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Volumn 3, Issue 2, 2004, Pages 115-124

Current status and future potential of transdermal drug delivery

Author keywords

[No Author keywords available]

Indexed keywords

2 NONYL 1,3 DIOXOLANE; ADRENALIN; ALCOHOL; CLONIDINE; DIMETHYL SULFOXIDE; ESCLIM; ESTER DERIVATIVE; ESTRADIOL; ESTRADIOL PLUS NORETHISTERONE ACETATE; ETHINYLESTRADIOL PLUS NORELGESTROMIN; FATTY ACID; FENTANYL; GLYCERYL TRINITRATE; IONTOCAINE; LAUROCAPRAM; LIDOCAINE; LIMONENE; NICOTINE; OLEIC ACID; OXYBUTYNIN; PENETRATION ENHANCING AGENT; SCOPOLAMINE; SOLVENT; SURFACTANT; TERPENE; TESTODERM TTS; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 1242308254     PISSN: 14741776     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrd1304     Document Type: Review
Times cited : (1199)

References (119)
  • 1
    • 0038234681 scopus 로고
    • Experimental electroendosmotic studies on living human skin
    • Rein, H. Experimental electroendosmotic studies on living human skin. Z. Biol. 81, 124- (1924).
    • (1924) Z. Biol. , vol.81 , pp. 124
    • Rein, H.1
  • 2
    • 0344299548 scopus 로고
    • Penetration of low-molecular weight alcohols into skin. I. Effect of concentration of alcohol and type of vehicle
    • Blank, I. H. Penetration of low-molecular weight alcohols into skin. I. Effect of concentration of alcohol and type of vehicle. J. Invest. Dermatol. 43, 415-420 (1964).
    • (1964) J. Invest. Dermatol. , vol.43 , pp. 415-420
    • Blank, I.H.1
  • 3
    • 0013812406 scopus 로고
    • Mechanism of percutaneous adsorption I. Routes of penetration and the influence of solubility
    • Scheuplein, R. J. Mechanism of percutaneous adsorption I. Routes of penetration and the influence of solubility. J. Invest. Dermatol. 45, 334-345 (1965).
    • (1965) J. Invest. Dermatol. , vol.45 , pp. 334-345
    • Scheuplein, R.J.1
  • 4
  • 5
    • 0016545625 scopus 로고
    • Drug permeation through human skin: Theory and in vitro experimental measurement
    • Michaels, A. S., Chandrasekaran, S. K. & Shaw, J. E. Drug permeation through human skin: theory and in vitro experimental measurement. AIChE J. 21, 985-996 (1975).
    • (1975) AIChE J. , vol.21 , pp. 985-996
    • Michaels, A.S.1    Chandrasekaran, S.K.2    Shaw, J.E.3
  • 7
    • 0028454788 scopus 로고
    • Translating safety, efficacy and compliance into economic value for controlled release dosage forms
    • Cramer, M. P. & Saks, S. R. Translating safety, efficacy and compliance into economic value for controlled release dosage forms. Pharmacoeconomics 5, 482-504 (1994).
    • (1994) Pharmacoeconomics , vol.5 , pp. 482-504
    • Cramer, M.P.1    Saks, S.R.2
  • 8
    • 0028849333 scopus 로고
    • Nicotine medications for smoking cessation
    • Henningfield, J. E. Nicotine medications for smoking cessation. N. Engl. J. Med. 333, 1196-1203 (1995).
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1196-1203
    • Henningfield, J.E.1
  • 9
    • 0025905569 scopus 로고
    • Overview and evolution of therapeutic systems
    • Zaffaroni, A. Overview and evolution of therapeutic systems. Ann. NY Acad. Sci. 618, 405-421 (1991).
    • (1991) Ann. NY Acad. Sci. , vol.618 , pp. 405-421
    • Zaffaroni, A.1
  • 12
    • 0035733383 scopus 로고    scopus 로고
    • Coordinate regulation of epidermal differentiation and barrier homeostasis
    • Elias, P. M. & Feingold, K. R. Coordinate regulation of epidermal differentiation and barrier homeostasis. Skin Pharmacol. Appl. Skin Physiol. 14 (Suppl. 1), 28-34 (2001).
    • (2001) Skin Pharmacol. Appl. Skin Physiol. , vol.14 , Issue.SUPPL. 1 , pp. 28-34
    • Elias, P.M.1    Feingold, K.R.2
  • 13
    • 0030264744 scopus 로고    scopus 로고
    • Permeation process of small molecules across lipid membranes studied by molecular dynamics simulations
    • Marrink, S. J. & Berendsen, J. C. Permeation process of small molecules across lipid membranes studied by molecular dynamics simulations. J. Phys. Chem. 100, 16729-16738 (1996).
    • (1996) J. Phys. Chem. , vol.100 , pp. 16729-16738
    • Marrink, S.J.1    Berendsen, J.C.2
  • 14
    • 0028101808 scopus 로고
    • Hindered diffusion of polar molecules through and effective pore radii estimates of intact and ethanol treated human epidermal membrane
    • Peck, K. D., Ghanem, A. H. & Higuchi, W. I. Hindered diffusion of polar molecules through and effective pore radii estimates of intact and ethanol treated human epidermal membrane. Pharm. Res. 11, 1306-1314 (1994).
    • (1994) Pharm. Res. , vol.11 , pp. 1306-1314
    • Peck, K.D.1    Ghanem, A.H.2    Higuchi, W.I.3
  • 15
    • 0037426686 scopus 로고    scopus 로고
    • Modeling skin permeability to hydrophilic and hydrophobic solutes based on four permeation pathways
    • Mitragotri, S. Modeling skin permeability to hydrophilic and hydrophobic solutes based on four permeation pathways. J. Control. Release 86, 69-92 (2003).
    • (2003) J. Control. Release , vol.86 , pp. 69-92
    • Mitragotri, S.1
  • 16
    • 0025310068 scopus 로고
    • Dermal absoprtion potential of industrial chemicals: Criteria for skin notation
    • Fiserova-Bergerova, V., Pierce, J. T. & Droz, P. O. Dermal absoprtion potential of industrial chemicals: criteria for skin notation. Am. J. Ind. Med. 17, 617-635 (1990).
