Effects of titanium dioxide nanoparticle exposure on neuroimmune responses in rat airways

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 73, Issue 20, 2010, Pages 1353-1369

  Scuri, Mario ^a   Chen, Bean T ^b   Castranova, Vincent ^b   Reynolds, Jeffrey S ^b   Johnson, Victor J ^b   Samsell, Lennie ^a   Walton, Cheryl ^a   Piedimonte, Giovanni ^a  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CXCL1 CHEMOKINE; NANOMATERIAL; NANOPARTICLE; NEUROTROPHIN; TITANIUM DIOXIDE;

AIRBORNE PARTICLE; AIRWAY DYNAMICS; AMBIENT AIR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; IMMUNE RESPONSE; INHALATION; LUNG DEPOSIT; LUNG LAVAGE; MALE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PARTICLE SIZE; PARTICULATE MATTER; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; RISK FACTOR;

AGE FACTORS; ANIMALS; ASTHMA; FEMALE; INHALATION EXPOSURE; MALE; NANOPARTICLES; NEUROIMMUNOMODULATION; PULMONARY ALVEOLI; RATS; RISK ASSESSMENT; TITANIUM;

ANIMALIA; RATTUS;

EID: 77956472725     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287394.2010.497436     Document Type: Article

References (64)

1. Atkinson, R. W., Anderson, H. R., Sunyer, J., Ayres, J., Baccini, M., Vonk, J. M., Boumghar, A., Forastiere, F., Forsberg, B., Touloumi, G., Schwartz, J., and Katsouyanni, K. 2001. Acute effects of particulate air pollution on respiratory admissions: Results from APHEA 2 project. Air Pollution and Health: A European Approach. Am. J. Respir. Crit. Care Med. 164:1860-1866.
2. Bedeschi, E., Campari, C., Candela, S., Collini, G., Caranci, N., Frasca, G., Galassi, C., Francesca, G., and Vigotti, M. A. 2007. Urban air pollution and respiratory emergency visits at pediatric unit, Reggio Emilia, Italy. J. Toxicol. Environ. Health A 70:261-265.
3. BeruBe, K., Balharry, D., Sexton, K., Koshy, L., and Jones, T. 2007. Combustion-derived nanoparticles: Mechanisms of pulmonary toxicity. Clin. Exp. Pharmacol. Physiol. 34:1044-1050.
4. Bonini, S., Lambiase, A., Bonini, S., Angelucci, F., Magrini, L., Manni, L., and Aloe, L. 1996. Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma. Proc. Natl. Acad. Sci. USA 93:10955-10960.
5. Braun, A., Appel, E., Baruch, R., Herz, U., Botchkarev, V., Paus, R., Brodie, C., and Renz, H. 1998. Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma. Eur. J. Immunol. 28:3240-3251.
6. Braun, A., Lommatzsch, M., Lewin, G. R., Virchow, J. C., and Renz, H. 1999. Neurotrophins: A link between airway inflammation and airway smooth muscle contractility in asthma? Int. Arch. Allergy Immunol. 118:163-165.
7. Brown, J. S., Wilson, W. E., and Grant, L. D. 2005. Dosimetric comparisons of particle deposition and retention in rats and humans. Inhal. Toxicol. 17:355-385.
8. Cade, A., Brownlee, K. G., Conway, S. P., Haigh, D., Short, A., Brown, J., Dassu, D., Mason, S. A., Phillips, A., Eglin, R., Graham, M., Chetcuti, A., Chatrah, M., Hudson, N., Thomas, A., and Chetcuti, P. A. 2000. Randomised placebo controlled trial of nebulised corticosteroids in acute respiratory syncytial viral bronchiolitis. Arch. Dis. Child. 82:126-130.
9. Chao, M. V. 2003. Neurotrophins and their receptors: A convergence point for many signalling pathways. Nat.Rev. Neurosci. 4:299-309.
10. Chen, B., Frazer, D., Stone, S., Schwegler-Berry, D., Cumpston, J., McKinney, W., Linsley, W., Frazer, A., Donlin, M., Vandestouwe, K., Castranova, V., and Nurkiewicz, T. 2006. Development of a small inhalation system for rodent exposure to fine and ultrafine titanium dioxide aerosols. 7th International Aerosol Conference, St. Paul, MN.
