Occupational toxicology of nickel and nickel compounds

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 28, Issue 3, 2009, Pages 177-208

  Zhao, Jinshun ^a   Shi, Xianglin ^b   Castranova, Vincent ^a   Ding, Min ^a  

^a NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Acute toxicity; Biological monitoring; Carcinogenicity; Chronic toxicity; Genotoxicity; Molecular mechanisms of carcinogenesis; Nickel; Nickel compounds; Occupational exposure; Occupational exposure limits; Reproductive toxicity; Toxicokinetics; Toxicology

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ASCORBATE PEROXIDASE; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LACTATE DEHYDROGENASE; MALONALDEHYDE; N ACETYL BETA GLUCOSAMINIDASE; NICKEL; NICKEL SUBSULFIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ABDOMINAL CRAMP; ABDOMINAL DISCOMFORT; ACUTE TOXICITY; AIR POLLUTANT; ASTHMA; BIOAVAILABILITY; BIOLOGICAL MONITORING; BRAIN EDEMA; CANCER RISK; CARCINOGENESIS; CARCINOGENICITY; CHROMOSOME ABERRATION; CHRONIC TOXICITY; CYANOSIS; DEATH; DIARRHEA; DIZZINESS; DUST; ECZEMA; ELECTROPLATING INDUSTRY; ENZYME INDUCTION; FIBROSIS; FUME; GENE MUTATION; GENOTOXICITY; HEADACHE; HUMAN; HYPEREMIA; HYPERPLASIA; IMMUNOGLOBULIN BLOOD LEVEL; INFLAMMATION; INGESTION; INHALATION; INSOMNIA; INTERSTITIAL PNEUMONIA; IRRITABILITY; LEUKOCYTOSIS; LIPID PEROXIDATION; LUNG ALVEOLUS EPITHELIUM; LUNG CANCER; LUNG EDEMA; LUNG FIBROSIS; LUNG HEMORRHAGE; MACROPHAGE; MELTING POINT; METABOLISM; MOLECULAR MECHANICS; MOLECULAR WEIGHT; NAUSEA; NEUTROPHIL; NONHUMAN; NOSE SEPTUM PERFORATION; OCCUPATIONAL EXPOSURE; OCCUPATIONAL TOXICOLOGY; POLLUTION; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; REVIEW; RHINITIS; SIGNAL TRANSDUCTION; SISTER CHROMATID EXCHANGE; SKIN ABSORPTION; SKIN ALLERGY; SKIN IRRITATION; SOLUBILITY; TACHYCARDIA; TACHYPNEA; THORAX PAIN; TOXICOKINETICS; ULCER; URINARY EXCRETION; VERTIGO; VOMITING; WEAKNESS; WELDING; WORK ENVIRONMENT;

EID: 70449484963     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/JEnvironPatholToxicolOncol.v28.i3.10     Document Type: Review

References (232)

1. D enkhaus E, Salnikow K. Nickel essentiality, toxicity, and carcinogenicity. Crit Rev Oncol Hematol. 2002;42(1):35-56.
2. IA RC. IA RC Monographs on the evaluation of carcinogenic risks to humans, vol.49. Chromium, nickel and welding summary of data reported and evaluation: World Health Organization International Agency for Research on Cancer; 1997.
3. Morgan LG, Usher V. Health problems associated with nickel refining and use. Ann Occup Hyg. 1994;38(2):189-198
4. U .S. Department of Health and Human Services, National Center for Environmental Assessment, Office of Research and Development. Public Health Service. Report on Carcinogens, 11th ed. Integrated Risk Information System (IRIS ) on Nickel Carbonyl. Washington, DC; 1999.
5. U .S. Department of Health and Human Services, National Center for Environmental Assessment, Office of Research and Development. Public Health Service. Integrated Risk Information System (IRIS) on Nickel Refinery Dust. Washington, DC; 1999.
6. A gency for Toxic Substances and Disease Registry (ATSD R). U.S. Department of Health and Human Services. Public Health Service. Toxicological Profile for Nickel (update). Syracuse Research Corporation; 2005.
7. Barceloux DG . Nickel. J Toxicol Clin Toxicol. 1999;37(2):239-258
8. IA RC. Chromium, Nickel and Welding. IA RC monographs on the evaluation of carcinogenic risk of chemicals to humans. Lyon, France: International Agency for Research on Cancer. 1990;49:677.
9. U .S. Department of Health and Human Services Public Health Service, National Toxicology Program. Report on Carcinogens, 11th Ed; 2009
10. U.S. Environmental Protection Agency, Office of Air and Radiation Office of Air Quality Planning and Standards. Locating and estimating air emission from sources of nickel. EPA -450/4-84-007f ed. Research Triangle Park, NC: U.S. EPA ; 1984.
11. Kuck PH. U.S. Geological Survey Minerals Yearbook, Nickel-2000; 2000.
12. Bencko V. Nickel: a review of its occupational and environmental toxicology. J Hyg Epidemiol Microbiol Immunol. 1983;27(2):237-247
13. Kuck PH. U.S. Geological Survey Minerals Yearbook-2005, Nickel-2005; 2005.
14. G awkrodger DJ, Lewis FM, Shah M. Contact sensitivity to nickel and other metals in jewelry reactors. J Am Acad Dermatol. 2000;43(1 Pt 1):31-36
15. Zhang Q, Kusaka Y, Zhu X, Sato K, Mo Y, Kluz T, Donaldson K. Comparative toxicity of standard nickel and ultrafine nickel in lung after intratracheal instillation. J Occup Health. 2003;45(1):23-30.
16. Kyono H, Kusaka Y, Homma K, Kubota H, Endo-Ichikawa Y. Reversible lung lesions in rats due to short-term exposure to ultrafine cobalt particles. Ind Health. 1992;30(3-4):103-118
17. Maynard AD , Kuempel ED . Airborne nanostructured particles and occupational health. J Nanopart Res. 2005(7):587-614.
18. NiPE RA. Safe use of nickel in the workplace. Incorporating European nickel risk assessment outcomes. A guide for health maintenance of workers exposed to nickel, its compounds and alloys. health guide. 3rd ed. Durham, NC : Nickel Producers Environmental Research Association; 2008.
19. IPCS . Environmental health criteria 108: Nickel. Geneva, Switzerland: International Programme on Chemical Safety World Health Organization; 1991.
20. Sullivan JB, Krieger JGR. Clinical Environmental Health and Toxic Exposures. Philadelphia: Lippincott Williams & Wilkins; 2001.