    • (1990) Am. J. Ind. Med. , vol.17 , pp. 617-635
    • Fiserova-Bergerova, V.1    Pierce, J.T.2    Droz, P.O.3
  • 17
    • 0027104963 scopus 로고
    • Estimating dermal uptake of non-ionic organic chemicals from water and soil: I. Unified fugacity-based models for risk assessment
    • McKone, T. E. & Howard, R. A. Estimating dermal uptake of non-ionic organic chemicals from water and soil: I. Unified fugacity-based models for risk assessment. Risk Analysis 12, 543-557 (1992).
    • (1992) Risk Analysis , vol.12 , pp. 543-557
    • McKone, T.E.1    Howard, R.A.2
  • 18
    • 0026606514 scopus 로고
    • Predicting skin permeability
    • Potts, R. O. & Guy, R. H. Predicting skin permeability. Pharm. Res. 9, 663-669 (1992).
    • (1992) Pharm. Res. , vol.9 , pp. 663-669
    • Potts, R.O.1    Guy, R.H.2
  • 19
    • 0036096659 scopus 로고    scopus 로고
    • Quantitative structure-permeability relationships (QSPRs) for percutaneous absorption
    • Moss, G. P., Dearden, J. C., Patel, H. & Cronin, M. T. D. Quantitative structure-permeability relationships (QSPRs) for percutaneous absorption. Toxicol. In Vitro 16, 299-317 (2002).
    • (2002) Toxicol. In Vitro , vol.16 , pp. 299-317
    • Moss, G.P.1    Dearden, J.C.2    Patel, H.3    Cronin, M.T.D.4
  • 20
    • 0024365207 scopus 로고
    • Solute structure-permeability relationships in human stratum corneum
    • Anderson, B. D. & Raykar, P. V. Solute structure-permeability relationships in human stratum corneum. J. Invest. Dermatol. 93, 280-286 (1989).
    • (1989) J. Invest. Dermatol. , vol.93 , pp. 280-286
    • Anderson, B.D.1    Raykar, P.V.2
  • 21
    • 0027521082 scopus 로고
    • A new method for estiamting dermal absorption from chemical exposure, 1. General approach
    • Cleek, R. L. & Bunge, A. L. A new method for estiamting dermal absorption from chemical exposure, 1. General approach. Pharm. Res. 10, 497-506 (1993).
    • (1993) Pharm. Res. , vol.10 , pp. 497-506
    • Cleek, R.L.1    Bunge, A.L.2
  • 22
    • 0030769232 scopus 로고    scopus 로고
    • Algorithms for skin permeability using hydrogen bond descriptors: The problem of steroids
    • Abraham, M. H., Martins, F. & Mitchell, R. C. Algorithms for skin permeability using hydrogen bond descriptors: the problem of steroids. J. Pharm. Pharmac. 49, 858-865 (1997).
    • (1997) J. Pharm. Pharmac. , vol.49 , pp. 858-865
    • Abraham, M.H.1    Martins, F.2    Mitchell, R.C.3
  • 23
    • 0034879036 scopus 로고    scopus 로고
    • A simple, predictive, structure-based skin permeability model
    • Buchwald, P. & Bodor, N. A simple, predictive, structure-based skin permeability model. J. Pharm. Pharmacol. 53, 1087-1098 (2001).
    • (2001) J. Pharm. Pharmacol. , vol.53 , pp. 1087-1098
    • Buchwald, P.1    Bodor, N.2
  • 24
    • 0028898732 scopus 로고
    • Quantitative structure-activity relationships for skin permeability
    • Barrat, M. D. Quantitative structure-activity relationships for skin permeability. Toxicol. In Vitro 9, 27-37 (1995).
    • (1995) Toxicol. In Vitro , vol.9 , pp. 27-37
    • Barrat, M.D.1
  • 26
    • 0036513217 scopus 로고    scopus 로고
    • Prediction of human skin permeability using a combination of molecular orbital calculations and artificial neural network
    • Lim, C. W., Fujiwara, S., Yamashita, F. & Hashida, M. Prediction of human skin permeability using a combination of molecular orbital calculations and artificial neural network. Biol. Pharm. Bull. 25, 361-366 (2002).
    • (2002) Biol. Pharm. Bull. , vol.25 , pp. 361-366
    • Lim, C.W.1    Fujiwara, S.2    Yamashita, F.3    Hashida, M.4
  • 27
    • 0035999509 scopus 로고    scopus 로고
    • A Random-walk model for skin permeation
    • Frasch, H. F. A Random-walk model for skin permeation. Risk. Anal. 22, 265-276 (2002).
    • (2002) Risk. Anal. , vol.22 , pp. 265-276
    • Frasch, H.F.1
  • 28
    • 0000877820 scopus 로고
    • Effect of lipid solubility and molecular size on percutaneous absorption
    • Kasting, G. B., Smith, R. L. & Cooper, E. R. Effect of lipid solubility and molecular size on percutaneous absorption. Pharmacol. Skin 1, 138-153 (1987).
    • (1987) Pharmacol. Skin , vol.1 , pp. 138-153
    • Kasting, G.B.1    Smith, R.L.2    Cooper, E.R.3
  • 30
    • 0034042520 scopus 로고    scopus 로고
    • Structure-activity relationship of chemical penetration enhancers in transdermal drug delivery
    • Kanikkannan, N., Kanimalla, K., Lamba, S. S. & Singh, M. Structure-activity relationship of chemical penetration enhancers in transdermal drug delivery. Curr. Med. Chem. 7, 593-608 (2000).
    • (2000) Curr. Med. Chem. , vol.7 , pp. 593-608
    • Kanikkannan, N.1    Kanimalla, K.2    Lamba, S.S.3    Singh, M.4
  • 31
    • 0024610233 scopus 로고
    • Topical application of penetration enhancers to the skin of nude mice: A histophatholgical study
    • Lashmar, U. T., Hadgraft, J. & Thomas, N. Topical application of penetration enhancers to the skin of nude mice: a histophatholgical study. J. Pharm. Pharmacol. 41, 118-122 (1989).
