Long-circulating vectors for the systemic delivery of genes

Current Opinion in Molecular Therapeutics

Volumn 3, Issue 2, 2001, Pages 153-158

  Fenske, D B ^a   MacLachlan, I ^a   Cullis, P R ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Gene therapy; Lipoplexes; Lipopolyplexes; Liposomes; Polyplexes; Stabilized plasmid lipid particles; Systemic drug delivery

Indexed keywords

LIPOSOME; LUCIFERASE; PLASMID DNA; POLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; CIRCULATION; CONTROLLED STUDY; DNA VECTOR; ENCAPSULATION; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC STABILITY; HALF LIFE TIME; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; TUMOR;

ANIMALS; DNA; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC VECTORS; HUMANS; LIPID METABOLISM; LIPOSOMES; PLASMIDS; POLYMERS;

ANIMALIA;

EID: 0035028214     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Liposomal gene delivery: A complex package
2. Improved DNA: Liposome complexes for increased systemic delivery and gene expression
3. Systemic gene therapy: Blodistribution and long-term expression of a transgene in mice
4. In vivo gene transfer by intravenous administration of stable cationic lipid/DNA complex
5. Effect of albumin and polyanion on the structure of DNA complexes with polycation containing hydrophilic nonionic block
6. Effects of membrane-active agents in gene delivery
7. Optimization of gene transfer using cationic lipids in cell lines and primary human CD4+ and CD34+ hematopoietic cells
8. In vivo gene transfer via intravenous administration of cationic lipid-protamine-DNA (LPD) complexes
9. Stabilized plasmidlipid particles for systemic gene therapy
10. Synthetic virus systems for systemic gene therapy
11. Progress towards a synthetic virus for systemic gene therapy
12. Liposomal vincristine which exhibits increased drug retention and increased circulation longevity cures mice bearing P388 tumors
13. Identification of vesicle properties that enhance the antitumor activity of liposomal vincristine against murine L1210 leukemia
14. Sphingomyelin-cholesterol liposomes significantly enhance the pharmacokinetic and therapeutic properties of vincristine in murine and human tumour models
15. Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules
16. Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery
17. Steric stabilization of poly-L-Lysine/DNA complexes by the covalent attachment of semitelechelic poly[N-(2-hydroxypropyl)methacrylamide]
18. Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin
19. Comparison between cationic polymers and lipids in mediating systemic gene delivery to the lungs
20. In vivo targeted gene transfer into liver cells mediated by a novel galactosyl-D-lysine/D-serine copolymer
21. Hepatocyte-targeted in vivo gene expression by intravenous injection of plasmid DNA complexed with synthetic multi-functional gene delivery system
22. Polyinosinic acid and polycationic liposomes attenuate the hepatic clearance of circulating plasmid DNA
23. PEGylated DNA/transferrin-PEI complexes: Reduced Interaction with blood components, extended circulation in blood and potential for systemic gene delivery
24. Lipofection: A highly efficient, lipid-mediated DNA-transfection procedure
25. Characteristics and biodistribution of cationic liposomes and their DNA complexes
26. Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes
27. Co-polymer of histidine and lysine markedly enhances transfection efficiency of liposomes
28. Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: Implications for intravenous lipofection
29. Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery
30. Polycation liposomes, a novel non-viral gene transfer system, constructed from cetylated polyethylenimine
31. Stabilized plasmid-lipid particles: Construction and characterization
32. Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles
33. A novel N-acyl phosphatidylethanolamine-containing delivery vehicle for spermine-condensed plasmid DNA
34. Efficient encapsulation of DNA plasmids in small neutral liposomes induced by ethanol and calcium
35. Non-invasive gene targeting to the brain
36. Stabilized plasmid-lipid particles: A systemic gene therapy vector
37. Stabilized plasmid-lipid particles: Factors Influencing plasmid entrapment and transfection properties
38. Stabilized plasmid-lipid particles for regional gene therapy: Formulation and transfection properties
39. Encapsulation of plasmid DNA in stabilized plasmid-lipid particles composed of different cationic lipid concentration for optimal transfection activity
40. Poly(ethylene glycol) - Lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserine