Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intractracheal instillation

Toxicological Sciences

Volumn 77, Issue 1, 2004, Pages 126-134

  Lam, Chiu Wing ^a,b   James, John T ^a   McCluskey, Richard ^a   Hunter, Robert L ^c  

^a NASA JOHNSON SPACE CENTER   (United States)

^b WYLE LABORATORIES   (United States)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Carbon nanotubes; Epithelioid granulomas; Nanotube toxicity; Pulmonary toxicity

Indexed keywords

CARBON NANOTUBE; SILICON DIOXIDE;

ANIMAL TISSUE; ARTICLE; CHEMICAL COMPOSITION; CHEMICAL PARAMETERS; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; HISTOPATHOLOGY; LUNG TOXICITY; LUNG WEIGHT; MALE; MOUSE; NONHUMAN;

ACUTE TOXICITY TESTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GRANULOMA, FOREIGN-BODY; GRANULOMA, RESPIRATORY TRACT; INHALATION EXPOSURE; INTUBATION, INTRATRACHEAL; LONGEVITY; LUNG; LUNG DISEASES; MALE; MICE; MICE, INBRED STRAINS; NANOTUBES, CARBON; SPECIFIC PATHOGEN-FREE ORGANISMS;

ANIMALIA;

EID: 1542726626     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg243     Document Type: Article

References (40)