    • (1989) J. Pharm. Pharmacol. , vol.41 , pp. 118-122
    • Lashmar, U.T.1    Hadgraft, J.2    Thomas, N.3
  • 33
    • 0037423779 scopus 로고    scopus 로고
    • Novel transdermal drug penetration enhancer: Synthesis and enhancing effect of alkyldisiloxane comounds containign glucopyranosyl group
    • Akimoto, T. & Nagase, Y. Novel transdermal drug penetration enhancer: synthesis and enhancing effect of alkyldisiloxane comounds containign glucopyranosyl group. J. Control. Rel. 88, 243-252 (2003).
    • (2003) J. Control. Rel. , vol.88 , pp. 243-252
    • Akimoto, T.1    Nagase, Y.2
  • 36
    • 0032883241 scopus 로고    scopus 로고
    • Transdermal penetration enhancers: Applications, limitations, and potential
    • Finin, B. C. & Morgan, T. M. Transdermal penetration enhancers: applications, limitations, and potential. J. Pharm. Sci. 88, 955-958 (1999).
    • (1999) J. Pharm. Sci. , vol.88 , pp. 955-958
    • Finin, B.C.1    Morgan, T.M.2
  • 37
    • 0025905320 scopus 로고
    • Evidence that oleic acid exists in a separate phase within stratum corneum lipids
    • Ongpipattnakul, B., Burnette, R. R., Potts, R. O. & Francoeur, M. L. Evidence that oleic acid exists in a separate phase within stratum corneum lipids. Pharm. Res. 8, 350-354 (1991).
    • (1991) Pharm. Res. , vol.8 , pp. 350-354
    • Ongpipattnakul, B.1    Burnette, R.R.2    Potts, R.O.3    Francoeur, M.L.4
  • 38
    • 0030470587 scopus 로고    scopus 로고
    • Transfersomes, liposomes and other lipid suspensions on the skin: Permeation enhancement, vesicle penetration, and transdermal drug delivery
    • Cevc, G. Transfersomes, liposomes and other lipid suspensions on the skin: permeation enhancement, vesicle penetration, and transdermal drug delivery. Crit. Rev. Ther. Drug Carrier Syst. 13, 257-388 (1996).
    • (1996) Crit. Rev. Ther. Drug Carrier Syst. , vol.13 , pp. 257-388
    • Cevc, G.1
  • 39
    • 0742288421 scopus 로고    scopus 로고
    • Discovery of transdermal penetration enhancers by high-throughput screening
    • 4 Jan (doi:10.1038/nbt928)
    • Karande, P., Jain, A. & Mitragotri, S. Discovery of transdermal penetration enhancers by high-throughput screening. Nature Biotechnol. 4 Jan 2004 (doi:10.1038/nbt928).
    • (2004) Nature Biotechnol.
    • Karande, P.1    Jain, A.2    Mitragotri, S.3
  • 40
    • 0029041507 scopus 로고
    • Iontophoresis: Applications in transdermal medication delivery
    • Costello, C. T. & Jeske, A. H. Iontophoresis: applications in transdermal medication delivery. Phys. Ther. 75, 554-563 (1995).
    • (1995) Phys. Ther. , vol.75 , pp. 554-563
    • Costello, C.T.1    Jeske, A.H.2
  • 41
    • 0022881509 scopus 로고
    • Evaluation of a cystic fibrosis screening system incorporating a miniature sweat stimulator and disposable chloride sensor
    • Warwick, W. J. et al. Evaluation of a cystic fibrosis screening system incorporating a miniature sweat stimulator and disposable chloride sensor. Clin. Chem. 32, 850-853 (1986).
    • (1986) Clin. Chem. , vol.32 , pp. 850-853
    • Warwick, W.J.1
  • 42
    • 0023263298 scopus 로고
    • Long-term efficacy and side effects of tap water iontophoresis of palmoplantar hyperhidrosis - The usefulness of home therapy
    • Hölzle, E. & Alberti, N. Long-term efficacy and side effects of tap water iontophoresis of palmoplantar hyperhidrosis - the usefulness of home therapy. Dermatologica 175, 126-135 (1987).
    • (1987) Dermatologica , vol.175 , pp. 126-135
    • Hölzle, E.1    Alberti, N.2
  • 43
    • 0034927167 scopus 로고    scopus 로고
    • 1% lidocaine injection, EMLA cream, or 'numby stuff' for topical analgesia associated with peripheral intravenous cannulation
    • Miller, K. A., Balakrishnan, G., Eichbauer, G. & Betley, K. 1% lidocaine injection, EMLA cream, or 'numby stuff' for topical analgesia associated with peripheral intravenous cannulation. AANA J. 69, 185-187 (2001).
    • (2001) AANA J. , vol.69 , pp. 185-187
    • Miller, K.A.1    Balakrishnan, G.2    Eichbauer, G.3    Betley, K.4
  • 44
    • 0033579205 scopus 로고    scopus 로고
    • Noninvasive glucose monitoring: Comprehensive clinical results. Cygnus Research Team
    • Tamada, J. et al. Noninvasive glucose monitoring: comprehensive clinical results. Cygnus Research Team. JAMA 282, 1839-1844 (1999).
    • (1999) JAMA , vol.282 , pp. 1839-1844
    • Tamada, J.1
  • 45
    • 0026924780 scopus 로고
    • Skin biological issues in electrically enhanced transdermal delivery
    • Ledger, P. W. Skin biological issues in electrically enhanced transdermal delivery. Adv. Drug Deliv. Rev. 9, 289-307 (1992).
    • (1992) Adv. Drug Deliv. Rev. , vol.9 , pp. 289-307
    • Ledger, P.W.1
  • 47
    • 0029357156 scopus 로고
    • Transdermal delivery of peptide and protein drugs: An overview
    • Amsden, B. G. & Goosen, M. F. A. Transdermal delivery of peptide and protein drugs: an overview. AIChE J. 41, 1972-1997 (1995).