11. De Haar, C., Hassing, I., Bol, M., Bleumink, R., and Pieters, R. 2006. Ultrafine but not fine particulate matter causes airway inflammation and allergic airway sensitization to co-administered antigen in mice. Clin. Exp. Allergy 36:1469-1479.
12. Dominici, F., A. McDermott, M. Daniels, S. L. Zeger and J. M. Samet. 2005. Revised analyses of the National Morbidity, Mortality, and Air Pollution Study: Mortality among residents of 90 cities. J. Toxicol. Environ. Health A 68:1071-1092.
13. Donaldson, K., Gilmour, M. I., and MacNee, W. 2000. Asthma and PM10. Respir. Res. 1:12-15.
14. Fox, G. F., Everard, M. L., Marsh, M. J., and Milner, A. D. 1999. Randomised controlled trial of budesonide for the prevention of post-bronchiolitis wheezing. Arch. Dis. Child. 80:343-347.
15. Fujimura, M., Tsujiura, M., Nomura, M., Mizuguchi, M., Matsuda, T., and Matsushima, K. 1996. Sensory neuropep-tides are not directly involved in bronchial hyperresponsiveness induced by interleukin-8 in guinea-pigs in vivo. Clin. Exp. Allergy 26:357-362.
16. Geiser, M., Casaulta, M., Kupferschmid, B., Schulz, H., Semmler-Behnke, M., and Kreyling, W. 2008. The role of macrophages in the clearance of inhaled ultrafine titanium dioxide particles. Am. J. Respir. Cell Mol. Biol. 38:371-376.
17. Goetzl, E. J., Xia, M., Ingram, D. A., Kishiyama, J. L., Kaltreider, H. B., Byrd, P. K., Ichikawa, S., and Sreedharan, S. P. 1995. Neuropeptide signaling of lymphocytes in immunological responses. Int. Arch. Allergy Immunol. 107:202-204.
18. Grassian, V. H., O'Shaughnessy, T., Adamcakova-Dodd, P. A., Pettibone, J. M., and Thorne, P. S. 2007. Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm. Environ. Health Perspect. 115:397-402.
19. Gwinn, M. R. and Vallyathan, V. 2006. Nanoparticles: Health effects\Pros and cons. Environ. Health Perspect. 114:1818-1825.
20. Hu, C., Wedde-Beer, K., Auais, A., Rodriguez, M. M., and Piedimonte, G. 2002. Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs. Am. J. Physiol. Lung Cell. Mol. Physiol. 283:L494-L502.
21. Huang, E. J., and Reichard, L. F. 2001. Neurotrophins: Roles in neuronal development and function. Annu. Rev. Neurosci. 24:677-736.
22. Huang, M., Khor, E., and Lim, L. Y. 2004. Uptake and cytotoxicity of chitosan molecules and nanoparticles: Effects of molecular weight and degree of deacetylation. Pharm. Res. 21:344-353.
23. Karr, C. J., Rudra, C. B., Miller, K. A., Gould, T. R., Larson, T., Sathyanarayana, S., and Koenig, J. Q. 2009. Infant exposure to fine particulate matter and traffic and risk of hos-pitalization for RSV bronchiolitis in a region with lower ambient air pollution. Environ. Res. 109:321-327.
24. Kernie, S. G., and Parada, L. F. 2000. The molecular basis for understanding neu-rotrophins and their relevance to neurologic disease. Arch. Neurol. 57:654-657.
25. Krewski, D., Burnett, R., Jerrett, M., Pope, C. A., Rainham, D., Calle, E., Thurston, G., and Thun, M. 2005. Mortality and long-term exposure to ambient air pollution: Ongoing analyses based on the American Cancer Society cohort. J. Toxicol. Environ. Health A 68:1093-1109.
26. Krewski, D., and Rainham, D. 2007. Ambient air pollution and population health: overview. J. Toxicol. Environ. Health A 70:275-283. (Pubitemid 46294864)
