Toxicology of engineered nanomaterials - A review of carcinogenic potential

Asian Pacific Journal of Cancer Prevention

Volumn 10, Issue 6, 2009, Pages 975-980

  Tsuda, Hiroyuki ^a,b   Xu, Jiegou ^b   Sakai, Yuta ^c   Futakuchi, Mitsuru ^b   Fukamachi, Katsumi ^b  

^a Nanotoxicology Project   (Japan)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^c NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Carbon black; Carcinogenicity; Nanoparticles; Titanium dioxide; Toxicology

Indexed keywords

CARCINOGEN; FULLERENE DERIVATIVE; NANOMATERIAL; TITANIUM; TITANIUM DIOXIDE;

ANIMAL; CHEMICALLY INDUCED DISORDER; ENVIRONMENTAL EXPOSURE; EXPOSURE; FOREIGN BODY REACTION; MOUSE; NANOTECHNOLOGY; NEOPLASM; RAT; REVIEW; RISK ASSESSMENT; SOOT;

ANIMALS; CARCINOGENS; ENVIRONMENTAL EXPOSURE; FOREIGN-BODY REACTION; FULLERENES; INHALATION EXPOSURE; MICE; NANOSTRUCTURES; NANOTECHNOLOGY; NEOPLASMS; RATS; RISK ASSESSMENT; SOOT; TITANIUM;

EID: 77955821126     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (22)

1. Baan RA (2007). Carcinogenic hazards from inhaled carbon black, titanium dioxide, and talc not containing asbestos or asbestiform fibers: recent evaluations by an IARC Monographs Working Group. Inhal Toxicol, 19 Suppl 1, 213-28.
2. Carrero-Sanchez JC, Elias AL, Mancilla R, et al (2006). Biocompatibility and toxicological studies of carbon nanotubes doped with nitrogen. Nano Lett, 6, 1609-16.
3. Dasenbrock C, Peters L, Creutzenberg O, Heinrich U (1996). The carcinogenic potency of carbon particles with and without PAH after repeated intratracheal administration in the rat. Toxicol Lett, 88, 15-21.
4. Emerich DF, Thanos CG (2003). Nanotechnology and medicine. Expert Opin Biol Ther, 3, 655-63.
5. Heinrich U, Fuhst R, Rittinghausen S, et al (1995). Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide. Inhal Toxicol, 7, 533-56.
6. Kamat JP, Devasagayam TP, Priyadarsini KI, Mohan H, Mittal JP (1998). Oxidative damage induced by the fullerene C60 on photosensitization in rat liver microsomes. Chem Biol Interact, 114, 145-59.
7. Koyama S, Endo M, Kim YA, et al (2006). Role of systemic Tcells and histopathological aspects after subcutaneous implantation of various carbon nanotubes in mice. Carbon, 44, 1079-92.
8. Lam CW, James JT, McCluskey R, Hunter RL (2004). Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci, 77, 126-34.
9. Liu M, Okada S (1994). Induction of free radicals and tumors in the kidneys of Wistar rats by ferric ethylenediamine-N, N'-diacetate. Carcinogenesis, 15, 2817-21.
10. Muller J, Delos M, Panin N, et al (2009). Absence of carcinogenic response to multiwall carbon nanotubes in a 2-year bioassay in the peritoneal cavity of the rat. Toxicol Sci, 110, 442-8.
11. Muller J, Huaux F, Moreau N, et al (2005). Respiratory toxicity of multi-wall carbon nanotubes. Toxicol Appl Pharmacol, 207, 221-31.
12. Nelson MA, Domann FE, Bowden GT, et al (1993). Effects of acute and subchronic exposure of topically applied fullerene extracts on the mouse skin. Toxicol Ind Health, 9, 623-30.
13. Newman MD, Stotland M and Ellis JI (2009). The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens. J Am Acad Dermatol, 61, 685-92.
14. Nikula KJ (2000). Rat lung tumors induced by exposure to selected poorly soluble nonfibrous particles. Inhal Toxicol, 12, 97-119.
15. Pott F, Roller M (2005). Carcinogenicity study with nineteen granular dusts in rats. Eur J Oncol, 10, 249.
16. Rittinghausen S, Mohr U, Dungworth DL (1997). Pulmonary cystic keratinizing squamous cell lesions of rats after inhalation/instillation of different particles. Exp Toxicol Pathol, 49, 433-46.
17. Roco MC (2003). Nanotechnology: convergence with modern biology and medicine. Curr Opin Biotechnol, 14, 337-46.
18. Sakamoto Y, Nakae D, Fukumori N, et al (2009). Induction of mesothelioma by a single intrascrotal administration of multiwall carbon nanotube in intact male Fischer 344 rats. J Toxicol Sci, 34, 65-76.
19. Sera N, Tokiwa H, Miyata N (1996). Mutagenicity of the fullerene C60-generated singlet oxygen dependent formation of lipid peroxides. Carcinogenesis, 17, 2163-9.
20. Shvedova AA, Castranova V, Kisin ER, et al (2003). Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J Toxicol Environ Health A, 66, 1909-26.
21. Takagi A, Hirose A, Nishimura T, et al (2008). Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci, 33, 105-16.
22. Warheit DB, Laurence BR, Reed KL, et al (2004). Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci, 77, 117-25.