Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells

Environmental Health Perspectives

Volumn 113, Issue 11, 2005, Pages 1555-1560

  Geiser, Marianne ^a   Rothen Rutishauser, Barbara ^a   Kapp, Nadine ^a   Schürch, Samuel ^a,b   Kreyling, Wolfgang ^c   Schulz, Holger ^c   Semmler, Manuela ^c   Im Hof, Vinzenz ^d   Heyder, Joachim ^c   Gehr, Peter ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF CALGARY   (Canada)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

Aerosol; Erythrocytes; Lungs; Macrophages; Microscopy; Nanoparticles; Rats; Surfactant

Indexed keywords

CELL PROTEIN; DNA; MICROSPHERE; POLYSTYRENE; TITANIUM DIOXIDE;

AIRBORNE PARTICLE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELL CULTURE; CELL INTERACTION; CELL MEMBRANE; CELL ORGANELLE; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DIFFUSION; ENDOSOME; ENERGY; ERYTHROCYTE; EXPERIMENTAL DESIGN; EXPOSURE; FILTRATION; FLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; LUNG ALVEOLUS CELL; LUNG ALVEOLUS MACROPHAGE; LUNG CAPILLARY; LUNG MECHANICS; LUNG PARENCHYMA; LUNG TOXICITY; MALE; MICROANALYSIS; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY;

AEROSOLS; AIR POLLUTANTS; ANIMALS; CELLS, CULTURED; DUST; ERYTHROCYTES; HUMANS; LUNG; MACROPHAGES, ALVEOLAR; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSPHERES; PARTICLE SIZE; POLYSTYRENES; RATS; RATS, INBRED WKY; SWINE; TITANIUM;

ANIMALIA;

EID: 27744533436     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.8006     Document Type: Article

References (43)

