Potential health impact on mice after nasal instillation of nano-sized copper particles and their translocation in mice

Journal of Nanoscience and Nanotechnology

Volumn 9, Issue 11, 2009, Pages 6335-6343

  Liu, Yang ^a,b,c   Gao, Yuxi ^a,b   Zhang, Lili ^a,b   Wang, Tiancheng ^d   Wang, Jiangxue ^a,b   Jiao, Fang ^a,b   Li, Wei ^a,b   Liu, Ying ^a,b   Li, Yufeng ^a,b   Li, Bai ^a,b   Chai, Zhifang ^a,e   Wu, Gang ^c   Chen, Chunying ^a,b  

^a INSTITUTE OF HIGH ENERGY PHYSICS   (China)

^b NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY   (China)

^c BAOTOU MEDICAL COLLEGE   (China)

^d PEKING UNIVERSITY THIRD HOSPITAL   (China)

^e SHANGHAI UNIVERSITY   (China)

Author keywords

Copper nanoparticles; Mice; Nasal instillation; Toxicity; Translocation

Indexed keywords

BIOCHEMICAL ASSAY; BODY WEIGHT; CONTROL GROUPS; COPPER CONTENT; COPPER NANOPARTICLES; COPPER PARTICLES; HEPATIC LESIONS; HEPATOCYTES; HIGH DOSE; HISTOLOGICAL CHANGES; LAMINATED STRUCTURES; LOW DOSE; MICE; NANO SCALE; NANO-SIZED; NASAL INSTILLATION; OLFACTORY BULBS; PATHOLOGICAL CHANGES; PHYSIOLOGICAL DAMAGES; POTENTIAL HEALTH; SENSITIVE ELEMENTS; TARGET ORGANS; TRANSLOCATION;

ANTHROPOMETRY; HEALTH RISKS; HISTOLOGY; LIVER; NANOPARTICLES; RISK ASSESSMENT; RISK MANAGEMENT; TOXICITY;

COPPER;

COPPER; NANOPARTICLE;

ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; DOSE RESPONSE; FEMALE; INSTITUTE FOR CANCER RESEARCH MOUSE; INTRANASAL DRUG ADMINISTRATION; MOUSE; PARTICLE SIZE; TISSUE DISTRIBUTION; ULTRASTRUCTURE;

ADMINISTRATION, INTRANASAL; ANIMALS; COPPER; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MICE; MICE, INBRED ICR; NANOPARTICLES; ORGAN SPECIFICITY; PARTICLE SIZE; TISSUE DISTRIBUTION;

EID: 70350328576     PISSN: 15334880     EISSN: None     Source Type: Journal    
DOI: 10.1166/jnn.2009.1320     Document Type: Article

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