21. NiDI. Safe use of nickel in the workplace, 2nd ed. Toronto: Nickel Development Institute; 1997.
22. ACGIH. TLVs and BEIs based on the documentation of the threshold limit values for chemical substances and physical agents & biological exposure indices. Cincinnati, OH: Signature Publications; 2008.
23. NIOSH. NIOSH pocket guide to chemical hazards: DHHS(NIOSH) publication no. 2005-2149; 2005.
24. ACGIH. TLVs® and BEIs® -Threshold limit values for chemical substances and physical agents and biological exposure indices. Cincinnati: Worldwide; 2001.
25. Robert F. M. Herber, John H. Duffus, Jytte Molin Christensen, Erik Olsen, Park MV. Risk assessment for occupational exposure to chemicals. A review of current methodology. Pure Appl Chem. 2001;73(6):993-1031.
26. Seilkop SK , Oller AR. Respiratory cancer risks associated with low-level nickel exposure: an integrated assessment based on animal, epidemiological, and mechanistic data. Regul Toxicol Pharmacol. 2003;37(2):173-190
27. Nickel Institute. Safe Use of Nickel in the Workplace: a guide for health maintenance of workers exposed to nickel, its compounds and alloys. 3rd ed. Ontario, Canada; 2008.
28. T he Japan Society for Occupational Health. Recommendation of occupational exposure limits (2007-2008). J Occup Health. 2007;49(4):328-344
29. Ministry of Health of the People's Republic of China. Occupational exposure limits for hazardous agents in the workplace Chemical hazardous agents. 2007. p. 11.
30. Korea Labor Ministry. Exposure Limits of Chemical and Physical Agents, Labor Ministrial Decree 2008-26 Korea; 2008.
31. Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for nickel, ATSDR/ U.S. Public Health Service, ATSD R/TP -88/19. Agency for Toxic Substances and Disease Registry. 1988.
32. Torjussen W, Andersen I. Nickel concentrations in nasal mucosa, plasma, and urine in active and retired nickel workers. Ann Clin Lab Sci. 1979;9(4):289-298 (Pubitemid 9228414)
33. Vincent JH. Aerosol Sampling: Science and Practice. London: Wiley; 1989.
34. Malten KE. Thoughts on irritant contact dermatitis. Contact Dermatitis. 1981;7(5):238-247
35. Agency for Toxic Substances and Disease Registry (ATSD R). Draft for Public Comment: Toxicological Profile for Nickel Atlanta (Georgia), USA: US Public Health Service; 2003.
36. Sunderman FW, Aitio A, Morgan LG, Norseth T. Biological monitoring of nickel. Toxicol and Ind Health. 1986;2(1):17-78.
37. Coogan TP, Latta DM, Snow ET, Costa M. Toxicity and carcinogenicity of nickel compounds, In: Critical Reviews in Toxicology. McClellan RO, ed. CRC Press, Boca Raton, FL : CRC Press. 1989, pp. 341-384
38. Tjalve H, Borg-Neczak K. Effects of lipophilic complex formation on the disposition of nickel in experimental animals. Sci Total Environ. 1994;148(2-3):217-242
39. Hendel RC, Sunderman FW Jr Species variations in the proportions of ultrafiltrable and protein-bound serum nickel. Res Commun Chem Pathol Pharmacol. 1972;4(1):141-146
40. L ucassen M, Sarkar B. Nickel(II )-binding constituents of human blood serum. J Toxicol Environ Health. 1979;5(5):897-905.
41. Cohn JR, Emmett EA . The excretion of trace metals in human sweat. Ann Clin Lab Sci. 1978;8(4):270-275
42. Sunderman FW Jr, Marzouk A, Hopfer SM, Zaharia O, Reid MC. Increased lipid peroxidation in tissues of nickel chloride-treated rats. Ann Clin Lab Sci. 1985;15(3):229-236
43. D ostal LA , Hopfer SM , Lin SM , Sunderman FW Jr. Effects of nickel chloride on lactating rats and their suckling pups, and the transfer of nickel through rat milk. Toxicol Appl Pharmacol. 1989;101(2):220-231
44. Sunderman FW. Biological monitoring of nickel in humans. Scandinavian Journal of Work, Health & Environment. 1993;19(Suppl 1):34-38
45. Sun Y, Sun D, Zhou Z, Zhu G, Lei L, Zhang H, Chang X, Jin T. Estimation of benchmark dose for bone damage and renal dysfunction in a Chinese male population occupationally exposed to lead. Ann Occup Hyg. 2008;52(6):527-533
46. Jarvisalo J, Olkinuora M, Kiilunen M, Kivisto H, Ristola P, Tossavainen A, Aitio A. Urinary and blood manganese in occupationally nonexposed populations and in manual metal arc welders of mild steel. Int Arch Occup Environ Health. 1992;63(7):495-501.
47. Sunderman FW Jr, Hopfer SM , Sweeney KR, Marcus AH, Most BM, Creason J. Nickel absorption and kinetics in human volunteers. Proc Soc Exp Biol Med. 1989;191(1):5-11.
48. Werner MA, Thomassen Y, Hetland S, Norseth T, Berge SR, Vincent JH. Correlation of urinary nickel excretion with observed 'total' and inhalable aerosol exposures of nickel refinery workers. J Environ Monit. 1999;1(6):557-562
49. Lauwery RR, P H. Industrial Chemical Exposure Guidelines for Biological Monitoring. 2 ed. Boca Raton, Florida: Lewis Publishers; 1993.
50. Angerer J, Lehnert G. Occupational chronic exposure to metals. II. Nickel exposure of stainless steel welders--biological monitoring. Int Arch Occup Environ Health. 1990;62(1):7-10.
51. Todorovska N, Karadjova I, Stafilov T. ETAAS determination of nickel in serum and urine. Anal Bioanal Chem. 2002;373(4-5):310-313
52. Hogetveit AC , Barton RT, Andersen I. Variations of nickel in plasma and urine during the work period. J Occup Med. 1980;22(9):597-600.
53. Baselt R. Biological Monitoring Methods for Industrial Chemicals. Davis, California: Biomedical Publications; 1980.
54. Wehner AP , Busch RH, Olson RJ, Craig DK . Chronic inhalation of nickel oxide and cigarette smoke by hamsters. Am Ind Hyg Assoc J. 1975;36(11):801-810
55. Ottolenghi AD, Haseman JK, Payne WW, Falk HL, MacFarland HN. Inhalation studies of nickel sulfide in pulmonary carcinogenesis of rats. J Natl Cancer Inst. 1975;54(5):1165-1172
56. Seet RC, Johan A, Teo CE , Gan SL , Lee KH. Inhalational nickel carbonyl poisoning in waste processing workers. Chest. 2005;128(1):424-429
57. Shi Z. Nickel carbonyl: toxicity and human health. Sci Total Environ. 1994;148(2-3):293-298
58. Morgan L. Problems in the toxicology, diagnosis, and treatment of nickel carbonyl poisoning. In Neiboer, E. and Nriagu, J. O., eds. Nickel and Human Health: Current Perspectives New York, NY: John Wiley & Sons, Inc.; 1992.