1. Aarts DG, Schmidt M, Lekkerkerker HN. 2004. Direct visual observation of thermal capillary waves. Science 304:847-850.
2. Bresme F, Quirke N. 1999. Nanoparticulates at liquid/liquid interfaces. Phys Chem Chem Phys 1:2149-2155.
3. Brown JS, Zeman KL, Bennett WD. 2002. Ultrafine particle deposition and clearance in the healthy and obstructed lung. Am J Respir Crit Care Med 166:1240-1247.
4. Burri HP, Dbaly J, Weibel EW. 1973. The postnatal growth of the rat lung. I. Morphometry. Anat Rec 178:711-730.
5. Chen H, Langer R, Edwards DA. 1997. A film tension theory of phagocytosis. J Colloid Interface Sci 190:118-133.
6. Conhaim RL, Eaton A, Staub NC, Heath TD. 1988. Equivalent pore estimate for the alveolar-airway barrier in isolated dog lung. J Appl Physiol 64:1134-1142.
7. Conner SD, Schmid SL. 2003. Regulated portals of entry into the cell. Nature 422:36-44.
8. Donaldson K, Brown D, Clouter A, Duffin R, MacNee W, Renwick L, et al. 2002. The pulmonary toxicology of ultrafine particles. J Aerosol Med 15:213-220.
9. Ferin J, Oberdörster G, Penney DP. 1992. Pulmonary retention of ultrafine and fine particles in rats. Am J Respir Cell Mol Biol 6:535-542.
10. Gehr P, Schürch S, Berthiaume Y, Im Hof V, Geiser M. 1990. Particle retention in airways by surfactant. J Aerosol Med 3:27-43.
11. Geiser M, Schürch S, Gehr P. 2003. Influence of surface chemistry and topography of particles on their immersion into the lung's surface-lining layer. J Appl Physiol 94:1793-1801.
12. Geiser M, Schürch S, Im Hof V, Gehr P. 2000. Structural and interfacial aspects of particle retention. In: Particle-Lung Interaction, Vol 143 (Gehr P and Heyder J, eds). New York:Marcel Dekker Inc., 291-322.
13. Harder, V, Gilmour P, Lentner B, Karg E, Takenaka S, Ziesenis A, et al. 2005. Cardiovascular responses in unrestrained WKY rats to inhaled ultrafine carbon particles. Inhal Toxicol 17:29-42.
14. Hermans C, Bernard A. 1999. Lung epithelium-specific proteins: characteristics and potential applications as markers. Am J Respir Crit Care Med 159:646-678.
15. Im Hof V, Scheuch G, Geiser M, Gebhard J, Gehr P, Heyder J. 1989. Techniques for the determination of particle deposition in lungs of hamsters. J Aerosol Med 2:247-259.
16. Kapp N, Kreyling W, Im Hof V, Schulz H, Gehr P, Geiser M. 2004. Electron energy loss spectroscopy for analysis of inhaled ultrafine particles in rat lungs. Microsc Res Tech 63:298-305.
17. Kreyling WG, Semmler M, Erbe F, Mayer P, Takenaka S, Schulz H. 2002. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. J Toxicol Environ Health 65:1513-1530.
18. Kreyling WG, Tuch T, Peters A, Pitz M, Heinrich J, Stolzel M, et al. 2003. Diverging long-term trends in ambient urban particle mass and number concentrations associated with emission changes caused by the German unification. Atmos Environ 37:3841-3848.
19. Kruth HS, Chang J, Ifrim I, Zhang WY. 1999. Characterization of patocytosis: endocytosis into macrophage surface-connected compartments. Eur J Cell Biol 78:91-99.
20. Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, et al. 2003. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect 111:455-460.
21. Luther W. 2004. Industrial Applications of Nanomaterials - Chances and Risks. 2004. Technological Analysis, Vol 54. Düsseldorf, Germany:VDI Technologiezentrum GmbH.
22. Oberdörster G. 2004. Kinetics of inhaled ultrafine particles in the organism. In: Effects of Air Contaminants on the Respiratory Tract - Interpretations from Molecules to Meta Analysis (Heinrich U, ed). Stuttgart, Germany:Fraunhofer IRB Verlag, 121-143.
23. Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, et al. 2004. Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16:437-445.
24. Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, et al. 2002. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health A 65:1531-1543.
25. Panté N, Kann M. 2002. Nuclear pore complex is able to transport macromolecules with diameters of ∼ 39 nm. Mol Biol Cell 13:425-434.
26. Peters A, Wichmann HE, Tuch T, Heinrich J, Heyder J. 1997. Respiratory effects are associated with the number of ultrafine particles. Am J Respir Crit Care Med 155:1376-1383.
27. Pietropaoli AP, Frampton MW, Hyde RW, Morrow PE, Oberdörster G, Cox C, et al. 2004. Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles. Inhal Toxicol 16(suppl 1):59-72.
28. Pinkerton KE, Gehr P, Crapo JD. 1992. Architecture and cellular composition of the air-blood barrier. In: Comparative Biology of the Normal Lung, Vol I. Treatise on Pulmonary Toxicology (Parent RA, ed). Boca Raton, FL:CRC Press Inc., 121-144.
29. Rimai DS, Quesnel DJ, Busnaia AA. 2000. The adhesion of dry particles in the nanometer to micrometer -size range. Colloids Surf A Physicochem Eng Aspects 165:3-10.
30. Rothen-Rutishauser BM, Messerli MJ, van der Voort H, Günthert M, Wunderli-Allenspach H. 1998. Deconvolution combined with digital colocalization analysis to study the spatial distribution of tight and adherens junction proteins. J Comp Assist Microsc 10:103-111.
31. Samet JM, DeMarini DM, Malling HV. 2004. Biomedicine. Do airborne particles induce heritable mutations? Science 304:971-972.
32. Schulz H, Harder V, Ibald-Mulli A, Khandoga A, Koenig W, Krombach F, et al. 2005. Cardiovascular effects of fine and ultrafine particles. J Aerosol Med 18:1-24.
33. Schürch S, Gehr P, Im Hof V, Geiser M, Green F. 1990. Surfactant displaces particles toward the epithelium in airways and alveoli. Respir Physiol 80:17-32.
34. Schürch S, Geiser M, Lee MM, Gehr P. 1999. Particles at the airway interfaces of the lung. Colloids Surf B Biointerfaces 15:339-353.
35. Semmler M, Regula J, Oberdörster G, Heyder J, Kreyling WG. 2004a. Lung-lining fluid proteins bind to ultrafine insoluble particles: a potential way for particles to pass air-blood barrier of the lung? [Abstract]. Eur Respir J 24(suppl 48):100s.
36. Semmler M, Seitz J, Erbe F, Mayer P, Heyder J, Oberdörster G, et al. 2004b. Long-term clearance kinetics of inhaled ultrafine insoluble iridium particles from the rat lung including transient translocation into secondary organs. Inhal Toxicol 16:453-459.
37. Shanahan MER. 1990. Capillary movement of nearly axisymmetric sessile drops. J Phys D Appl Phys 23:321-327.
38. Stearns RC, Paulauskis JD, Godleski JJ. 2001. Endocytosis of ultrafine particles by A549 cells. Am J Respir Cell Mol Biol 24:108-115.
39. Templeton DM. 1994. Titanium. In: Handbook on Metals in Clinical and Analytical Chemistry (Seiler HG, Sigel A, Sigel H, eds). New York:Marcel Dekker, Inc., 627-630.
40. The Royal Society and The Academy of Engineering. 2004. Nanoscience and Nanotechnologies: Opportunities and Uncertainties. Available; http://www.nanotec.org.uk/finalReport.htm [accessed 13 September 2005].
41. Thiele L, Rothen-Rutishauser B, Jilek S, Wunderli-Allenspach H, Merkle HP, Walter E. 2001. Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does phagocytosis activity of dendritic cells measure up with macrophages? J Control Release 76:59-71.
42. Tschanz SA, Damke BM, Burri HP. 1995. Influence of postnatally administrated glucocorticoids on rat lung growth. Biol Neonate 68:229-245.
43. Tschanz SA, Makanya AN, Hänni B, Burri HP. 2003. Effects of neonatal high-dose short-term glucocorticoid treatment on the lung: a morphologic and morphometric study in the rat. Pediatr Res 53:72-80.