Tissue distribution of 20 nm, 100 nm and 1000 nm fluorescent polystyrene latex nanospheres following acute systemic or acute and repeat airway exposure in the rat

Toxicology

Volumn 263, Issue 2-3, 2009, Pages 117-126

  Sarlo, Katherine ^a   Blackburn, Karen L ^a   Clark, Edwin D ^b   Grothaus, Jeff ^a   Chaney, Joel ^a   Neu, Suzanne ^c   Flood, Janine ^a   Abbott, Dana ^a   Bohne, Clarence ^a   Casey, Keith ^a   Fryer, Charles ^a   Kuhn, Mike ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

^b Essential Immunotox Services   (United States)

^c VetPathServices   (United States)

Author keywords

Nanoparticles; Tissue distribution; Toxicokinetics

Indexed keywords

NANOSPHERE; POLYSTYRENE;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPIRATION; BLOOD ANALYSIS; BONE MARROW; BRAIN TISSUE; CONTROLLED STUDY; EXPOSURE; EYE; FECES; FEMALE; HEART; HISTOPATHOLOGY; INTESTINE; KIDNEY PARENCHYMA; LIVER PARENCHYMA; LUNG PARENCHYMA; MUSCLE TISSUE; NONHUMAN; OVARY; PARTICLE SIZE; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; SKIN; SPLEEN; TARGET ORGAN; THYMUS; TISSUE DISTRIBUTION; TONGUE; TOXICOKINETICS; URINALYSIS; UTERUS;

ADMINISTRATION, INHALATION; ADMINISTRATION, ORAL; ANIMALS; FECES; FEMALE; GUIDELINES AS TOPIC; HALF-LIFE; INHALATION EXPOSURE; INJECTIONS, INTRAVENOUS; LIVER; LUNG; NANOSPHERES; PARTICLE SIZE; POLYSTYRENES; RANDOM ALLOCATION; RATS; RATS, INBRED F344; SPLEEN; THYMUS GLAND; TISSUE DISTRIBUTION;

RATTUS;

EID: 68549095935     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.07.002     Document Type: Article

References (23)

1. Absher M.P., Hemenway D.R., Leslie K.O., Trombley L., and Vacek P. Intrathoracic distribution and transport of aerosolized silica in the rat. Exp. Lung Res. 18 (1992) 743-757
2. Avital A., Shapiro E., Dovinar V., Sherman Y., Margel S., Tsuberi M., and Springer C. Polystyrene microspheres as a specific marker for the diagnosis of aspiration in hamsters. Am. J. Respir. Cell. Mol. Biol. 27 (2002) 511-514
3. Brown D.M., Wilson M.R., MacNee E., Stone V., and Donaldson K. Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultra fines. Toxicol. Appl. Pharm. 175 (2001) 191-199
4. ® (F-344) CrlBR as a Function of Sex and Age (1984). www.criver.com/techdocs/84jan_tb
5. Eggli P., Schaffner T., Gerber H.A., Hess M.W., and Cottier H. Accessibility of thymic cortical lymphocytes to particles translocated from the peritoneal cavity to parathymic lymph nodes. Thymus 8 (1986) 129-139
6. Fabian E., Landseidel R., Ma-Hock L., Wiench K., Wohlleben W., and vanRazenzwaay B. Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats. Arch. Toxicol. (2007) 10.1007/s00204-007-0253-y
7. Fischer H.C., Liu L., Pang S., and Chan W.C.W. Pharmacokinetics of nanoscale quantum dots: in vivo distribution, sequestration and clearance in the rat. Adv. Funct. Mater. 16 (2006) 1299-1305
8. Gratton S.E.A., Pohlhaus P.D., Lee J., Gua J., Cho M.J., and DeSimone J.M. Nanofabricated particles for engineered drug therapies; a preliminary biodistribution study of PRINT nanoparticles. J. Control. Release 121 (2007) 10-18
9. Jain T.K., Reddy M.K., Morales M.A., Leslie-Pelecky D., and Labhasetwar V. Biodistribution, clearance and biocompatibility of iron oxide magnetic nanoparticles in rats. Mol. Pharma. (2008) 10.1021/mp7001285
10. Kearns P., Gonzalez M., Oki N., Lee K., and Rodriguez F. The Safety of Nanotechnologies at the OECD in Nanomaterials (2009), Risks and Benefits, Springer, Netherlands pp. 351-358
11. Kim J.S., Yoon T.J., Yu K.N., Kim B.G., Park S.J., Kim H.W., Lee K.H., Park S.B., Lee J.K., and Cho M.Y. Toxicity and tissue distribution of magnetic nanoparticles in mice. Toxicol. Sci. 89 (2006) 338-347
12. Kreyling W.G., Semmler M., Erbe F., Mayer P., Takenaka S., Schulz H., Oberdorster G., and Ziesenis A. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. J. Toxicol. Environ. Health 65 (2002) 1513-1530
13. Ma H.L., Xu Y.F., Qi X.R., Maitani Y., and Nagai T. Superparamagnetic iron oxide nanoparticles stabilized by alginate: pharmacokinetics, tissue distribution and applications in detecting liver cancers. Int. J. Pharm. 354 (2008) 217-226
14. Nemmar A., Vanbilloen H., Hoylaerts M.F., Hoet P.H., Verbruggen A., and Nemery B. Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation of hamsters. Am. J. Respir. Crit. Care Med. 164 (2001) 1665-1668
15. Niwa Y., Hiura Y., Sawamura H., and Iwai N. Inhalation exposure to carbon black induces inflammatory response in rats. Circ. J. 72 (2008) 144-149
16. Oberdorster G., Sharp Z., Atudorei V., Elder A., Gelein R., Lunts A., Kreyling W., and Cox C. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J. Toxicol. Environ. Health 65 (2002) 1531-1543
17. Oberdorster G., Oberdorster E., and Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 113 (2005) 823-839
18. Rolland A., Collet B., Leverage R., and Toujas L. Blood clearance and organ distribution of intravenously administered polymethyacrylic nanoparticles in mice. J. Pharm. Sci. 78 (1989) 481-484
19. Simon B.H., Ando H.Y., and Gupta P.K. Circulation time and body distribution of 14C-labeled amino-modified polystyrene nanoparticles in mice. J. Pharm. Sci. 84 (1995) 1249-1253
20. Stradling G.N., Ham G.J., Smith H., Cooper J., and Breadmore S.E. Factors affecting the mobility of plutonium-238 dioxide in the rat. Int. J. Rad. Biol. 34 (1978) 37-47
21. Takenaka S., Karg E., Roth C., Schulz H., Ziessenis A., Heinzmann U., Schramel P., and Heyder J. Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats. Environ. Health Perspect. 109 (2001) 651-657
22. Takenaka S., Karg E., Kreyling W.G., Lenter B., Moller W., Jennen L., Walch A., Michalke B., Schramel P., Heyder J., and Schultzer H. Distribution pattern of inhaled ultra-fine gold particles in the rat lung. Inhal. Toxicol. 18 (2006) 733-740
23. Weibert P., Crespo A., Falk R., Philipson K., Lundin A., Larsson S., Moller W., Kreyling W., and Svartengren M. No significant translocation of inhaled 35 nm carbon particles to the circulation of humans. Inhal. Toxicol. 18 (2006) 741-747