27. Kreyling, W. 2003. Deposition, retention, and clearance of ultrafine particles. BIA-Workshop, Ultrafine Aerosols at Workplaces. Neuherberg/Munich: Germany.
28. Kreyling, W. G., Semmler, M., Erbe, F., Mayer, P., Takenaka, S., Schulz, H., Oberdorster, G., and Ziesenis, A. 2002. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. J. Toxicol. Environ. Health A 65:1513-1530.
29. Krishna, M. T., Chauhan, A. J., Frew, A. J., and Holgate, S. T. 1998. Toxicological mechanisms underlying oxidant pollutant-induced airway injury. Rev. Environ. Health 13: 59-67
30. Lambert, A. L., Mangum, J. B., DeLorme, M. P., and Everitt, J. I. 2003. Ultrafine carbon black particles enhance respiratory syncytial virus-induced airway reactivity, pulmonary inflammation, and chemokine expression. Toxicol. Sci. 72:339-346.
31. Levi-Montalcini, R. 1987. The nerve growth factor35yearslater.Science237: 1154-1162.
32. Lewin, G. R., and Barde, Y. A. 1996. Physiology of the neurotrophins. Annu. Rev. Neurosci. 19:289-317.
33. Lindsay, R. M., and Harmar, A. J. 1989. Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons. Nature 337:362-364.
34. Maggi, C. A. 1997. The effects of tachykinins on inflammatory and immune cells. Regul. Pept. 70:75-90.
35. Marple, V. A., Liu, B. Y., and Rubow, K. L. 1978. A dust generator for laboratory use. Am Ind Hyg Assoc J 39:26-32.
36. Maynard, A. D., Aitken, R. J., Butz, T., Colvin, V., Donaldson, K., Oberdorster, G., Philbert, M. A., Ryan, J., Seaton, A., Stone, V., Tinkle, S. S., Tran, L., Walker, N. J., and Warheit, D. B. 2006. Safe handling of nan-otechnology. Nature 444:267-269.
37. Moller, W., Felten, K., Sommerer, K., Scheuch, G., Meyer, G., Meyer, P., Haussinger, K., and Kreyling, W. G. 2008. Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery. Am. J. Respir. Crit. Care Med. 177:426-432.
38. Mossman, B. T., Borm, P. J., Castranova, V., Costa, D. L., Donaldson, K., and Kleeberger, S. R. 2007. Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases. Particle Fibre Toxicol. 4:4.
39. Nassenstein, C., Schulte-Herbruggen, O., Renz, H., and Braun, A. 2006a. Nerve growth factor: The central hub in the development of allergic asthma? Eur. J. Pharmacol. 533:195-206.
40. Nockher, W. A. and Renz, H. 2006b. Neurotrophins and asthma: novel insight into neuroimmune interaction. J. Allergy Clin. Immunol. 117:67-71.
41. Nockher, W. A., and Renz, H. 2006. Neurotrophins in allergic diseases: From neuronal growth factors to intercellular signaling molecules. J. Allergy Clin. Immunol. 117:583-589.
42. Oberdorster, G. 2001. Pulmonary effects of inhaled ultrafine particles. Int. Arch. Occup. Environ. Health 74:1-8.
43. Oberdorster, G., Maynard, A., Donaldson, K., Castranova, V., Fitzpatrick, J., Ausman, K., Carter, J., Karn, B., Kreyling, W., Lai, D., Olin, S., Monteiro-Riviere, N., Warheit, D., and Yang, H. 2005. Principles for characterizing the potential human health effects from exposure to nanomaterials: Elements of a screening strategy. Particle Fibre Toxicol. 2:8.
44. Peters, A., von Klot, S., Heier, M., Trentinaglia, I., Hormann, A., Wichmann, H. E., and Lowel, H. 2004. Exposure to traffic and the onset of myocardial infarction. N. Engl. J. Med. 351:1721-1730.
45. Piedimonte, G. 2001. Neural mechanisms of respiratory syncytial virus-induced inflammation and prevention of respiratory syncy-tial virus sequelae. Am. J. Respir. Crit. Care Med. 163:S18-S21.
