963 scopus 로고
    • A simple technique for quantitation of low levels of DNA damage in individual cells
    • Singh NP, McCoy MT, Tice RR, Schneider EL. 1988. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175:184-191.
    • (1988) Exp Cell Res , vol.175 , pp. 184-191
    • Singh, N.P.1    McCoy, M.T.2    Tice, R.R.3    Schneider, E.L.4
  • 43
    • 0023245758 scopus 로고
    • Free radicals fact or fiction?
    • Slater TFS. 1987. Free radicals fact or fiction? Br J Cancer 55:5-10.
    • (1987) Br J Cancer , vol.55 , pp. 5-10
    • Slater, T.F.S.1
  • 45
    • 34047255787 scopus 로고    scopus 로고
    • Protective effect of ferulic acid on nicotine-induced DNA damage and cellular changes in cultured rat peripheral blood lymphocytes: A comparison with N-acetylcysteine
    • Sudheer AR, Muthukumaran S, Kalpana C, Srinivasan M, Menon VP. 2007. Protective effect of ferulic acid on nicotine-induced DNA damage and cellular changes in cultured rat peripheral blood lymphocytes: A comparison with N-acetylcysteine. Toxicol In Vitro 21:576-585.
    • (2007) Toxicol In Vitro , vol.21 , pp. 576-585
    • Sudheer, A.R.1    Muthukumaran, S.2    Kalpana, C.3    Srinivasan, M.4    Menon, V.P.5
  • 47
    • 0032820452 scopus 로고    scopus 로고
    • Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader
    • Wang H, Joseph JA. 1999. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 27:612-616.
    • (1999) Free Radic Biol Med , vol.27 , pp. 612-616
    • Wang, H.1    Joseph, J.A.2
  • 48
    • 33847256798 scopus 로고    scopus 로고
    • 2 particles in cultured human lymphoblastoid cells
    • 2 particles in cultured human lymphoblastoid cells. Mutat Res 2,628:99-106.
    • (2007) Mutat Res , vol.2 , Issue.628 , pp. 99-106
    • Wang, J.J.1    Sanderson, B.J.2    Wang, H.3
  • 49
    • 0022590966 scopus 로고
    • Titanium dioxide deposition and adenocarcinoma of the lung
    • Yamadori I, Ohsumi S, Taguchi K. 1986. Titanium dioxide deposition and adenocarcinoma of the lung. Acta Pathol Jpn 36:783-790.
    • (1986) Acta Pathol Jpn , vol.36 , pp. 783-790
    • Yamadori, I.1    Ohsumi, S.2    Taguchi, K.3
  • 51
    • 7044247906 scopus 로고    scopus 로고
    • 2 nanoparticles on Ls-174-t human colon carcinoma cells
    • 2 nanoparticles on Ls-174-t human colon carcinoma cells. World J Gastroenterol 10:3191-3193.
    • (2004) World J Gastroenterol , vol.10 , pp. 3191-3193
    • Zhang, A.P.1    Sun, Y.P.2
  • 52
    • 21244450353 scopus 로고    scopus 로고
    • The ATM/p53/p21 pathway influences cell fate decision between apoptosis and senescence in reoxygenated hematopoietic progenitor cells
    • Zhang X, Li J, Sejas DP, Pang Q. 2005. The ATM/p53/p21 pathway influences cell fate decision between apoptosis and senescence in reoxygenated hematopoietic progenitor cells. J Biol Chem 280: 19635-19640.
    • (2005) J Biol Chem , vol.280 , pp. 19635-19640
    • Zhang, X.1    Li, J.2    Sejas, D.P.3    Pang, Q.4


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