Nanotech approaches to drug delivery and imaging

Drug Discovery Today

Volumn 8, Issue 24, 2003, Pages 1112-1120

  Sahoo, Sanjeeb K ^a   Labhasetwar, Vinod ^b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Diagnosis; Drug Discovery; Drug therapy; Imaging; Liposomes; Nanoparticles; Techniques Methods

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CISPLATIN; COPOLYMER; DENDRIMER; DEXAMETHASONE; DOXORUBICIN; FLUOROURACIL; IRON; LEUCINE ENKEPHALIN[2 DEXTRO ALANINE 6 ARGININE]; LIPOSOME; MACROGOL; NANOPARTICLE; POLYMER; POLYSORBATE 80;

BIODEGRADABILITY; BIOTECHNOLOGY; CERAMICS; COST EFFECTIVENESS ANALYSIS; CRYSTAL STRUCTURE; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG EFFECT; DRUG FORMULATION; DRUG PENETRATION; DRUG SOLUBILITY; ECONOMIC ASPECT; HUMAN; IMAGING SYSTEM; INDUSTRY; LIQUID; MAGNETISM; MICELLE; NANOTECHNOLOGY; REVIEW; SIDE EFFECT; SURFACE PROPERTY;

DRUG DELIVERY SYSTEMS; DRUG DESIGN; NANOTECHNOLOGY;

EID: 0346848865     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(03)02903-9     Document Type: Review

References (89)