46. Piedimonte, G. 2002b. The association between respiratory syncytial virus infection and reactive airway disease. Respir. Med. 96(suppl. B):S25-S29.
47. Piedimonte, G. 2002a. Origins of reactive airways disease in early life: Do viral infections play a role? Acta Paediatr. Suppl. 91: 6-11.
48. Piedimonte, G. 2002c. Pathophysiological mechanisms for the respiratory syncytial virus-reactive airway disease link. Respir. Res. 3(suppl. 1):S21-S25.
49. Piedimonte, G. 2003. Contribution of neu-roimmune mechanisms to airway inflammation and remodeling during and after respiratory syncytial virus infection. Pediatr. Infect. Dis. J. 22:S66-S74; discussion S74-S75.
50. Piedimonte, G., Hegele, R. G., and Auais, A. 2004. Persistent airway inflammation after resolution of respiratory syncytial virus infection in rats. Pediatr. Res. 55:657-665.
51. Qi, H., Lu, K., and Wang, W. 1999. The relationship between interleukin-8 and airway hyperresponsiveness in guinea pigs. Chin. Med. J. (Engl.) 112:985-987.
52. Reynolds, J. S., Johnson, V. J., and Frazer, D. G. 2008. Unrestrained acoustic plethys-mograph for measuring specific airway resistance in mice. J. Appl. Physiol. 105: 711-717.
53. Richter, H., and Sheddon, P. 1998. Early nebulized budesonide in the treatment of bron-chiolitis and the prevention of postbronchi-olitic wheezing. J. Pediatr. 132:849-853.
54. Shieh, K. J., Li, M., Lee, Y. H., Sheu, S. D., Liu, Y. T., and Wang, Y. C. 2006. Antibacterial performance of photocatalyst thin film fabricated by defection effect in visible light. Nanomedicine 2:121-126.
55. Shvedova,A.A.,Fabisiak,J.P.,Kisin,E.R.,Murray, A. R., Roberts, J. R., Tyurina, Y. Y., Antonini, J. M., Feng, W. H., Kommineni, C., Reynolds, J., Barchowsky, A., Castranova, V., and Kagan, V. E. 2008. Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity. Am. J. Physiol. Lung Cell. Mol. Physiol. 38:579-590.
56. 2: Role of the specific surface area and of surface methylation of the particles. Toxicol. Appl. Pharmacol. 222:141-151.
57. Sly, P. D., Turner, D. J., Collins, R. A., and Hantos, Z. 2005. Penh is not a validated technique for measuring airway function in mice. Am. J. Respir. Crit. Care Med. 172:256.
58. Verri, W. A., Jr., Cunha, T. M., Parada, C. A., Poole, S., Cunha, F. Q., and Ferreira, S. H. 2006. Hypernociceptive role of cytokines and chemokines: targets for analgesic drug development? Pharmacol. Ther. 112: 116-138.
59. von Klot, S., Wolke, G., Tuch, T., Heinrich, J., Dockery, D. W., Schwartz, J., Kreyling, W. G., Wichmann, H. E., and Peters, A. 2002. Increased asthma medication use in association with ambient fine and ultrafine particles. Eur. Respir. J. 20:691-702.
60. 2 particles: Differential responses related to surface properties. Toxicology 230:90-104.
61. Wong, G. W., and Lai, C. K. 2004. Outdoor air pollution and asthma. Curr. Opin. Pulmon. Med. 10:62-66.
62. Yang, L., and Watts, D. J. 2005. Particle surface characteristics may play an important role in phytotoxicity of alumina nanoparticles. Toxicol. Lett. 158:122-132.
63. Zhang, Q., Kusaka, Y., Zhu, X., Sato, K., Mo, Y., Kluz, T., and Donaldson, K. 2003. Comparative toxicity of standard nickel and ultrafine nickel in lung after intratracheal instillation. J. Occup. Health 45:23-30.
64. Zhou, Y. M., Zhong, C. Y., Kennedy, I. M., Leppert, V. J., and Pinkerton, K. E. 2003. Oxidative stress and NFkappaB activation in the lungs of rats: A synergistic interaction between soot and iron particles. Toxicol. Appl. Pharmacol. 190:157-169.