59. Vuopala U, Huhti E, Takkunen J, Huikko M. Nickel carbonyl poisoning. Report of 25 cases. Ann Clin Res. 1970;2(3):214-222
60. Rendall RE, Phillips JI, Renton KA . Death following exposure to fine particulate nickel from a metal arc process. Ann Occup Hyg. 1994;38(6):921-930
61. Sunderman FW Jr, Dingle B, Hopfer SM, Swift T. Acute nickel toxicity in electroplating workers who accidently ingested a solution of nickel sulfate and nickel chloride. Am J Ind Med. 1988;14(3):257-266
62. Jensen CS, Lisby S, Baadsgaard O, Byrialsen K, Menne T. Release of nickel ions from stainless steel alloys used in dental braces and their patch test reactivity in nickel-sensitive individuals. Contact Dermatitis. 2003;48(6):300-304
63. Kasprzak KS , Sunderman FW Jr, Salnikow K. Nickel carcinogenesis. Mutat Res. 2003;533(1-2):67-97.
64. Berge SR, Skyberg K. Radiographic evidence of pulmonary fibrosis and possible etiologic factors at a nickel refinery in Norway. J Environ Monit. 2003;5(4):681-688
65. Jones JG, Warner CG. Chronic exposure to iron oxide, chromium oxide, and nickel oxide fumes of metal dressers in a steelworks. Br J Ind Med. 1972;29(2):169-177
66. Xu X, Lou J, Wang S. Dynamic observations on pulmonary function in retired miners exposed to nickel dust. Zhonghua Yu Fang Yi Xue Za Zhi. 1997;31(5):278-280
67. Benson JM, Henderson RF, McClellan RO, Hanson RL, Rebar AH. Comparative acute toxicity of four nickel compounds to F344 rat lung. Fundam Appl Toxicol. 1986;7(2):340-347
68. Benson JM, Burt DG, Carpenter RL, Eidson AF, Hahn FF , Haley PJ, Hanson RL, Hobbs CH, Pickrell JA, Dunnick JK. Comparative inhalation toxicity of nickel sulfate to F344/N rats and B6C3F1 mice exposed for twelve days. Fundam Appl Toxicol. 1988;10(1):164-178
69. Benson JM, Burt DG, Cheng YS, Hahan FF, Haley PJ, Henderson RF, Hobbs CH, Pickrell JA, Dunnick JK. Biochemical responses of rat and mouse lung to inhaled nickel compounds. Toxicology. 1989;57(3):255-266
70. Benson JM, Carpenter RL, Hahn FF, Haley PJ, Hanson RL, Hobbs CH, Pickrell JA, Dunnick JK. Comparative inhalation toxicity of nickel subsulfide to F344/N rats and B6C3F1 mice exposed for 12 days. Fundam Appl Toxicol. 1987;9(2):251-265
71. Dunnick JK, Benson JM, Hobbs CH, Hahn FF, Cheng YS, Eidson AF. Comparative toxicity of nickel oxide, nickel sulfate hexahydrate, and nickel subsulfide after 12 days of inhalation exposure to F344/N rats and B6C3F1 mice. Toxicology. 1988;50(2):145-156
72. S hannon HS, Walsh C, Jadon N, Julian JA, Weglo JK, Thornhill PG, Cecutti AG . Mortality of 11,500 nickel workers--extended follow up and relationship to environmental conditions. Toxicol Ind Health. 1991;7(4):277-294
73. Stettler LE, Groth DH, MacKay GR. Identification of stainless steel welding fume particulates in human lung and environmental samples using electron probe microanalysis. Am Ind Hyg Assoc J. 1977;38(2):76-82.
74. Vyskocil A, Senft V, Viau C, Cizkova M, Kohout J. Biochemical renal changes in workers exposed to soluble nickel compounds. Hum Exp Toxicol. 1994;13(4):257-261
75. Shum KW, Meyer JD, Chen Y, Cherry N, Gawkrodger DJ. Occupational contact dermatitis to nickel: experience of the British dermatologists (EPIDERM) and occupational physicians (OPRA) surveillance schemes. Occup Environ Med. 2003;60(12):954-957
76. Bencko V, Wagner V, Wagnerova M, Reichrtova E. Immuno-biochemical findings in groups of individuals occupationally and non-occupationally exposed to emissions containing nickel and cobalt. J Hyg Epidemiol Microbiol Immunol. 1983;27(4):387-394
77. Bencko V, Wagner V, Wagnerova M, Zavazal V. Human exposure to nickel and cobalt: biological monitoring and immunobiochemical response. Environ Res. 1986;40(2):399-410. (Pubitemid 16074505)
78. Westphalen GH, Menezes LM, Pra D, Garcia GG, Schmitt VM, Henriques JA, Medina-Silva R. In vivo determination of genotoxicity induced by metals from orthodontic appliances using micronucleus and comet assays. Genet Mol Res. 2008;7(4):1259-1266
79. Arrouijal FZ, Hildebrand HF, Vophi H, Marzin D. Genotoxic activity of nickel subsulphide alpha-Ni3S2. Mutagenesis. 1990;5(6):583-589
80. Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K. Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals. Environ Mol Mutagen. 1992;19(Suppl 21):2-141.
81. D hir H, Agarwal K, Sharma A, Talukder G. Modifying role of Phyllanthus emblica and ascorbic acid against nickel clastogenicity in mice. Cancer Lett. 1991;59(1):9-18.
82. Ogawa HI, Shibahara T, Iwata H, Okada T, Tsuruta S, Kakimoto K, Sakata K, Kato Y, Ryo H, Itoh T. Genotoxic activities in vivo of cobaltous chloride and other metal chlorides as assayed in the Drosophila wing spot test. Mutat Res. 1994;320(1-2):133-140
83. Rasmuson A. Mutagenic effects of some watersoluble metal compounds in a somatic eye-color test system in Drosophila melanogaster. Mutat Res. 1985;157(2-3):157-162
84. Morita T, Asano N, Awogi T, Sasaki YF , Sato S, Shimada H, Sutou S, Suzuki T, Wakata A, Sofuni T, Hayashi M. Evaluation of the rodent micronucleus assay in the screening of IA RC carcinogens (groups 1, 2A and 2B) the summary report of the 6th collaborative study by CSGMT /JEMS MMS . Collaborative Study of the Micronucleus Group Test. Mammalian Mutagenicity Study Group. Mutat Res. 1997;389(1):3-122.
85. Deknudt G, Leonard A. Mutagenicity tests with nickel salts in the male mouse. Toxicology. 1982;25(4):289-292
86. M 'Bemba-Meka P, Lemieux N, Chakrabarti SK . Role of oxidative stress and intracellular calcium in nickel carbonate hydroxide-induced sister-chromatid exchange, and alterations in replication index and mitotic index in cultured human peripheral blood lymphocytes. Arch Toxicol. 2007;81(2):89-99.
87. C hen CY , Wang YF , Huang WR, Huang YT . Nickel induces oxidative stress and genotoxicity in human lymphocytes. Toxicol Appl Pharmacol. 2003;189(3):153-159
88. Wozniak K, Blasiak J. Free radicals-mediated induction of oxidized DNA bases and DNAprotein cross-links by nickel chloride. Mutat Res. 2002;514(1-2):233-243
89. P ikalek P, Necasek J. The mutagenic activity of nickel in Corynebacterium sp. Folia Microbiol (Praha). 1983;28(1):17-21.
90. Chin YE , Snow ET , Christie NT . The stimulatory effect of nickel chloride on DNA replication in human HeLa cells and Escherichia coli. Carcinogenesis. 1994;15(5):1013-1016
91. Biggart NW, Murphy EC Jr. Analysis of metalinduced mutations altering the expression or structure of a retroviral gene in a mammalian cell line. Mutat Res. 1988;198(1):115-129
92. Biggart NW, Gallick GE, Murphy EC Jr. Nickelinduced heritable alterations in retroviral transforming gene expression. J Virol. 1987;61(8):2378-2388
93. Amacher DE, Paillet SC. Induction of trifluorothymidine-resistant mutants by metal ions in L5178Y/ TK+/-cells. Mutat Res. 1980;78(3):279-288
94. McGregor DB, Brown A, Cattanach P, Edwards I, McBride D, Riach C, Caspary WJ. Responses of the L5178Y tk+/tk-mouse lymphoma cell forward mutation assay: III. 72 coded chemicals. Environ Mol Mutagen. 1988;12(1):85-154. (Pubitemid 18204860)
95. F letcher GG, Rossetto FE, Turnbull JD, Nieboer E. Toxicity, uptake, and mutagenicity of particulate and soluble nickel compounds. Environ Health Perspect. 1994;102(Suppl 3):69-79.
96. Patierno SR, Costa M. DNA -protein crosslinks induced by nickel compounds in intact cultured mammalian cells. Chem Biol Interact. 1985;55(1-2):75-91.
97. P atierno SR, Sugiyama M, Basilion JP, Costa M. Preferential DNA-protein cross-linking by NiCl2 in magnesium-insoluble regions of fractionated Chinese hamster ovary cell chromatin. Cancer Res. 1985;45(11 Pt 2):5787-5794
98. Robison SH, Cantoni O, Costa M. Strand breakage and decreased molecular weight of DNA induced by specific metal compounds. Carcinogenesis. 1982;3(6):657-662
99. Conway K, Costa M. Nonrandom chromosomal alterations in nickel-transformed Chinese hamster embryo cells. Cancer Res. 1989;49(21):6032-6038
100. Costa M, Heck JD, Robison SH. Selective phagocytosis of crystalline metal sulfide particles and DNA strand breaks as a mechanism for the induction of cellular transformation. Cancer Res. 1982;42(7):2757-2763
101. L ei YX, Chen XM, Wu GR, Chen JK. Abnormal expression of eukaryotic translation factors in malignant transformed human bronchial epithelial cells induced by crystalline nickel sulfide. Biomed Environ Sci. 2006;19(1):53-60.
102. Biggart NW, Costa M. Assessment of the uptake and mutagenicity of nickel chloride in salmonella tester strains. Mutat Res. 1986;175(4):209-215
103. M arzin DR, Phi HV. Study of the mutagenicity of metal derivatives with Salmonella typhimurium TA 102. Mutat Res. 1985;155(1-2):49-51.
104. Green MH, Muriel WJ, Bridges BA. Use of a simplified fluctuation test to detect low levels of mutagens. Mutat Res. 1976;38(1):33-42.
105. Hamilton-Koch W, Snyder RD, Lavelle JM. Metalinduced DNA damage and repair in human diploidfibroblasts and Chinese hamster ovary cells. Chem Biol Interact. 1986;59(1):17-28.
106. Miura T, Patierno SR, Sakuramoto T, Landolph JR. Morphological and neoplastic transformation of C3H/10T1/2 Cl 8 mouse embryo cells by insoluble carcinogenic nickel compounds. Environ Mol Mutagen. 1989;14(2):65-78.
107. Rodriguez-Arnaiz R, Ramos P. Mutagenicity of nickel sulphate in Drosophila melanogaster. Mutat Res. 1986;170(3):115-117
108. Mathur AK, Dikshith TS, Lal MM, Tandon SK. Distribution of nickel and cytogenetic changes in poisoned rats. Toxicology. 1978;10(2):105-113
109. Tveito G, Hansteen IL , Dalen H, Haugen A. Immortalization of normal human kidney epithelial cells by nickel(II). Cancer Res. 1989;49(7): 1829-1835
110. Haugen A, Ryberg D, Hansteen IL , Dalen H. Transformation of human kidney epithelial cells to tumorigenicity by nickel(II) and V-HARAS oncogene. Biol Trace Elem Res. 1989;21: 451-458
111. Biedermann KA , Landolph JR. Induction of anchorage independence in human diploid foreskin fibroblasts by carcinogenic metal salts. Cancer Res. 1987;47(14):3815-3823
112. Ohshima S. Induction of genetic instability and chromosomal instability by nickel sulfate in V79 Chinese hamster cells. Mutagenesis. 2003;18(2):133-137
113. M 'Bemba-Meka P, Lemieux N, Chakrabarti SK . Nickel compound-induced DNA single-strand breaks in chromosomal and nuclear chromatin in human blood lymphocytes in vitro: role of oxidative stress and intracellular calcium. Mutat Res. 2005;586(2):124-137
114. L echner JF, Tokiwa T, McClendon IA, Haugen A. Effects of nickel sulfate on growth and differentiation of normal human bronchial epithelial cells. Carcinogenesis. 1984;5(12):1697-1703 (Pubitemid 15127039)
115. C asto BC, Meyers J, DiPaolo JA. Enhancement of viral transformation for evaluation of the carcinogenic or mutagenic potential of inorganic metal salts. Cancer Res. 1979;39(1):193-198
116. Arlauskas A, Baker RS, Bonin AM, Tandon RK, Crisp PT, Ellis J. Mutagenicity of metal ions in bacteria. Environ Res. 1985;36(2):379-388
117. Singh I. Induction of gene conversion and reverse mutation by manganese sulphate and nickel sulphate in Saccharomyces cerevisiae. Mutat Res. 1984;137(1):47-49
118. Oller AR, Erexson G. Lack of micronuclei formation in bone marrow of rats after repeated oral exposure to nickel sulfate hexahydrate. Mutat Res. 2007;626(1-2):102-110
119. Waksvik H, Boysen M. Cytogenetic analyses of lymphocytes from workers in a nickel refinery. Mutat Res. 1982;103(2):185-190
120. Hansen K, Stern RM. Toxicity and transformation potency of nickel compounds in BHK cells in vitro. IARC Sci Publ. 1984(53):193-200.
121. Kanematsu N, Hara M, Kada T. Rec assay and mutagenicity studies on metal compounds. Mutat Res. 1980;77(2):109-116
122. Mayer C, Klein RG, Wesch H, Schmezer P. Nickel subsulfide is genotoxic in vitro but shows no mutagenic potential in respiratory tract tissues of BigBlue rats and Muta Mouse mice in vivo after inhalation. Mutat Res. 1998;420(1-3):85-98.
123. Saxholm HJ, Reith A, Brogger A. Oncogenic transformation and cell lysis in C3H/10T 1/2 cells and increased sister chromatid exchange in human lymphocytes by nickel subsulfide. Cancer Res. 1981;41(10):4136-4139
124. Arrouijal FZ, Marzin D, Hildebrand HF, Pestel J, Haguenoer JM. Differences in genotoxic activity of alpha-Ni3S2 on human lymphocytes from nickelhypersensitized and nickel-unsensitized donors. Mutagenesis. 1992;7(3):183-187
125. Costa M, Mollenhauer HH. Phagocytosis of nickel subsulfide particles during the early stages of neoplastic transformation in tissue culture. Cancer Res. 1980;40(8 Pt 1):2688-2694
126. Swierenga SH, Marceau N, Katsuma Y, French SW, Mueller R, Lee F. Altered cytokeratin expression and differentiation induction during neoplastic transformation of cultured rat liver cells by nickel subsulfide. Cell Biol Toxicol. 1989;5(3):271-286
127. Heck JD, Costa M. Surface reduction of amorphous NiS particles potentiates their phagocytosis and subsequent induction of morphological transformation in Syrian hamster embryo cells. Cancer Lett. 1982;15(1):19-26.
128. Abbracchio MP, Heck JD, Costa M. The phagocytosis and transforming activity of crystalline metal sulfide particles are related to their negative surface charge. Carcinogenesis. 1982;3(2):175-180
129. DiPaolo JA, Casto BC. Quantitative studies of in vitro morphological transformation of Syrian hamster cells by inorganic metal salts. Cancer Res. 1979;39(3):1008-1013
130. Ji W, Yang L, Yu L, Yuan J, Hu D, Zhang W, Yang J, Pang Y, Li W, Lu J, Fu J, Chen J, Lin Z, Chen W, Zhuang Z. Epigenetic silencing of O6-methylguanine DNA methyltransferase gene in NiS-transformed cells. Carcinogenesis. 2008;29(6): 1267-1275
131. Ji WD, Chen JK, Lu JC, Wu ZL, Yi F, Feng SM. Alterations of FHIT gene and P16 gene in nickeltransformed human bronchial epithelial cells. Biomed Environ Sci. 2006;19(4):277-284
132. Montanaro L, Cervellati M, Campoccia D, Arciola CR. Promising in vitro performances of a new nickel-free stainless steel. J Mater Sci Mater Med. 2006;17(3):267-275
133. Josephy PD, Weadge JJ, Meissner J, Ng F. Ames test evaluation of two commercially available zero-valent nickel compounds. Mutat Res. 2008;654(1):64-68
134. Haber LT, Diamond GL, Zhao Q, Erdreich L, Dourson ML . Hazard identification and dose response of ingested nickel-soluble salts. Regul Toxicol Pharmacol. 2000;31(2 Pt 1):231-241 (Pubitemid 30314349)
135. Casey CE, Robinson MF. Copper, manganese, zinc, nickel, cadmium and lead in human foetal tissues. Br J Nutr. 1978;39(3):639-646
136. Chen CY, Lin TH. Nickel toxicity to human term placenta: in vitro study on lipid peroxidation. J Toxicol Environ Health A. 1998;54(1):37-47.
137. Haber LT , Erdreicht L, Diamond GL, Maier AM, Ratney R, Zhao Q, Dourson ML. Hazard identification and dose response of inhaled nickel-soluble salts. Regul Toxicol Pharmacol. 2000;31(2 Pt 1):210-230 (Pubitemid 30314348)
138. Chashschin VP, Artunina GP , Norseth T. Congenital defects, abortion and other health effects in nickel refinery workers. Sci Total Environ. 1994;148(2-3):287-291
139. Vaktskjold A, Talykova LV, Chashchin VP, Odland JO, Nieboer E. Spontaneous abortions among nickel-exposed female refinery workers. Int J Environ Health Res. 2008;18(2):99-115.
140. Vaktskjold A, Talykova LV, Chashchin VP, Odland JO, Nieboer E. Small-for-gestational-age newborns of female refinery workers exposed to nickel. Int J Occup Med Environ Health. 2007;20(4):327-338
141. Vaktskjold A, Talykova LV, Chashchin VP, Nieboer E, Thomassen Y, Odland JO. Genital malformations in newborns of female nickel-refinery workers. Scand J Work Environ Health. 2006;32(1):41-50.
142. Vaktskjold A, Talykova LV, Chashchin VP, Odland JO, Nieboer E. Maternal nickel exposure and congenital musculoskeletal defects. Am J Ind Med. 2008;51(11):825-833
143. Grimsrud TK, Berge SR, Martinsen JI, Andersen A. Lung cancer incidence among Norwegian nickelrefinery workers 1953-2000. J Environ Monit. 2003;5(2):190-197 (Pubitemid 36503016)
144. Kuo CY , Wong RH, Lin JY, Lai JC, Lee H. Accumulation of chromium and nickel metals in lung tumors from lung cancer patients in Taiwan. J Toxicol Environ Health A. 2006;69(14):1337-1344
145. Grimsrud TK, Berge SR, Haldorsen T, Andersen A. Exposure to different forms of nickel and risk of lung cancer. Am J Epidemiol. 2002;156(12):1123-1132
146. Grimsrud TK, Berge SR, Haldorsen T, Andersen A. Can lung cancer risk among nickel refinery workers be explained by occupational exposures other than nickel? Epidemiology. 2005;16(2):146-154
147. Harris GK, Shi X. Signaling by carcinogenic metals and metal-induced reactive oxygen species. Mutat Res. 2003;533(1-2):183-200.
148. Waris G, Ahsan H. Reactive oxygen species: role in the development of cancer and various chronic conditions. J Carcinog. 2006;5:14.
149. Buechter DD. Free radicals and oxygen toxicity. Pharm Res. 1988;5(5):253-260
150. Susin SA, Daugas E, Ravagnan L, Samejima K, Zamzami N, Loeffler M, Costantini P, Ferri KF, Irinopoulou T, Prévost MC, Brothers G, Mak TW, Penninger J, Earnshaw WC, Kroemer G. Two distinct pathways leading to nuclear apoptosis. J Exp Med. 2000;192(4):571-580
151. Lubos E, Handy DE, Loscalzo J. Role of oxidative stress and nitric oxide in atherothrombosis. Front Biosci. 2008;13:5323-5344
152. Kojda G, Harrison D. Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure. Cardiovasc Res. 1999;43(3):562-571
153. Yao H, Guo L, Jiang BH, Luo J, Shi X. Oxidative stress and chromium(VI) carcinogenesis. J Environ Pathol Toxicol Oncol. 2008;27(2):77-88.
154. Das KK, Das SN, Dhundasi SA. Nickel, its adverse health effects & oxidative stress. Indian J Med Res. 2008;128(4):412-425
155. Lynn S, Yew FH, Chen KS, Jan KY. Reactive oxygen species are involved in nickel inhibition of DNA repair. Environ Mol Mutagen. 1997;29(2):208-216
156. Kasprzak KS. Possible role of oxidative damage in metal-induced carcinogenesis. Cancer Invest. 1995;13(4):411-430
157. Costa M. Molecular mechanisms of nickel carcinogenesis. Annu Rev Pharmacol Toxicol. 1991;31:321-337
158. Klein CB, Frenkel K, Costa M. The role of oxidative processes in metal carcinogenesis. Chem Res Toxicol. 1991;4(6):592-604.
159. Huang X, Klein CB, Costa M. Crystalline Ni3S2 specifically enhances the formation of oxidants in the nuclei of CHO cells as detected by dichlorofluorescein. Carcinogenesis. 1994;15(3):545-548
160. Salnikow K, Gao M, Voitkun V, Huang X, Costa M. Altered oxidative stress responses in nickel-resistant mammalian cells. Cancer Res. 1994;54(24):6407-6412
161. S alnikow K, Su W, Blagosklonny MV, Costa M. Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygenspecies-independent mechanism. Cancer Res. 2000;60(13):3375-3378
162. Huang X, Frenkel K, Klein CB, Costa M. Nickel induces increased oxidants in intact cultured mammalian cells as detected by dichlorofluorescein fluorescence. Toxicol Appl Pharmacol. 1993;120(1):29-36.
163. Huang X, Zhuang Z, Frenkel K, Klein CB, Costa M. The role of nickel and nickel-mediated reactive oxygen species in the mechanism of nickel carcinogenesis. Environ Health Perspect. 1994;102(Suppl 3):281-284
164. Chakrabarti SK, Bai C. Role of oxidative stress in nickel chloride-induced cell injury in rat renal cortical slices. Biochem Pharmacol. 1999;58(9):1501-1510
165. Jia J, Chen J. Chronic nickel-induced DNA damage and cell death: the protection role of ascorbic acid. Environ Toxicol. 2008;23(3):401-406
166. Chen CY , Wang YF , Lin YH, Yen SF . Nickel-induced oxidative stress and effect of antioxidants in human lymphocytes. Arch Toxicol. 2003;77(3):123-130
167. Li W, Zhao Y, Chou IN. Alterations in cytoskeletal protein sulfhydryls and cellular glutathione in cultured cells exposed to cadmium and nickel ions. Toxicology. 1993;77(1-2):65-79.
168. Kang J, Zhang Y, Chen J, Chen H, Lin C, Wang Q, Ou Y. Nickel-induced histone hypoacetylation: the role of reactive oxygen species. Toxicol Sci. 2003;74(2):279-286
169. Huang C, Li J, Costa M, Zhang Z, Leonard SS, Castranova V, Vallyathan V, Ju G, Shi X. Hydrogen peroxide mediates activation of nuclear factor of activated T cells (NFAT) by nickel subsulfide. Cancer Res. 2001;61(22):8051-8057 (Pubitemid 33091588)
170. Zhang D, Shen J, Wang C, Zhang X, Chen J. GSHdependent iNOS and HO-1 mediated apoptosis of human Jurkat cells induced by nickel(II). Environ Toxicol. 2009;24(4):404-414
171. Doreswamy K, Shrilatha B, Rajeshkumar T, Muralidhara. Nickel-induced oxidative stress in testis of mice: evidence of DNA damage and genotoxic effects. J Androl. 2004;25(6):996-1003.
172. Mandava V, Sheetal SP , Sunita LC . Vitamin-E supplementation ameliorates chromium-and/or nickel induced oxidative stress in vivo. J Health Sci. 2006;52(2):142-147
173. Kasprzak KS , Hernandez L. Enhancement of hydroxylation and deglycosylation of 2'-deoxyguanosine by carcinogenic nickel compounds. Cancer Res. 1989;49(21):5964-5968
174. Doyle CM, Arp DJ. Nickel affects expression of the nickel-containing hydrogenase of Alcaligenes latus. J Bacteriol. 1988;170(9):3891-3896
175. Sunderman FW Jr, Reid MC, Bibeau LM, Linden JV. Nickel induction of microsomal heme oxygenase activity in rodents. Toxicol Appl Pharmacol. 1983;68(1):87-95.
176. Chen CY , Huang YL , Lin TH. Association between oxidative stress and cytokine production in nickel-treated rats. Arch Biochem Biophys. 1998;356(2):127-132
177. Joshi S, Hasan SK , Chandra R, Husain MM , Srivastava RC. Scavenging action of zinc and green tea polyphenol on cisplatin and nickel induced nitric oxide generation and lipid peroxidation in rats. Biomed Environ Sci. 2004;17(4):402-409
178. Gajewska E, Sklodowska M. Effect of nickel on ROS content and antioxidative enzyme activities in wheat leaves. Biometals. 2007;20(1):27-36.
179. Cavallo D, Ursini CL, Setini A, Chianese C, Piegari P, Perniconi B, Iavicoli S. Evaluation of oxidative damage and inhibition of DNA repair in an in vitro study of nickel exposure. Toxicol In Vitro. 2003;17(5-6):603-607
180. Kawanishi S, Oikawa S, Inoue S, Nishino K. Distinct mechanisms of oxidative DNA damage induced by carcinogenic nickel subsulfide and nickel oxides. Environ Health Perspect. 2002;110(Suppl 5):789-791
181. Zhong ZJ, Troll W, Koenig KL , Frenkel K. Carcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes. Cancer Res. 1990;50(23):7564-7570
182. Kawanishi S, Inoue S, Oikawa S, Yamashita N, Toyokuni S, Kawanishi M, Nishino K. Oxidative DNA damage in cultured cells and rat lungs by carcinogenic nickel compounds. Free Radic Biol Med. 2001;31(1):108-116
183. Cruz MT, Goncalo M, Figueiredo A, Carvalho AP, Duarte CB, Lopes MC. Contact sensitizer nickel sulfate activates the transcription factors NF -kB and AP-1 and increases the expression of nitric oxide synthase in a skin dendritic cell line. Exp Dermatol. 2004;13(1):18-26.
184. Misra M, Rodriguez RE, North SL, Kasprzak KS. Nickel-induced renal lipid peroxidation in different strains of mice: concurrence with nickel effect on antioxidant defense systems. Toxicol Lett. 1991;58(2):121-133
185. Kasprzak KS, Diwan BA, Rice JM, Misra M, Riggs CW, Olinski R, Dizdaroglu M. Nickel(II)-mediated oxidative DNA base damage in renal and hepatic chromatin of pregnant rats and their fetuses. Possible relevance to carcinogenesis. Chem Res Toxicol. 1992;5(6):809-815
186. Chakrabarti SK, Bai C, Subramanian KS. DNAprotein crosslinks induced by nickel compounds in isolated rat lymphocytes: role of reactive oxygenspecies and specific amino acids. Toxicol Appl Pharmacol. 2001;170(3):153-165
187. Andrew AS , Klei LR, Barchowsky A. Nickel requires hypoxia-inducible factor-1 alpha, not redox signaling, to induce plasminogen activator inhibitor-1. Am J Physiol Lung Cell Mol Physiol. 2001;281(3):L607-15.
188. Buzard GS, Kasprzak KS. Possible roles of nitric oxide and redox cell signaling in metal-induced toxicity and carcinogenesis: a review. J Environ Pathol Toxicol Oncol. 2000;19(3):179-199
189. Chen F, Shi X. Intracellular signal transduction of cells in response to carcinogenic metals. Crit Rev Oncol Hematol. 2002;42(1):105-121
190. Chen F, Ding M, Castranova V, Shi X. Carcinogenic metals and NF -kappaB activation. Mol Cell Biochem. 2001;222(1-2):159-171
191. Meplan C, Richard MJ, Hainaut P. Redox signalling and transition metals in the control of the p53 pathway. Biochem Pharmacol. 2000;59(1): 25-33.
192. L iu XH, Kirschenbaum A, Yao S, Stearns ME , Holland JF, Claffey K, Levine AC . Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line. Clin Exp Metastasis. 1999;17(8):687-694
193. Baldwin AS Jr. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:649-683
194. Misra UK, Gawdi G, Pizzo SV. Beryllium fluorideinduced cell proliferation: a process requiring P21(ras)-dependent activated signal transduction and NF-kappaB-dependent gene regulation. J Leukoc Biol. 2002;71(3):487-494
195. S imeonova PP, Luster MI. Arsenic carcinogenicity: relevance of c-Src activation. Mol Cell Biochem. 2002;234-235(1-2):277-282
196. Simeonova PP, Wang S, Hulderman T, Luster MI. c-Src-dependent activation of the epidermal growth factor receptor and mitogen-activated protein kinase pathway by arsenic. Role in carcinogenesis. J Biol Chem. 2002;277(4):2945-2950
197. Huang Y, Davidson G, Li J, Yan Y, Chen F, Costa M, Chen LC , Huang C. Activation of nuclear factor-kappaB and not activator protein-1 in cellular response to nickel compounds. Environ Health Perspect. 2002;110(Suppl 5):835-839
198. Goebeler M, Roth J, Brocker EB, Sorg C, Schulze-Osthoff K. Activation of nuclear factor-kappa B and gene expression in human endothelial cells by the common haptens nickel and cobalt. J Immunol. 1995;155(5):2459-2467
199. Li J, Davidson G, Huang Y, Jiang BH, Shi X, Costa M, Huang C. Nickel compounds act through phosphatidylinositol-3-kinase/Akt-dependent, p70(S6k)-independent pathway to induce hypoxia inducible factor transactivation and Cap43 expression in mouse epidermal Cl41 cells. Cancer Res. 2004;64(1):94-101.
200. Salnikow K, Davidson T, Zhang Q, Chen LC, Su W, Costa M. The involvement of hypoxia-inducible transcription factor-1-dependent pathway in nickel carcinogenesis. Cancer Res. 2003;63(13):3524-3530
201. Aiba S, Manome H, Nakagawa S, Mollah ZU, Mizuashi M, Ohtani T, Yoshino Y, Tagami H. p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene. J Invest Dermatol. 2003;120(3):390-399
202. Goebeler M, Gillitzer R, Kilian K, Utzel K, Brocker EB, Rapp UR, Ludwig S. Multiple signaling pathways regulate NF -kappaB-dependent transcription of the monocyte chemoattractant protein-1 gene in primary endothelial cells. Blood. 2001;97(1):46-55.
203. Salnikow K, An WG, Melillo G, Blagosklonny MV, Costa M. Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors. Carcinogenesis. 1999;20(9):1819-1823
204. Salnikow K, Wang S, Costa M. Induction of activating transcription factor 1 by nickel and its role as a negative regulator of thrombospondin I gene expression. Cancer Res. 1997;57(22):5060-5066
205. Wagner M, Klein CL , Kleinert H, Euchenhofer C, Forstermann U, Kirkpatrick CJ. Heavy metal ion induction of adhesion molecules and cytokines in human endothelial cells: the role of NF-kappaB, I kappaBalpha and AP-1. Pathobiology. 1997;65(5):241-252
206. Wagner M, Klein CL, van Kooten TG, Kirkpatrick CJ. Mechanisms of cell activation by heavy metal ions. J Biomed Mater Res. 1998;42(3):443-452
207. Ding J, Zhang X, Li J, Song L, Ouyang W, Zhang D, Xue C, Costa M, Meléndez JA, Huang C. Nickel compounds render anti-apoptotic effect to human bronchial epithelial Beas-2B cells by induction of cyclooxygenase-2 through an IKKbeta/p65-dependent and IKK alpha-and p50-independent pathway. J Biol Chem. 2006;281(51):39022-39032
208. Davidson T, Salnikow K, Costa M. Hypoxia inducible factor-1 alpha-independent suppression of aryl hydrocarbon receptor-regulated genes by nickel. Mol Pharmacol. 2003;64(6):1485-1493
209. Salnikow K, Blagosklonny MV, Ryan H, Johnson R, Costa M. Carcinogenic nickel induces genes involved with hypoxic stress. Cancer Res. 2000;60(1): 38-41.
