A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice

Nature Nanotechnology

Volumn 3, Issue 4, 2008, Pages 216-221

  Schipper, Meike L ^a   Nakayama Ratchford, Nozomi ^b   Davis, Corrine R ^a   Kam, Nadine Wong Shi ^b   Chu, Pauline ^a   Liu, Zhuang ^b   Sun, Xiaoming ^b   Dai, Hongjie ^b   Gambhir, Sanjiv S ^a  

^a STANFORD UNIVERSITY   (United States)

^b Department of Chemistry ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE TRANSFER; GENES; HISTOLOGY; MAMMALS; MEDICAL APPLICATIONS; NANOTUBES; NUCLEIC ACIDS; PROTEINS; TOXICITY; TUMORS; YARN;

AGE-RELATED CHANGES; BIOMEDICAL APPLICATIONS; CHRONIC TOXICITY; FUNCTIONALIZED; GENE SILENCING; IN-VIVO; SMALL SAMPLES;

SINGLE-WALLED CARBON NANOTUBES (SWCN);

CARBON NANOTUBE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; BLOOD CLOT; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HISTOLOGY; LABORATORY; MACROPHAGE; MALE; MEDICAL TECHNOLOGY; NONHUMAN; PRIORITY JOURNAL; RAMAN SPECTROMETRY; SURVIVAL; TOXICOLOGY;

EID: 41849126454     PISSN: 17483387     EISSN: 17483395     Source Type: Journal    
DOI: 10.1038/nnano.2008.68     Document Type: Article

References (30)

1. Bianco, A. et al. Biomedical applications of functionalised carbon nanotubes. Chem. Commun. 571-577 (2005).
2. Bianco, A., Kostarelos, K. & Prato, M. Applications of carbon nanotubes in drug delivery. Curr. Opin. Chem. Biol. 9, 674-679 (2005).
3. Klumpp, C. et al. Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics. Biochim. Biophys. Acta 1758, 404-412 (2006).
4. Wu, W. et al. Targeted delivery of amphotericin B to cells by using functionalized carbon nanotubes. Angew. Chem. Int. Edn 44, 6358-6362 (2005).
5. Kam, N. W. et al. Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc. Natl Acad. Sci. USA 102, 11600-11605 (2005).
6. Kam, N. W., Liu, Z. & Dai, H. Carbon nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathway. Angew. Chem. Int. Edn 45, 577-581 (2006).
7. Pantarotto, D. et al. Translocation of bioactive peptides across cell membranes by carbon nanotubes. Chem. Commun. 16-17 (2004).
8. Pantarotto, D. et al. Functionalized carbon nanotubes for plasmid DNA gene delivery. Angew. Chem. Int. Edn 43, 5242-5246 (2004).
9. Singh, R. et al. Binding and condensation of plasmid DNA onto functionalized carbon nanotubes: toward the construction of nanotube-based gene delivery vectors. J. Am. Chem. Soc. 127, 4388-4396 (2005).
10. Liu, Y. et al. Polyethylenimine-grafted multiwalled carbon nanotubes for secure noncovalent immobilization and efficient delivery of DNA. Angew. Chem. Int. Edn 44, 4782-4785 (2005).
11. Kam, N. W., Liu, Z. & Dai, H. Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing. J. Am. Chem. Soc. 127, 12492-12493 (2005).
12. Liu, Z. et al. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nature Nanotech. 2, 47-52 (2007).
13. Lison, D. & Muller, J. Lung and systemic responses to carbon nanotubes (CNT) in mice. Toxicol. Sci. 101, 179-180 (2008).
14. Mitchell, L. A. et al. Pulmonary and systemic immune response to inhaled multiwalled carbon nanotubes. Toxicol. Sci. 100, 203-214 (2007).
15. Monteiro-Riviere, N. A. et al. Multi-walled carbon nanotube interactions with human epidermal keratinocytes. Toxicol. Lett. 155, 377-384 (2005).
16. Shvedova, A. A. et al. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J. Toxicol. Environ. Health A 66, 1909-1926 (2003).
17. Cui, D. et al. Effect of single wall carbon nanotubes on human HEK293 cells. Toxicol. Lett. 155, 73-85 (2005).
18. Bottini, M. et al. Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicol. Lett. 160, 121-126 (2006).
19. Kagan, V. E. et al. Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: Role of iron. Toxicol. Lett. 165, 88-100 (2006).
20. Tian, F. et al. Cytotoxicity of single-wall carbon nanotubes on human fibroblasts. Toxicol. In Vitro 20(7) 1202-1212 (2006).
21. Sayes, C. M. et al. Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro. Toxicol. Lett. 161, 135-142 (2006).
22. Magrez, A. et al. Cellular toxicity of carbon-based nanomaterials. Nano Lett. 6, 1121-1125 (2006).
23. Shvedova, A. A. et al. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am. J. Physiol. Lung Cell Mol. Physiol. 289, L698-L708 (2005).
24. Lam, C. W. et al. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol. Sci. 77, 126-134 (2004).
25. Warheit, D. B. et al. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol. Sci. 77, 117-125 (2004).
26. Radomski, A. et al. Nanoparticle-induced platelet aggregation and vascular thrombosis. Br. J. Pharmacol. 146, 882-893 (2005).
27. Wang, H. et al. Biodistribution of carbon single-wall carbon nanotubes in mice. J. Nanosci. Nanotechnol. 4, 1019-1024 (2004).
28. Singh, R. et al. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc. Natl Acad. Sci. USA 103, 3357-3362 (2006).
29. Cherukuri, P. et al. Near-infrared fluorescence microscopy of single-walled carbon nanotubes in phagocytic cells. J. Am. Chem. Soc. 126, 15638-15639 (2004).
30. Urch, B. et al. Acute blood pressure responses in healthy adults during controlled air pollution exposures. Environ. Health Perspect. 113, 1052-1055 (2005).