Quantum dots for live cells, in vivo imaging, and diagnostics

Science

Volumn 307, Issue 5709, 2005, Pages 538-544

  Michalet, X ^a   Pinaud, F F ^a   Bentolila, L A ^a   Tsay, J M ^a   Doose, S ^a,d   Li, J J ^a   Sundaresan, G ^b   Wu, A M ^b   Gambhir, S S ^b,c   Weiss, S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BIELEFELD UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; INFRARED IMAGING; MATERIALS SCIENCE; MEDICAL IMAGING; NANOSTRUCTURED MATERIALS; SURGERY; TUMORS;

CELL TRAFFICKING; HIGH-RESOLUTION CELLULAR IMAGING; NEAR-INFRARED EMISSION; TUMOR TARGETING;

SEMICONDUCTOR QUANTUM DOTS;

GLYCINE RECEPTOR; NANOPARTICLE; QUANTUM DOT;

SCIENCE AND TECHNOLOGY;

BIOLOGY; CELL TRANSPORT; CYTOLOGY; DIAGNOSTIC PROCEDURE; DIFFUSION; ELECTRONICS; EXPERIMENTATION; IMAGING; IN VIVO STUDY; LYMPH NODE; NEAR INFRARED SPECTROSCOPY; NERVE CELL; PRIORITY JOURNAL; QUANTUM MECHANICS; REVIEW; SEMICONDUCTOR; SOLUBILIZATION; SYNTHESIS;

ANIMALS; CELL PHYSIOLOGY; DIAGNOSTIC IMAGING; DIAGNOSTIC TECHNIQUES AND PROCEDURES; FLUORESCENCE; HUMANS; MOLECULAR PROBES; QUANTUM DOTS;

EID: 19944433260     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1104274     Document Type: Review

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83. Supported by NIH grant 5-R01-EB000312, Keck Foundation grant 04074070, and Defense Advanced Research Projects Agency-Air Force Office of Scientific Research grant FA955004-10048. We are grateful for exchanges with our collaborators D. King, H.-P. Moore, A. P. Alivisatos, C. A. Larabell, D. Gerion, O. N. Witte, L. H. Rome, and G. Payne. Fluorescence microscopy images in Fig. 3 were obtained at the California NanoSystems Institute Advanced Light Microscopy/Spectroscopy Shared Facility (ALMSSF), Department of Chemistry and Biochemistry, at UCLA. We thank K. Hamadani, G. Iyer, and the referees for helpful comments on the manuscript; E. Margeat for help with the experiments described in Fig. 3; and T. Olafsen for help with the experiments described in Fig. 4, A and B. Requests for materials should be sent to qdot-info@chem.ucla. edu.