210. Salnikow K, Davidson T, Kluz T, Chen H, Zhou D, Costa M. GeneChip analysis of signaling pathways effected by nickel. J Environ Monit. 2003;5(2):206-209
211. Zhang D, Li J, Wu K, Ouyang W, Ding J, Liu ZG, Costa M, Huang C. JNK1, but not JNK2, is required for COX-2 induction by nickel compounds. Carcinogenesis. 2007;28(4):883-891
212. Ouyang W, Zhang D, Li J, Verma UN, Costa M, Huang C. Soluble and insoluble nickel compounds exert a differential inhibitory effect on cell growth through IKKalpha-dependent cyclin D1 downregulation. J Cell Physiol. 2009;218(1):205-214
213. Gazel A, Rosdy M, Tornier C, De Fraissinette Ade B, Blumenberg M. Transcriptional profiling defines the effects of nickel in human epidermal keratinocytes. J Cell Physiol. 2008;217(3):686-692
214. Lisby S, Muller KM , Jongeneel CV, Saurat JH, Hauser C. Nickel and skin irritants up-regulate tumor necrosis factor-alpha mRNA in keratinocytes by different but potentially synergistic mechanisms. Int Immunol. 1995;7(3):343-352
215. Ding J, Huang Y, Ning B, Gong W, Li J, Wang H, Chen CY, Huang C. TNF-alpha induction by nickel compounds is specific through ERKs/AP-1-dependent pathway in human bronchial epithelial cells. Curr Cancer Drug Targets. 2009;9(1):81-90.
216. Viemann D, Schmidt M, Tenbrock K, Schmid S, Muller V, Klimmek K, Ludwig S, Roth J, Goebeler M. The contact allergen nickel triggers a unique inflammatory and proangiogenic gene expression pattern via activation of NF-kappaB and hypoxia-inducible factor-1alpha. J Immunol. 2007;178(5):3198-3207
217. Lewis JB, Messer RL, Pitts L, Hsu SD, Hansen JM, Wataha JC. Ni(II) ions dysregulate cytokine secretion from human monocytes. J Biomed Mater Res B Appl Biomater. 2009;88(2):358-365
218. Lewis JB, Wataha JC, McCloud V, Lockwood PE, Messer RL, Tseng WY. Au(III), Pd(II), Ni(II), and Hg(II ) alter NF kappa B signaling in THP1 monocytic cells. J Biomed Mater Res A. 2005;74(3):474-481
219. Ade N, Antonios D, Kerdine-Romer S, Boisleve F, Rousset F, Pallardy M. NF-kappaB plays a major role in the maturation of human dendritic cells induced by NiSO(4) but not by DNCB. Toxicol Sci. 2007;99(2):488-501.
220. Eckers A, Reimann K, Klotz LO. Nickel and copper ion-induced stress signaling in human hepatoma cells: analysis of phosphoinositide 3'-kinase/Akt signaling. Biometals. 2009;22(2):307-316
221. Schoeters E, Nuijten JM, Van Den Heuvel RL, Nelissen I, Witters H, Schoeters GE, Van Tendeloo VF, Berneman ZN, Verheyen GR. Gene expression signatures in CD 34+-progenitor-derived dendritic cells exposed to the chemical contact allergen nickel sulfate. Toxicol Appl Pharmacol. 2006;216(1):131-149
222. Li Q, Suen TC, Sun H, Arita A, Costa M. Nickel compounds induce apoptosis in human bronchial epithelial Beas-2B cells by activation of c-Myc through ERK pathway. Toxicol Appl Pharmacol. 2009;235(2):191-198
223. Karaczyn A, Ivanov S, Reynolds M, Zhitkovich A, Kasprzak KS , Salnikow K. Ascorbate depletion mediates up-regulation of hypoxia-associated proteins by cell density and nickel. J Cell Biochem. 2006;97(5):1025-1035
224. Barchowsky A, Soucy NV, O'Hara KA, Hwa J, Noreault TL, Andrew AS. A novel pathway for nickel-induced interleukin-8 expression. J Biol Chem. 2002;277(27):24225-24231
225. Lee SH, Choi JG, Cho MH. Apoptosis, bcl2 expression, and cell cycle analyses in nickel(II)-treated normal rat kidney cells. J Korean Med Sci. 2001;16(2):165-168
226. Shiao YH, Lee SH, Kasprzak KS. Cell cycle arrest, apoptosis and p53 expression in nickel(II) acetatetreated Chinese hamster ovary cells. Carcinogenesis. 1998;19(7):1203-1207
227. Lee SH. Differential gene expression in nickel(II)-treated normal rat kidney cells. Res Commun Mol Pathol Pharmacol. 2006;119(1-6):77-87.
228. Andrew AS , Klei LR, Barchowsky A. AP -1-dependent induction of plasminogen activator inhibitor-1 by nickel does not require reactive oxygen. Am J Physiol Lung Cell Mol Physiol. 2001;281(3):L616-23.
229. Govindarajan B, Klafter R, Miller MS, Mansur C, Mizesko M, Bai X, LaMontagne K Jr, Arbiser JL. Reactive oxygen-induced carcinogenesis causes hypermethylation of p16(Ink4a) and activation of MAP kinase. Mol Med. 2002;8(1):1-8.
230. Zhang Q, Kusaka Y, Sato K, Nakakuki K, Kohyama N, Donaldson K. Differences in the extent of inflammation caused by intratracheal exposure to three ultrafine metals: role of free radicals. J Toxicol Environ Health A. 1998;53(6):423-438
231. Serita F, Kyono H, Seki Y. Pulmonary clearance and lesions in rats after a single inhalation of ultrafine metallic nickel at dose levels comparable to the threshold limit value. Ind Health. 1999;37(4):353-363
232. Zhao J, Bowman L, Zhang X, Shi X, Jiang B, Castranova V, Ding M. Metallic nickel nano-and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway. J Nanobiotechnology. 2009;7:2.