Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats

Toxicological Sciences

Volumn 77, Issue 1, 2004, Pages 117-125

  Warheit, David B ^a   Laurence, B R ^a   Reed, K L ^a   Roach, D H ^a   Reynolds, G A M ^a   Webb, T R ^a  

^a DUPONT COMPANY   (United States)

Author keywords

Carbon nanotubes; Nanoparticle toxicity; Pulmonary; Single wall carbon nanotubes; SWCNT; Toxicity

Indexed keywords

CARBON NANOTUBE; CARBONYL IRON; GRAPHITE; SILICON DIOXIDE; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; HISTOPATHOLOGY; LUNG INJURY; LUNG LAVAGE; LUNG PARENCHYMA; LUNG TOXICITY; LUNG WEIGHT; MALE; MORTALITY; NONHUMAN; RAT; STATISTICAL ANALYSIS; UPPER RESPIRATORY TRACT OBSTRUCTION;

ACUTE TOXICITY TESTS; ALKALINE PHOSPHATASE; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; GRANULOMA, FOREIGN-BODY; GRANULOMA, RESPIRATORY TRACT; INHALATION EXPOSURE; INTUBATION, INTRATRACHEAL; L-LACTATE DEHYDROGENASE; LONGEVITY; LUNG; LUNG DISEASES; MALE; NANOTUBES, CARBON; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0942269167     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg228     Document Type: Article

References (15)

1. Adelmann, P., Baierl, T., Drosselmeyer, E., Politis, C., Polzer, G., Seidel, A., Schwegler-Berry, D., and Steinleitner, C. (1994). Effects of fullerenes on alveolar macrophages in vitro. In Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract (U. Mohr, D. L. Dungworth, J. Mauderly, and G. Oberdoerster, Eds.), pp. 405-407, ILSI Press, Washington, DC.
2. Baron, P. A., Maynard, A. D., and Foley, M. (2002). Evaluation of aerosol release during the handling of unrefined single walled carbon nanotube material. NIOSH Report. NIOSH DART-02-191, December 2002.
3. Driscoll, K. E., Carter, J. M., Howard, B. W., Hassenbein, D. G., Pepelko, W., Baggs, R. B., and Oberdoerster, G. (1996). Pulmonary inflammatory, chemokine, and mutagenic responses in rats after subchronic inhalation of carbon black. Toxicol. Appl. Pharmacol. 136, 372-380.
4. Heinrich, U., Peters, L., Creutzenberg, O., Dasenbrock, C., and Hoymann, H. G. (1994). Inhalation exposure of rats to tar/pitch condensation aerosol or carbon black alone or in combination with irritant gases. In Toxic and Carcinogenic Effects of Solid Particles in the Respiratory Tract (U. Mohr, D.L. Dungworth, J. L. Mauderly, and G. Oberdørster, Eds.), pp. 433-441, ILSI Press, Washington, DC.
5. Heinrich, U., Fuhst, R., Rittinghausen, S., Creutzenberg, O., Bellmann, B., Koch, W., and Levsen, K. (1995). Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide. Inhal. Toxicol. 7, 533-556.
6. Huczko, A., Lange, H., Calko, E., Grubek-Jaworska, H., and Droszcz, P. (2001). Physiological testing of carbon nanotubes: Are they asbestos-like? Pol. Fullerene Sci. Technol. 9, 251-254 (abstract).
7. Joseph, G. (2002). Industrial hygiene air monitoring report. DuPont Co. internal report, October, 2002.
8. Lam, C., James, J, T., McCloskey, R., and Hunter, R. L. (2003). Pulmonary toxicity of carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicologist 72 (S-1), 44.
9. Maynard, A. D., Baron, P. A., Foley, M., Shvedova, A. A., Kisin, E. R., and Castranova, V. (2003). Exposure to carbon nanotube material I: Aerosol release during the handling of unrefined single walled carbon nanotube material. J. Toxicol. Environ. Health (in press).
10. Nikula, K. J., Snipes, M. B., Barr, E. B., Griffith, W. C., Henderson, R. F., and Mauderly, J. L. (1995). Comparative pulmonary toxicities and carcinogenicities of chronically inhaled diesel exhaust and carbon black in F344 rats. Fundam. Appl. Toxicol. 25, 80-94.
11. Rinzler, A. G., Liu, J., Dai, H., Nikolaev, P., Huffman, C. B., Rodriguez-Macias, F. J., Boul, P. J., Lu, A. H., Heymann, D., Colbert, D. T., et al. (1998). Large-scale purification of single-wall carbon nanotubes. Process, product, and characterization. Applied Physics A: Mater. Sci. Process. A67(1), 29-37.
12. Shvedova, A. A., Castranova, V., Kisin, E. R., Murray, A. R., Schwegler-Berry, D., Gandelsman, V. Z., Maynard, A, and Baron P. (2003). Exposure to nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J. Toxicol. Environ. Health 66, 1901-1918.
13. Warheit, D. B., Hill, L. H., George, G., and Brody, A. R. (1986) Time course of chemotactic factor generation and the corresponding macrophage response to asbestos inhalation. Amer. Rev. Respir. Dis. 134, 128-133.
14. Warheit, D. B., Carakostas, M. C., Hartsky, M. A., and Hansen, J. F. (1991). Development of a short-term inhalation bioassay to assess pulmonary toxicity of inhaled particles: Comparisons of pulmonary responses to carbonyl iron and silica. Toxicol. Appl. Pharmacol. 107, 350-368.
15. Warheit, D. B., Hansen, J. F., Yuen, I. S., Kelly, D. P., Snajdr, S., and Hartsky, M.A. (1997). Inhalation of high concentrations of low toxicity dusts in rats results in pulmonary and macrophage clearance impairments. Toxicol. Appl. Pharmacol. 145, 10-22.