    • (1995) AIChE J. , vol.41 , pp. 1972-1997
    • Amsden, B.G.1    Goosen, M.F.A.2
  • 48
    • 0035289973 scopus 로고    scopus 로고
    • The role of electroosmotic flow in transdermal iontophoresis
    • Pikal, M. J. The role of electroosmotic flow in transdermal iontophoresis. Adv. Drug Deliv. Rev. 46, 281-305 (2001).
    • (2001) Adv. Drug Deliv. Rev. , vol.46 , pp. 281-305
    • Pikal, M.J.1
  • 49
    • 0032852720 scopus 로고    scopus 로고
    • Mechanistic aspects of iontophoresis in human epidermal membrane
    • Higuchi, W. I., Li, S. K., Ghanem, A. H., Zhu, H. & Song, Y. Mechanistic aspects of iontophoresis in human epidermal membrane. J. Control. Release 62, 13-23 (1999).
    • (1999) J. Control. Release , vol.62 , pp. 13-23
    • Higuchi, W.I.1    Li, S.K.2    Ghanem, A.H.3    Zhu, H.4    Song, Y.5
  • 50
    • 0030574682 scopus 로고    scopus 로고
    • The effects of electric current applied to the skin: A review for transdermal drug delivery
    • Prausnitz, M. R. The effects of electric current applied to the skin: a review for transdermal drug delivery. Adv. Drug Deliv. Rev. 18, 395-425 (1996).
    • (1996) Adv. Drug Deliv. Rev. , vol.18 , pp. 395-425
    • Prausnitz, M.R.1
  • 51
    • 0031904017 scopus 로고    scopus 로고
    • Electrical properties of skin at moderate voltages: Contribution of appendegeal macropores
    • Chizmadzhev, Y. A. et al. Electrical properties of skin at moderate voltages: contribution of appendegeal macropores. Biophys. J. 74, 843-856 (1998).
    • (1998) Biophys. J. , vol.74 , pp. 843-856
    • Chizmadzhev, Y.A.1
  • 52
    • 0027379355 scopus 로고
    • Electroporation of mammalian skin: A mechanism to enhance transdermal drug delivery
    • Prausnitz, M. R., Bose, V. G., Langer, R. & Weaver, J. C. Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proc. Natl Acad. Sci. USA 90, 10504-10508 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10504-10508
    • Prausnitz, M.R.1    Bose, V.G.2    Langer, R.3    Weaver, J.C.4
  • 53
    • 0033521545 scopus 로고    scopus 로고
    • A practical assessment of transdermal drug delivery by skin electroporation
    • Prausnitz, M. R. A practical assessment of transdermal drug delivery by skin electroporation. Adv. Drug Deliv. Rev. 35, 61-76 (1999).
    • (1999) Adv. Drug Deliv. Rev. , vol.35 , pp. 61-76
    • Prausnitz, M.R.1
  • 54
    • 0033521602 scopus 로고    scopus 로고
    • Theory of electrical creation of aqueous pathways across skin transport barriers
    • Weaver, J. C., Vaughan, T. E. & Chizmadzhev, Y. Theory of electrical creation of aqueous pathways across skin transport barriers. Adv. Drug Deliv. Rev. 35, 21-40 (1999).
    • (1999) Adv. Drug Deliv. Rev. , vol.35 , pp. 21-40
    • Weaver, J.C.1    Vaughan, T.E.2    Chizmadzhev, Y.3
  • 56
    • 0345434850 scopus 로고    scopus 로고
    • In vivo efficacy and safety of skin electroporation
    • Vanbever, R. & Preat, V. In vivo efficacy and safety of skin electroporation. Adv. Drug Deliv. Rev. 35, 77-88 (1999).
    • (1999) Adv. Drug Deliv. Rev. , vol.35 , pp. 77-88
    • Vanbever, R.1    Preat, V.2
  • 57
    • 0035337773 scopus 로고    scopus 로고
    • Topical delivery of lidocaine in healthy volunteers by electroporation, electroincorporation, or iontophoresis: An evaluation of skin anesthesia
    • Wallace, M. S. et al. Topical delivery of lidocaine in healthy volunteers by electroporation, electroincorporation, or iontophoresis: an evaluation of skin anesthesia. Reg. Anesth. Pain Med. 26, 229-238 (2001).
    • (2001) Reg. Anesth. Pain Med. , vol.26 , pp. 229-238
    • Wallace, M.S.1
  • 59
    • 0037136038 scopus 로고    scopus 로고
    • Transdermal insulin delivery using lipid enhanced electroporation
    • Sen, A., Daly, M. E. & Hui, S. W. Transdermal insulin delivery using lipid enhanced electroporation. Biochim. Biophys. Acta 1564, 5-8 (2002).
    • (2002) Biochim. Biophys. Acta , vol.1564 , pp. 5-8
    • Sen, A.1    Daly, M.E.2    Hui, S.W.3
  • 60
    • 0032873475 scopus 로고    scopus 로고
    • Needle-free, non-adjuvanted skin immunization by electroporation-enhanced transdermal delivery of diphtheria toxoid and a candidate peptide vaccine against hepatitis B virus
    • Misra, A., Ganga, S. & Upadhyay, P. Needle-free, non-adjuvanted skin immunization by electroporation-enhanced transdermal delivery of diphtheria toxoid and a candidate peptide vaccine against hepatitis B virus. Vaccine 18, 517-523 (1999).
    • (1999) Vaccine , vol.18 , pp. 517-523
    • Misra, A.1    Ganga, S.2    Upadhyay, P.3
  • 61
    • 0029125323 scopus 로고
    • Transdermal transport of DNA antisense oligonucleotides by electroporation
    • Zewert, T. E., Pliquett, U. F., Langer, R. & Weaver, J. C. Transdermal transport of DNA antisense oligonucleotides by electroporation. Biochem. Biophys. Res. Com. 212, 286-292 (1995).