1. ACGIH (2001). Documentation of the Threshold Limit Values and Biological Exposure Indices. American Conference of Governmental Industrial Hygienists, Cincinnati, OH.
2. Ajayan, P. M., Charlier, J., and Rinzler, A. G. (1999). Carbon nanotubes: from macromolecules to nanotechnology. Proc. Natl. Acad. Sci. 96, 14199-14200.
3. Ajayan, P. M., and Ebbesen, T. W. (1997). Nanometre-size tubes of carbon. Rep. Prog. Phys. 60, 1025-1062.
4. Arepalli, S., Nikolaev, P., Holmes, W., and Files, B. S. (2001). Production and measurements of individual single-wall nanotubes and small ropes of carbon. Appl. Phys. Lett. 78, 1610-1612.
5. Aranyi, C., Rajendran, N., and Bradof, J. (1992). Thirteen-week inhalation toxicity study with aerosol mixtures of fog oil and graphite particles in F344/N male rats. Prepared by IIT Research Institute, Chicago, for U.S. Army Medical Research and Development Command, Fort Detrick, MD.
6. Ball, P. (1999). Focus carbon nanotubes. Nature Scienceupdate. http://www.nature.com/nsu/991202/991202-1.html.
7. Ball, P. (2001). Roll-up for the revolution. Nature 414, 142-144. http://www.phys.washington.edu/~cobden/P600/Philip_Ball_tube_news.pdf.
8. Baron, P. A., Maynard, A. D., and Foley, M. (2003). Evaluation of aerosol release during the handling of unrefined single walled carbon nanotube material. NIOSH DART-02-191, National Institute of Occupational Safety and Health, Cincinnati, OH, NTIS PB2003-102401.
9. Bates, D. V., Fish, B. R., Hatch, T. F., Mercer, T. T., and Morrow, P. E. (1966). Deposition and retention models for internal dosimetry of the human respiratory tract. Health Phys. 12, 173-207.
10. Benson, J. M., Carpenter, R. L., Hahn, F. F., Haley, P. J., Hanson, R. L., Hobbs, C. H., Pickrell, J. A., and Dunnick, J. K. (1987). Comparative inhalation toxicity of nickel subsulfide to F344/N rats and B6C3F1 mice exposed for 12 days. Fundam. Appl. Toxicol. 9, 251-265.
11. Bronikowski, M. J., Willis, P. A., Colbert, D. T., Smith, K. A., and Smalley, R. E. (2001). Gas-phase production of carbon single-walled nanotubes from carbon monoxide via the HiPco process: A parametric study. J. Vac. Sci. Technol. A 19, 1800-1805.
12. CNI (2003). Buckytube MSDS. Carbon Nanotechnologies Incorporated. http://www.cnanotech.com/download_files/MSDS%20for%20CNI%20SWNT.pdf.
13. Charles River (1998). Rodent health monitoring summary. Charles River Laboratories, Wilmington, MA. http://www.criver.com/techdocs/healthmon-sum.html.
14. Driscoll, K. E., Costa, D. L., Hatch, G., Henderson, R., Oberdorster, G., Salem, H., and Schlesinger, R. B. (2000). Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: Uses and limitations. Toxicol. Sci. 55, 24-35.
15. Eden, K. G., and von Seebach, H. B. (1976). Atypical quartz dust-induced pneumoconiosis in SPF rats. Aspects of the role of the lymphatic system in the pathogenesis of silicosis. Virchows Arch. A Pathol. Anat. Histol. 372, 1-9.
16. Gaensler, E. A., Cadigan, J. B., Sasahara, A. A., Fox, E. O., and MacMahon, H. E. (1966). Graphite pneumoconiosis of electrotypers. Am. J. Med. 41, 864-882.
17. Gorman, J. (2002). Taming high-tech particles. Cautious steps into the nanotech future. Science News 161, 200. http://www.sciencenews.org/20020330/bob8.asp.
18. Hanoa, R. (1983). Graphite pneumoconiosis. A review of etiological and epidemiologic aspects. Scand. J. Work Environ. Health 9, 303-314.
19. ISI (2002). Nanotechnology. An interview with Dr. Richard Smalley. ISI Essential Science Indicators Special Topics, March 2002. http://www.esi-topics.com/nano/interviews/Richard-Smalley.html.
20. Jaffé, F. A. (1951). Graphite pneumoconiosis. Am. J. Pathol. 17, 909-923.
21. Lam, C.-W., James, J. T., Latch, J. N., Hamilton, R. F., and Holian, A. (2002a). Pulmonary toxicity of simulated lunar and Martian dusts in mice. II. Biomarkers of acute responses after intratracheal instillation. Inhal. Toxicol. 14, 917-928.
22. Lam, C.-W., James, J. T., McCluskey, R., Cowper, S., and Muro-Cacho, C. (2002b). Pulmonary toxicity of simulated lunar and Martian dusts in mice. I. Histopathology 7 and 90 days after intratracheal instillation. Inhal. Toxicol. 14, 901-916.
23. Leong, B. K., Coombs, J. K., Sabaitis, C. P., Rop, D. A., and Aaron, C. S. (1998). Quantitative morphometric analysis of pulmonary deposition of aerosol particles inhaled via intratracheal nebulization, intratracheal instillation or nose-only inhalation in rats. J. Appl. Toxicol. 18, 149-160.
24. Lippmann, M. (1994). Nature of exposure to chrysotile. Ann. Occup. Hyg. 38(4), 459-467.
25. Maynard, A. D., Baron, P. A., Foley, M., Shvedova, A. A, Kisin, E. R., and Castranova, V. (2003). Exposure to carbon nanotube material I: Aerosol release during the handling of unrefined single walled carbon nanotube material. J. Toxicol. Environ. Health (submitted).
26. McClellan, R. (1997). Nuisance dusts. In Toxicology of the Respiratory System (I. G. Sipes, C. A. McQueen, and A. J. Gandolfi, Eds.), Vol. 8. Elsevier Science, New York.
27. NIOSH/OSHA (1988). Synthetic graphite. National Institute for Occupational Safety and Health. http://www.cdc.gov/niosh/pel88/npelname.html. http://www.cdc.gov/niosh/pel88/SYNGRAPH.html
28. NRC (1999). Toxicity of Military Smokes and Obscurants. National Research Council Subcommittee on Military Smokes and Obscurants. National Academies Press, Washington, DC. http://books.nap.edu/books/0309063299/html/97.html.
29. NTP (1995). NTP Technical Report on Toxicity Studies of Cadmium Oxide (CAS No. 1306-19-0) Administered by Inhalation to F344/N Rats and B6C3F1 Mice. Toxicity Report Series No. 39. National Toxicology Program, National Institutes of Health, Research Triangle Park, NC.
30. Oberdorster, G. (2000). Determinants of the pathogenicity of man-made vitreous fibers (MMVF). Int. Arch. Occup. Environ. Health 73 (Suppl.), S60-S68.
31. Okutani, H., Shima, S., and Sano, T. (1964). Graphite pneumoconiosis in carbon electrode makers. In Proceedings of the XIV International Congress of Occupational Health, 1963, Madrid, Spain, pp. 626-632. Excerpta Medica Foundation, Amsterdam, the Netherlands.
32. Parent, R. A. (1992). Comparative Biology of the Normal Lung. CRC Press, Boca Raton, FL.
33. Reiser, K. M., Hesterberg, T. W., Haschek, W. M., and Last, J. A. (1982). Experimental silicosis. I. Acute effects of intratracheally instilled quartz on collagen metabolism and morphologic characteristics of rat lungs. Am. J. Pathol. 107, 176-185.
34. Rinzler, A. G., Liu, J., Dai, H., Nikolaev, P., Huffman, C. B., Rodriguez-Macias, F. J., Boul, P. J., Lu, A. H., Heymann, D., Colbert, D. T., et al. (1998). Large-scale purification of single-wall carbon nanotubes: Process, product, and characterization. Appl. Phys. A 67, 29-37.
35. Unrau, L. (1996). Associates carry research forward in form of nanotube. Rice News 6. http://www.rice.edu/projects/reno/rn/19961017/Carry.html, published online October 17, 1996.
36. Walters, D. A., Casavant, M. J., Qin, X. C., Huffman, C. B., Boul, P. J., Ericson, L. M., Haroz, E. H., O'Connell, M. J., Smith, K., Colbert, D. T., et al. (2001). In-plane-aligned membranes of carbon nanotubes. Chem. Phys. Lett. 338, 14-20.
37. Warheit, D. B., Hansen, J. F., and Hartsky, M. A. (1991). Physiological and pathophysiological pulmonary responses to inhaled nuisance-like or fibrogenic dusts. Anat. Rec. 231, 107-118.
38. Warheit, D. B., Laurence, B. R., Reed, K. L., Roach, D. H., Reynolds, G. A. M., and Webb, T. R. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol. Sci. 76, 117-125.
39. White House (2000). National Nanotechnology Initiative: Leading to the next industrial revolution. The White House, Office of the Press Secretary, Washington, DC. http://clinton4.nara.gov/textonly/WH/New/html/20000121_4.html.
40. Wilson, T., Scheuchenzuber, W. J., Eskew, M. L., and Zarkower, A. (1986). Comparative pathological aspects of chronic olivine and silica inhalation in mice. Environ. Res. 39, 331-344.