1. Wilkinson J.M. Nanotechnology applications in medicine. Med. Device Technol. 14:(5):2003;29-31.
2. Roco M.C. Nanotechnology: convergence with modern biology and medicine. Curr. Opin. Biotechnol. 14:2003;337-346.
3. Roco, M.C. and Bainbridge, W. eds. (2001) Social Implications of Nanoscience and Technology. National Science Foundation Report.
4. Roco, M.C. and Bainbridge, W.S. eds. (2002) Converging Technologies for Improving Human Performance. National Science Foundation and Department of Commerce Report, Kluwer Academic Publishers.
5. Brigger I., et al. Nanoparticles in cancer therapy and diagnosis. Adv. Drug Deliv. Rev. 54:2002;631-651.
6. Panyam J., et al. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev. 55:2003;329-347.
7. Lamprecht A., et al. Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease. J. Pharmacol. Exp. Ther. 299:2001;775-781.
8. Desai M.P., et al. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm. Res. 13:1996;1838-1845.
9. Desai M.P., et al. The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharm. Res. 14:1997;1568-1573.
10. Panyam J., et al. Fluorescence and electron microscopy probes for cellular and tissue uptake of poly(D,L-lactide-co-glycolide) nanoparticles. Int. J. Pharm. 262:2003;1-11.
11. Thomas M., et al. Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 100:2003;9138-9143.
12. Panyam J., et al. Rapid endo-lysosomal escape of poly(DL-lactide-co- glycolide) nanoparticles: implications for drug and gene delivery. FASEB J. 16:2002;1217-1226.
13. Davda J., et al. Characterization of nanoparticle uptake by endothelial cells. Int. J. Pharm. 233:2002;51-59.
14. Panyam, J. et al. Sustained cytoplasmic delivery of drugs with intracellular receptors using biodegradable nanoparticles, Mol. Pharm. (in press).
15. Hussain N., et al. Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics. Adv. Drug Deliv. Rev. 50:2001;107-142.
16. Van Der Lubben I.M., et al. In vivo uptake of chitosan microparticles by murine Peyer's patches: visualization studies using confocal laser scanning microscopy and immunohistochemistry. J. Drug Target. 9:2001;39-47.
17. Lutsiak M.E., et al. Analysis of poly(D,L-lactic-co-glycolic acid) nanosphere uptake by human dendritic cells and macrophages in vitro. Pharm. Res. 19:2002;1480-1487.
18. Moghimi S.M., et al. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol. Rev. 53:2001;283-318.
19. Scherer F., et al. Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo. Gene Ther. 9:2002;102-109.
20. Monsky W.L., et al. Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. Cancer Res. 59:1999;4129-4135.
21. Maeda H. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv. Enzyme Regul. 41:2001;189-207.
22. Sahoo S.K., et al. Pegylated zinc protoporphyrin: a water-soluble heme oxygenase inhibitor with tumor-targeting capacity. Bioconjugate Chem. 13:2002;1031-1038.
23. Panyam J., et al. Efficiency of Dispatch® and Infiltrator® cardiac infusion catheters in arterial localization of nanoparticles in a porcine coronary model of restenosis. J. Drug Target. 10:2002;515-523.
24. Guzman L.A., et al. Local intraluminal infusion of biodegradable polymeric nanoparticles, A novel approach for prolonged drug delivery after balloon angioplasty. Circulation. 94:1996;1441-1448.
25. Lanza G.M., et al. Targeted antiproliferative drug delivery to vascular smooth muscle cells with a magnetic resonance imaging nanoparticle contrast agent: implications for rational therapy of restenosis. Circulation. 106:2002;2842-2847.
26. Lockman P.R., et al. Nanoparticle technology for drug delivery across the blood-brain barrier. Drug Dev. Ind. Pharm. 28:2002;1-13.
27. Fisher R.S., et al. Potential new methods for antiepileptic drug delivery. CNS Drugs. 16:2002;579-593.
28. Kastin A.J., et al. Interleukin-10 as a CNS therapeutic: the obstacle of the blood-brain/blood-spinal cord barrier. Mol. Brain Res. 114:2003;168-171.
29. Sun H., et al. Drug efflux transporters in the CNS. Adv. Drug Deliv. Rev. 55:2003;83-105.
30. Kreuter J., et al. Direct evidence that polysorbate-80-coated poly(butylcyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles. Pharm. Res. 20:2003;409-416.
31. Cherian A.K., et al. Self-assembled carbohydrate-stabilized ceramic nanoparticles for the parenteral delivery of insulin. Drug Dev. Ind. Pharm. 26:2000;459-463.
32. Jain T.K., et al. Nanometer silica particles encapsulating active compounds: a novel ceramic drug carrier. J. Am. Chem. Soc. 120:1998;11092-11095.
33. Roy I., et al. Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery. Int. J. Pharm. 250:2003;25-33.
34. Lal M.L., et al. Silica nanobubbles containing an organic dye in a multilayered organic/inorganic heterostructure with enhanced luminescence. Chem. Mater. 19:2000;2632-2639.
35. Badley R.D., et al. Surface modification of colloidal silica. Langmuir. 6:1990;792-801.
36. Roy I., et al. Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy. J. Am. Chem. Soc. 125:2003;7860-7865.
37. Nishiyama N., et al. Polymeric micelle drug carrier systems: PEG-PAsp(Dox) and second generation of micellar drugs. Adv. Exp. Med. Biol. 519:2003;155-177.
38. Kataoka K., et al. Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv. Drug Deliv. Rev. 47:2001;113-131.
39. Rosler A., et al. Advanced drug delivery devices via self-assembly of amphiphilic block copolymers. Adv. Drug Deliv. Rev. 53:2001;95-108.
40. Jones M., et al. Polymeric micelles - a new generation of colloidal drug carriers. Eur. J. Pharm. Biopharm. 48:1999;101-111.
41. Savic R., et al. Micellar nanocontainers distribute to defined cytoplasmic organelles. Science. 300:2003;615-618.
42. Nakanishi T., et al. Development of the polymer micelle carrier system for doxorubicin. J. Control. Release. 74:2001;295-302.
43. Yokoyama M., et al. Selective delivery of adriamycin to a solid tumor using a polymeric micelle carrier system. J. Drug Target. 7:1999;171-186.
44. Matsumura Y., et al. Reduction of the side effects of an antitumor agent, KRN5500, by incorporation of the drug into polymeric micelles. Jpn. J. Cancer Res. 90:1999;122-128.
45. Torchilin V.P. Structure and design of polymeric surfactant-based drug delivery systems. J. Control. Release. 73:2001;137-172.