    • (1995) Biochem. Biophys. Res. Com. , vol.212 , pp. 286-292
    • Zewert, T.E.1    Pliquett, U.F.2    Langer, R.3    Weaver, J.C.4
  • 62
    • 0029892620 scopus 로고    scopus 로고
    • Depth-targeted efficient gene delivery and expression in the skin by pulsed electric fields: An approach to gene therapy of skin aging and other diseases
    • Zhang, L., Li, L., Hofmann, G. A. & Hoffman, R. M. Depth-targeted efficient gene delivery and expression in the skin by pulsed electric fields: an approach to gene therapy of skin aging and other diseases. Biochem. Biophys. Res. Comm. 220, 633-636 (1996).
    • (1996) Biochem. Biophys. Res. Comm. , vol.220 , pp. 633-636
    • Zhang, L.1    Li, L.2    Hofmann, G.A.3    Hoffman, R.M.4
  • 63
    • 0000180845 scopus 로고
    • Electro-incorporation of microcarriers as a method for the transdermal delivery of large molecules
    • Hofmann, G. A., Rustrum, W. V. & Suder, K. S. Electro-incorporation of microcarriers as a method for the transdermal delivery of large molecules. Bioelectrochem. Bioenerg. 38, 209-222 (1995).
    • (1995) Bioelectrochem. Bioenerg. , vol.38 , pp. 209-222
    • Hofmann, G.A.1    Rustrum, W.V.2    Suder, K.S.3
  • 64
    • 0027944964 scopus 로고
    • Rapid temporal control of transdermal drug delivery by electroporation
    • Prausnitz, M. R., Pliquett, U., Langer, R. & Weaver, J. C. Rapid temporal control of transdermal drug delivery by electroporation. Pharm. Res. 11, 1834-1837 (1994).
    • (1994) Pharm. Res. , vol.11 , pp. 1834-1837
    • Prausnitz, M.R.1    Pliquett, U.2    Langer, R.3    Weaver, J.C.4
  • 66
    • 0033521683 scopus 로고    scopus 로고
    • Mechanistic studies of molecular transdermal transport due to skin electroporation
    • Pliquett, U. Mechanistic studies of molecular transdermal transport due to skin electroporation. Adv. Drug Deliv. Rev. 35, 41-60 (1999).
    • (1999) Adv. Drug Deliv. Rev. , vol.35 , pp. 41-60
    • Pliquett, U.1
  • 67
    • 0030457097 scopus 로고    scopus 로고
    • Imaging of transport pathways across human stratum corneum during high-voltage and low-voltage electrical exposures
    • Prausnitz, M. R. et al. Imaging of transport pathways across human stratum corneum during high-voltage and low-voltage electrical exposures. J. Pharm. Sci. 85, 1363-1370 (1996).
    • (1996) J. Pharm. Sci. , vol.85 , pp. 1363-1370
    • Prausnitz, M.R.1
  • 68
    • 0003826623 scopus 로고
    • Klinik and therapies des chromischen gelenkreumatismus
    • Maudrich Vienna, Austria
    • Fellinger, K. & Schmidt, J. Klinik and therapies des chromischen gelenkreumatismus. Maudrich Vienna, Austria 549-552 (1954).
    • (1954) , pp. 549-552
    • Fellinger, K.1    Schmidt, J.2
  • 69
    • 0024319473 scopus 로고
    • Drug delivery by phonophoresis
    • Tyle, P. & Agrawala, P. Drug delivery by phonophoresis. Pharm. Res. 6, 355-361 (1989).
    • (1989) Pharm. Res. , vol.6 , pp. 355-361
    • Tyle, P.1    Agrawala, P.2
  • 70
    • 0037945771 scopus 로고    scopus 로고
    • Ultrasound-enhanced transdermal transport
    • Merino, G., Kalia, Y. N. & Guy, R. H. Ultrasound-enhanced transdermal transport. J. Pharm. Sci. 92, 1125-1137 (2003).
    • (2003) J. Pharm. Sci. , vol.92 , pp. 1125-1137
    • Merino, G.1    Kalia, Y.N.2    Guy, R.H.3
  • 71
    • 0029125922 scopus 로고
    • Ultrasound-mediated transdermal protein delivery
    • Mitragotri, S., Blankschtein, D. & Langer, R. Ultrasound-mediated transdermal protein delivery. Science 269, 850-853 (1995).
    • (1995) Science , vol.269 , pp. 850-853
    • Mitragotri, S.1    Blankschtein, D.2    Langer, R.3
  • 72
    • 0034813451 scopus 로고    scopus 로고
    • Transdermal delivery of heparin and low-molecular weight heparin using low-frequency ultrasound
    • Mitragotri, S. & Kost, J. Transdermal delivery of heparin and low-molecular weight heparin using low-frequency ultrasound. Pharm. Res. 18, 1151-1156 (2000).
    • (2000) Pharm. Res. , vol.18 , pp. 1151-1156
    • Mitragotri, S.1    Kost, J.2
  • 73
    • 0026721597 scopus 로고
    • Transdermal delivery of insulin to alloxan-diabetc rabits by ultrasound exposure
    • Tachibana, K. Transdermal delivery of insulin to alloxan-diabetc rabits by ultrasound exposure. Pharm. Res. 9, 952-954 (1992).
    • (1992) Pharm. Res. , vol.9 , pp. 952-954
    • Tachibana, K.1
  • 74
    • 0034080281 scopus 로고    scopus 로고
    • Low-frequency sonophoresis: A non-invasive method for drug delivery and diagnostics
    • Mitragotri, S. & Kost, J. Low-frequency sonophoresis: a non-invasive method for drug delivery and diagnostics. Biotech. Progress 16, 488-492 (2000).
    • (2000) Biotech. Progress , vol.16 , pp. 488-492
    • Mitragotri, S.1    Kost, J.2
  • 75
    • 0034061329 scopus 로고    scopus 로고
    • Transdermal extraction of glucose and other analytes using ultrasound
    • Kost, J., Mitragotri, S., Gabbay, R., Pishko, M. & Langer, R. Transdermal extraction of glucose and other analytes using ultrasound. Nature Med. 6, 347-350 (2000).
