Acute and subacute toxicity studies of chitosan reduced gold nanoparticles: A novel carrier for therapeutic agents

Journal of Biomedical Nanotechnology

Volumn 5, Issue 3, 2009, Pages 233-239

  Pokharkar, Varsha ^a   Dhar, Sheetal ^a   Bhumkar, Devika ^a   Mali, Vishal ^a   Bodhankar, Subhash ^a   Prasad, B L V ^b  

^a BHARATI VIDYAPEETH DEEMED UNIVERSITY   (India)

^b NATIONAL CHEMICAL LABORATORY   (India)

Author keywords

Acute toxicity; Chitosan; Gold nanoparticles; Sub acute toxicity; Wistar rats

Indexed keywords

ACUTE TOXICITY; BIOCHEMICAL ANALYSIS; BLOOD SAMPLES; BODY WEIGHT; CLINICAL SIGNS; DRUG DELIVERY APPLICATIONS; FEMALE RAT; FOOD CONSUMPTION; GOLD NANOPARTICLES; HAEMATOLOGY; HEMATOLOGICAL PARAMETERS; HISTOPATHOLOGICAL ANALYSIS; ORAL ADMINISTRATION; SUB-ACUTE TOXICITY; THERAPEUTIC AGENTS; THERAPEUTIC APPLICATION; WISTAR RATS;

ANIMALS; CHITIN; CHITOSAN; DRUG DELIVERY; FOOD SUPPLY; GOLD; NANOPARTICLES; RATS;

TOXICITY;

CHITOSAN; GOLD NANOPARTICLE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CHEMICAL ANALYSIS; CONTROLLED STUDY; FEMALE; FOOD INTAKE; HEMATOLOGY; HISTOPATHOLOGY; MALE; NONHUMAN; ORGAN WEIGHT; RAT; SEX DIFFERENCE;

ANIMALS; CHITOSAN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG TOXICITY; FEMALE; GOLD; LETHAL DOSE 50; MALE; MATERIALS TESTING; NANOPARTICLES; RATS; RATS, WISTAR; SURVIVAL RATE;

EID: 69249196803     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2009.1027     Document Type: Article

References (20)

1. Nanoscience and nanotechnologies: Opportunities and uncertainties, The royal society and the royal academy of engineering. Available online at http://www.nanotec.org.uk/report/Nano%20report% 202004%20fin.pdf (2004).
2. R. A. Freitas, Jr., What is nanomedicine, Nanomedicine: Nanotechnology, Biology and Medicine 1, 2 (2005).
3. P. K. Jain, I. H. El-Sayed, and M. A. El-Sayed, Au nanoparticles target cancer. Nanotoday 2, 18 (2007).
4. V. Kattumuri, K. Katti, S. Bhaskaran, E. J. Boote, S. W. Casteel, G. M. Fent, D. J. Robertson, M. Chandrasekhar, R. Kannan, and K. V. Katti, Gum arabic as a phytochemical construct for the stabilization of gold nanoparticles: In vivo pharmacokinetics and X-ray contrast imaging studies. Small 3, 333 (2007).
5. S. Shukla, A. Priscilla, M. Banerjee, R. R. Bhonde, J. Ghatak, P. V. Satyam, and M. Sastry, Porous gold nanosphere by controlled transmetalation reaction. A novel material for application in cell imaging. Chem Mater. 17, 5000 (2005).
6. L. Olofsson, T. Rindzevicius, I. Pfeiffer, M. Kall, and F. Hook, Surface based gold nanoparticle sensor for specific and quantitative DNA hybridization detection. Langmuir 19, 10414 (2003).
7. H. M. Joshi, D. R. Bhumkar, K. Joshi, V. Pokharkar, and M. Sastry, Gold nanoparticles as carriers for efficient transmucosal insulin delivery. Langmuir 22, 300 (2006).
8. J. D. Gibson, B. P. Khanal, and E. R. Zubarev, Paclitaxel-functionalized gold nanoparticles. J. Am. Chem. Soc. 129, 11653 (2007).
9. K. Donaldson, R. Aitken, L. Tran, V. Stone, R. Duffin, G. Forrest, and A. Alexander, Carbon nanotubes: A review of their properties in relation to pulmonary toxicology and workplace safety. Toxicol. Sci. 92, 5 (2006).
10. Nanotech safety-Hazards magazine issue 87, Dangers come in small particles [on line]. Available from URL: http://www.hazards.org/ nanotech/safety.htm (2006).
11. J. R. C. Smith, An electron microscopic study of injured and abnormally permeable lymphatics. Ann. New York Acad. Sci. 116, 803 (1964).
12. N. Hussain, V. Jaitley, and A. T. Florence, Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics. Adv. Drug Deliv. Rev. 50, 107 (2001).
13. S. Dhar, E. M. Reddy, A. Shiras, V. Pokharkar, and B. L. V. Prasad, Natural gum reduced/stabilized gold nanoparticles for drug delivery formulations. Chem. Eur. J. 14, 10244 (2008).
14. J. F. Hillyer and R. M. Albrecht, Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles. J. Pharm. Sci. 90, 1927 (2001).
15. D. R. Bhumkar, H. M. Joshi, M. Sastry, and V. B. Pokharkar, Chitosan reduced gold nanoparticles as novel carriers for transmucosal delivery of insulin. Pharm. Res. 24, 1415 (2007).
16. OECD guidelines for the testing of chemicals. Test guideline number 425. Acute oral toxicity study. Organisation for Economic Co-operation and Development, Paris (2001).
17. OECD guidelines for the testing of chemicals. Test guideline number 407. Repeated dose 28-day oral toxicity in rodents. Organisation for Economic Co-operation and Development, Paris (2001).
18. R. Shukla, V. Bansal, M. Chaudhary, A. Basu, R. R. Bhonde, and M. Sastry, Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: A microscopic overview. Langmuir 21, 10644 (2005).
19. E. E. Connor, J. Mwamuka, A. Gole, C. J. Murphy, and M. D. Wyatt, Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small 1, 325 (2005).
20. Committee for the purpose of control and supervision on experiments on animals, CPCSEA guidelines for laboratory animal facility. Annexure I and II. Page 21-22, Available online at http://envfor. nic.in/divisions/awd/cpcsea- laboratory.pdf (2001).