46. Torchilin V.P., et al. Immunomicelles: targeted pharmaceutical carriers for poorly soluble drugs. Proc. Natl. Acad. Sci. U. S. A. 100:2003;6039-6044.
47. Kataoka K., et al. Doxorubicin-loaded poly(ethylene glycol)-poly(beta- benzyl-L-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance. J. Control. Release. 64:2000;143-153.
48. Nishiyama N., et al. Cisplatin-loaded polymer-metal complex micelle with time-modulated decaying property as a novel drug delivery system. Pharm. Res. 18:2001;1035-1041.
49. Mizumura Y., et al. Cisplatin-incorporated polymeric micelles eliminate nephrotoxicity, while maintaining antitumor activity. Jpn. J. Cancer Res. 92:2001;328-336.
50. Adams M.L., et al. Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(L-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. Biomacromolecules. 4:2003;750-757.
51. Lavasanifar A., et al. Block copolymer micelles for the encapsulation and delivery of amphotericin B. Pharm. Res. 19:2002;418-422.
52. Sessa G., et al. Formation of artificial lysosome in vitro. J. Clin. Invest. 48:1969;76a-77a.
53. Bangham A.D., et al. Diffusion of univalent ions across the lamellae of swollen phospholipids. J. Mol. Biol. 13:1965;238-252.
54. Gabizon A., et al. Development of liposomal anthracyclines: from basics to clinical applications. J. Control. Release. 53:1998;275-279.
55. Allen T.M. Liposomes, Opportunities in drug delivery. Drugs. 54:(Suppl. 4):1997;8-14.
56. Lasic D.D., et al. Sterically stabilized liposomes in cancer therapy and gene delivery. Curr. Opin. Mol. Ther. 1:1999;177-185.
57. Tomalia D.A., et al. A new class of polymers: starburst-dendritic macromolecules. Polym. J. 17:1985;117-132.
58. Quintana A., et al. Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor. Pharm. Res. 19:2002;1310-1316.
59. Padilla De Jesus O.L., et al. Polyester dendritic systems for drug delivery applications: in vitro and in vivo evaluation. Bioconjugate Chem. 13:2002;453-461.
60. Kihara F., et al. Effects of structure of polyamidoamine dendrimer on gene transfer efficiency of the dendrimer conjugate with alpha-cyclodextrin. Bioconjugate Chem. 13:2002;1211-1219.
61. Tripathi P.K., et al. Dendrimer grafts for delivery of 5-fluorouracil. Pharmazie. 57:2002;261-264.
62. Emerich D.F., et al. Nanotechnology and medicine. Expert Opin. Biol. Ther. 3:2003;655-663.
63. Akerman M.E., et al. Nanocrystal targeting in vivo. Proc. Natl. Acad. Sci. U. S. A. 99:2002;12617-12621.
64. Chan W.C., et al. Luminescent quantum dots for multiplexed biological detection and imaging. Curr. Opin. Biotechnol. 13:2002;40-46.
65. Han M., et al. Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules. Nat. Biotechnol. 19:2001;631-635.
66. Mitchell P. Turning the spotlight on cellular imaging. Nat. Biotechnol. 19:2001;1013-1017.
67. Clark H.A., et al. Optical nanosensors for chemical analysis inside single living cells. 2. Sensors for pH and calcium and the intracellular application of PEBBLE sensors. Anal. Chem. 71:1999;4837-4843.
68. Sumner J.P., et al. A fluorescent PEBBLE nanosensor for intracellular free zinc. Analyst. 127:2002;11-16.
69. Peira E., et al. In vitro and in vivo study of solid lipid nanoparticles loaded with superparamagnetic iron oxide. J. Drug Target. 11:2003;19-24.
70. Ito A., et al. Tumor regression by combined immunotherapy and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanoma. Cancer Sci. 94:2003;308-313.
71. Chemla Y.R., et al. Ultrasensitive magnetic biosensor for homogeneous immunoassay. Proc. Natl. Acad. Sci. U. S. A. 97:2000;14268-14272.
72. Lubbe A.S., et al. Preclinical experiences with magnetic drug targeting: tolerance and efficacy. Cancer Res. 56:1996;4694-4701.
73. Babincova M., et al. High-gradient magnetic capture of ferrofluids: implications for drug targeting and tumor embolization. Z. Naturforsch. (Sect. C). 56:2001;909-911.
74. Tsavellas G., et al. Flow cytometry correlates with RT-PCR for detection of spiked but not circulating colorectal cancer cells. Clin. Exp. Metastasis. 19:2002;495-502.
75. Collarini E.J., et al. Comparison of methods for erythroblast selection: application to selecting fetal erythroblasts from maternal blood. Cytometry. 45:2001;267-276.
76. Ehrlich, P. (1906) The relations existing between chemical constitution, distribution and pharmacological action, In Collected Studies on Immunity, (Ehrlich, P., ed.), pp. 404-442, Wiley & Sons.
77. Langer R. Drug delivery and targeting. Nature. 392:1998;5-10.
78. LaVan D.A., et al. Moving smaller in drug discovery and delivery. Nat. Rev. Drug Discov. 1:2002;77-84.
79. Davis S.S. Biomedical applications of nanotechnology - implications for drug targeting and gene therapy. Trends Biotechnol. 15:1997;217-224.
80. Passirani C., et al. Long-circulating nanoparticles bearing heparin or dextran covalently bound to poly(methyl methacrylate). Pharm. Res. 15:1998;1046-1050.
81. Roser M., et al. Surface-modified biodegradable albumin nano- and microspheres. II: effect of surface charges on in vitro phagocytosis and biodistribution in rats. Eur. J. Pharm. Biopharm. 46:1998;255-263.
82. Gref R., et al. Biodegradable long-circulating polymeric nanospheres. Science. 263:1994;1600-1603.
83. Yowell S.L., et al. Novel effects with polyethylene glycol modified pharmaceuticals. Cancer Treat. Rev. 28(Suppl. A):2002;3-6.
84. Harris J.M., et al. Effect of pegylation on pharmaceuticals. Nat. Rev. Drug Discov. 2:2003;214-221.
85. Uwatoku T., et al. Application of nanoparticle technology for the prevention of restenosis after balloon injury in rats. Circ. Res. 92:2003;e62-e69.
86. Luisa Corvo M., et al. Superoxide dismutase entrapped in long-circulating liposomes: formulation design and therapeutic activity in rat adjuvant arthritis. Biochim. Biophys. Acta. 1564:2002;227-236.
87. Jain S., et al. RGD-anchored magnetic liposomes for monocytes/ neutrophils-mediated brain targeting. Int. J. Pharm. 261:2003;43-55.
88. Dayton P.A., et al. Targeted imaging using ultrasound. J. Magn. Reson. Imaging. 16:2002;362-377.
89. Wadghiri Y.Z., et al. Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging. Magn. Reson. Med. 50:2003;293-302.