    • (2000) Nature Med. , vol.6 , pp. 347-350
    • Kost, J.1    Mitragotri, S.2    Gabbay, R.3    Pishko, M.4    Langer, R.5
  • 76
    • 0029070955 scopus 로고
    • A mechanistic study of ultrasonically enhanced transdermal drug delivery
    • Mitragotri, S., Edwards, D. A., Blankschtein, D. & Langer, R. A mechanistic study of ultrasonically enhanced transdermal drug delivery. J. Pharm. Sci. 84, 697-706 (1995).
    • (1995) J. Pharm. Sci. , vol.84 , pp. 697-706
    • Mitragotri, S.1    Edwards, D.A.2    Blankschtein, D.3    Langer, R.4
  • 78
    • 0041342090 scopus 로고    scopus 로고
    • Ultrastructural evidence of stratum corneum permeabilization induced by photomechanical waves
    • Menon, G. K., Kollias, N. & Doukas, A. G. Ultrastructural evidence of stratum corneum permeabilization induced by photomechanical waves. J. Invest. Dermatol. 121, 104-109 (2003).
    • (2003) J. Invest. Dermatol. , vol.121 , pp. 104-109
    • Menon, G.K.1    Kollias, N.2    Doukas, A.G.3
  • 81
    • 0031852494 scopus 로고    scopus 로고
    • Microfabricated microneedles: A novel method to increase transdermal drug delivery
    • Henry, S., McAllister, D., Allen, M. G. & Prausnitz, M. R. Microfabricated microneedles: a novel method to increase transdermal drug delivery. J. Pharm. Sci. 87, 922-925 (1998).
    • (1998) J. Pharm. Sci. , vol.87 , pp. 922-925
    • Henry, S.1    McAllister, D.2    Allen, M.G.3    Prausnitz, M.R.4
  • 82
    • 0344270926 scopus 로고    scopus 로고
    • Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies
    • McAllister, D. V. et al. Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies. Proc. Natl Acad. Sci. USA 100, 13755-13760 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 13755-13760
    • McAllister, D.V.1
  • 83
    • 0035659567 scopus 로고    scopus 로고
    • Transdermal delivery of antisense oligonucleotides with microprojection patch (Macroflux) technology
    • Lin, W. et al. Transdermal delivery of antisense oligonucleotides with microprojection patch (Macroflux) technology. Pharm. Res. 18, 1789-1793 (2001).
    • (2001) Pharm. Res. , vol.18 , pp. 1789-1793
    • Lin, W.1
  • 85
    • 1842697613 scopus 로고    scopus 로고
    • (eds Rathbone, M. J., Hadgraft, J. & Roberts, M. S.) (Marcel Dekker, Now York)
    • Cormier, M. & Daddona, P. E. in Modified-Release Drug Delivery Technology (eds Rathbone, M. J., Hadgraft, J. & Roberts, M. S.) 589-598 (Marcel Dekker, Now York, 2003).
    • (2003) Modified-Release Drug Delivery Technology , pp. 589-598
    • Cormier, M.1    Daddona, P.E.2
  • 86
    • 0036007129 scopus 로고    scopus 로고
    • Macroflux microprojection array patch technology: A new and efficient approach for intracutaneous immunization
    • Matriano, J. A. et al. Macroflux microprojection array patch technology: a new and efficient approach for intracutaneous immunization. Pharm. Res. 19, 63-70 (2002).
    • (2002) Pharm. Res. , vol.19 , pp. 63-70
    • Matriano, J.A.1
  • 87
    • 0036105150 scopus 로고    scopus 로고
    • Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery
    • Mikszta, J. A. et al. Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery. Nature Med. 8, 415-419 (2002).
    • (2002) Nature Med. , vol.8 , pp. 415-419
    • Mikszta, J.A.1
  • 88
    • 0035142406 scopus 로고    scopus 로고
    • Lack of pain associated with microfabricated microneedles
    • Kaushik, S. et al. Lack of pain associated with microfabricated microneedles. Anesth. Analg. 92, 502-504 (2001).
    • (2001) Anesth. Analg. , vol.92 , pp. 502-504
    • Kaushik, S.1
  • 89
    • 23544463503 scopus 로고
    • Drug delivery device
    • US Patent 3,964,482
    • Gerstel, M. S. & Place, V. A. Drug delivery device. US Patent 3,964,482 (1976).
    • (1976)
    • Gerstel, M.S.1    Place, V.A.2
  • 90
    • 0037472111 scopus 로고    scopus 로고
    • Radiofrequency-driven skin microchanneling as a new way for electrically assisted transdermal delivery of hydrophilic drugs
    • Sintov, A. C. et al. Radiofrequency-driven skin microchanneling as a new way for electrically assisted transdermal delivery of hydrophilic drugs. J. Control. Release 89, 311-320 (2003).
    • (2003) J. Control. Release , vol.89 , pp. 311-320
    • Sintov, A.C.1
  • 91
    • 0037322494 scopus 로고    scopus 로고
    • Enabling topical immunization via microporation: A novel method for pain-free and needle-free delivery of adenovirus-based vaccines
    • Bramson, J. et al. Enabling topical immunization via microporation: a novel method for pain-free and needle-free delivery of adenovirus-based vaccines. Gene Ther. 10, 251-260 (2003).
    • (2003) Gene Ther. , vol.10 , pp. 251-260
    • Bramson, J.1
  • 92
    • 12444301362 scopus 로고    scopus 로고
    • Glucose sensing in transdermal body fluid collected under continuous vacuum pressure via micropores in the stratum corneum
    • Gebhart, S. et al. Glucose sensing in transdermal body fluid collected under continuous vacuum pressure via micropores in the stratum corneum. Diabetes Technol. Ther. 5, 159-166 (2003).
    • (2003) Diabetes Technol. Ther. , vol.5 , pp. 159-166
    • Gebhart, S.1
  • 93
    • 0004566242 scopus 로고
    • A survey of the development of jet injection in parenteral therapy
    • Hingson, R. A. & Figge, F. H. A survey of the development of jet injection in parenteral therapy. Curr. Res. Anesth. Analg. 31, 361-366 (1952).
