Uptake by hepatocytes and biliary excretion of intravenously administered polystyrene microspheres in rats

Journal of Drug Targeting

Volumn 7, Issue 3, 1999, Pages 213-221

  Ogawara, Ken Ichi ^a   Yoshida, Minoru ^a   Furumoto, Kentaro ^a   Takakura, Yoshinobu ^b   Hashida, Mitsuru ^b   Higaki, Kazutaka ^a   Kimura, Toshikiro ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Biliary excretion; Hepatocytes; Opsonin; Phagocytosis; Polystyrene microsphere

Indexed keywords

APOLIPOPROTEIN E; FLUORESCEIN ISOTHIOCYANATE; MICROSPHERE; POLYSTYRENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DRUG EXCRETION; DRUG UPTAKE; LASER MICROSCOPY; LIVER CELL; LIVER PERFUSION; MALE; NONHUMAN; PARTICLE SIZE; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT;

EID: 0033378774     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611869909085504     Document Type: Article

References (20)

1. Bachofen, V.K. (1992) Uptake of silica particles by isolated rat liver macrophages (Kupffer cells) is receptor mediated and can be blocked by competition. J. Clin. Invest., 90, 1819-1824.
2. Blunk, T., Hochstrasser, D.F., Sanchez, J., Muller, B.W. and Muller, R.H. (1993) Colloidal carriers for intravenous drug targeting: Plasma protein adsorption on surface-modified latex particles evaluated by two-dimensional polyacrylamide gel electrophoresis (2-D PAGE). Electrophoresis, 14, 1382-1387.
3. Cooper, A.D. (1997) Hepatic uptake of chylomicron remnants. J. Lipid Res., 38, 2173-2192.
4. Gatmaitan, Z., Varticovski, L., Ling, L., Mikkelsen, R., Steffan, A.M. and Arias, I.M. (1996) Studies on fenestral concentration in rat liver endothelial cells in culture. Am. J. Pathol., 148, 2027-2041.
5. Hardonk, M.J., Harms, G. and Koudstaal, J. (1985) Zonal heterogeneity of rat hepatocytes in the in vivo uptake of 17 nm colloidal gold granules. Histochemistry, 83, 473-477.
6. Hirabayashi, H., Nishikawa, M., Takakura, Y. and Hashida, M. (1996) Development and pharmacokinetics of galactosylated poly-L-glutamic acid as a biodegradable carrier for liver-specific delivery. Pharm. Res., 13, 880-884.
7. 1-containing liposomes. Biochim. Biophys. Acta, 1104, 95-101.
8. 1. Pharm. Res., 12, 1775-1780.
9. Liu, D., Liu, F. and Song, Y.K. (1995b) Recognition of clearance of liposomes containing phosphatidylserine are mediated by serum opsonin. Biochim. Biophys. Acta, 1235, 140-146.
10. Mahato, R.I., Takemura, S., Akamatsu, K., Nishikawa, M., Takakura, Y. and Hashida, M. (1997) Physicochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(L-lysine). Biochem. Pharmacol., 53, 887-895.
11. Matsuo, H., Funato, K., Harashima, H. and Kiwada, H. (1994) The complement but not mannose receptor-mediated phagocytosis is involved in the hepatic uptake of cetylmannoside-modified liposomes in situ. J. Drug Targeting. 2, 141-146.
12. 2 incorporated in lipid microspheres, for targeted delivery. J. Controlled Release, 28, 243-249.
13. Ogawara, K., Yoshida, M., Higaki, K., Kimura, T., Shiraishi, K., Nishikawa, M., Takakura, Y. and Hashida, M. (1999a) Hepatic uptake of polystyrene microspheres in rats: Effect of particle size on intrahepatic distribution. J. Controlled Release, 59, 15-22.
14. Ogawara, K., Yoshida, M., Kubo, J., Nishikawa, M., Takakura, Y., Hashida, M., Higaki, K. and Kimura, T. (1999b) Mechanisms of hepatic disposition of polystyrene microspheres in rats: Effects of serum depend on the sizes of microspheres. J. Controlled Release, 61, 241-250.
15. Ogawara, K., Hasegawa, S., Nishikawa, M., Takakura, Y. and Hashida, M. (1999c) Pharmacokinetic evaluation of mannosylated bovine serum albumin as a liver cell-specific carrier: Quantitative comparison with other hepatotropic ligands. J. Drug Targeting, 6, 349-360.
16. Rensen, P.C.N., Dijk, M.C.M., Havenaar, E.C., Bijsterbosch, M.K., Kruijt, J.K. and Berkel, T.J.C. (1995) Selective liver targeting of antivirals by recombinant chylomicrons: A new therapeutic approach to hepatitis B. Nature Medicine, 1, 221-225.
17. Schiff, J.M., Fisher, M.M., Jones, A.L. and Underdown, B.J. (1984) Receptor-mediated biliary transport of immunoglobulin A and asialoglycoprotein: Sorting and missorting of ligands revealed by two radiolabeling methods. J. Cell Biol., 98, 79-98.
18. Seki, J., Sasaki, H., Doi, M., Yoshikawa, H., Takahashi, Y., Yamane, S., Fukui, H., Sonoke, S., Yamamoto, H., Hirose, M., Ezure, Y., Ando, T., Ushimaru, K. and Sugiyama, M. (1994) Lipid nano-sphere (LNS), a protein-free analogue of lipoproteins, as a novel drug carrier for parenteral administration IV. J. Controlled Release, 28, 352-353.
19. Soji, T., Murata, Y., Ohira, A., Nishizono, H., Tanaka, M. and Herbert, D.C. (1992) Evidence that hepatocyte can phagocytize exogenous substances. Anat. Rec., 233, 543-546.
20. Yamaoka, K., Nakagawa, T. and Uno, T. (1978) Statistical moments in pharmacokinetics. J. Pharmacokinet. Biopharm., 6, 547-558.