    • (1952) Curr. Res. Anesth. Analg. , vol.31 , pp. 361-366
    • Hingson, R.A.1    Figge, F.H.2
  • 94
    • 0034946760 scopus 로고    scopus 로고
    • Delivery of insulin by jet injection: Recent observations
    • Bremseth, D. L. & Pass, F. Delivery of insulin by jet injection: recent observations. Diabetes Technol. Ther. 3, 225-232 (2001).
    • (2001) Diabetes Technol. Ther. , vol.3 , pp. 225-232
    • Bremseth, D.L.1    Pass, F.2
  • 95
    • 0032863151 scopus 로고    scopus 로고
    • Transdermal and transmucosal powdered drug delivery
    • Burkoth, T. L. et al. Transdermal and transmucosal powdered drug delivery. Crit. Rev. Ther. Drug Carrier Syst. 16, 331-384 (1999).
    • (1999) Crit. Rev. Ther. Drug Carrier Syst. , vol.16 , pp. 331-384
    • Burkoth, T.L.1
  • 96
    • 0034086895 scopus 로고    scopus 로고
    • A pharmacokinetic and tolerability evaluation of two continuous subcutaneous infusion systems compared to an oral controlled-release morphine
    • Mikkelsen Lynch, P. et al. A pharmacokinetic and tolerability evaluation of two continuous subcutaneous infusion systems compared to an oral controlled-release morphine. J. Pain Symptom Manage. 19, 348-356 (2000).
    • (2000) J. Pain Symptom Manage. , vol.19 , pp. 348-356
    • Mikkelsen Lynch, P.1
  • 97
    • 0034493157 scopus 로고    scopus 로고
    • Synergistic effect of enhancers for transdermal drug delivery
    • Mitragotri, S. Synergistic effect of enhancers for transdermal drug delivery. Pharm. Res. 17, 1354-1359 (2000).
    • (2000) Pharm. Res. , vol.17 , pp. 1354-1359
    • Mitragotri, S.1
  • 98
    • 0025346716 scopus 로고
    • Iontophoresis of polypeptides: Effect of ethanol pretreatment of human skin
    • Srinivasan, V., Su, M. H., Higuchi, W. I. & Behl, C. R. Iontophoresis of polypeptides: effect of ethanol pretreatment of human skin. J. Pharm. Sci. 79, 588-591 (1990).
    • (1990) J. Pharm. Sci. , vol.79 , pp. 588-591
    • Srinivasan, V.1    Su, M.H.2    Higuchi, W.I.3    Behl, C.R.4
  • 99
    • 0032509907 scopus 로고    scopus 로고
    • Enhanced transdermal delivery of AZT (Zidovudine) using iontophoresis and penetration enhancer
    • Oh, S. Y., Jeong, S. Y., Park, T. G. & Lee, J. H. Enhanced transdermal delivery of AZT (Zidovudine) using iontophoresis and penetration enhancer. J. Control. Release 51, 161-168 (1998).
    • (1998) J. Control. Release , vol.51 , pp. 161-168
    • Oh, S.Y.1    Jeong, S.Y.2    Park, T.G.3    Lee, J.H.4
  • 100
    • 0025253212 scopus 로고
    • Enhancement of the in vitro skin permeability of azidothymidine (AZT) via ontophoresis and chemical enhancers
    • Wearley, L. & Chien, Y. W. Enhancement of the in vitro skin permeability of azidothymidine (AZT) via ontophoresis and chemical enhancers. Pharm. Res. 7, 34-40 (1990).
    • (1990) Pharm. Res. , vol.7 , pp. 34-40
    • Wearley, L.1    Chien, Y.W.2
  • 101
    • 0030272493 scopus 로고    scopus 로고
    • Effect of azone on the iontophoretic transdermal delivery of metoprolol tartarate through human epidermis in vitro
    • Ganga, S., Ramarao, J. & Singh, J. Effect of azone on the iontophoretic transdermal delivery of metoprolol tartarate through human epidermis in vitro. J. Control. Rel. 42, 57-64 (1996).
    • (1996) J. Control. Rel. , vol.42 , pp. 57-64
    • Ganga, S.1    Ramarao, J.2    Singh, J.3
  • 102
    • 0031003156 scopus 로고    scopus 로고
    • Effetct of penetration enhancers and iontophoresis on the FT-IR spectroscopy and LHRH permeability
    • Bhatia, K. S., Gao, S. & Singh, J. Effetct of penetration enhancers and iontophoresis on the FT-IR spectroscopy and LHRH permeability. J. Control. Rel. 47, 81-89 (1997).
    • (1997) J. Control. Rel. , vol.47 , pp. 81-89
    • Bhatia, K.S.1    Gao, S.2    Singh, J.3
  • 103
    • 0030056826 scopus 로고    scopus 로고
    • Synergistic effect of ultrasound and chemical enhancers on transdermal drug delivery
    • Johnson, M. E., Mitragotri, S., Patel, A., Blankschtein, D. & Langer, R. Synergistic effect of ultrasound and chemical enhancers on transdermal drug delivery. J. Pharm. Sci. 85, 670-679 (1996).
    • (1996) J. Pharm. Sci. , vol.85 , pp. 670-679
    • Johnson, M.E.1    Mitragotri, S.2    Patel, A.3    Blankschtein, D.4    Langer, R.5
  • 104
    • 0033823142 scopus 로고    scopus 로고
    • Synergistic effect of ultrasound and sodium lauryl sulfate on transdermal drug delivery
    • Mitragotri, S. et al. Synergistic effect of ultrasound and sodium lauryl sulfate on transdermal drug delivery. J. Pharm. Sci. 89, 892-900 (2000).
    • (2000) J. Pharm. Sci. , vol.89 , pp. 892-900
    • Mitragotri, S.1
  • 105
    • 0033755812 scopus 로고    scopus 로고
    • Combined effect of low-frequency ultrasound and iontophoresis: Applications for transdermal heparin delivery
    • Le, L., Kost, J. & Mitragotri, S. Combined effect of low-frequency ultrasound and iontophoresis: applications for transdermal heparin delivery. Pharm. Res. 17, 1151-1154 (2000).
    • (2000) Pharm. Res. , vol.17 , pp. 1151-1154
    • Le, L.1    Kost, J.2    Mitragotri, S.3
  • 106
    • 0030902518 scopus 로고    scopus 로고
    • Macromolecules as novel transdermal transport enhancers for skin electroporation
    • Vanbever, R., Prausnitz, M. R. & Preat, V. Macromolecules as novel transdermal transport enhancers for skin electroporation. Pharm. Res. 14, 638-644 (1997).
    • (1997) Pharm. Res. , vol.14 , pp. 638-644
    • Vanbever, R.1    Prausnitz, M.R.2    Preat, V.3
  • 107
    • 0032733727 scopus 로고    scopus 로고
    • Creation of transdermal pathways for macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule
    • Zewert, T. E., Pliquett, U. F., Vanbever, R., Langer, R. & Weaver, J. C. Creation of transdermal pathways for macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule. Bioelectrochem. Bioenerg. 49, 11-20 (1999).
    • (1999) Bioelectrochem. Bioenerg. , vol.49 , pp. 11-20
    • Zewert, T.E.1    Pliquett, U.F.2    Vanbever, R.3    Langer, R.4    Weaver, J.C.5
  • 108
    • 0028020044 scopus 로고
    • Effects of electroporation on transdermal iontophoretic delivery of leutinizing hormone releasing hormone
    • Bommanon, D. B., Tamada, J., Leung, L. & Potts, R. O. Effects of electroporation on transdermal iontophoretic delivery of leutinizing hormone releasing hormone. Pharm. Res. 11, 1809-1814 (1994).
    • (1994) Pharm. Res. , vol.11 , pp. 1809-1814
    • Bommanon, D.B.1    Tamada, J.2    Leung, L.3    Potts, R.O.4
  • 109
    • 0024215844 scopus 로고
    • Drug therapy. Pharmacologic aspects of cigarette smoking and nicotine addition
    • Benowitz, N. L. Drug therapy. Pharmacologic aspects of cigarette smoking and nicotine addition. N. Engl. J. Med. 319, 1318-1330 (1988).
    • (1988) N. Engl. J. Med. , vol.319 , pp. 1318-1330
    • Benowitz, N.L.1
  • 110
    • 0026420103 scopus 로고
    • Cigarette smoking among adults - United States, 1988
    • Centers for Disease Control and Prevention. 765
    • Centers for Disease Control and Prevention. Cigarette smoking among adults - United States, 1988. MMWR Morb. Mortal. Wkly Rep. 40, 757-759,765 (1991).
    • (1991) MMWR Morb. Mortal Wkly Rep. , vol.40 , pp. 757-759
  • 111
    • 0027312239 scopus 로고
    • Nicotine transdermal systems
    • Gora, M. L. Nicotine transdermal systems. Ann. Pharmacother 27, 742-750 (1993).
    • (1993) Ann. Pharmacother. , vol.27 , pp. 742-750
    • Gora, M.L.1
  • 112
    • 0034602601 scopus 로고    scopus 로고
    • Validation protocol of an automated in-line flow-through diffusion equipment for in vitro permeation studies
    • Cordoba-Diaz, M. et al. Validation protocol of an automated in-line flow-through diffusion equipment for in vitro permeation studies. J. Control. Release 69, 357-367 (2000).
    • (2000) J. Control. Release , vol.69 , pp. 357-367
    • Cordoba-Diaz, M.1
  • 113
    • 0033846513 scopus 로고    scopus 로고
    • Automated In Vitro Dermal Absorption (AIVDA): Predicting skin permeation of atrazine with finite and infinite (swimming/bathing) exposure models
    • Moody, R. P. Automated In Vitro Dermal Absorption (AIVDA): predicting skin permeation of atrazine with finite and infinite (swimming/bathing) exposure models. Toxicol. In Vitro 14, 467-474 (2000).
    • (2000) Toxicol. In Vitro , vol.14 , pp. 467-474
    • Moody, R.P.1
  • 114
    • 0037331778 scopus 로고    scopus 로고
    • Dependence of skin permeability on contact area
    • Karande, P. & Mitragotri, S. Dependence of skin permeability on contact area. Pharm. Res. 20, 257-263 (2003).
    • (2003) Pharm. Res. , vol.20 , pp. 257-263
    • Karande, P.1    Mitragotri, S.2
  • 115
    • 23544469403 scopus 로고    scopus 로고
    • System and method for optimizing tissue barrier transfer of compounds
    • WO 02/06518
    • Cima, M., Chen, H. & Gyory, J. R. System and method for optimizing tissue barrier transfer of compounds. WO 02/06518 (2002).
    • (2002)
    • Cima, M.1    Chen, H.2    Gyory, J.R.3
  • 116
    • 0038004738 scopus 로고    scopus 로고
    • Making better drugs: Decision gates in non-clinical drug development
    • Pritchard, J. F. et al. Making better drugs: decision gates in non-clinical drug development. Nature Rev. Drug Discov. 2, 542-553 (2003).
    • (2003) Nature Rev. Drug Discov. , vol.2 , pp. 542-553
    • Pritchard, J.F.1
  • 117
    • 0000455130 scopus 로고
    • Introduction of medicinal substances into the depth of tissues by electric current
    • Leduc, S. Introduction of medicinal substances into the depth of tissues by electric current. Ann. d'Electrobiol. 3, 545-560 (1900).
    • (1900) Ann. D'Electrobiol. , vol.3 , pp. 545-560
    • Leduc, S.1
  • 118
    • 0025891212 scopus 로고
    • Transdermal delivery of insulin by ultrasonic vibration
    • Tachibana, K. & Tachibana, S. Transdermal delivery of insulin by ultrasonic vibration. J. Pharm. Pharmocol. 43, 270-271 (1991).
    • (1991) J. Pharm. Pharmocol. , vol.43 , pp. 270-271
    • Tachibana, K.1    Tachibana, S.2


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